Articles tagged with Fatty Liver Disease
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A new study published in JAMA found that neither vitamin E nor the diabetes drug metformin successfully reduced liver enzymes in children and teens with nonalcoholic fatty liver disease. However, a biopsy of the liver showed improvement in injury pattern with vitamin E therapy in patients with severe fatty liver disease. The study high...
A study funded by NIH found that vitamin E improved the most severe form of fatty liver disease in children, reversing NASH in at least half. The treatment showed significant reductions in liver cell death and improvements in liver enzyme levels.
A randomized controlled trial found that vitamin E and metformin did not demonstrate significant efficacy in reducing liver disease severity or improving insulin resistance in children. The study suggests that lifestyle modification is crucial, while further research into non-invasive markers is warranted.
Daily walks increase insulin sensitivity, improve liver health marker PUI, and boost hormone adiponectin levels, linked to fat-burning effects. The study suggests exercise as a medicine for managing non-alcoholic fatty liver disease.
Researchers found that walking for one hour a day improved insulin sensitivity, increased adiponectin levels, and reduced oxidative damage in obese individuals with prediabetes. This exercise regimen may help slow the progression of nonalcoholic fatty liver disease.
A new study has identified a molecular switch, TBL1, that appears to be a common feature in the development of fatty liver disease. The discovery is consistent with data from human patients and suggests an underlying explanation for the condition.
New data show that NAFLD prevalence in the US is expected to increase by 50% by 2030, driven by rising obesity and diabetes rates. The condition can progress to advanced liver disease, significantly impacting mortality rates.
Researchers discovered new genetic variants affecting nonalcoholic fatty liver disease (NAFLD), which may help doctors diagnose and treat the condition more effectively. The study found that approximately one quarter of NAFLD variation is influenced by genetics, with potential applications for clinical algorithms and novel therapeutics.
UCSF researchers have discovered a crucial hormone pathway that contributes to the development of fatty liver disease. By disrupting this pathway, they found that fat accumulation in the liver can occur even without alcohol consumption. The study's findings may lead to the development of new therapeutic drugs targeting this pathway.
A study by St. Michael's Hospital researchers found that people with fatty liver disease are three times more likely to suffer a stroke than those without the condition. High levels of liver enzymes were also found in adults who had an acute stroke, suggesting a potential link between the two.
Researchers at Mayo Clinic have found that mortality rates from liver diseases are underestimated, with the condition ranking as high as fourth for certain age groups. The study analyzed data from 1979-2006 and found a significant correlation between national statistics and local mortality data.
Research finds pentoxifylline improves NASH, reducing fat and inflammation; vitamin E also shows promise in improving liver histology independently of insulin resistance. Studies suggest new treatment options for overweight individuals with liver disease.
Researchers found a strong association between obesity and an increased risk of liver cancer, as well as adenoma recurrence in patients with colorectal polyps. Additionally, studies revealed that inflammatory bowel disease is an independent risk factor for coronary artery disease.
A new mouse model has revealed that a diet high in fructose and trans fats can lead to fatty liver disease with scar tissue. The study also identified potential biomarkers for early detection and suggests therapeutic interventions may reverse or protect against progressive liver damage.
New research presents findings on non-alcoholic fatty liver disease (NAFLD), showing it significantly affects transplant outcomes and highlighting alternative diagnostic methods. A scoring system, known as the NAFLD fibrosis score, also predicts poor outcomes in patients with NAFLD.
Recent studies suggest that cigarette smoking and high fructose corn syrup consumption exacerbate nonalcoholic fatty liver disease (NAFLD) in overweight individuals. Modifying these risk factors may improve patient outcomes for those with NAFLD, who are at risk of disease progression.
Patients with non-alcoholic fatty liver disease (NAFLD) have a higher overall mortality rate compared to the general population. The study found that cardiovascular disease and extra-hepatic malignancies were the primary causes of death among NAFLD patients.
Researchers confirm accuracy of transient elastography for diagnosing nonalcoholic fatty liver disease (NAFLD) and excluding advanced fibrosis. The study found TE to be superior to other non-invasive tests in detecting advanced fibrosis, with the potential to spare two-thirds of NAFLD patients from liver biopsies.
A recent metobolomics study found that impaired peroxisomal oxidation of polyunsaturated fatty acids is associated with progression to NASH. The study also revealed significantly higher plasma monounsaturated fatty acids in patients with NAFL and NASH.
Research finds incidental NAFLD associated with higher c-IMT and carotid plaque prevalence in outpatients. Patients with NAFLD have an increased relative risk of developing carotid plaques, highlighting the importance of metabolic risk assessment.
Researchers at the University of Southampton discovered a link between a mother's high-fat diet during pregnancy and her child's development of fatty liver disease. The study found that a high-fat diet can affect the developing liver of a fetus, making it more susceptible to fatty liver disease later in life.
