Articles tagged with Respiratory Failure
A clinical trial conducted by RCSI researchers found that administering alpha-1 antitrypsin to critically ill COVID-19 patients reduced inflammation after one week. The study's results are promising and may form the basis for a larger trial.
A four-year cohort study found children who survived invasive mechanical ventilation had significantly lower subsequent IQ scores than matched siblings. Researchers also identified the existence and epidemiology of pediatric post-intensive care syndrome after acute respiratory failure.
Researchers investigated the association between acute respiratory failure in early childhood and long-term neurocognitive outcomes. The study found that children who experienced severe respiratory distress were more likely to have impaired cognitive function and behavioral problems later in life.
A study found that using two cannulas to place newborns in respiratory failure on life-sustaining ECMO increases mortality rates. The safest path is a single cannula in the right internal jugular, which can remove oxygen-poor blood and add oxygen before returning it to the baby.
A new study by Dr. Brian Stansfield and Dr. Jessica Gancar found a clear linear relationship between mortality and red blood cell transfusion volume in newborns on ECMO, with a 14% decrease in survival chances for every transfusion. The study suggests that reducing transfusion volumes may improve outcomes.
Researchers at Medical University of Vienna discovered that certain microbiome profiles following lung transplantation can provide prognostic information for future changes in lung function. Machine Learning analyzed multiomics data, including the microbiome, lipidome, and metabolome, to predict lung function deterioration.
A global study found that hospitalized COVID-19 patients with metabolic syndrome had a 20% higher risk of developing acute respiratory distress syndrome (ARDS) and dying. The study examined records of over 46,000 patients in 181 hospitals across 26 countries.
A clinical trial has revealed that COVID-19 patients on ventilators have less surfactant in their lungs due to the virus. The researchers suggest that giving extra surfactant for a longer period could help save lives by supporting breathing and allowing lung cells to repair after the infection passes.
Researchers found that macrophages play a central role in COVID-19-related respiratory failure, leading to fibroproliferative ARDS and prolonged ventilation. Extensive tissue damage and scar tissue formation are characteristic of severe lung failure.
A study by West Virginia University researcher Sunil Sharma found that rural COVID patients who end up in an intensive care unit are more likely to die within 30 days compared to their urban counterparts. The researchers also discovered that rural patients with COVID-linked ARDS have a higher mortality rate, even when controlling for d...
A clinical trial of 465 patients found that administering heparin in therapeutic doses reduced mortality from COVID-19 by 78%, with benefits only observed when administered between seven and 14 days after symptom onset. The study suggests that timing is crucial for treatment efficacy.
A study found that racial bias in oxygen readings during the pandemic can lead to unequal access to life-saving ECMO therapy. The analysis, using a comprehensive international database, revealed higher rates of discrepancies in Black patients compared to white patients.
A new study found that the survival rate of COVID-19 patients on ECMO has decreased over time, with those treated later in the pandemic having lower chances of survival. Careful patient selection and resource management are essential for hospitals offering ECMO to maximize survival rates.
A low-cost prototype breathing device designed for poorer-resourced healthcare settings has shown promising results in a pilot trial involving healthy volunteers. The device provides continuous positive airway pressure (CPAP) therapy and operates with oxygen concentrators, which are commonly used in low-pressure systems.
Researchers used a hamster model to study COVID-19 lung damage, discovering that the immune system's response plays a crucial role in disease progression. They found that certain cells involved in lung immunity ingest the virus, triggering an inflammatory response that can be brought under control by T cells.
Scientists successfully deliver oxygen through the lining of the intestine, a process called enteral ventilation or EVA, to alleviate respiratory failure. The method shows promise for reducing negative effects of oxygen deprivation and has potential as a less invasive alternative to traditional ventilators.
Researchers have found that rodents and pigs can survive with the help of oxygen administered through their rectum. A liquid-based alternative has also been developed, which reversed symptoms in both models without producing side effects.
Two studies from Michigan Medicine reveal COVID-19 deaths are primarily due to lung damage, unlike other lung failures. Evidence-based interventions like prone positioning and mechanical ventilation improve outcomes.
Researchers detected a significant spike in cough and acute respiratory failure cases at UCLA Health facilities between Dec. 2019 and Feb. 2020, exceeding previous year's averages by 1,000. This unexpected increase may indicate early COVID-19 cases in the area.
Researchers successfully used single-access, dual-stage venovenous ECMO to treat COVID-19 patients with severe respiratory failure. The study found early extubation during ECMO support was crucial in improving patient outcomes.
Researchers at LMU Munich found activated immune cells and blood platelets play a major role in COVID-19 pathologies, leading to lung failure and systemic clot formation. The study identified a link between virus-induced changes in the lungs and increased thrombotic risk.
The prone position is associated with improved oxygenation and decreased risk for intubation in patients with severe COVID-19 hypoxemic respiratory failure. This observational study investigated the effects of prone positioning on patients who are spontaneously breathing.
Researchers at Rush University Medical Center found that high plasma suPAR levels are associated with worse lung outcomes and increased risk of intubation. The study suggests that measuring suPAR could help identify patients who may need ventilatory support, enabling earlier intervention and potentially improving outcomes.
Researchers identified specific microRNAs that predict pneumonia complications, enabling early detection and intervention. The study found correlations between microRNA profiles and sepsis and respiratory failure in pneumonia patients.
A review of nearly 2.5 million patient records found that regions with greater primary care usage had lower respiratory failure admissions, particularly among patients with chronic diseases like asthma and COPD. This suggests that more primary care may reduce rates of respiratory failure and ICU admissions.
A new trial led by Queen's University Belfast aims to improve survival rates for critically ill patients with respiratory failure. The 'extracorporeal carbon dioxide removal' procedure could significantly reduce mortality rates and provide gentler ventilation, reducing lung damage caused by mechanical ventilation.
