Articles tagged with Lung Cancer
A new 'QTA' technique allows for precise treatment and progress tracking in lung cancer patients with high accuracy. The study found that nearly 90% of tumor cells can be analyzed to detect K-ras gene mutations, enabling personalized treatment.
The US Preventive Services Task Force recommends annual screening for abdominal aortic aneurysms in men aged 65-75 who have ever smoked, while cautioning against widespread lung cancer screening among high-risk older adults due to insufficient evidence. The committee cited age-related risks and diminishing benefits of extended life fro...
Researchers at UCLA have discovered how factors regulating adult stem cells in lungs can lead to precancerous lesions. The study found that disrupting normal ROS regulation drives repair process, causing precancerous lesions to form.
A study published in JNCI: Journal of the National Cancer Institute found that a shorter time to first cigarette (TTFC) is associated with an increased risk of lung cancer in both heavy and light smokers. The researchers analyzed data from over 3,200 current and former smokers, revealing that TTFC was statistically significantly higher...
Researchers develop device that spots lung cancer in exhaled breath, combining novel technologies for early detection and diagnosis. The breathalyzer test uses a nanotech chip to detect unique chemical signatures of lung cancer tumors, accurately distinguishing between benign and malignant lesions.
A recent study found that a 5-year low-dose computed tomography (LDCT) screening protocol can detect lung cancer effectively, with a high proportion of cancers being treated and good long-term survival rates. The results show improved diagnostic performance compared to other studies, including the National Lung Cancer Screening Trial.
A systematic review of 8215 studies found that low-dose computed tomography (LDCT) screening does not significantly influence overall quality of life or result in long-term anxiety or distress. However, positive results can lead to short-term increases in distress levels.
Researchers at Rochester Institute of Technology create algorithms to quantify lung nodule growth on CT scans, identifying small cancers and obviating risky biopsies. The software compensates for background factors and estimates nodule volumes, enabling accurate doubling time calculation and malignant growth detection.
A new class of tumor-targeting agents can seek out and find dozens of solid tumors, even illuminating brain cancer stem cells that resist current treatments. The agents deliver two types of payloads directly to cancer cells, resulting in direct imaging or treatment.
A landmark ESMO survey of over 700 specialists provides insight into treatments most oncologists choose for lung cancer patients with incomplete resection. The study reveals that chemotherapy and radiotherapy are commonly prescribed, but treatment decisions vary depending on the specialty of the treating physician.
A University of Colorado Cancer Center study found NTRK1 mutations in over 1% of non-small cell lung cancer patients. The study also developed a test for rapid detection of NTRK1 oncogenes, marking a new frontier in lung cancer treatment.
A non-invasive breath test has been developed to detect lung cancer by analyzing volatile organic compounds in exhaled breath. The device can distinguish between patients with lung cancer and chronic obstructive pulmonary disease (COPD), as well as define the stage of any present cancer.
Researchers have found that crizotinib produces significant responses in patients with intermediate and high MET amplification, resulting in a 60-67% overall objective response rate. The drug showed early activity against MET-dependent cells in preclinical laboratory studies.
A study found that smokers are more likely to quit after receiving a serious lung cancer screening result. The effect appeared to be durable, lasting up to 5 years after the last screening.
A study found that genetic alterations in lung cancer tumors can help select targeted treatments, resulting in improved survival rates for patients. The researchers identified actionable oncogenic drivers in 64% of patients and used this data to guide treatment decisions.
A study by Memorial Sloan Kettering Cancer Center found that genomic tumor testing can improve survival for patients with advanced lung cancers. The test identified oncogenic drivers in 64% of tumors, leading to improved outcomes when matched with targeted therapies.
The study found lung cancer rates declining in 47 of 52 populations among young women (30-49 years), while increasing in most countries among older women (50-74 years). Tobacco control efforts and increased awareness have contributed to the decline, but more needs to be done to curtail future deaths.
A patient diagnosed with advanced, incurable lung cancer was found to have early stage, curable lung cancer after stopping a rare antibiotic that caused liver and lung damage. The team's findings suggest that toxicity due to the antibiotic may be mistaken for cancer spread.
Researchers at Wake Forest Baptist Medical Center have successfully treated patients with recurrent lung cancers using a second course of radiation therapy, achieving a cure rate of over 70%. The innovative treatment approach uses precise targeting and high doses to knock the cancer back, offering new hope for these patients.
A new technique that brings CT imaging into the operating room enables precise demarcation and removal of small sub-centimeter lung nodules while minimizing damage to healthy lung tissue. This approach has shown promising results in reducing errors and increasing accuracy in lung cancer surgery.
