Articles tagged with Respiratory Disorders
A landmark Australian study found even low levels of PM2.5, fine particulate matter in air pollution, increase risk of death from cardiovascular and respiratory diseases. For every 1 ug/m3 increase, there is a 2% increased risk of early death, threatening WHO safety standards.
A new review reveals COVID-19 poses a global threat to the nervous system, causing neurological manifestations in about half of hospitalized patients. These symptoms include headaches, seizures, and muscle pain, and may appear before fever or cough.
A new study by ISGlobal found that heat is now more lethal than cold for people with respiratory diseases in Spain, particularly women and older adults. The study analyzed data on over 1.3 million deaths between 1980 and 2016 and found a significant decline in temperature-attributable mortality during the colder months.
The American College of Cardiology and global partners will host a Week of Action from May 18 to 24 to raise awareness about non-communicable diseases. The event celebrates the launch of the ACC's NCD Academy, which provides free mobile app-based training for primary care providers.
A genetic disorder affecting Airedale Terriers has been discovered and found to be associated with a surfactant deficiency in their lungs. The study identifies the LAMP3 gene as a candidate gene for this disease and suggests a potential link to human newborn respiratory issues.
Researchers have identified three genes linked to idiopathic pulmonary fibrosis (IPF), a devastating lung disease. The discovery provides potential targets for new drugs and may lead to improved treatments.
Researchers aim to characterize coal dust properties and investigate biological effects of nano-coal dust on lung cells, using a 3D lung-on-a-chip device. This study seeks to understand the toxicity of nano-coal dusts and their impact on human health.
A rare form of lung scarring, typically found in metal workers, has been linked to vaping. The condition can cause breathing difficulties and chronic coughing due to damage to lung cells and the formation of 'giant' cells.
Researchers identified gene expression changes specific to early, progressive and end-stage fibrosis, as well as distinct molecular regulators for each stage. The study provides the first computational model of disease progression in IPF lung, accompanied by an interactive website.
Researchers observed reversed halo signs in most cases of CT-based septic pulmonary embolism diagnosis related to IV substance use disorder. The sign is an early and reliable imaging finding.
Researchers have identified a genetic mutation in the SFTPA1 gene that causes idiopathic pulmonary fibrosis (IPF), a progressive lung disease characterized by scar tissue buildup. Inhibiting necroptosis, a cell death pathway, could be a new therapeutic approach to treating IPF.
A new study suggests that metabolites produced by the body's breakdown of toxins may protect against obstructive airway disease in 9/11 first responders. Researchers identified specific compounds, including protein-building amino acids and omega-3 fatty acids, which are found in diets rich in fish and olive oil.
Researchers used a 'One Health' approach to study three bacterial species in the noses of young cattle, finding patterns that differ remarkably between the bacteria. The findings could help prevent and control respiratory diseases, particularly when infection becomes established in the lower respiratory tract within the lungs.
Research by Ohio State University found that low-income and African-American communities continue to face disproportionate levels of air pollution, exacerbating existing health disparities. The study's findings suggest that efforts to control pollution are not effectively addressing these inequities.
Lung scarring can lead to pulmonary fibrosis and life-threatening complications. Researchers found increased MMP activity in lung tissue affected by Hermansky-Pudlak syndrome, suggesting a new link for diagnosis and treatment.
Researchers studying a $750,000 grant at the University of Illinois Chicago aim to understand how various mining dusts contribute to lung disease. They plan to collect dust samples and expose mice to different combinations to determine the most damaging mixtures.
Progressive massive fibrosis, a severe form of black lung disease, is increasing among coal miners, despite unknown causes. Analysis of lung tissue samples from 1996 to 2019 failed to detect an increase in silicotic PMF, suggesting alternative explanations for the trend
Researchers developed a syndromic surveillance system to detect respiratory disease outbreaks in wild chimpanzees. The system identified 14 outbreaks from 2005 to 2012, including eight previously unrecorded cases, allowing for early interventions and potential disease transmission understanding worldwide.
A new magnetic resonance imaging (MRI) protocol has been developed to identify premature babies with chronic lung disease, allowing for earlier diagnosis and personalized treatment. The study, published in Thorax, reveals increased T2 and decreased T1 relaxation times in MRI data, indicating the presence of Bronchopulmonary Dysplasia.
Researchers at Vanderbilt University Medical Center developed a cross-circulation technique to rehabilitate damaged lungs, extending the assessment time from six hours to 36 hours. The regenerated lungs meet transplantation criteria, potentially increasing organ availability.
