Research on lung cancer detection and treatment. Covers microbial predictors of immunotherapy, MRI detection, microplastics, and RAS-mutant drugs.
Researchers identified ACSL3 as essential for mutant KRAS gene activity in lung cancer cells, leading to cell death when suppressed. The study provides a critical role for fatty acids in lung cancer and meets an urgent need for targeted therapies.
Researchers developed liquid biopsies to detect EGFR mutations in urine, plasma, and blood samples. The tests showed high sensitivity and specificity for identifying patients suitable for targeted treatment and predicting cancer recurrence.
Researchers identify unique immune cells that enhance anti-tumor T cell responses in early-stage lung cancer. These hybrid neutrophils may help stimulate natural protection against tumor development.
A new minimally invasive surgical approach for lung cancer patients has shown promise in reducing bleeding risk and post-operative pain. The VATS lobectomy procedure uses ultrasonic energy to seal pulmonary arteries, allowing for faster recovery times and potentially improving survival rates.
A new study confirms that annual follow-up with low-dose computed-tomography (CT) scans is sufficient for some lung nodules, eliminating the need for biopsy or surgery. The findings suggest that these nodules can be safely monitored and do not require immediate treatment.
The College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology announced a revised evidence-based guideline for molecular testing in lung cancer patients. The guidelines aim to improve patient selection and targeted therapies.
A Yale-led study found that the EGFR cancer gene silences tumor suppressor genes in lung and glioblastoma brain cancers using a common mechanism. This discovery informs future research directions and may help determine how effective treatments will be against different EGFR mutations.
Researchers found that combining radiotherapy with PD-1 blockade therapy improved survival rates in a murine lung cancer model. However, this treatment approach showed no benefits for tumors that had relapsed after radiation therapy, highlighting the need for personalized medicine strategies.
A large cohort of 29,908 patients with pathologic stage T2N0M0 NSCLC showed improved median overall survival and 5-year OS when receiving adjuvant chemotherapy. The study demonstrated a benefit from adjuvant chemotherapy in patients with completely resected stage T2N0M0 NSCLC regardless of tumor size.
A study analyzing over 34,000 lung cancer patients in England found that those aged 50-64 are more likely to be diagnosed at a late stage compared to older age groups. Younger patients in their 70s are more likely to be diagnosed with early-stage disease.
A recent survey found that less than half of family physicians believe that lung cancer screening using low-dose computed tomography (LDCT) reduces lung cancer-related deaths. Despite the American Cancer Society's support for LDCT screening, many physicians are unsure about current recommendations.
A new breath test has been developed to identify lung cancer after surgery, using a simple, affordable process that analyzes carbonyl volatile organic compounds in exhaled breath. The test shows great potential for detecting lung cancer at any point, both as primary screening and post-surgery monitoring.
A study published in JNCI found that patients treated at high-volume centers had statistically significant longer overall survival compared to those at low-volume centers. The difference was greater than 10% at two years, suggesting improved disease control and management of adverse effects.
A new study led by MD Anderson Cancer Center found an eight-month progression-free survival benefit in patients treated with local consolidative therapy, a significant shift in clinical care for thousands of lung cancer patients. The treatment improved outcomes for those with oligometastases, defined as three or fewer sites of metastasis.
Researchers at UT Southwestern Medical Center discovered that between 14 to 25 percent of lung cancer patients also have immune disease, making them unsuitable for immunotherapy treatments. This finding raises critical questions about the effectiveness and toxicity of these treatments among patients with autoimmune diseases.
A recent UK lung cancer screening trial found that patients with high-risk disease can be identified and have a 73% chance of surviving five years or more. The trial's results provide crucial evidence for implementing a national screening programme in the UK.
Research in Italy found a strong association between living near landfills and increased risk of lung cancer, as well as hospitalizations for respiratory diseases. Exposure to air pollutants from waste treatment plants was linked to higher rates of respiratory symptoms among residents.
The International Association for the Study of Lung Cancer calls on Asian-Pacific governments to take action against lung cancer, citing the need for effective tobacco control, affordable healthcare, and early diagnosis. The goal is to reduce lung cancer deaths by one-third by 2030.
The IASLC consensus statement provides key pathologic, diagnostic, and therapeutic considerations for managing EGFR mutation positive NSCLC patients. It recommends optimal choice of EGFR TKIs, management of brain metastasis, and use of circulating free DNA for molecular studies.
Researchers found that inhibiting an enzyme adds palmitate onto proteins creates dependence on EGFR signaling for survival. Inhibiting this enzyme makes cancer cells more sensitive to EGFR inhibitors, which could lead to a new treatment option for lung cancers.
