Articles tagged with Neurological Disorders
A research team developed an algorithm that instantly assesses and adjusts brain stimulation placement using electroencephalography (EEG) feedback. The method can find the optimal stimulation parameters in just 1-2 minutes, potentially improving the efficacy of TMS treatment for brain disorders like chronic pain and depression.
A study tracking 425 patients post-COVID-19 found high prevalence of cognitive deficits, psychiatric impairments, and significant memory decline. Researchers observed no correlation between the severity of the disease or socio-economic factors with psychiatric alterations, suggesting a possible link to delayed inflammatory processes.
Prenatal exposure to industrial toxin TCDD may cause long-term damage to brain circuits and potentially lead to neurodevelopmental disorders like autism and ADHD. Researchers found that pharmacological manipulation can restore microglia function, suggesting a possible therapeutic avenue for these disorders.
A new Dartmouth-led study found that antimony and other metals are associated with lower birthweight, while some metals show group- and sex-dependent associations. The research suggests that reducing exposure to these metals could help prevent harmful effects on fetal growth.
Researchers have identified a specific location in the hippocampus called the dentate gyrus where schizophrenia may originate. Studying rats with damaged SAP97, they found changes in activity in this region, directly linking alterations to the development of schizophrenia.
A University of Houston researcher has identified potential biomarkers for neuropsychiatric symptoms of lupus, which include CSF Lipocalin-2, M-CSF, IgM, and complement C3. Elevated levels of these proteins in cerebrospinal fluid may indicate a diagnosis of NPSLE.
Researchers found that 30% of fetuses who later developed ASD had heart, kidney, and head anomalies detected during routine prenatal ultrasounds. These anomalies were more common in girls and linked to the severity of ASD. The study suggests that doctors can use these signs to evaluate the probability of a child being born with ASD.
Markita del Carpio Landry, a young immigrant scientist, receives the Vilcek Prize for Creative Promise for her groundbreaking research on neurochemical communication and gene-editing technologies. Her work aims to address medicine's most compelling problems, including aberrations in neurotransmitter signaling.
Researchers found lower functional connectivity between brain areas involved in social and emotional processing in individuals at risk of developing alcohol use disorder. This impairment may affect their ability to interpret facial expressions and respond to their environment, increasing the likelihood of disordered drinking.
Researchers discovered that toxic goiter causes shrinkage in central brain regions, such as the hippocampus and amygdala, which can lead to mental symptoms. The study provides key insights for patients with Graves' disease, a common form of hyperthyroidism.
New research reveals that one in three US stroke survivors experience food insecurity, which can exacerbate cardiovascular disease and stroke risk. Healthcare professionals can play a crucial role in addressing food insecurity by engaging with patients and providing support or resources.
Researchers analyzed fMRI studies on healthy individuals and stroke survivors to understand the neural mechanisms underlying prism adaptation therapy. The study found differences in brain activity patterns between healthy individuals and those with spatial neglect, suggesting a shift in spatial processing to the left hemisphere.
Researchers used 3D mini-brain models to study the effects of three autism risk genes on neural formation and development. The study found that despite unique molecular mechanisms, the genes converged on affecting specific types of neurons, suggesting potential therapeutic targets for autism treatment.
Women with GAD exhibit abnormal interoception, perceiving intense heartbeats and lower neural activity in the ventromedial prefrontal cortex. The study suggests a causal link between cardiovascular sensitivity and frontal cortex insensitivity, contributing to anxiety symptoms.
A team of scientists from Pusan National University conducted an updated meta-analysis to clarify the relationship between alcohol consumption and unprovoked seizures and epilepsy. They found that overall, alcohol drinkers were at a significantly higher risk of developing epilepsy compared to non-drinkers.
A phase 3 clinical trial is underway to test the safety and efficacy of jacifusen, an experimental drug that lowered levels of toxic protein FUS in a patient with juvenile ALS. The trial aims to determine if the drug can slow disease progression in symptomatic patients.
Scientists have identified a new tool to control the movement of motor proteins in neurons, which could lead to new treatments for cancer and neurodegenerative diseases. The study found that the GSK3β enzyme can act as a stop switch for kinesin 1 motors, preventing them from detaching from microtubule tracks.
Researchers report COVID-19 can cause a range of neurological symptoms, including loss of taste and smell, headaches, and brain inflammation. A new study suggests Long Covid may share common risk factors with myalgic encephalomyelitis/chronic fatigue syndrome.
A study published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association found that 12 to 14 intervention sessions can improve cognition in older adults at risk of dementia. The optimal dose was determined by analyzing data from the Multidomain Alzheimer Preventive Trial, taking into account individual characteristics su...
