Articles tagged with Neurological Disorders
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The journal Bioelectronics in Medicine explores the innovative field of bioelectronic neural prostheses, aiming to revolutionize healthcare. The first issue features articles on vagus nerve stimulation, neuromodulation, and peripheral nerves, among others.
Researchers conclude that 2-hydroxypropyl-β-cyclodextrin (HPβCD) does not cross the blood-brain barrier, which is crucial for addressing neurological manifestations of NPC1. This finding suggests that direct CNS administration may be necessary to achieve therapeutic efficacy.
Researchers successfully used microstimulation to elicit movements in monkeys by associating specific areas of the premotor cortex with particular actions. This breakthrough could lead to the development of brain/computer interfaces that bypass damaged brain areas, benefiting individuals with stroke or neurological disorders.
The NIH has awarded the Center for BrainHealth $2.5 million to examine cannabis use disorders and understand brain mechanisms behind problems related to cannabis use. The study aims to identify individual and cultural effects on severity of cannabis use disorder and inform public health policies.
This special issue highlights innovations in MALDI mass spectrometry for characterizing proteomes, detecting analytes, and screening non-covalent binding of small molecules to target proteins. MALDI imaging is used to study diseases and therapeutics, including the distribution of glycosphingolipids in a Gaucher Disease model mouse brain.
Researchers used brain MRI to identify differences in brain regions among ADHD patients, distinguishing between subtypes with high accuracy. The study suggests that psychoradiology, a field combining imaging analysis and mental health expertise, could improve diagnosis and treatment planning.
Geneticists at Emory University School of Medicine have discovered a mysterious DNA modification in animals, specifically adenine methylation, which increases four-fold under conditions of stress in the brain. This epigenetic modification may play a role in neuropsychiatric disorders.
The Azrieli Centre for Autism Research will foster innovations in therapy and a better understanding of autism spectrum disorder. Researchers will use advanced brain imaging techniques to map differences in children and adults living with ASD, leading to earlier diagnosis and effective intervention.
Researchers develop mathematical model that uncovers link between OCD beliefs and actions. People with OCD develop accurate sense of how things work but disregard it when making decisions, leading to second-guessing themselves.
The National Institutes of Health has awarded four grants to establish a coordinated scientific research effort on myalgic encephalomyelitis/chronic fatigue syndrome. Researchers will collaborate on projects, share data, and engage with the ME/CFS community to advance knowledge and potential treatments for this debilitating disease.
A new global study reveals that countries have saved more lives over the past decade, particularly among children under 5, but persistent health problems such as obesity, conflict, and mental illness continue to hinder progress. The 'triad of troubles' poses a stubborn barrier to active lifestyles.
Scientists identified network inefficiencies in six-month-old infants who later developed autism, with these abnormalities linked to severity of symptoms at 24 months. This study brings us closer to understanding the pathology of autism and developing effective interventions.
A study published in Neuropsychopharmacology found decreased brain pH levels in mouse models of schizophrenia, bipolar disorder, and autism spectrum disorder. The research suggests that lower brain pH may be an underlying pathophysiology for these mental disorders.
Researchers have discovered a new biomarker associated with mucopolysaccharidoses (MPS), a group of rare genetic disorders. Elevated CSF spermine levels were linked to CNS symptoms in patients, providing a potential diagnostic tool and target for novel therapeutics.
A new map of brain protein interactions could lead to more effective treatments for complex brain disorders like autism and schizophrenia. The map, created by USC researcher Marcelo P. Coba, highlights problematic pathways that current drugs are not targeting.
HIV-associated neurocognitive disorders (HAND) affect approximately one in four people living with HIV, causing symptoms such as memory loss and cognitive decline. Researchers have found elevated levels of microRNAs affecting brain development, providing a potential biomarker for diagnosis and monitoring disease progression.
Researchers at McGill University have shown that practice can alter the way the brain uses sensory information, including visual perception. By temporarily deactivating a critical brain region, subjects who practiced with moving lines were able to perceive motion despite the region's inactivation.
A clinical study showed that patients wearing a smart walking assist immediately improved their locomotor abilities and could perform daily activities without support. The algorithm tailors assistance to each patient based on leg movement, stride length, and muscle activity to promote natural walking patterns.
Researchers analyzed cerebrospinal fluid from Ebola survivors and found no viral RNA, but the results may suggest potential for dormant virus transmission. The findings highlight the need for monitoring EVD survivors for neurologic symptoms suggesting relapse in the CNS.