A case study describes a patient with combined complex I+IV defect of the respiratory chain, manifesting as muscular respiratory insufficiency. The condition can also affect peripheral nerves, brain, heart, and extra-ocular muscles, requiring long-term mechanical ventilation.
A new mobile Critical Care Recovery Program aims to bring post-ICU care to patients in their homes, improving brain health and reducing rehospitalization rates. The 12-month program will be followed by a multi-disciplinary team to develop personalized recovery plans.
Researchers found that treatments don't fit a 'one size fits all' model for patients with myotonic dystrophy type 1. Targeted therapies were more effective when matched to individual symptoms, with 29% of patients benefiting from treatments such as CPAP and modafinil.
The Extracorporeal Life Support Organization (ELSO) registry report finds that ECLS is becoming more widely available and frequently used globally. Adults with respiratory failure are the fastest-growing group of ECLS patients, while rates of survival to hospital discharge have improved for this age group. In contrast, newborns with re...
A study comparing standardized rehabilitation therapy to usual ICU care found no difference in median hospital length of stay, despite improved functional-related and health-related quality-of-life outcomes at discharge.
A new technology called 'extracorporeal carbon dioxide removal' aims to minimize damage to lungs caused by mechanical ventilation. The study will test its effectiveness in reducing mortality rates and improving long-term survival for patients with respiratory failure.
A new method of oxygen delivery, high-flow nasal oxygen therapy, was found to be non-inferior to traditional noninvasive ventilation in treating postoperative respiratory failure. The study compared outcomes between 830 patients who received either high-flow nasal oxygen therapy or bilevel positive airway pressure.
A new study published in JAMA found that a nurse-implemented sedation protocol did not reduce the duration of mechanical ventilation in children. The protocol aimed to provide targeted sedation and adjust doses every 8 hours, but it had no significant impact on time on ventilator or recovery from acute respiratory failure.
A study suggests that busier emergency centers may give the best chance of surviving life-threatening medical crises, with a 10% lower death rate compared to less busy centers. Patients with sepsis had a 26% lower death rate at busiest centers.
A study found clinically important sleep apnea is common among survivors of acute respiratory failure, with 93% meeting criteria for sleep-disordered breathing. Evaluating and treating sleep apnea may significantly impact the health and well-being of these patients, particularly those taking central-acting medications.
A study published in JAMA found that patients with severe 2009 H1N1 influenza who developed respiratory failure and received extracorporeal membrane oxygenation (ECMO) treatment had a lower rate of in-hospital death compared to those who did not receive ECMO. The study used matching techniques to analyze data from 1,756 patients.
A study of nearly 600 patients found that anaemia was frequently found in patients with severe non-inflammatory respiratory diseases. The research team discovered that older patients, those with other health problems and poor nutrition were more likely to have anaemia.
The Canadian Medical Association Journal published new clinical practice guidelines for noninvasive ventilation, addressing its use in various settings. Key findings include recommending noninvasive positive-pressure ventilation as the first choice for patients with chronic obstructive pulmonary disease or cardiogenic pulmonary edema.
Researchers found helmet ventilation improves PaO2 in most ARF patients, low intubation rate and good tolerability. Admission to teaching hospitals increases mortality in ARF patients, study suggests factors needed to be explored.
A study published in JAMA found that most patients with severe respiratory failure due to 2009 influenza A(H1N1) and treated with an oxygenating system survived the disease. The study analyzed data from 68 patients who received extracorporeal membrane oxygenation (ECMO) support, and found that 54 had survived and 14 had died.
Patients with chronic respiratory disorders who received early noninvasive ventilation after extubation had a lower risk of death and respiratory failure compared to those given conventional oxygen therapy. Non-invasive ventilation was associated with an 83% decreased risk of respiratory failure after extubation.
Researchers found that diabetic patients are less likely to develop acute respiratory failure during severe sepsis. They discovered that people with diabetes and sepsis were more likely to develop acute renal failure than those without diabetes.
HealthGrades study reveals medical errors cost Medicare program $8.8 billion and result in 1.1 million patient safety incidents, with top-performing hospitals having 43% lower incident rate. Potentially preventable deaths total 238,337, and could have been avoided at a savings of over $2 billion.
The HealthGrades study found that patient-safety incidents rose 3% over the years 2003 to 2005, resulting in 1.16 million preventable incidents and 247,662 deaths. Top-performing hospitals had a 40% lower rate of medical errors compared to the poorest performers.
The study found that patients' lung volumes are lower following surgery and general anesthesia, increasing the risk of developing pneumonia, respiratory failure, or worsening existing lung disease. The guidelines provide patient-related risk factors and surgery-related risk factors to assess pulmonary complications.
Study identifies chronic conditions, including NNMD, as increasing risk of respiratory failure in children hospitalized with influenza. Children with these conditions are 6-4 times more likely to develop respiratory failure compared to those without.
Researchers found a significant risk factor for early respiratory failure following stem cell transplantation: patients with low lung function test scores prior to treatment. The study analyzed 2,852 patients who received allogeneic transplants between 1990 and 2001.
A study found that acute eosinophilic pneumonia (AEP) was diagnosed in 18 US military personnel deployed to Iraq, with a high incidence rate of 9.1 per 100,000 person-years. All patients reported significant exposure to fine airborne sand or dust and used tobacco, but no common source exposure was identified.
The survival rate of ICU patients with acute respiratory failure (ARF) is influenced by the presence or absence of organ failure in other vital organs. Patients with ARF alone have a lower mortality rate compared to those with multiple organ failure. The study emphasizes the importance of treating all organs simultaneously for optimal ...