Articles tagged with Respiratory Failure
Experts weigh the pros and cons of an upper age limit for lung transplants, citing concerns over organ shortage and quality of life. Some argue that setting a hard age limit ignores biological variability and comorbidities, while others suggest increasing donor supply and utilization could solve the issue.
Researchers developed a machine learning model to predict 28-day mortality in patients with sepsis complicated by acute respiratory failure. The model demonstrated strong discrimination for predicting mortality, with key variables including oxygenation indices, serum albumin levels, and disease severity scores.
Decisions on extracorporeal membrane oxygenation (ECMO) for severe respiratory failure rely heavily on clinical judgments rather than objective guidelines. Variability in decision-making may lead to inconsistent allocation of this life-supporting treatment. The study aims to improve ECMO accessibility and equity.
Severe COVID-19 and influenza infections can prime the lungs for cancer development, according to new research. Vaccination, however, largely prevents these changes, suggesting a reduced risk of lung cancer.
The American College of Chest Physicians' CHEST Critical Care journal has been added to the Web of Science Core Collection through the Emerging Sources Citation Index. This indexing marks a significant milestone for the journal, increasing access to high-quality research and supporting its commitment to advancing critical care medicine.
A study published in EBioMedicine found changes in blood samples from almost 1,000 people hospitalized for COVID-19 may pinpoint patients at risk of long-term lung disease. The study identified elevated levels of certain molecules, which could lead to the development of simple blood tests to detect ongoing lung problems.
The American College of Chest Physicians (CHEST) received the 2025 Glenview Environmental Sustainability Award for Innovation, recognizing its commitment to clean energy and reduced emissions. The organization's solar panel installation at its headquarters powers medical simulation facilities using renewable energy.
The American College of Chest Physicians released a new clinical guideline on biologic management in severe asthma. The guideline provides evidence-based recommendations for selecting biologics for different patient populations, considering factors such as baseline oral corticosteroid use and comorbid conditions.
A new diagnostic method using AI and genetic information can accurately identify pneumonia in critically ill patients, distinguishing between infectious and non-infectious causes. The model has been shown to reduce inappropriate antibiotic use by over 80% and could lead to faster diagnosis and improved patient outcomes.
A European consortium developed a new decision-making framework to predict COPD exacerbation severity and prognostic risk, integrating three key factors: baseline health status, event intensity, and triggers. This framework, known as BAt model, aims to guide treatment strategies and improve consistency across clinical settings.
Research published in ERJ Open Research suggests that assessing hospital patients' reported shortness of breath could help doctors prioritize care for those at high risk of death. Patients who developed shortness of breath were six times more likely to die than those who did not, with a higher rating indicating greater risk.
A new Northwestern University study reveals that abnormal cells in transplanted lungs engage in harmful 'conversations' with the immune system, leading to damage and rejection. The findings provide a comprehensive roadmap for treating chronic lung allograft dysfunction and other scarring lung diseases.
The American College of Chest Physicians has designated October 19, 2025, as 'Love Your Lungs Day' in recognition of respiratory health. This initiative aims to raise awareness about lung diseases such as asthma and COPD, promoting equity and supporting healthcare providers.
Researchers aim to determine if biomarkers can identify adults at risk of developing interstitial lung disease (ILD), a chronic condition that causes inflammation and scarring in the lung tissue. The approach could lead to the development of new, better treatments with more tolerable side effects.
A pilot study found that hypnosis significantly improved patients' tolerance of masks, allowing them to breathe more comfortably. The study showed a substantial improvement in non-invasive ventilation (NIV) tolerance, reduced agitation, and lower requirements for sedation and anti-anxiety medication.
The American College of Chest Physicians has achieved a critical milestone in its advocacy efforts, leading to changes in federal coverage guidelines for noninvasive ventilation devices used in the home. These revised guidelines reflect major recommendations submitted by CHEST and aim to enhance patient care.
A new genetic study has identified genes involved in neuronal signalling and sensory pathways as key drivers of chronic cough. The findings advance our understanding of cough reflex hypersensitivity as a nervous system-mediated process, opening up opportunities for targeted treatments.
Research found that chronic exposure to PM10 and PM2.5 air pollutants activates harmful allergic-like immune responses in the lungs, leading to inflammation and scarring. The study suggests targeting oxidative stress or modulating NRF2 activity could be a new strategy to treat pollution-induced allergic inflammation.
Research warns that GLP-1 drugs may not provide the long-term health benefit of improved heart and lung function. While they help with weight loss, patients may experience significant muscle loss, which can increase cardiovascular disease risk. Doctors are urging additional research to better understand the effects of these drugs.