A study by Harvard T.H. Chan School of Public Health researchers found a strong association between Epstein-Barr virus infection and multiple sclerosis. The risk of MS increased 32-fold after EBV infection, while serum levels of neurofilament light chain, a biomarker of nerve degeneration, only increased after EBV infection.
Scientists at the University of Missouri discovered that bisphenol A (BPA) exposure during pregnancy can negatively impact fetal brain development. MicroRNAs in the placenta play a key role in regulating cellular functions, including neural development. Researchers believe that microRNA packages could reach the brain through the placen...
Researchers have developed a promising treatment approach for chronic stroke patients using carefully tuned electrical stimulation of the neuromuscular system. This method has been shown to improve motor control, sensory capabilities, and body perception in patients with long-term disabilities.
Researchers have uncovered how the brain processes sensory information, revealing new insights into perception and cognition. The study's findings have significant implications for understanding neurological disorders such as Autism Spectrum Disorder and stroke, as well as targeted treatments and interventions.
A new study led by Mount Sinai researchers found that microglia may play a critical role in some cases of brain disease, and provides a comprehensive guide for future studies. The study identified two new genes linked to brain disorders, including Alzheimer's and Parkinson's diseases.
A new study reveals distinct DNA methylation profiles of human microglia cells across different age groups, disease states, and brain regions. The researchers found that interindividual differences in methylation variability had a larger impact than regional or diagnostic differences.
Cleveland Clinic researchers have identified the gut microbial gene cluster responsible for converting carnitine into TMAO, which promotes heart disease and stroke. The study found that dietary modifications may help reduce diet- and TMAO-associated cardiovascular disease risk by targeting the gbu gene cluster.
A long-term study found that academic education can positively affect aging of the brain, with reduced degenerative processes and improved cognitive performance. Participants with an academic background showed a lower increase in signs of brain degeneration and faster processing speeds.
Researchers found that a genetic mutation associated with severe congenital epilepsy also leads to neural degeneration, inflammation and behavioral symptoms in mice. The study suggests the mutation as a potential target for treatment.
Researchers found correlations between brain morphology and sensory characteristics in adults with ASD, suggesting structural changes may cause sensory abnormalities. The study aims to improve diagnosis and treatment options for ASD beyond behavioral indicators.
A new study using the world's largest twin registry data finds that hormone levels before birth may contribute to migraine risk in adulthood. The research also suggests that genetic factors for migraine risk are different between men and women, potentially leading to more effective treatment options.
Researchers from Tel Aviv University have identified the biological mechanism causing nerve destruction in ALS, a fatal neurodegenerative disease. They found that TDP-43 protein accumulation in neuromuscular junctions inhibits local protein synthesis and mitochondrial activity, leading to degeneration and death of motor neurons.
A study by UC Riverside researchers shows that reactivating the Fmr1 gene in young transgenic mice with Fragile X syndrome eliminates symptoms. This breakthrough treatment offers hope for young children living with FXS and suggests targeting early brain development may be effective.
Researchers at the University of Göttingen studied how blocking certain enzymes affects brain adaptability in healthy and diseased mice. In healthy mice, inhibiting these enzymes blocked neuronal plasticity, while in stroke-affected mice, it restored lost plasticity.
Researchers have found consistent patterns in GABAergic neuron development between humans and mice, shedding light on the causes of neurodevelopmental disorders like autism and schizophrenia. The study uses single-cell RNA sequencing to create detailed maps of gene expression during human brain development.
A team of researchers has recorded electrical signals in the human brain associated with ebbs and flows in OCD symptoms over an extended period. The study could lead to an emerging therapy called deep brain stimulation that adjusts to everyday changes in OCD symptoms, potentially providing more relief and fewer side effects for patients.
Researchers from Tokyo Medical and Dental University found that PQBP1 interacts with Tau protein to drive an immune response in the brain. The study reveals a mechanism of inflammation that functions in both viral infection and neurodegenerative disease.
Children with autism spectrum disorder should be screened for abnormally high or low cholesterol levels, according to physicians. Research found reduced HDL-C levels in individuals with ASD, indicating a risk factor for cardiovascular disease.
A new web-based application can predict which epilepsy patients will not benefit from stereo-electroencephalography (SEEG), a costly and invasive procedure. The '5-SENSE' score reliably identifies patients who will not have a focal seizure onset zone, allowing clinicians to avoid unnecessary procedures.
The study, published in Nature Aging, found that sildenafil reduces the likelihood of developing Alzheimer's disease by 69% compared to non-users. Sildenafil also shows promise in treating the disease by increasing brain cell growth and decreasing hyperphosphorylation of tau proteins.
