Research on lung cancer detection and treatment. Covers microbial predictors of immunotherapy, MRI detection, microplastics, and RAS-mutant drugs.
A new study found annual low-dose CT screening to be safe and effective for identifying pre-cancerous lung nodules. The study identified cases of cancer in participants with nonsolid lung nodules, which can progress to invasive cancer.
A new study finds that providing direct assistance, such as counseling and nicotine replacement therapy, significantly improves the likelihood of patients quitting smoking. The research team analyzed data from over 1,600 participants who underwent lung cancer screening, finding that active clinician support increased quit rates by 40%.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that lung cancer patients with comorbidities such as chronic obstructive pulmonary disease, diabetes, or congestive heart failure had a higher risk of death. These patients also experienced poorer survival rates at each stage of the disease.
A new technique combines dynamic PET imaging with parametric tumor mapping to detect tumors and metastases throughout the body, providing quantitative evaluation and improved contrast. This method has the potential to be used for early diagnosis and more accurate prognosis of various cancers.
Researchers at the Weizmann Institute have developed a three-pronged approach to prevent lung cancer cells from developing resistance to chemotherapy. The new strategy involves targeting two main growth receptor siblings, HER2 and HER3, in addition to an existing anti-EGFR antibody.
Researchers at The Wistar Institute have identified a protein biomarker AKAP4 that appears to be more accurate in detecting non-small cell lung cancer. This discovery could lead to the development of a simple blood test for annual screening, potentially saving lives by detecting the disease earlier.
The global burden of disease study estimated 14.9 million new cancer cases and 8.2 million deaths in 2013. Lung and breast cancers were the leading causes of cancer-related deaths, with tracheal bronchus and lung cancer being the most common among men.
Researchers at Winship Cancer Institute of Emory University have discovered a novel strategy to exploit apoptosis in lung cancer treatment by inhibiting the Bcl-2 protein. A new class of compounds has been identified that bind to the BH4 domain of Bcl-2, promoting cancer cell death.
A study found that 38% of lung cancer survivors developed recurrent or new cancer during a 8.3-year surveillance period. Key risk factors for recurrence included smoking status, prior cancers, and asbestos exposure, highlighting the need for close monitoring and quitting smoking to reduce cancer recurrence.
Researchers at Johns Hopkins Medicine have designed a molecule called RK-33 to target the enzyme DDX3, which is overexpressed in over 90% of lung cancer samples. The therapy has shown promising results in mice, with the ability to lower radiation doses while increasing its effectiveness.
Researchers found that adding genetic information to a smoker's clinical risk profile results in improved lung cancer screening adherence, with higher-risk individuals more likely to adhere to follow-up CT scans. The study suggests that gene-based risk assessment can improve screening compliance and reduce the need for reclassification.
A new genomic test has been validated for detecting lung cancer with high sensitivity, allowing physicians to identify patients at low probability of having the disease. This test can spare patients from costly and risky procedures, improving diagnosis and patient anxiety.
A phase III randomized clinical trial suggests that Stereotactic Ablative Radiotherapy (SABR) is equally effective to surgery in treating operable stage I non-small cell lung cancer patients, with better survival rates and lower toxicity. SABR appears to be a suitable alternative for elderly and comorbidity-prone patients.
Researchers from the University of Waterloo discovered a new family of nonplatinum-based halogenated molecules that selectively target cancer cells while protecting healthy cells. These molecules generate reactive radicals that kill cancer cells, and increase the protective molecule glutathione in healthy cells.
Researchers from CNIO have discovered a new approach to fighting cancer by targeting telomeres and blocking the TRF1 gene. This method shows dramatic improvements in mice with lung cancer, with minimal toxic effects, offering a promising therapeutic target for cancer therapy.
Myriad Genetics presented 19 clinical studies on advanced companion diagnostic and molecular diagnostic tests for cancer treatment and prevention. The company's research focuses on personalized medicine, including selecting effective pharmaceuticals, preventing disease through hereditary cancer tests, and optimizing treatment decisions...
Researchers found that relatives play a crucial role in encouraging loved ones to seek medical help for lung cancer, while online information poses problems. A new website is planned to provide tailored guidance for those experiencing symptoms.
Research shows that family members are more likely to search online for lung cancer information, encouraging loved ones to seek medical help. Psychologists aim to develop a website providing tailored information for those experiencing lung cancer symptoms.
Researchers at the University of Manchester have developed a new genetic profiling approach to identify patients with right lung cancer who are eligible for targeted therapies. The method uses smaller tissue biopsies and has been shown to detect genetic changes in over 95% of samples.