A team of scientists from Colorado State University and the University of São Paulo have developed a seismological solution to improve the resolution of ultrasound images for lung monitoring. This breakthrough could lead to improved critical care for patients, including continuous lung monitoring at the bedside. The technique uses seis...
Researchers will present AI models that predict chronic respiratory failure and detect airway obstruction, with key findings on asthma susceptibility, small airway disease, and lung inflammation. The studies use nasal epithelial gene expression analyses and bronchoscopy to identify potential biomarkers for ICU patient outcomes.
A groundbreaking study from the University of Virginia Health System reveals distinct immune patterns in patients with persistent breathing issues after COVID-19. The research identifies specific T cell changes linked to lung damage and fibrosis, paving the way for personalized treatments.
A new method, CIBA, enables safe delivery of stem-cell-based treatments directly into the lungs of ECMO-supported patients. The technique has been proven to be well-tolerated and has shown potential for treating end-stage interstitial lung disease.
The American College of Chest Physicians' CHEST Critical Care and CHEST Pulmonary journals have been indexed in Elsevier's Scopus database. This achievement is a testament to the high-quality research published in these journals, which provide open access content in pulmonary and critical care medicine.
CHEST MedCast offers over 400 videos and podcasts with personalized content recommendations, available on-demand and at any time from any device. The platform features an algorithm-based recommendation engine and up to 100 available CME credits/MOC points.
The collaboration aims to close gaps in early recognition and management of IPF by equipping healthcare providers, public health professionals, and patients with necessary resources. The organizations will employ designated activities to build a knowledge base, develop survey tools, and create educational and awareness assets.
The American College of Chest Physicians (CHEST) has developed an educational program and formal certification exam for nurse practitioners and physician assistants/associates in critical care. The program validates clinical expertise and demonstrates professional acumen, aiming to improve patient care.
Arnulfo Duarte, a first-year fellow, will receive the APCCMPD and CHEST Medical Educator Scholar Diversity Fellowship for a second year. The program aims to improve diversity in pulmonary and critical care education by providing mentorship and training opportunities.
A study published in ERJ Open Research found that women are less likely to receive a lung transplant and wait an average of six weeks longer for one. Despite this, women who undergo transplantation have higher survival rates five years post-transplant.
John Howington, MD, MBA, FCCP, is the new President of CHEST, succeeding Neil S. Freedman, who will be President-Elect in 2026. Dr. Howington has extensive leadership experience and has published over 49 research publications.
High-flow nasal oxygen was found to be more effective than noninvasive ventilation in preventing endotracheal intubation or death within 7 days in four of five patient groups with acute respiratory failure. However, the results were sensitive to analysis models and may require further study in specific patient populations.
The American College of Chest Physicians' CHEST Critical Care and CHEST Pulmonary journals have been indexed with the Directory of Open Access Journals (DOAJ), enhancing their open access content's accessibility and usage. The indexation is attributed to strong editorial boards led by Hayley Gershengorn and Matthew Miles.
A new study found that treatment with piperacillin/tazobactam increased 90-day mortality by 5% compared to cefepime. The antibiotic depletes the gut microbiome, which plays a crucial role in metabolism, immunity, and preventing infections.
Researchers at the University of Rochester are developing a multimodal, non-invasive method to study the brain's physiology and reduce neurological issues associated with ECMO therapy. The technique uses electroencephalography, diffuse correlation spectroscopy, and evoked potentials to monitor blood flow and neural activity in the brain.
A new study found that Hispanic patients with moderate to severe ARDS were more likely to be deeply sedated while on a ventilator, spending nearly 75% of their days in deep sedation. This disparity may be driven by factors such as language barriers, cultural differences, and implicit bias in clinical decision making.
A study of 824 N95 masks used by 412 emergency department workers found that trifold N95s had a higher incidence of fit failure compared to dome N95s. The results highlight the importance of selecting appropriate N95 masks for reuse and extended use in pandemic preparedness
Researchers discovered COVID-19 causes epigenetic scars in lung tissue that lead to hyperinflammation and fibrosis. These changes are associated with increased interferons and chemokines, promoting inflammation.
A multicenter clinical trial found that high-dose inhaled nitric oxide improved oxygenation and reduced the risk of sensory and motor neurologic symptoms in adults with severe COVID-19 pneumonia. The treatment was also linked to lower levels of SARS-CoV-2 in the blood and sputum.
The 'Crystal Ribcage' technology enables scientists to study lung function at a cellular level while maintaining physiological processes. This innovation holds immense potential for understanding lung diseases and developing new treatments.