The 2016 Asia Pacific Lung Cancer Conference presented the latest advances in lung cancer research, including immunotherapy and multidisciplinary practices. Tobacco use was also a major concern, with experts emphasizing the need for stricter control measures to reduce deaths from lung cancer in Southeast Asia.
Ana Sofia Silva received the Best Ph.D. Thesis Award for her research on multifunctional nano-in-micro formulations for lung cancer theragnosis, proposing a new therapeutic approach to combat the disease.
A new study published in Journal of Laparoendoscopic & Advanced Surgical Techniques shows that robotic video-assisted lung resection achieves comparable outcomes to conventional VATS and preserves more healthy lung tissue. The robotic approach allows for fewer conversions to open thoracotomy and more lymph nodes retrieved for testing.
A new study found that cancer increases the risk for certain health issues beyond normal aging, including declines in activities of daily living and physical function. However, having a cancer diagnosis did not increase the likelihood of developing arthritis or vision/hearing problems, and did not exacerbate existing conditions.
Researchers found that 5-year survival for older lung cancer patients is favorable, with median survival at 6.7 years, and long-term patient outcomes including reduced hospital readmission rates and reinterventions.
A study compared four PD-L1 IHC diagnostic assays in lung cancer, demonstrating similarities and differences. The findings support the use of each assay according to its specific indication, recommending utilization for distinct scoring algorithms.
Researchers found a small but significant association between high doses of radiotherapy to the heart and increased risk of non-cancer death in early stage NSCLC patients. The study suggests that heart-sparing radiotherapy techniques may be beneficial, but further research is needed.
Researchers found that long-term exposure to environmental pollutants, specifically fine particulate matter (PM2.5), was linked to a higher risk of death from multiple types of cancer in an elderly Hong Kong population. The study showed a significant association between PM2.5 and increased mortality from breast, lung, and other cancers.
Patients with EGFR expressing advanced squamous non-small-cell lung cancer benefit most from necitumumab added to gemcitabine and cisplatin chemotherapy. The addition of necitumumab improves overall survival and progression-free survival by 21% and 16%, respectively, in patients whose tumours express the EGFR protein.
Researchers confirmed plasma genotyping's benefit in predicting treatment benefit for NSCLC patients, particularly those with higher tumor burden and younger age. However, tissue biopsies remain the gold standard due to low sensitivity of plasma tests, which may not fully replace them.
A late-breaking abstract at the European Lung Cancer Conference presented findings on osimertinib's effectiveness as first-line treatment for EGFR mutated non-small-cell lung cancer. The study showed a high overall response rate and prolonged progression-free survival, suggesting that osimertinib may alter the biology of the disease.
A phase Ib trial demonstrated that combining immunotherapy with live bacterium CRS-207 and chemotherapy resulted in a 94% disease control rate and 59% response rate in patients with malignant pleural mesothelioma. The therapy also showed good immune activation and synergistic efficacy with chemotherapy.
Suresh Senan, a renowned expert in radiation oncology, has been awarded the Heine H. Hansen Award for his pioneering work in lung cancer therapy and research. The award recognizes his significant contributions to the field of lung cancer on an international basis.
Researchers found that combining computed bioconductance (CB) with positron emission tomography (PET) before biopsy can improve the detection of potentially cancerous lung lesions. This non-invasive diagnostic tool may aid in the accurate evaluation of suspicious lung lesions.
Researchers identified a novel mutation in the KIT gene that contributes to crizotinib resistance in ROS1+ non-small cell lung cancer patients. Ponatinib, a KIT tyrosine kinase inhibitor, demonstrates potential as a therapeutic option for overcoming this resistance.
Researchers found that pericardial window operation, a treatment for malignant pericardial effusion, is less effective in lung cancer cases compared to other types of cancer. The study suggests alternative, less invasive methods such as needle punctures may be more efficient over time.
A University of Colorado Cancer Center study identifies epiregulin as a potential biomarker for lung cancer, with mice lacking the growth factor developing fewer tumors and reduced inflammation. The findings suggest epiregulin increases cell proliferation, promoting tumor growth.
Researchers identified a class of drugs called histone deacetylase (HDAC) inhibitors that stimulate T cell movement into tumors and enhance their activity. HDAC inhibitor romidepsin combined with PD-1-targeting antibody leads to lung tumor regression.
A recent U.S. Preventive Services Task Force recommendation suggests pairing smoking cessation with lung cancer screening to maximize benefits and reduce risk. This guideline aims to provide tobacco treatment in conjunction with lung screening to encourage smokers to quit.
Researchers will analyze data from DECAMP consortium to advance targeted therapeutics for COPD and lung cancer using molecular biomarkers. The goal is to screen people at risk, predict disease progression, and intercept disease.