A phase 1/2 trial of rociletinib in EGFR-mutant non-small cell lung cancer showed a 59% response rate and 13.1 month progression-free survival, offering hope for patients with previously treated disease.
Researchers at the University of Louisville have detailed a crucial connection between silica exposure and rapid lung cancer progression, highlighting the role of inflammatory mediator LTB4 and its receptor BLT1. The study's findings suggest that novel treatment strategies for both silicosis and associated lung cancers may be possible.
A new study found that lung cancer surgery patients have a higher risk of developing venous thromboembolism (VTEs) than previously thought. The study, which analyzed data from 157 patients, showed that the incidence rate was 12.1%, with most events occurring after discharge from the hospital and without symptoms.
A study of over 8000 patients found that surgeons with higher volumes are less likely to perform high-risk pneumonectomies, leading to better long-term survival. The researchers suggest that surgeon experience is an important factor in determining surgical outcomes for non-small cell lung cancer patients.
A new analysis of the Surveillance, Epidemiology, and End Results (SEER) database found significant variation in health insurance coverage among cancer patients based on demographics and cancer type. Younger, non-White, and rural patients were more likely to be uninsured, while males were less likely than females to have insurance.
A systematic review of cigar smoking and all-cause and smoking-related mortality found that cigar smoking carries the same fatal health risks as cigarette smoking, including oral, esophageal, and lung cancers. The risk of death from these cancers increases with inhalation of cigar smoke.
Researchers at MD Anderson Cancer Center have uncovered a novel mechanism by which the tumor suppressor gene p53 regulates PD-L1, allowing non-small cell lung cancer to grow. MicroRNA delivery with existing treatments may represent a new therapeutic approach for lung cancer.
Research by University of Colorado Cancer Center investigator Tim Byers found that taking more dietary supplements than needed can lead to a higher risk of developing cancer. The study, which involved thousands of patients and ten years of research, showed that some supplements may even increase cancer risk by 20%.
Researchers have developed a new diagnostic method called spectral histopathology that facilitates marker-free detection of individual subtypes of lung cancers. The accuracy of this method is higher than traditional histopathology, reaching over 92%, allowing for more precise diagnosis and personalized treatment options.
Researchers from MD Anderson Cancer Center are part of two new Stand Up to Cancer Dream Teams focused on lung cancer driven by KRAS mutations and preventing high-risk ovarian cancer. The teams aim to test combination therapies and launch prevention efforts.
The $20 million SU2C-American Cancer Society Lung Cancer Dream Team will focus on targeting KRAS mutant lung cancer using a three-pronged approach. The team aims to develop novel therapies that combine targeted drug therapies with immunotherapies to improve patient outcomes.
Researchers at MD Anderson Cancer Center identified three subsets of lung cancer with KRAS gene mutations, each with unique signaling patterns and susceptibility to different therapeutic strategies. These subsets may offer new approaches for treating lung adenocarcinoma, the most common form of lung cancer.
A study of oncologists in Europe, Asia, and the US found that nearly one in four patients with advanced lung cancer began treatment without knowing their EGFR mutation status. This lack of testing may compromise treatment outcomes and access to effective therapies.
A survey of French people aged 40-75 found that many incorrectly believed low cigarette consumption was risk-free for lung cancer. Only half of current smokers considered themselves at higher risk than the average population.
A subset of lung cancer patients with BRAF-mutant cancers may derive significant clinical benefits from treatment with BRAF inhibitors, according to a European study. The trial found an overall response rate of 53% and progression-free survival time of 5 months among patients treated with vemurafenib or dabrafenib.
A new DNA blood test can identify EGFR mutations in lung cancer patients without accessible tumor tissue, showing an 89% agreement rate with tissue testing. The test's sensitivity was found to be around half of that of traditional tissue testing.
A recent study by the Journal of the American College of Surgeons found that socioeconomic factors such as income level, education, and hospital type significantly impact lung cancer patients' odds of death within 30 days after surgery. Patients from lower-income households were 25% more likely to die than those in higher-income areas.
A new study finds that racial disparities in cancer outcomes are decreasing, with African Americans showing faster decreases in cancer mortality than Caucasians. The causes of these disparities include low education and income, as well as reduced access to quality healthcare.
The first Heine H. Hansen Award recipient, Pieter Postmus, has made significant contributions to lung cancer research and education globally. He was recognized for his work in developing research programs in pulmonary circulation, pneumothorax, and thoracic oncology.
The study of over 160,000 postmenopausal women revealed no significant link between lung cancer risk and reproductive history or hormone therapy. However, some subgroups showed reduced risks for specific types of lung cancer, emphasizing the need for further research into complex relationships.