A new study found that poor global QOL scores do not predict worse survival in high-risk lung cancer patients undergoing sublobar resection, contradicting prior studies. Patients with breathing problems at baseline or decline in function after surgery had poorer overall survival.
Researchers used breath analysis to detect lung cancer with a sensitivity comparable to PET scanning and a higher specificity, distinguishing patients with benign disease from those with early-stage cancer. The method shows promise as a non-invasive diagnostic tool, expediting treatment for patients with lung cancer.
A new study using National Cancer Data Base data reveals that major lung resection has become progressively safer over the last few decades. The study found that mortality rates after surgery have decreased, especially at the busiest hospitals with high volumes of surgeries performed.
Researchers have discovered that some lung cancers with EGFR gene mutations are uniformly treated throughout the tumor, while others have variable mutation presence. This finding has significant implications for diagnostic accuracy and precision medicine in lung adenocarcinoma.
The EORTC and SIOG have updated their expert opinion on NSCLC management in elderly patients, highlighting the need for personalized treatment decisions based on life expectancy and biological age. Multidisciplinary geriatric assessments can improve treatment outcomes for this population.
A Michigan State University study highlights the emotional toll of lung cancer stigma, with patients feeling guilt, self-blame, and discomfort around healthcare providers. The research aims to raise awareness among healthcare providers and develop strategies to strengthen coping skills and symptom management for affected individuals.
A new study by Mathew S. Isaac and Aaron R. Brough found that people are more likely to predict outcomes when items are grouped into larger categories. In a series of experiments, participants showed a bias towards wagering more money on winning the lottery if they had blue tickets rather than yellow ones.
Researchers at Beth Israel Deaconess Medical Center have identified a key enzyme responsible for lactate production in cancer cells, which they inhibit to halt tumor growth and even cause regression. The study's findings offer promising results for new treatments targeting cancer metabolism.
A study by TGen found that specific growth factor receptors, HGFR/MET and FN14, are elevated in metastatic tumors of non-small cell lung cancer (NSCLC). Suppression of these receptors reduces tumor cell invasion. These findings suggest new targets for therapy to prevent or halt the spread of this deadly cancer.
A meta-analysis of randomized controlled trials found that chemotherapy improved progression-free survival compared to epidermal growth factor receptor tyrosine kinase inhibitors in patients with wild-type EGFR tumors. However, overall survival did not differ between the two groups.
A phase II trial of efatutazone with erlotinib failed to improve efficacy in patients with refractory non-small cell lung cancer, but researchers hope to refine future treatments by identifying the right biomarker for individual patients. The study found that fluid retention was a key factor contributing to the lack of success.
Researchers found that women who underwent radiotherapy for breast cancer have a small but significantly increased risk of developing a primary lung tumour. The risk increases with the amount of radiation absorbed by the tissue, with an estimated relative risk of 8.5% per delivered Gy to the lung.
Researchers estimate that up to 100% of lung cancer patients experience sexual dysfunction, which can persist after treatment. Experts call for open discussions and specialized help from healthcare professionals to address these issues.
Immunotherapy has shown huge potential in treating lung cancer by preventing tumour cells from escaping the immune system. New data on immunocheckpoint regulators such as PD-1 and PD-L1 have resulted in impressive global overall response rates of 20% to 25%.
A study found that preoperative PET imaging reduced unnecessary surgeries for non-small cell lung cancer patients by 50%, eliminating approximately half of them. The use of PET increased during the study period, suggesting its potential to change policy and recommendations regarding tumor staging.
Researchers developed a new technology called MaMTH to study human proteins, particularly membrane proteins that contribute to disease. The technology identifies a protein, CRKII, that plays a role in non-small cell lung cancer and suggests a potential therapeutic approach.
A new study by UT Southwestern Medical Center found that people with an inherited mutated gene have a high chance of getting lung cancer, even without smoking. Women and those who have never smoked are mostly affected, with a one-in-three chance of developing the disease.
Researchers found a rare hereditary syndrome associated with a 31% risk of disease in never-smokers carrying the germline EGFR T790M mutation. The study highlights the need for increased surveillance and screening for affected carriers, regardless of smoking status.
A study by UC Davis researchers found that the investigational cancer vaccine tecemotide, when administered with cisplatin, boosted immune response and reduced the number of tumors in mice with lung cancer. The vaccine also increased interferon gamma levels and stimulated production of killer T-lymphocytes.
Lung cancer cells use high levels of TGF-β to suppress NK cell activity, leading to reduced DAP12 expression and impaired cytotoxic pathways. The researchers identified a critical role for miR-183 in this process, providing new insight into the exploitation of immune evasion mechanisms by cancer cells.