Researchers at Imperial College London found that a protein called MARK4 enables cancer cells to break free and move around the body. A silencer molecule called miR-515-5p helps silence the gene that produces MARK4, preventing cancer cells from spreading.
Researchers found that high-risk lung cancer patients who are cleared of disease in their initial test do not need annual low-dose computed tomography (LDCT) screenings. The study suggests that reducing the frequency of screening could save millions in healthcare costs and spare patients from radiation exposure and false positive results.
Physician-scientists Ethan Dmitrovsky and Waun Ki Hong recognized for their efforts in cancer prevention and control. Dmitrovsky's work on retinoids has led to a significant impact on leukemia treatment, while Hong's research in cancer chemoprevention and personalized therapies has advanced the field.
CV screening workstations aid technicians in accurately reviewing LDCT scans, leading to reduced false positives and improved efficiency. The study found 97.8% sensitivity and 98% specificity in identifying abnormal scans, with average review time of 208 seconds.
New research reveals that African Americans are less likely to start smoking in late teens but continue smoking into later years, leading to lower average pack-years and reduced eligibility for lung cancer screening. This disparity results in higher risk of death from tobacco-related diseases among African Americans.
Researchers at Thomas Jefferson University have found that Nit1, a gene previously thought to be a tumor suppressor, actually promotes cancer growth. The study suggests that Nit1 may represent a new target for drug therapy, offering hope for treating aggressive non-small cell lung cancer.
Researchers are developing personalized assessment tools to predict and prevent radiation-induced cancers in astronauts and on Earth. High-energy ions, like those used in cancer treatments, pose a risk of new tumors and more aggressive cancer types.
Adults aged 55-74 with a history of current or former smoking and 30+ pack-years are advised to undergo annual low-dose CT scans up to three times. This guideline aims to detect lung cancer at an early stage, reducing serious illness and death. Screening should be conducted in healthcare settings with expertise in diagnosing lung cancer.
A cross-sectional survey found that detailed clinician communication can alleviate patient distress associated with incidental pulmonary nodules. Patients who received accurate information about their nodule size and diagnosis had a more reassuring experience, reducing anxiety and improving overall well-being.
The ALCF-IASLC Joint Fellowship Award supports novel research with the potential to positively impact lung cancer patients. Dr. Robin Mjelle's project aims to develop a risk-prediction tool and serum poly-marker kit for early lung cancer detection, leveraging pre-diagnostic serum samples from Norway's HUNT biobank.
A new method using proton nuclear magnetic resonance (H-NMR) of blood plasma identifies unique metabolic biomarkers for early and late-stage lung cancer. The technique correctly classifies 78% of patients and 92% of controls, showing promise as a complementary tool to improve lung cancer screening.
A national look at PET scan use for lung and esophageal cancer survivors found widespread variation between hospitals, with some using scans eight times more often than others. The study suggests that this approach doesn't improve survival rates and is being inappropriately used at many hospitals.
A recent study published in Journal of Thoracic Oncology found that the FDA-approved VENTANA anti-ALK(D5F3)CDx assay is superior to the 5A4 IHC assay for selecting patients with non-small cell lung cancer eligible for ALK tyrosine kinase inhibitor treatment.
Researchers identified 5 autoantibody classifiers that can distinguish lung cancer from smoker controls with high sensitivity and specificity, as well as those from benign lung nodules. These findings have the potential to improve early detection of lung cancer through companion molecular diagnostic modalities.
A combination of durvalumab and tremelimumab has been found to be effective in treating advanced non-small cell lung cancer patients, with 23% achieving a complete or partial response. The treatment also appears to be active in PD-L1-negative tumors.
Scientists at CRI have discovered new complexities underlying cancer biology, overturning a nearly century-old perception about cancer metabolism. The study found that tumors use multiple nutrients for energy, and the surrounding environment influences metabolic activity.
A team of researchers used a fruit fly model to identify a potential targeted therapy for non-small cell lung cancer, which may lead to improved overall survival. The study found that combining two FDA-approved drugs suppressed tumor formation and inhibited key genetic mutations associated with NSCLC.
A study found that HER2-positive lung cancer is caused by either gene amplification or mutation, rather than both. This distinction implies the need for different treatment options, including targeted therapies approved for breast cancer.
A study by Mayo Clinic researchers found that people who quit smoking for over 15 years are still at a higher risk of developing lung cancer. Expanding lung cancer screening to include this group could detect more cases and further reduce mortality.
Death rates from leukemia in Europe are expected to decline, with the greatest falls seen among children and young adults. Improvements in treatment and management have contributed to this trend, but some leukaemias remain challenging to treat.