The August issue of CHEST journal features a new clinical practice guideline for managing patients with neuromuscular weakness and a multisociety evidence review on the effect of race and ethnicity on pulmonary function testing interpretation. This is complemented by other research and reviews covering various aspects of chest medicine.
The inaugural issue of CHEST Critical Care focuses on clinically relevant research and patient management guidance for critical care medicine. The journal accepts submissions of original research, case series, and research letters, covering topics such as intensive care medicine and diverse populations.
The June issue of CHEST features 49 articles on clinically relevant topics, including asthma, COPD, and critical care. The journal offers web and multimedia resources to expand the reach of its research.
The May issue of the CHEST journal features cutting-edge research on pulmonary, critical care, and sleep medicine. The journal also highlights awareness for cystic fibrosis, a once-fatal childhood condition now affecting adults.
Nearly half of COVID-19 patients develop secondary bacterial pneumonia, which can lead to death. Machine learning analysis found that this complication offsets the mortality rate from the viral infection itself.
The American College of Chest Physicians released a clinical practice guideline on respiratory management for patients with neuromuscular weakness, providing evidence-based recommendations for mouthpiece ventilation and airway clearance therapies. The guideline aims to improve care for this vulnerable population.
The January issue of the CHEST journal features a range of clinically relevant research on COPD, bronchiectasis, and pulmonary vascular disease. The journal's education portal offers continuing medical education (CME) credit for select articles.
The American Thoracic Society will host ATS 2023 in Washington, DC from May 21-24. The event will cover the latest developments in pulmonary, critical care, and sleep medicine. Register now to attend or access recorded sessions.
A study found that patients with severe COVID-19 who suffered progressive lung failure had a different gut microbiome composition compared to those who recovered. The research identified key differences in bacteria and metabolites, including higher levels of Proteobacteria and lower levels of secondary bile acids in dying patients.
Regenstrief Institute Research Scientist Sikandar Khan received the prestigious Paul Beeson Emerging Leaders Career Development Award to study the role of reactive oxygen species in cognitive impairment. The award supports his work on delirium, a common complication in ICU patients with acute respiratory failure, which can lead to post...
The December issue of CHEST journal features articles on COVID-19 lessons learned and future pandemic preparedness. The journal also explores various topics in chest medicine, including asthma, critical care, and sleep medicine.
Lying prone reduces the risk of needing a breathing tube in COVID-19 patients by 24.2% compared to usual care, but evidence for its effect on mortality or other outcomes is inconclusive. The intervention also results in 55 fewer intubations per 1,000 patients.
A University of California Riverside study found that Salton Sea dust triggers lung neutrophil inflammation in mice, with potential implications for asthma sufferers and other terminal lake regions. The research highlights the need for further funding to understand dust-triggered inflammation and its effects on human health.
A recent study found that ECMO survivors have a 24% higher rate of new mental health diagnoses compared to other ICU survivors. The study, published in JAMA, analyzed data from over 3,800 patients and found that depression, anxiety, and traumatic disorders were the most common diagnoses.
The October issue of CHEST journal showcases 43 clinically relevant articles on topics such as asthma, COPD, critical care, and sleep medicine. The journal also offers web and multimedia activities, including visual abstracts, to expand its reach.
Researchers developed a universal screening tool for IPF that can alert primary care physicians to its possible presence, enabling earlier diagnosis and treatment. The Zero-burden Co-Morbidity Risk Score for IPF (ZCoR-IPF) algorithm uses existing patient records to identify patients at risk of developing the disease.
A new study reveals that exploiting mitohormesis, a biological phenomenon where mild cellular stress boosts health and viability, can induce tolerance to influenza infection. Researchers identified a novel molecule, 9-tert-butyldoxycycline, which triggers beneficial mitochondrial responses that reduce tissue damage and inflammation.
A large multicenter trial found no difference in intubation requirement between awake prone positioning and standard positioning for COVID-19 patients. The study included 400 patients who required oxygen therapy, but the prone positioning strategy did not significantly reduce the risk of intubation or mortality.
The American College of Chest Physicians' flagship journal CHEST published its June issue featuring 58 articles on various chest medicine topics, including asthma and COPD. The journal is set to expand with two new open-access journals, CHEST Pulmonary and CHEST Critical Care.
Researchers at Cranfield University found that leaving cabin doors open on passenger ships accelerates the spread of Covid-19. Closing doors limits the area affected by infected particles to within a seat's width.
Researchers have identified a new family of proteins in blood vessels that prevent fluid from entering the lungs, offering a potential new avenue for treating acute respiratory distress syndrome. Stimulating these bitter taste receptors has been shown to provide protection against fluid leak into the lung.