Researchers at UC Riverside found that second-hand cigarette smoke exposure can lead to fat accumulation in liver cells, causing nonalcoholic fatty liver disease (NAFLD). The study highlights the potential for targeting molecular regulators SREBP and AMPK to develop new treatments for NAFLD.
A new study found that exercise counseling leads to significant improvements in physical activity, fitness, and liver health in patients with nonalcoholic fatty liver disease. Patients who increased their physical activity had better metabolic indices, including lower liver enzymes and improved insulin resistance.
Recent research found that Tribble 3 can block the insulin signaling pathway, contributing to insulin resistance and NAFLD. The study provides an experimental basis for future studies on the role of TRB3 in NAFLD.
Researchers presented two groundbreaking studies at DDW 2009: a text messaging system improved medication adherence in pediatric liver transplant recipients, reducing organ rejection and costs. A new non-invasive breath test accurately predicts long-term prognosis for patients with chronic liver disease.
Research reveals a strong association between nonalcoholic fatty liver disease (NAFLD) and both increased intestinal permeability and bacterial overgrowth in the small intestine. The study suggests that these factors contribute to the severity of steatosis, but not to more severe liver diseases like steatohepatitis or fibrosis.
A new non-invasive diagnostic index, the Pediatric NAFLD Fibrosis Index (PNFI), uses age, waist circumference, and triglycerides to predict liver fibrosis in children with non-alcoholic fatty liver disease (NAFLD). This index may help reduce the need for invasive biopsies, improving patient comfort and outcomes.
Research connects poor fitness to non-alcoholic fatty liver disease (NAFLD), highlighting a crucial link between obesity-related illnesses. Exercise may potentially treat or prevent NAFLD by protecting against metabolic diseases.
Researchers at UT Southwestern Medical Center found that African-Americans tend to store fat in subcutaneous adipose tissues, which may protect them from insulin resistance and non-alcoholic fatty liver disease. This fundamental difference in lipid metabolism could lead to targeted therapies for populations prone to NAFLD.
A study found that a mother's high-fat diet during pregnancy can increase the risk of obesity-related diseases in her offspring. Reverting to a low-fat diet after a high-fat diet period reduced these risks.
A University of Iowa researcher and colleagues have discovered a direct link between cellular stress and fatty liver disease in mice. The study found that disrupted protein folding causes abnormal fat metabolism in the liver, which may lead to serious conditions like diabetes and cirrhosis.
New research suggests that excess liver fat is a key contributor to metabolic problems, including high blood pressure and cardiovascular disease. The study found that children with fatty liver disease had abnormalities in glucose and fat metabolism, including lower levels of HDL cholesterol.
A recent study found that bariatric surgery leads to improvement of histopathological features of nonalcoholic fatty liver disease (NAFLD) in most patients. The risk of progression of inflammatory changes and fibrosis is minimal, with complete resolution of NAFLD reported in a majority of patients.
A new study found that exercise can prevent fatty liver disease, with obese individuals at high risk. The researchers discovered that a sudden transition to a sedentary lifestyle can lead to symptoms of nonalcoholic fatty liver disease.
Researchers found a specific form of the PNPLA3 gene linked to higher liver-fat content and increased risk of liver inflammation. Hispanics are more likely to carry this gene variant than African-Americans and Caucasians, highlighting a genetic explanation for ethnic disparities in fatty liver disease.
A study found that nonalcoholic fatty liver disease (NAFLD) patients with normal alanine aminotransferase (ALT) levels have advanced fibrosis, indicating the need for liver biopsy. The researchers discovered that patients with normal ALT had milder inflammation and steatosis, but still at risk of severe hepatic disease.
A new study by the American Heart Association found that fatty liver disease in overweight and obese children is associated with higher levels of cardiovascular risk factors, including fasting glucose, cholesterol, and blood pressure. The research suggests that fat accumulation in the liver may play a more important role than obesity i...
A study found that non-alcoholic fatty liver disease (NAFLD) is linked to an increased risk of chronic kidney disease (CKD) in type 2 diabetes patients. NAFLD was associated with a 69% higher risk of CKD compared to those without the condition.
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of persistently elevated serum ALT levels among Iranians, associated with obesity, insulin resistance, and urban lifestyle. NAFLD also increases the risk of type 2 diabetes mellitus by up to 2 folds.
A recent study published in World Journal of Gastroenterology suggests that short-term lifestyle intervention is more effective than vitamin E capsule therapy in managing non-alcoholic fatty liver disease (NAFLD) in Chinese obese children. The researchers recommend lifestyle modification as the first step in treating NAFLD, citing its ...