A new study found sporadic presence of Legionella pneumophila and Mycobacterium avium in tap water across the US. Microbial persistence was more common in office buildings than residences, with older homes being more prone to L. pneumophila contamination.
Researchers have identified an association between a MUC5B gene variant and systemic vasculitis, a lung disease prevalent in the Japanese population. The study found that patients with antineutrophil cytoplasmic antibody-associated vasculitis are more likely to have ILD if they carry this specific genetic variation.
A novel treatment targeting solitary B cells improved lung disease in CVID patients, offering a safer alternative to broad immunosuppressive therapies. Researchers identified elevated IgM levels as a marker of lung disease progression, allowing for precise timing of treatment and potential future therapeutic targets.
A study published in Nature Communications reveals that genes in lung cells lose synchronized behavior with age, leading to changes in gene activity and metabolic pathways. The researchers also found alterations in the extracellular matrix surrounding lung cells, affecting protein composition.
Patients with interstitial lung disease often experience significant treatment burdens, including drug-disease interactions. The study highlights the importance of careful evaluation before treatment initiation to minimize complications.
The American Thoracic Society has developed a new clinical practice guideline for home oxygen therapy in children with chronic hypoxemia. The guideline makes specific recommendations for treating various respiratory and pulmonary conditions, such as cystic fibrosis, bronchopulmonary dysplasia, and interstitial lung disease.
Researchers from UNIGE develop in vitro system to form microtubule doublets, revealing crucial role of tubulin in preventing uncontrolled ciliary structure formation. This discovery may lead to new treatments targeting differences between human and pathogen cilia.
A Malaysian study found that 42.6% of smokers who attended a quit clinic successfully quit, with daily cigarette count and previous attempts as key predictors. The study suggests these factors should be considered in interventions for smokers trying to quit.
A study published in Nature Communications identifies extracellular DNA degradation as a key mechanism of lung inflammation induced by silica exposure. Treatment with DNase I may prevent silica-induced lung inflammation, suggesting a new therapeutic target for silicosis.
A European Research Council Consolidator grant has been awarded to Dr. Yuval Rinkevich's team at Helmholtz Munich to study the role of fibroblasts in wound healing, with a focus on determining how differences in their populations affect scarring outcomes.
The life expectancy gap between rich and poor in England is increasing, with the poorest women's life expectancy falling since 2011. The study reveals that the richest live up to 9 years longer than the poorest men and women.
Researchers found Mycobacterium bacteria thriving in US showerheads, particularly in areas with high rates of lung disease. The study also revealed geographic patterns and material-specific influences on bacterial growth.
Research suggests a BMI of 21-25kg/m2 is associated with the lowest risk of dying from cancer and heart disease. The study found that underweight individuals were more likely to die from various causes, including cardiovascular disease, respiratory disease, and dementia.
Scientists have discovered new genetic pathways associated with severe lung disease in premature infants, including those related to gonadotropin releasing hormone and heart development. These findings offer promise for earlier risk detection and the development of more precise treatments for this life-threatening condition.
A team of CU researchers has identified a genetic connection between rheumatoid arthritis-associated interstitial lung disease and idiopathic pulmonary fibrosis. The study found that patients with RA are at risk of developing progressive pulmonary fibrosis, enabling potential interventions to prevent this condition.
A new technology called EFIRM has been developed to detect two cancer-linked mutations in blood or saliva samples from patients with early-stage lung cancer. The platform shows promise in identifying stages 1 and 2 NSCLC when surgical resection is still possible, offering a potential cure.
A new study by George Mason University found an estimated 2,035 emergency department visits from e-cigarette explosion and burn injuries between 2015-2017, underscoring the need for improved surveillance and regulation. The devices contain harmful substances like nicotine and ultrafine particles, posing serious health risks.
A new analysis published in The Lancet found that more than half of all countries are not on track to meet the UN target to reduce premature deaths from non-communicable diseases by a third by 2030. For women aged 30-70, only 9% of countries are on track, and for men, it's just 3%. The study highlights the need for policy changes to ad...
Researchers have developed a mouse model that induces scarring and damage similar to human idiopathic pulmonary fibrosis, allowing for the study of new pathways and targets. The model enables the testing of drugs in more clinically relevant ways, potentially leading to more effective therapeutic options.
Researchers demonstrate that a single transplantation of iPSC-derived macrophages into the lungs of mice with herPAP can effectively treat this life-threatening disease. The transplanted macrophages adapt and differentiate to function efficiently, providing long-term therapeutic benefits.
