Articles tagged with Respiratory Disorders
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A new study developed a novel risk tool to predict 30-day readmission rates in patients undergoing transcatheter aortic valve replacement (TAVR). The tool calculates a score based on several variables, including chronic kidney disease, anemia, and discharge disposition, with a c-statistic of 0.63.
Researchers at Cincinnati Children's Hospital Medical Center have identified a new molecular target, FOXF1, that slows or stops idiopathic pulmonary fibrosis (IPF) in preclinical laboratory tests. The study found that FOXF1 inhibits IPF disease process by regulating genes involved in lung scarring and inflammation.
Researchers estimate the risk of infectious disease transmission on airplanes, finding that movement patterns can facilitate disease spread. Passengers seated within one row and two seats lateral to an infected individual have a high probability of infection, while others are at low risk.
Rheumatologist Shervin Assassi is developing a blood test to determine which drugs work best for patients with lung disease and scleroderma. The new project aims to create prediction models that identify patients who are likely to respond to immunosuppression.
Researchers at Helmholtz Zentrum München have discovered a novel mechanism that causes malignant pleural effusion in lung cancer patients. The mechanism involves inflammatory messengers from the immune system, leading to fluid buildup and accompanying malignant cells.
Scientists have solved the puzzle of why some people with primary ciliary dyskinesia have non-functional cilia. Researchers found that mutations in non-motor proteins cause cilia to assemble incorrectly, leading to respiratory infections and other symptoms. The study offers new hope for treatment and potential screening for medications.
Research shows cystic fibrosis patients in the US have better nutritional status and faster lung function improvements compared to those in Canada. The study suggests early implementation of newborn screening and quality improvement initiatives may contribute to these positive trends.
A new study published in Acta Paediatrica indicates that survival rates for babies born weighing 500g are alarmingly low. Short-term morbidity is prevalent among surviving infants, with retinopathy of prematurity and chronic lung disease being common issues.
A 52-gene risk profile predicts individual patient survival for idiopathic pulmonary fibrosis (IPF) patients, improving the accuracy of current clinical tools. The study's findings have important implications for disease management and treatment decisions.
A study from Oregon State University found that people who experience stigma are more likely to self-identify as disabled and develop pride in their disability. The researchers also discovered that severe impairments lead to greater stigma, which can increase the likelihood of self-identification. Developing disability pride is associa...
Researchers found that neutrophils lose oxygen-sensing protein, leading to overactive response to infection and chronic inflammation. Studying glucose regulation in neutrophils may lead to new treatments for patients with low oxygen levels and lung disease.
Researchers from Helmholtz Munich found that cellular senescence in lung epithelial cells can contribute to the development and worsening of IPF. Senescent cells secrete mediators that promote fibrosis and impair lung function by preventing cell division.
A large study found that higher childhood intelligence is associated with a lower lifetime risk of death from various causes, including respiratory disease, coronary heart disease, and stroke. The study of over 65,000 individuals suggests that lifestyle factors like tobacco smoking play a significant role in this relationship.
A survey of lung disease patients reveals equipment issues, access barriers, and anxiety over running out of oxygen as major concerns. The study highlights the need for improved home oxygen services that support mobility and quality of life.
Researchers at Columbia University Irving Medical Center have created miniature lung structures, known as organoids, that replicate key features of a full-sized lung. These tiny organs may aid in understanding and treating respiratory diseases such as idiopathic pulmonary fibrosis.
Researchers review key two-component systems in pathogens causing CF lung disease, finding potential for histidine kinase inhibitors to treat infections. TCS inhibitors alone or combined with existing treatments show promise for addressing antibiotic resistance in CF patients.
A prospective study in patients with cirrhosis found that severe periodontitis strongly predicted higher mortality, mainly due to complications of cirrhosis. The study also showed a strong association between gum disease and risk of death in liver patients.
Researchers at Boston University School of Medicine have found a genomic biomarker in the nasal passage that can accurately determine lung cancer likelihood. This non-invasive test may spare patients from costly and risky procedures by identifying those at low probability for having lung cancer.
Scientists have developed a method to observe gene editing in real-time, enabling the investigation of CRISPR-Cas9's biological processes and potential applications for treating genetic diseases such as sickle cell anemia and cystic fibrosis.
Researchers at Helmholtz Zentrum München found that nanoparticles from combustion engines can reactivate latent herpes viruses in lung tissue cells. This process can lead to increased viral proteins and acute infection patterns. Further studies aim to investigate the molecular mechanism of virus reactivation by nanoparticles.
