Articles tagged with Colorectal Cancer
The US Multisociety Task Force on Colorectal Cancer recommends genetic evaluation and personalized surveillance plans for patients with hamartomatous polyps. Genetic testing is critical in cancer prevention, allowing for tailored cancer surveillance to prevent progression and save lives.
Researchers at Texas A&M University developed a low-cost, minimally invasive wireless device that uses photodynamic therapy to kill cancer cells. The device enables precise and safe treatment options during surgery, potentially reducing the need for additional treatments like chemotherapy.
A study published in Gastroenterology found that artificial intelligence reduced the rate of missed precancerous polyps in colorectal cancer screening by twofold compared to standard colonoscopy. The AI detection method identified smaller, flatter polyps and improved false negative rates.
Researchers identified rural Georgia counties with high mortality rates from breast, prostate, colorectal, and lung cancer. These hotspots were concentrated in the eastern Piedmont to southern Coastal Plain regions, as well as southwestern and northern rural areas.
Researchers used mathematical modeling to characterize the interplay between immune suppression, immune blockade and antigenicity in pre-cancerous cells. They found that an immunosuppressive environment is crucial for colorectal cancer progression.
Researchers found that modeling studies have been assuming colonoscopies are more accurate than they really are, detecting fewer small adenomas. However, colonoscopy still appears effective in finding precursors of cancer.
A clinical trial reveals that lamivudine, a widely used HIV treatment, halted disease progression in 28% of patients with fourth-line metastatic colorectal cancer. The study suggests an unexpected promising direction for cancer treatment and encourages the exploration of pairing reverse transcriptase inhibitor therapy with immunotherapy.
The study reveals a narrowing gap between cancer profiles in China and the USA, with converging trends in lung, breast, and colorectal cancers. China's cancer burden is expected to rise, while the US has seen reduced rates since the 1990s due to effective prevention strategies.
A machine-learning algorithm detected potential signs of colorectal cancer in high-risk patients who missed routine screenings. The algorithm identified patients as high-risk by analyzing age, gender, and recent CBC results, and subsequent screenings showed significant findings in 70% of the flagged group.
Researchers develop innovative non-contact agitation technology to assess motility and invasive capacity of cancer cells in tissue sections. The study reveals significant increases in Rac/Cdc42 activity in tumor areas, with stronger correlations found in advanced cancer stages.
A University of Illinois review examines how food deserts, poor diet, and racial disparities affect bile acids, gut microbes, and cancer incidence. The study suggests that Western diets contribute to the development of colorectal cancer, particularly among Black Americans.
A new study finds that clinics supporting patients throughout the entire FIT process improve return rates and reduce colorectal cancer-related illness. Additionally, a telephone survey for dementia detection shows promise as a low-cost diagnostic tool, especially in primary care settings.
A new study found that clinics with higher FIT completion rates had added staff to support patients, provided educational materials, and offered on-call support. This approach reduced disparities among low-income and racially diverse populations, improving colorectal cancer screening outcomes.
Researchers have created a new type of colon tattoo ink that is more biocompatible and less prone to diffusion than existing inks. The ink uses metal-derived nanoparticles and polymers to adhere to the submucosal surface in the colon, allowing for better identification and removal of complex polyps and tumors.
A new study reveals that the COVID-19 pandemic has led to significant declines in cancer screening rates across the US, particularly for colorectal, cervical, breast, and lung cancers. The American Cancer Society's National Consortium has announced nine recommendations to increase cancer screening rates and improve quality care.
A study of 5,635 individuals with colorectal cancer and 4,515 controls found that living with overweight or obesity for more years increases the risk of developing colorectal cancer. The findings suggest that weight management may be crucial in preventing this type of cancer.
Researchers have discovered that cancer cells carrying a common mutation accumulate large amounts of ferrous iron, which can be exploited to deliver powerful anticancer drugs. The therapeutic strategy could treat various cancers driven by KRAS mutations.
A new study found that nearly one-third of older adult female survivors of colorectal, endometrial, and ovarian cancer experience quality-of-life-impacting challenges with physical activity due to chronic lower extremity lymphedema. The researchers urge the medical community to include regular lymphedema assessments in survivorship care.
A recent study by City of Hope researchers highlights the limitations of Signatera, a popular liquid biopsy test for detecting colorectal cancer recurrence. The study found that standard-of-care CT scan plus CEA blood draw test was more effective in identifying early disease recurrence.
A new fluorescent DNA label has been developed to visualize disrupted DNA architecture in cancer cells, with promising results for improved cancer diagnoses and risk stratification. The study showed that the label can distinguish normal tissue from precancerous and cancerous lesions.