Researchers at Johns Hopkins Medicine have developed a modified skin biopsy technique to hasten the diagnosis of transthyretin amyloidosis, a rare and lethal nerve disease. The test, which detects protein clumps in skin samples, shows promise for more rapid clinical trials and improved treatment options.
Researchers developed FAST - a fast whole-brain imaging system that can visualize individual cells and subcellular structures in the entire brain. This technique allows for faster comparison of multiple brains to gain new insights into brain diseases.
A study published in the Journal of Neuroinflammation found that measuring two proteins in the blood can accurately diagnose autism spectrum disorder in approximately 75% of children. The diagnostic accuracy increases to 82% when both proteins are measured together.
Researchers used mathematics and MRI to better understand how neurological disorders affect brain connections. They discovered sub-networks called eigenmodes, which communicate information between brain regions.
A new brain network model suggests that understanding brain connections and structure can help predict how brain function changes after injury. The study identified key white matter pathways and lesions responsible for network disruptions, which could lead to more accurate treatment plans and therapeutic targets.
A new brain imaging study by CAMH researchers shows that brain inflammation is more than 30% higher in people with OCD compared to those without the condition. The study provides compelling evidence for a new potential direction for treating this anxiety disorder.
A new disease gene, MCM3AP, has been identified as causing early-onset axonal neuropathy and mild intellectual disability in multiple families worldwide. The gene was discovered using a global genetic matching platform, connecting patients and researchers from Finland to countries like Australia, Canada, Turkey, and Belgium.
The Child Mind Institute has released a comprehensive open dataset from the Healthy Brain Network study, featuring behavioral and cognitive assessments, brain imaging, genetics, and more. This dataset will enable researchers to identify biomarkers for childhood mental health disorders and develop new diagnostic tools.
A new robotic tool has been introduced for assessing muscle overactivity and movement dysfunction in stroke survivors. The robotic-assisted rehabilitation therapy is expected to improve the mobility of patients surviving a stroke.
Researchers found strong association between cognitive decline and small blood vessel disease in the brain, with 61% of older adults having at least one component of the condition. The study, part of the Atahualpa Project, suggests that vascular neurology may be an important factor in stroke and neurological disorders in Latin America.
A new study published in Nature Communications identifies specific neurons in the Lateral Prefrontal Cortex that encode perceived and memorized information. The researchers found that these neurons can signal whether a representation is real or imaginary, which may help treat disorders like schizophrenia.
Neurofibromatosis type I, an inherited disorder affecting brain development and function, will be studied by Assistant Professor Seth Tomchik. The disease predisposes individuals to behavioral symptoms such as ADHD, autism-like symptoms, learning disabilities, and chronic pain.
A study published in Scientific Reports reveals that diagnosing diseases and prescribing treatments engage the same brain system involved in everyday identification tasks. This finding may lead to new approaches to reduce medical errors by decreasing attentional focus during diagnosis.
A recent study published in JAMA Neurology found that US military service members who experienced a mild concussion after blast injury may continue to experience mental health symptoms and decreased quality of life for at least five years. The study also highlights the need for more effective, long-term treatment strategies.
Researchers created 3D brain organoids that replicate human forebrain circuitry, revealing the role of cell migration in autism. They successfully corrected defective neuron migration using a drug, paving the way for personalized treatments.
A study led by Dr. Juan Pascual found that a modified Atkins diet can help reduce seizures and improve patients' long-term health. Clinical trials testing an edible oil derived from castor beans may also improve cognitive abilities in patients with Glut1 deficiency.
Researchers developed nondestructive nanowire technology to record electrical activity of neurons with high sensitivity and resolution. The technology enables simultaneous measurement of multiple neurons and can isolate individual signals, paving the way for accelerated drug development and better understanding of brain function.
A team of researchers has identified the cause of a rare genetic disorder known as dystonia, which affects 70,000 people in the UK. The study found that mutations in the hippocalcin gene lead to overactivation of specific calcium channels, causing abnormal neuronal signaling and movement disorders.
Researchers grew stem cells from children with Pelizaeus-Merzbacher Disease to understand the genetic causes of common symptoms. The study identified defects in brain cell function linked to patient genetics, suggesting distinct subgroups requiring different clinical approaches.
A US study reveals that the annual cost of neurological diseases in the US is nearly $800 billion, with an estimated $600 billion to be spent on stroke and dementia treatment by 2030. The study emphasizes the need for increased funding to develop treatments and cures for these conditions.
Researchers found activation of maternal immune system during pregnancy alters expression of key genes and processes associated with autism, leading to potential neurological repercussions. MIA-induced effects involve single genes and pathways essential for early fetal neurodevelopment.