Researchers from Cincinnati Children's Hospital Medical Center identify novel targets and molecular pathways for IPF, which inflames and scars lung tissues. Analysis of single-cell RNA sequence data reveals genetic markers linked to abnormal cell formation and loss of normal genetic control systems.
Researchers found a link between the loss of hyaluronan and AEC2 stem cell failure, leading to scarring in lungs. The study highlights potential treatment pathways using drugs that stimulate AEC2 cell reproduction.
Unproven stem cell therapies are on the rise for lung disease patients, despite promise of new treatments. Researchers warn that aggressive marketing and lack of regulation are exacerbating perceptions of these therapies.
A new four-dimensional lung scanning platform developed at Monash University has the potential to transform treatment for millions of people with lung disease. The technology allows clinicians to detect changes in lung function earlier, enabling them to quantify the effects of treatment.
A new rare genetic condition has been discovered, characterized by severe infections and lung disease in infants. The NSMCE3 gene mutations were found to be responsible for the devastating symptoms, offering a potential explanation and diagnostic tool for this deadly disease.
Scientists at Helmholtz Zentrum München are developing new tests to assess risks posed by nanomaterials in the airways, aiming to reduce complex toxicity tests. The project uses modern methods like systems biology and computer modeling to predict nanotoxicity.
Researchers found that women who experienced sexual assault had higher rates of diseases like circulatory and respiratory issues, epilepsy, and liver disease before and after the assault. The study also showed increased visits to general practitioners for exposed women.
A Johns Hopkins study suggests that over 250,000 deaths per year in the US are due to medical error. The researchers advocate for updated criteria for classifying deaths on death certificates to better reflect reality.
Researchers at the University of Southampton have successfully applied advanced 3D imaging technology to study Idiopathic Pulmonary Fibrosis (IPF) lung tissue samples. The study found that active scarring in IPF progresses in multiple individual sites rather than a large 'wave', offering new hope for targeted treatments.
Researchers at VIB-UGent demonstrate that adult circulating monocytes can differentiate into macrophages with identical tissue-specific functions and self-maintenance capacities as those from embryonic origin. This discovery paves the way for monocyte-based cellular therapy in diseases associated with macrophage dysfunction, such as pu...
Scientists at the University of Nottingham have developed a process to create hyperpolarized krypton gas for MRI scanning of the lungs, offering a clearer picture of lung disease. This technology uses clean energy combustion to retain the hyperpolarized state of krypton during preparation.
A study found that people newly diagnosed with MS are more likely to have depression and other chronic conditions. The study also showed that the rates of these conditions differ between men and women with MS.
Researchers at the University of Edinburgh found a compound called cathelicidin that directly attacks and stops RSV from binding to cells. Boosting natural production of this compound could protect babies and vulnerable adults from life-threatening illnesses.
Researchers developed a mouse model to study the effects of abnormal vascular endothelial growth factor (VEGF) levels on lung development. The study found that reduced VEGF signaling can 'turn on' lung disease, even in full-term animals, and replicate key features of neonatal respiratory distress syndrome.
A Harvard T.H. Chan School of Public Health study found diacetyl, a flavoring chemical, in over 75% of flavored e-cigarettes and refill liquids, posing a risk to respiratory health.
There are around 500,000 new work-related illnesses every year, with over 13,000 deaths caused by occupational exposures. However, only 0.3% of these cases are reported to the Health and Safety Executive, leading to a lack of enforcement of employers' duty to protect workers.
A new strategy to determine monocyte subsets involved in diseases has been developed, which may improve the diagnosis of sarcoidosis. The analysis of an additional marker molecule called slan allows a more precise determination of monocyte subgroups.
A new study reveals that smokers are up to 3.6 times more likely to lose their teeth, with male smokers being the most affected. Quitting smoking can reduce this risk, although it may take over a decade for ex-smokers to regain the same level of dental health as non-smokers.
A study in nearly 800,000 patients found a positive association between carbonated beverage consumption and out-of-hospital cardiac arrests of cardiac origin. Limiting carbonated drink consumption may help reduce the risk of fatal cardiovascular disease.
Research at the University of Surrey reveals peak concentrations of ultrafine particles reach up to 4000 times local background levels during building activities. Breathing these particles can lead to cardiovascular and respiratory system diseases.