Researchers found improvements in verbal learning and memory and preservation of hippocampal volume in participants with relapsing-remitting multiple sclerosis after 12 weeks of supervised treadmill walking exercise. A targeted pilot randomized controlled trial demonstrated the effectiveness of this intervention for managing cognitive ...
Researchers found that gut microbiome changes can reduce b-amyloid deposits in male mice, indicating a potential target for preventing and treating dementia. Daily fecal matter transplants restored the pre-antibiotic microbiome, suggesting microglia memory plays a role.
A new 'image analysis pipeline' called TDAExplore gives scientists rapid insight into how cells are changed by disease, using a combination of microscopy, topology, and artificial intelligence. This approach can provide objective information on cell changes, such as the movement of proteins like actin, even with limited training data.
Researchers discovered that frequency-following responses to speech sounds are highly conserved across species, including monkeys, guinea pigs and humans. This finding could lead to the development of specific markers for speech impairments and improve clinical diagnostics.
Young veterans with mTBI experience premature cognitive decline in specific domains, matching elder normative scores and early-stage Parkinson's patients. The study highlights the significant negative impact of mTBI on cognitive function compared to healthy non-veterans.
Researchers developed a technology that accurately detects lies by analyzing facial muscle contractions, achieving a success rate of 73%. The study identified two distinct groups of 'liars' based on cheek muscle and eyebrow activation, with potential implications for real-life deception detection.
Researchers discovered short bursts of activity in the brain, known as 'events,' which occur regardless of brain state or activity. These events are guided by the brain's structural network and may be tied to the physical structure of brain regions, offering a potential new avenue for understanding brain injuries and disorders.
Researchers found that candesartan reduces accumulation of extracellular matrix proteins and normalizes blood flow in mice with hereditary cerebral small vessel disease. The study suggests a potential new treatment avenue for age-related cerebral arteriopathy.
Researchers at Universidad Complutense de Madrid have discovered alterations caused by ALS in the retina, which can be used as biomarkers for diagnosis and treatment monitoring. The study found changes in microglial cells and ganglion cell loss, with modifications evolving over the course of the disease.
Research reveals that dyslexic children process visual information slower and less accurately than their peers, with brain activity differences detected. This study challenges previous assumptions about the effects of dyslexia on brain processes.
Research published in JNeurosci found that children with dyslexia take longer to gather visual evidence, indicating altered motion processing and decision-making. This slowdown corresponds to differences in brain activity, particularly in centro-parietal regions involved in decision making.
Studies using virtual reality environments revealed that individuals with anxiety disorders exhibited increased brain activity in response to perceived threats, even in safe areas. The findings highlight the need for personalized treatments that help patients regain control over their body.
Researchers have created a mouse model of A-T, a disorder characterized by severe motor coordination loss and premature death, to test a promising new therapy. The study demonstrates that the therapy restores ATM production in tissues from A-T mutant mice.
A new report highlights the alarming global impact of Group B streptococcus, which can lead to up to 150,000 infant deaths annually. Maternal vaccination is seen as a cost-effective solution to reduce this toll, with significant health benefits in all regions.
A study by GIST scientists found that physical interaction between children with cerebral palsy and horses improves motor skills and balance. The research team recorded horse and child movements, tracking acceleration and angular velocity to quantify interactions, which were linked to improved outcomes.
A review of current literature found irregular brain responses to challenging tasks and mistakes may be key to understanding links between abnormal behaviors in mental illness and cognitive disorders. Studies suggest that people with conditions like anxiety, OCD, and ADHD have different brain waves following mistakes compared to health...
Researchers at the University of Waterloo have created a deep neural network that detects disease biomarkers with high accuracy, achieving 98 per cent detection of peptide features. This breakthrough could enable earlier and more accurate disease detection through tissue sample analysis.
Researchers found that small fiber neuropathy affects 13.3 per 100,000 people, with rates increasing over time. The condition is often associated with obesity, diabetes, insomnia, and heart attacks, highlighting the need for screening and prevention methods.
A new canine mutant model mimics human cerebrovascular disease by exhibiting severe arteriosclerosis, thrombosis, and stroke. The ApoE knockout dogs show extensive and severe arteriosclerosis plaques and arterial stenosis, consistent with human cerebral arteries and coronary arteries.
Researchers at GIST create an optical technique called optical speckle image velocimetry that can image dynamic changes in cerebral blood flow, allowing for the diagnosis of brain health. The technique provides high-time resolution and measures both speed and direction of blood flow.
Researchers from the University of Tsukuba found that blocking CD300a enhances efferocytosis and ameliorates neuronal deficits after ischemic stroke. This process involves the removal of damaged cells in the brain, reducing inflammation and neurological impairment.