Researchers say there is enough evidence to declare indoor UV radiation tanning causes skin cancer. The authors urge the US Surgeon General to make a stronger statement regarding UV tanning devices, citing eight out of nine Bradford Hill criteria as satisfied.
A University of Colorado Cancer Center opinion argues that announcing the causality could save lives. The link between UV tanning and skin cancer is supported by eight out of nine criteria used to determine a causal relationship in disease, including strength of association, consistency of association, and temporality.
A WSU study found that young adults learn more about the dangers of smoking when warnings are presented in images and text, leading to increased worry and discouragement from smoking. The labels used in the study emphasized negative consequences associated with lung cancer, heart disease, and stroke.
Researchers at Moffitt Cancer Center have discovered a novel mechanism controlling lung cancer stem cell growth, suggesting that targeting YAP1 protein could lead to new therapeutic targets. The study found that YAP1 interacts with OCT4 and SOX2 proteins, regulating stem cell self-renewal and tumor growth.
Physical activity has been shown to reduce symptoms, increase exercise tolerance, and improve quality of life in lung cancer patients. Additionally, increased physical activity may also benefit lung cancer survivors by improving exercise capacity and symptom burden.
A Cancer Research UK review found that older people, women, and less affluent individuals are at a higher risk of emergency cancer diagnoses. The study also revealed that emergency-diagnosed cancers tend to have poorer survival rates compared to those diagnosed through other routes.
Researchers found that patients with stage I non-small cell lung cancer (NSCLC) and low tumor metabolic activity have increased overall survival. A diagnostic test using fluorodeoxyglucose positron emission tomography (FDG/PET) can help identify patients who may benefit from post-surgical chemotherapy.
A study published in JAMA Oncology found that high fitness levels in midlife were associated with a lower risk of lung and colorectal cancer. High fitness also reduced the risk of death from these cancers, as well as cardiovascular disease death among men diagnosed with cancer.
A new study from the University of Waterloo found that almost one in four high school seniors try smoking hookah, with over 78,200 youth current water pipe users. The study warns that water pipes carry similar toxins as cigarettes and can lead to increased cancer risk.
The study found a significant decline in early recall rates from 20% to 3-4% in subsequent rounds, while lung cancer detection rates decreased by 50%. A well-organized screening program with access to previous images and results is crucial to manage false positives.
Two new studies present striking findings on depression's influence on cardiovascular health, with depressed patients facing nearly double the risk of dying from heart disease. Additionally, survivors of heart attacks are found to be at higher risk for certain cancers, including lung and bladder cancer.
Patients treated at high-volume facilities for stage III non-small cell lung cancer (NSCLC) have longer overall survival when receiving definitive concurrent chemotherapy and radiation therapy. Studies show improved outcomes for patients treated at these centers, regardless of academic or community status.
Scientists at UTHealth received grants to identify new compounds that may treat lethal cancers by targeting K-Ras protein mutations. The research aims to develop anti-KRas drugs to improve treatment outcomes for millions suffering from these cancers.
A global review of health issues highlights the UK's National Health Service (NHS) reduced spending on low-value procedures, while sub-Saharan Africans rate their health among the lowest in the world. The study also suggests that US cancer care may provide less value compared to Western Europe.
A team at the University of Illinois Chicago has identified a signaling mechanism that permanently places lung cells into a state of suspended animation called senescence. This finding represents a new potential therapeutic strategy for treating lung cancer by inducing senescence through this pathway.
Researchers at the University of Granada have discovered that specific microRNAs can deactivate the SMARCA4 gene, a tumor suppressor. This finding opens up new avenues for diagnosis and treatment of lung cancer.
An interactive online education tool has been developed to help practicing oncologists with therapeutic decision-making for advanced non-small cell lung cancer (NSCLC) by providing feedback from an expert panel. The tool integrates clinical, histological, and molecular features into treatment plans, leading to a change in treatment cho...
A study analyzed lung cancer incidence and screening trends, finding a decline in the proportion of patients meeting high-risk screening criteria. The decline indicates an increasing number of patients with lung cancer would not have been candidates for screening.
Research at Mayo Clinic found that a decline in smoking rates may lead to fewer people qualifying for early detection of lung cancer through low-dose CT scans. As smokers quit earlier, more patients are diagnosed at a later stage, increasing mortality.
The University of Texas MD Anderson Cancer Center has received over $22 million in CPRIT research grants to study breast, skin, prostate, and lung cancers, as well as leukemia and brain cancer. The funding will also support prevention and early detection efforts.
Fourth and subsequent PET/CT scans improved clinical assessment and management change in lung cancer patients, with 52.28% positive and 47.7% negative results for recurrence or metastasis. The scans resulted in treatment changes in 28.1% of cases, with new treatments initiated in 20.4%.