New studies validate non-invasive methods for diagnosing liver fibrosis and cirrhosis, with enhanced panels showing good diagnostic accuracy and simple markers augmenting performance, offering potential for eliminating the need for liver biopsy in over 80% of cases.
A mouse study suggests that high-glycemic index diets can cause fatty liver disease, while low-glycemic index diets may prevent it. Researchers plan a clinical trial to confirm the findings and explore reversing the condition in overweight children.
Researchers introduce novel methods for evaluating patients with non-alcoholic fatty liver disease (NAFLD), including a blood test to determine caspase three-generated cytokeratin 18 fragment levels. These tests may help differentiate NASH from simple steatosis and predict treatment outcomes, potentially improving patient care.
Researchers developed a non-invasive method to predict advanced fibrosis in patients with nonalcoholic fatty liver disease (NAFLD) using routine clinical and laboratory values. The study found that age, hyperglycemia, body mass index, platelet count, albumin, and AST/ALT ratio were independent indicators of advanced liver fibrosis.
A study found that patients with NAFLD have a significant risk of developing end-stage liver disease, cardiovascular complications, and diabetes. Lifestyle modifications are recommended to reduce the risk of type 2 diabetes and improve liver histology.
A study found that 13% of children and adolescents with autopsy records had fatty liver, while 9.6% of the living population in San Diego County had the disease. The team identified major risk factors, including age, ethnicity, gender, and obesity.
A study found that cholesterol accumulation in the liver depletes a powerful antioxidant, making cells susceptible to inflammation and damage. Cholesterol-lowering therapies may offer a useful treatment for nonalcoholic steatohepatitis (NASH) and fatty liver disease.
A simple blood test can indicate the presence of non-alcoholic steatohepatitis by measuring caspase 3-generated cytokeratin-18 fragments. This test has shown high sensitivity and specificity in differentiating NASH from non-NASH in patients with suspected NAFLD.
Researchers found patients with NAFLD had an increased risk of heart disease, particularly among women. Elevated ALT activity in the absence of viral hepatitis or excessive alcohol consumption is most commonly due to NAFLD and associated with an increased risk of coronary heart disease.
A new study reveals that combined contrast enhanced MRI (CCE-MRI) closely matches the staging of non-alcoholic fatty liver disease (NAFLD) using conventional pathology. CCE-MRI offers a safer alternative to invasive liver biopsy, directly visualizing fibrosis and detecting liver cancers simultaneously.
Accumulated liver lipids come from serum fatty acids, newly made fatty acids within the liver, and dietary fatty acids. Insulin-sensitizing agents may help reduce oxidative stress and treat NAFLD.
A recent study led by Elizabeth Parks from the University of Minnesota has made a groundbreaking discovery about the origin of fatty liver disease. The research found that excess dietary fat can lead to liver toxicity, causing it to malfunction in its role as the body's central storage and distribution center for fat.
A study of Southern Italian residents found that over 12% had abnormal liver values, with a significant correlation between age, gender, and excessive alcohol consumption. Nonalcoholic fatty liver disease emerged as an important cause of altered liver tests in the region.
Research suggests statins can cause asymptomatic elevation of aminotransferases, especially at higher doses, but rare reports of significant liver injury exist; monitoring liver values is recommended for patients on statins, particularly those with known liver conditions.
A study of 742 patients with newly diagnosed chronic liver disease found that ethnicity significantly impacts NAFLD prevalence, particularly among Hispanic and Asian populations. The study highlights the need for culturally sensitive education and representation in future clinical studies to address disparities in diagnosis and treatment.
Researchers found significant ethnic differences in NAFLD prevalence, with striking variations among Hispanics, whites, and blacks. Hepatic steatosis was more common in Hispanics and less common in blacks, highlighting fundamental differences in lipid homeostasis.
The Mayo Clinic discovery sheds light on the cellular mechanisms behind Non-Alcoholic Fatty Liver Disease (NAFLD), a growing global problem related to affluence and diet. Early signs include accumulation of fat in the liver, inflammation, and scarring, which can lead to impaired function.
Researchers have identified a link between obesity, digestive system malfunctions, and excessive alcohol production in the liver. Feeding obese mice antibiotics significantly reduced alcohol production, suggesting a potential treatment strategy using oral antibiotics or yogurt to constrain intestinal bacterial overgrowth.
A new study reveals that free radicals, generated by the macrophage enzyme NADPH oxidase, are essential for the development of alcoholic liver disease. The researchers found that mice lacking this enzyme were resistant to liver injury and had lower levels of covalent adducts in their bile.
A study published in Nature Medicine found that metformin may help treat fatty liver disease in patients with obesity-related insulin resistance. The drug completely cured fatty liver in mice and showed promise in reducing liver inflammation and improving insulin sensitivity.