Researchers discovered that cholesterol disruption causes PAP, a condition where air sacs clog with surfactant. A clinical trial to test statin therapy is planned, showing improved respiratory function in patients and laboratory models.
A large study found that consuming fish was associated with a reduced risk of mortality from all causes, as well as specific chronic diseases like cardiovascular disease, cancer, respiratory disease, and Alzheimer's. Higher intake of long-chain omega-3 fatty acids also showed significant protective effects.
A recent study published in Respiration has found that people with type 2 diabetes are significantly more likely to suffer from breathlessness and restrictive lung disease. The research team also discovered an association between albuminuria and RLD, suggesting a possible link between lung and kidney diseases.
A recent study published in Addiction found that abstainers had a higher risk of sickness absence due to mental disorders, while at-risk drinkers were more prone to absence due to injury or poisoning. The U-shaped association suggests different underlying health issues for the two groups.
A new biotechnology, lung-on-a-chip, has been developed to simulate pulmonary fibrosis, a serious lung disease. This innovation could streamline the drug-testing process, making it quicker and less expensive.
A feasibility study suggests that airway transplantation using cryopreserved aortic grafts may be an effective treatment option for patients with lung cancer and end-stage tracheobronchial disease. The study shows promising results, including low mortality rates and successful breathing through newly formed airways.
A new study analyzing MSHA data found that mines that comply with health regulations experience a substantially lower number of lung diseases over time. The majority of cases originated in the Appalachian region, where coal mines were 16-17.8 times more likely to report a lung disease diagnosis.
A new study developed a novel risk tool to predict 30-day readmission rates in patients undergoing transcatheter aortic valve replacement (TAVR). The tool calculates a score based on several variables, including chronic kidney disease, anemia, and discharge disposition, with a c-statistic of 0.63.
Researchers at Cincinnati Children's Hospital Medical Center have identified a new molecular target, FOXF1, that slows or stops idiopathic pulmonary fibrosis (IPF) in preclinical laboratory tests. The study found that FOXF1 inhibits IPF disease process by regulating genes involved in lung scarring and inflammation.
Researchers estimate the risk of infectious disease transmission on airplanes, finding that movement patterns can facilitate disease spread. Passengers seated within one row and two seats lateral to an infected individual have a high probability of infection, while others are at low risk.
Rheumatologist Shervin Assassi is developing a blood test to determine which drugs work best for patients with lung disease and scleroderma. The new project aims to create prediction models that identify patients who are likely to respond to immunosuppression.
Researchers at Helmholtz Zentrum München have discovered a novel mechanism that causes malignant pleural effusion in lung cancer patients. The mechanism involves inflammatory messengers from the immune system, leading to fluid buildup and accompanying malignant cells.
Scientists have solved the puzzle of why some people with primary ciliary dyskinesia have non-functional cilia. Researchers found that mutations in non-motor proteins cause cilia to assemble incorrectly, leading to respiratory infections and other symptoms. The study offers new hope for treatment and potential screening for medications.
Research shows cystic fibrosis patients in the US have better nutritional status and faster lung function improvements compared to those in Canada. The study suggests early implementation of newborn screening and quality improvement initiatives may contribute to these positive trends.
A new study published in Acta Paediatrica indicates that survival rates for babies born weighing 500g are alarmingly low. Short-term morbidity is prevalent among surviving infants, with retinopathy of prematurity and chronic lung disease being common issues.
A 52-gene risk profile predicts individual patient survival for idiopathic pulmonary fibrosis (IPF) patients, improving the accuracy of current clinical tools. The study's findings have important implications for disease management and treatment decisions.
A study from Oregon State University found that people who experience stigma are more likely to self-identify as disabled and develop pride in their disability. The researchers also discovered that severe impairments lead to greater stigma, which can increase the likelihood of self-identification. Developing disability pride is associa...
Researchers found that neutrophils lose oxygen-sensing protein, leading to overactive response to infection and chronic inflammation. Studying glucose regulation in neutrophils may lead to new treatments for patients with low oxygen levels and lung disease.
Researchers from Helmholtz Munich found that cellular senescence in lung epithelial cells can contribute to the development and worsening of IPF. Senescent cells secrete mediators that promote fibrosis and impair lung function by preventing cell division.
A large study found that higher childhood intelligence is associated with a lower lifetime risk of death from various causes, including respiratory disease, coronary heart disease, and stroke. The study of over 65,000 individuals suggests that lifestyle factors like tobacco smoking play a significant role in this relationship.