A meta-analysis of 280,660 cases of colorectal cancer and 14,139 cases of adenoma found that taller individuals have a higher risk of developing colorectal cancer and precancerous colon polyps. The study suggests that adults over 4 inches (10 cm) above the average U.S. height may be at increased risk.
Researchers created implantable beads that produce high concentrations of interleukin-2, a natural compound activating white blood cells to fight cancer. The treatment eradicated ovarian and colorectal cancer in mice within six days, paving the way for human clinical trials later this year.
Scientists have discovered a new therapeutic approach to aid the immune system in fighting cancer, offering hope for better solutions for patients. Researchers found that blocking the EP4 molecule can 'free' the immune system and restore its cancer-fighting functions.
A regionwide, structured colorectal cancer screening program eliminated disparities in colorectal cancer death rates between Black and white Kaiser Permanente members. Organized screening outreach markedly increased screening rates and led to significant decreases in incidence and death rates.
A recent review highlights the effects of different intestinal bacteria on colorectal cancer, exploring new therapies for disease prevention and treatment. Beneficial probiotics, such as Akkermansia muciniphila and Lactobacillus rhamnosus GG, exhibit anticancer properties and reduce CRC cell proliferation.
A new study highlights alternative treatment options that consider a patient's likelihood of recovery and quality of life. Total Definitive Treatment (TDT) is an approach that combines chemotherapy, radiation therapy, and close monitoring to potentially cure patients without surgery.
A recent study published in JAMA Network Open found that the COVID-19 pandemic led to fewer early-stage and more late-stage breast cancer diagnoses. Researchers at UC San Diego Health surveyed patients with breast and colorectal cancers in 2019 and 2020, finding a significant increase in stage IV diagnoses.
Researchers compared early- and late-stage breast and colorectal cancer diagnoses before and during the pandemic at a California cancer center. The study found significant changes in diagnosis stages during the pandemic.
New studies from Michigan Medicine researchers aim to remove financial barriers for patients who receive abnormal test results, enabling them to complete the diagnostic process. The findings suggest that removing cost barriers could save lives by increasing screening uptake, particularly among women and underserved populations.
Researchers have developed a new therapeutic approach to block mutated RAS proteins, which are frequently found in cancers. The method, using small molecules, has the potential to work with multiple mutant forms of RAS in various types of cancers, including pancreatic, lung, and colorectal cancers.
Researchers discover that chemotherapy triggers the secretion of mucins in colorectal cancer cells, forming a physical barrier that prevents drugs from reaching their intended target. The study found potential new biomarkers for disease prognosis and a promising treatment strategy using NCX blockers like SN-6.
A culturally tailored patient navigation program improved the rate of colorectal cancer screening among Hispanic adults, reducing historical gender disparities. The program's colonoscopy completion rate was 85%, with no difference between males and females.
A new study finds that weight loss is associated with a 46% reduced risk of developing colorectal adenoma. Adults who are initially overweight or obese may be able to reduce their risk by losing weight, while weight gain increases the chance of developing adenoma.
A new polygenic risk score is made from genetic variants and lifestyle factors to identify younger adults at risk of colorectal cancer. The study found those with the highest risk scores were four times more likely to develop colorectal cancers than those with lower scores.
USC researchers will use $18.5 million funding to study colorectal cancer in Hispanic patients, aiming to close the gap in understanding the disease and developing effective treatments. The project aims to improve patient engagement in genomic research and develop culturally relevant educational materials.
A study analyzing US SEER data from 2000-2016 found that younger age groups experienced the steepest increase in distant-stage early-onset colorectal adenocarcinoma incidence. Younger non-Hispanic Black and Hispanic populations showed greater proportions of distant-stage disease.
Researchers outline a comprehensive framework to tackle early-onset colorectal cancer, addressing epidemiology, molecular landscape, and treatment options. The framework emphasizes the need for tailored support, including peer support, educational counseling, and financial guidance.
Ovarian cancer death rates are predicted to decrease by 17% in the UK and 7% in EU countries in 2022. The main contributor is the long-term use of oral contraceptives, reducing the risk by 40%. Other factors include improved diagnosis, treatment, and advancements in treatments for other cancers.
Researchers discovered a bacterial toxin that can accelerate colon cancer in mice, sharing similarities with human tumors. The study's findings suggest a potential link between transient food poisoning and colorectal cancer development, highlighting the need for further epidemiological studies.
Researchers have revealed mechanisms by which polyps develop into colorectal cancer, setting the stage for improved surveillance utilizing precision medicine. The study found that serrated polyps derive from metaplasia, an abnormal change of cells into non-native tissue.