The Roy Castle Lung Cancer Foundation has funded two new projects at the University of Liverpool, one aiming to improve survival rates for UK lung cancer patients and the other focusing on developing an early blood test for diagnosis. The foundation has invested $20m in lung cancer research over 23 years.
Researchers at TGen identified the key protein Mcl-1 that enables non-small cell lung cancer tumors to resist radiation and chemotherapy. By inhibiting Mcl-1, researchers believe they can make lung cancer more responsive to standard therapies.
A new protein called Merm1 has been discovered to play a role in controlling cell growth and division in lung tissue. This finding could lead to the development of new drugs targeting lung cancer.
A recent study found that female hormone therapy, particularly estrogen plus progesterone, significantly improved survival among women with non-small cell lung cancer. The combination of hormone therapy and long-term use showed the most notable improvements in median survival time.
Researchers have developed a novel technique for detecting ALK rearrangements in non-small cell lung cancers (NSCLCs) using quantitative (q)RT-PCR. The assay overcomes limitations of existing methods, including cost and interpretation challenges, with high sensitivity and ease of use.
A study found significant discrepancies between fluorescent in situ hybridization (FISH) and immunohistochemistry (IHC) results for ALK testing, leading to the detection of approximately 25% of ALK-positive cases. The findings support the need for combined testing using both FISH and IHC methods.
A recent study found that EGFR mutations are prevalent among the Asian population, with a frequency of 51.4% in stage IIIB or IV adenocarcinomas of the lung. The mutation was more common among women and never-smokers than previously reported.
The cumulative success rate for new agents in advanced NSCLC is lower than industry estimates, but biomarker- and receptor-targeted therapies substantially increase success rates. Biomarker-targeted therapy shows a 62% cumulative success rate, nearly six times higher than non-biomarker targeted trials.
Researchers at TSRI will explore Notch signaling pathways as therapeutic options for non-small cell lung cancer. The grant aims to improve treatment outcomes for advanced disease, where survival rates remain poor despite falling death rates.
A combination of two drugs has successfully halted the growth of lung adenocarcinomas carrying KRAS mutations, a common genetic subtype of lung cancer. The treatment targets KRAS's accomplices rather than the gene itself, and its potential as a clinical trial is being explored.
The American Cancer Society and Stand Up To Cancer have announced a collaborative research effort focused on lung cancer, the leading cause of cancer mortality in the US. The $20 million Dream Team grant will be awarded to support the development of new therapies for lung cancer.
Researchers at the University of Colorado Cancer Center have identified shared genetic signatures between lung and bladder cancers, which may refine patient prognoses and treatment choices.
The European Society for Medical Oncology warns that Eastern Europe lacks sufficient data, highlighting the need for a unified system. Despite this, many Western European countries are expected to have enough medical oncologists to meet growing cancer demands by 2020.
Cancer death rates have declined by 20% over the past two decades, with middle-aged black men experiencing a 50% reduction in mortality. The American Cancer Society estimates that there will be 1,665,540 new cancer cases and 585,720 cancer deaths in 2014.
The US Preventive Services Task Force recommends annual low-dose computed tomography (LDCT) screening for high-risk adults between 55 and 80 years old. Heavy smokers or former heavy smokers who have quit within the past 15 years are considered high risk due to increased lung cancer risk. The recommendation is based on comprehensive evi...
A University of Colorado Cancer Center study found that ALK and ROS1 gene rearrangements, known to drive subsets of lung cancer, are also present in some colorectal cancers. This implies that drugs used to target ALK and ROS1 in lung cancer may have applications in treating a subset of colorectal cancer patients.
Death rates for lung cancer, colorectal, breast, and prostate cancers have been declining, driving a reduction in cancer deaths. However, some cancers, including liver and pancreas, saw increased death rates. Comorbid conditions also impact survival, with one-third of patients aged 65+ having multiple medical conditions.
New data from the NLST suggests that low-dose CT screening for lung cancer may overdiagnose up to 22% of non-small cell lung cancers. However, the rate is significantly lower than projected for other cancer screenings, supporting the implementation of lung cancer screening programs.
A recent study found that over 18% of lung cancers detected by low-dose computed tomography (LDCT) may be cases of overdiagnosis, where the cancer would not have become clinically apparent without screening. This could lead to unnecessary treatment, anxiety, and increased healthcare costs.
A special issue of the Journal of the American College of Radiology addresses imaging-based screening and radiology's role in preventive medicine. The issue explores breast density legislation, digital breast tomosynthesis, lung cancer screening, and CT colonography reimbursement, highlighting both benefits and controversies.