A major European mouse study has identified the roles of 320 genes in mice, shedding light on their functions and potential links to human diseases. The study, led by Helmholtz Munich, provides valuable insights into genetic variations that can be used to develop personalized medicine approaches.
A novel mass spectrometry technique has enabled scientists to quantify and profile dynamic changes in lung tissue composition during regeneration. The study reveals the importance of extracellular matrix proteins in activating stem cells, offering a new avenue for treating chronic lung diseases like pulmonary fibrosis.
Early screening echocardiography for patent ductus arteriosus among extremely preterm infants reduced in-hospital mortality and pulmonary hemorrhage rates. The study found no significant differences in severe complications like necrotizing enterocolitis or bronchopulmonary dysplasia.
A recent study published in Respirology found that patients with idiopathic pulmonary fibrosis (IPF) have significantly shorter telomere lengths than healthy individuals. The study suggests that mutations in the enzyme responsible for maintaining full-length telomeres may play a key role in the development of IPF.
A new five-year grant aims to develop novel treatments for diseases that inhibit blood cell growth and abnormalities in the bone marrow environment. The study focuses on the role of laminin in maintaining healthy bone marrow and identifying potential targets for treating bone marrow failure syndromes.
Researchers at Helmholtz Munich have identified FKBP10 as a potential new target molecule for treating idiopathic pulmonary fibrosis (IPF), a chronic lung disease. Analysis of patient data revealed elevated levels of the protein in IPF patients, which may lead to a new therapeutic approach.
Research suggests people with MS may have double the risk of dying early compared to those without the disease. Younger individuals with MS are particularly vulnerable, facing a three times higher risk of death.
A new genomic test has been validated for detecting lung cancer with high sensitivity, allowing physicians to identify patients at low probability of having the disease. This test can spare patients from costly and risky procedures, improving diagnosis and patient anxiety.
Researchers predict that personalized medicine interventions could generate significant healthcare gains, including a $607 billion reduction in heart disease incidence. However, weak incentives to develop these interventions hinder their adoption, and experts suggest reimbursement reform could strengthen manufacturers' incentives.
Scientists have discovered a new autoimmune syndrome characterized by severe lung disease and arthritis in early childhood. The disorder is caused by mutations in the COPA gene, which disrupts protein trafficking within cells, leading to cellular stress and an immune response. Researchers believe that targeting Th17 cells with drugs ma...
Research reveals FGFR1 amplification in 22.7% of small cell lung cancer tumors, implying applicability to non-small cell lung cancer treatments
A team of UC researchers will study the rare lung disease pulmonary alveolar microlithiasis, which causes 'lung stones' and reduces life expectancy by several decades. The grant will help them develop a mouse model to understand the cause of the disease and design trials for treatment.
The increasing use of asbestos in Asia poses a significant threat to public health, with the potential for widespread mesothelioma and lung cancer cases. Government and non-government groups must work together to improve recognition and diagnosis of asbestos-related lung diseases.
Researchers have created a disease signature for alpha-1 antitrypsin deficiency using induced pluripotent stem cells (iPSCs), which may lead to new treatments. The study found that liver cells derived from AAT deficient iPSCs are more sensitive to drugs that cause liver toxicity than normal cells.
Researchers have found a correlation between metabolic imbalance and increased risk of respiratory diseases in early childhood. Elevated concentrations of specific sugars, such as hexoses, were associated with elevated inflammatory immune parameters.
New connections in gene regulation have been discovered in normal lung cells that may contribute to lung tumor formation. The researchers found that the transcription factor Nkx2-1 regulates lung cell proliferation, tumor growth, and progression by binding to microRNAs.
A pulmonary rehabilitation programme will be assessed and implemented in Uganda, Tanzania, and Zambia to improve treatment and quality of life for patients with chronic lung disease. The study aims to reduce the burden on local communities and economies by developing an effective and inclusive programme.
A nationwide survey of 2200 French adults reveals significant knowledge gaps about lung cancer, including misconceptions about screening, treatment options, and prognosis. The study emphasizes the need for public education to address these gaps and improve outcomes.
As people live longer, soaring levels of chronic illness and diminished wellbeing threaten the quality of life of older people. Strategies are needed to prevent and manage chronic conditions through affordable healthcare and social environment changes.
The NIH has awarded $29 million to expand the Rare Diseases Clinical Research Network, a collaborative effort of physician scientists and patient advocacy groups. This funding will support clinical research and investigation of new treatments for patients with rare diseases, with a focus on improving diagnosis and treatment outcomes.