A Phase 2 clinical trial showed sotorasib can shrink tumors and achieve disease control in heavily pretreated patients with advanced colorectal cancer. The study results exceeded the historic benefits linked to approved therapies, offering new hope for a population with limited treatment options.
A study found that primary care clinicians prefer noninvasive options for patients who are unwilling to undergo invasive procedures, concerned about work time, or unconvinced of the need for screening. The researchers suggest tailoring recommendations to patient preferences to improve adherence to colorectal cancer screening.
Researchers have discovered that a common class of targeted therapies can help more colorectal cancer patients than previously thought. By analyzing cell studies and computer modeling, the team identified 10 distinct RAS mutations that do not preclude the use of EGFR inhibitors, which are already approved for other uses.
A study found that rural women are less likely to get screened for colorectal cancer compared to urban counterparts, despite similar breast cancer screening rates. The disparity may be attributed to limited access to testing and financial constraints, highlighting the need for targeted public health interventions.
A new study found that bowel cancer patients are at high risk of clinical levels of depression, with over a third experiencing symptoms up to five years after surgery. The study identified risk factors such as pre-existing depression and anxiety, low social support, and poor health.
A new AI model has been developed to classify colorectal polyps, demonstrating accuracy and sensitivity at a level comparable to practicing pathologists. The model was tested in a clinical trial involving 15 pathologists, showing significant improvements in accuracy compared to traditional methods.
This study reveals cellular composition changes in colon organoids exposed to smoking and red/processed meat carcinogens, suggesting an overlap between inherited and environmental CRC risk. The findings provide novel insights into CRC etiology and reveal potential avenues for future research.
A recent study found that Black patients in the US between 40-49 years old have lower incidence rates of colorectal cancer compared to their white counterparts. Rectal cancer rates were also significantly lower among Black individuals, highlighting a disparity in disease prevalence.
Flexible sigmoidoscopy screening significantly reduces colorectal cancer incidence and mortality, with a substantial protective effect maintained up to 19 years. The study's findings confirm the safety and effectiveness of flexible sigmoidoscopy as a preventive measure.
A team of scientists developed a drug-like molecule that can counteract the effects of mutated epigenetic regulators, which are known to drive certain types of cancer. The molecule targets the 'reader' CBX8, which is critical for the proliferation of cancer cells, but more dispensable in healthy cells.
A new study by Dana-Farber Cancer Institute found that younger patients with metastatic colorectal cancer have a similar overall survival time as older patients, defying expectations. The study included data from the CALGB/SWOG 80405 clinical trial and compared survival times in 514 younger patients under 50 with 1,812 older patients.
Researchers developed two model systems to study peritoneal metastases from colorectal cancer patients. Biomarkers were identified, including severe mutations of the BRCA2 gene, which predict therapy response. These findings offer new hope for treating advanced cases.
A survey of adults shows low colonoscopy rates during the pandemic, but home-based fecal occult blood testing increased by 30% among respondents. The study highlights the need for tailored screening options to address patient concerns and improve colorectal cancer screening rates.
A study published in Oncotarget identified four genetic variants linked to an increased risk of sporadic colorectal adenocarcinoma in the Kazakhstani population. The findings suggest that these variants, including rs10506868, may contribute to CRC development and highlight the importance of understanding genetic factors in this disease.
New research reveals that boosting numbers of immune cells called dendritic cells may be key to overcoming colorectal cancers' immunotherapy resistance. By augmenting dendritic cells in liver metastases, treatment led to increased cytotoxic T lymphocytes and made tumors sensitive to immune checkpoint inhibitors.
Researchers have discovered a way to bring cancer-killing T cells to bear against a specific type of colorectal cancer, showing promising results. The findings may represent a therapeutic strategy to target other types of cancers, and the next step is to further explore how T cells become activated in the tumor environment.
A peptide-drug conjugate called CBX-12 has been shown to enhance the efficacy of immune checkpoint inhibitors in preclinical cancer models by targeting the acidic environment of cancer cells. The treatment exhibited significantly delayed tumor growth, improved survival, and complete tumor regressions compared to immunotherapy alone.
A new study reveals a small molecule, RGX-202, that targets and prevents metastasis in colorectal cancer by blocking the uptake of phosphocreatine into cancer cells. The findings have led to a clinical trial in humans and may eventually increase survival rates for multiple gastrointestinal cancers.
Researchers developed novel scoring tools to predict colon cancer risk in average-risk individuals, especially useful in low-screening countries. The tools consider factors like age, smoking history, and aspirin use to determine personalized risk.
A recent study found that colorectal cancer diagnoses fell dramatically by 40% in a year during the COVID-19 pandemic. This decline was attributed to the suspension of screening programs and postponed non-urgent colonoscopy investigations.