Researchers have discovered a critical finding about Alexander disease, a rare and fatal neurological disorder. Using mouse models, they found that the GFAP protein behind the symptoms is broken down more rapidly than previously thought.
A study found a link between defects in non-coding DNA and severe language impairment, as well as other neurodevelopmental disorders. Variants in the 3'UTRome region of the genome were associated with changes in protein expression, which may contribute to these conditions.
Researchers discovered that dendrites, a key component of neurons, generate nearly 10 times more electrical spikes than somas, challenging the long-held belief in neural computation. The finding may pave the way for treating neurological disorders and developing brain-like computers.
Researchers at WashU Medicine discovered that mice scratch in response to seeing other mice scratch due to the release of gastrin-releasing peptide (GRP), a key transmitter of itch signals. This behavior is hardwired into the brain and not a form of empathy.
Researchers will measure circulating biomarkers in over 17,000 persons enrolled in the Framingham Heart Study to identify new biomarkers for cerebral small vessel disease. The goal is to develop a gold standard for early detection and intervention with treatment.
Researchers assessed 6,711 adults with periodontal disease for 15 years and found participants with mild, moderate or severe gum disease were 1.9-2.2 times more likely to suffer an ischemic stroke than those without periodontal disease. The association was strongest in cardioembolic and thrombotic stroke subtypes.
A large imaging study of over 3200 people confirms that Attention Deficit Hyperactivity Disorder (ADHD) is associated with delayed development of five brain regions, supporting the notion that it is a brain disorder. The study found differences in brain volume across all age groups, but most pronounced in children.
Researchers identified a mutation in UNC13 protein associated with autism spectrum disorder, hyperactivity, and dyskinesia. The mutation disturbed fine-tuning of neuronal communication, leading to enhanced synaptic strength and increased neurotransmission.
Research suggests males are more likely to be diagnosed with dyslexia, possibly due to differences in reading performance and processing speed. Variability in processing speed may also contribute to co-occurring attention deficit/hyperactivity disorder.
Researchers at TGen identified a novel mutation in brain protein CASK that causes physical abnormalities and developmental delays in children. The study found a nearly 40% diagnosis rate among 440 sequenced genomes, offering insights into rare medical disorders.
Dr. McCullough will investigate the effects of social isolation on stroke damage and recovery using miRNAs. The study aims to develop new therapies reducing disability in patients after a stroke.
Researchers developed novel brain-mapping techniques to identify subtle changes in skull and brain shapes, giving a greater insight into conditions. The study focused on Cavalier King Charles Spaniel breed and identified characteristics that cause painful Chiari malformation and Syringomyelia disorder.
Researchers analyzed a large dataset of brain images from over 500 individuals to identify correlations between brain cortical anatomy and the Big Five personality traits. High levels of neuroticism were associated with increased thickness in certain regions, while openness was linked to reduced thickness and increased area and folding.
A study published in Addiction Biology found that long-term heavy drinking in adolescents alters brain electrical activity, particularly in the gamma-aminobutyric acid (GABA) neurotransmission system. This alteration may be detrimental to a developing brain, warranting tighter diagnostic criteria for substance abuse disorders.
Researchers developed a multiregional brain-on-a-chip to study how diseases impact different regions of the brain. The model characterized differences between neurons from distinct brain regions and mimicked system connectivity.
Scientists have developed a new technique to examine blood vessels in the brain using 3D Image Analysis, allowing for greater understanding of how diseases like dementia, brain cancer, and stroke affect veins and capillaries. This innovative method could help identify early warning signs of these illnesses, potentially saving lives.
Neuroscientists identify key brain areas responsible for delusional misidentification syndromes, a group of rare disorders where patients mistake people or places for imposters. The study's findings may help patients' families cope with the condition and improve treatment options.
Researchers challenged a popular autism hypothesis by studying brain responses to repeated visual and tactile stimuli. The findings showed that brain responses were as stable as those of healthy controls, contradicting the idea that unreliable brain activity causes autism symptoms.
Elyn Saks, a professor of law and psychology at USC, received the ACNP Media Award for her tireless efforts to educate the public about mental illness. Her work, including her memoir The Center Cannot Hold, has helped advance compassionate care and legal protections for people with mental illness.
Dr. Martin M. Katz has been recognized with the ACNP Paul Hoch Distinguished Service Award for his over 50 years of dedication to the organization and its mission. He made significant contributions to the theoretical understanding of antidepressant mechanisms, serving on key committees and editing notable publications.