Articles tagged with Blood Samples
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Researchers have developed a new imaging technique that rapidly and accurately identifies cancerous tissues in breast samples. The method uses machine learning algorithms trained on hyperspectral dark-field microscopy data to pinpoint regions of invasive ductal carcinoma and invasive mucinous carcinoma.
Researchers at ETH Zurich have developed a new device for taking blood samples using the leech principle, reducing invasiveness and increasing reliability. The device is made of silicone and steel microneedles, with plans to create biodegradable versions in the future.
Researchers have identified an inflammatory protein profile associated with poor survival in aggressive B-cell lymphoma patients. Protein profiles from blood samples can help classify subtypes of the disease and monitor patient response to treatment.
A large-scale study revealed a profound link between dietary patterns and brain health, with a balanced diet associated with better mental health, superior cognitive functions and higher grey matter in the brain. The researchers suggest that gradual dietary modifications can lead to healthier food choices and improved wellbeing.
Scientists have identified a consistent signature of multiple sclerosis in the blood of patients years before they develop symptoms. The discovery, published in Nature Medicine, could lead to earlier diagnosis and treatment of the disease, affecting nearly 1 million people in the US.
Researchers at NTU Singapore have created a chip that can directly isolate blood plasma from a tube of blood in just 30 minutes, removing over 99.9% of blood cells and platelets. The device, called ExoArc, enables high-quality plasma for disease screening and research, improving diagnosis accuracy and reducing waiting times.
A new study finds that e-cigarette users with a limited smoking history experience similar DNA changes to specific cheek cells as smokers. The researchers also found that some smoking-related epigenetic changes remain more stable after giving up smoking, suggesting that e-cigarettes may not be completely safe.
The chikungunya virus infects CD14+ CD16+ monocytes and affects proteins holding epithelial cells of the blood-brain barrier together. The study found severe alterations in coagulation cascade, hemodynamic damage in organs, and high levels of inflammatory cytokines.
A new biomarker developed by researchers at Monash University and the University of Birmingham can accurately detect when someone has not slept for 24 hours. The test has a 99.2% probability of being correct and could inform future tests to identify sleep-deprived drivers, reducing the risk of accidents and fatalities.
Researchers at Aarhus University have developed a new cell-based assay to measure total cortisol levels accurately, improving diagnosis and treatment of stress-related illnesses and chronic conditions. This method has the potential to reduce misdiagnoses and side effects, enabling more precise treatment.
Researchers at the University of Waterloo have developed a rapid blood testing method that can detect fentanyl and other opioids in under three minutes, making it twice as quick as traditional approaches. This new technique has the potential to save lives by quickly identifying overdoses.
Scientists have created a simple blood test to quickly diagnose sarcoidosis, a chronic inflammatory disease. The tool uses a combination of molecular techniques to detect two newly described disease-specific antigen biomarkers.
A new method uses digital DNA melting analysis to detect pathogens in blood samples, producing results in under six hours and reducing false positives compared to traditional blood cultures. This technology has the potential to save lives by accurately diagnosing sepsis, a leading cause of death worldwide.
A new blood test uses the biomarker BD-tau to predict functional outcomes in patients after ischemic stroke. Higher levels of BD-tau are associated with more severe outcomes.
Researchers at Uppsala University have developed a tool that uses standard blood test results to identify individuals at increased risk of having a heart attack within six months. The study analyzed data from 169,053 individuals and identified 90 molecules linked to a first heart attack.
Researchers found Mad2 gene expression levels correlate with chromosomal abnormalities in esophageal squamous cell carcinoma, highlighting potential as a clinical biomarker. The study also revealed the deregulation of the Rb-E2F1 circuit and its impact on histone modifications.
A new study led by University of Bristol researchers found that weight loss in people with type 2 diabetes can alter levels of cancer-related chemicals circulating in the blood. Nine cancer-related proteins were changed by the weight loss intervention, suggesting a potential reduction in cancer risk.
Researchers at Kaunas University of Technology found that low-frequency ultrasound influences blood parameters, improving oxygen saturation and lowering blood pressure. The study used artificial intelligence to analyze 300 blood samples, revealing the potential for non-pharmaceutical treatment to improve oxygen circulation.
A team of researchers from MIT and the Broad Institute developed two types of injectable molecules called 'priming agents' that can boost DNA levels in blood samples, allowing for earlier cancer diagnosis and more sensitive detection of tumor mutations. The approach could also help improve detection of cancer recurrence.
Researchers from UTHealth Houston discovered that Epstein-Barr virus (EBV)-specific T-cells are present in high numbers in the cerebrospinal fluid of people with multiple sclerosis at its earliest stages. The study suggests that these cells may be contributing to the disease's pathogenesis.
A recent study in Uganda found that asymptomatic individuals with low-level malaria infections had highly variable parasite dynamics and species present. Frequent sampling every other day or daily was sufficient to detect a proportion of infections similar to daily testing, but less frequent tests may miss up to one-third of cases.
A research team developed a novel blood test called desNIPT to screen pregnant women for genetic diseases in their unborn children. The test has demonstrated effectiveness in identifying alterations in fetal genes, similar to invasive procedures like chorionic villus sampling or amniocentesis.
A novel technique to test platelet function within a person's blood sample is faster, easier and more precise than methods currently in use. The technology has the potential to assess the effects of antiplatelet drugs on individuals and gain a clearer picture of bleeding risks for patients undergoing cardiopulmonary bypass surgery.
Researchers at Uppsala University have developed an instrument to measure 21 biomarkers for cardiovascular disease, improving prediction and treatment. The CVD-21 panel reflects functional disturbances influencing cardiovascular development and treatment outcomes.
A study of 144 Covid survivors found that women with elevated inflammatory biomarkers during the acute phase were more likely to experience lingering symptoms like fatigue, breathlessness, and sleep disturbance. This research sheds light on a potential link between inflammation and persistent Long Covid symptoms in women.
A new Duke University-led study finds that Gulf War Illness significantly reduces the ability of white blood cells to make energy, creating measurable biochemical differences in veterans with the disease. The study reveals impaired mitochondrial function, leading to lower levels of extracellular acidification and oxygen consumption.
Researchers developed an environmental risk score to assess ALS risk and survival using a blood sample, associating several individual pollutants with disease risk. A mixture of pesticides in the blood significantly increased ALS risk, with those in the highest group having twice the risk as those in the lowest.
University of Alberta researchers have identified taurine as a key player in predicting poor clinical outcomes and treating long COVID. A predictive test and proposed supplement trial aim to minimize symptoms and improve patient outcomes.
A recent study by the University of Gothenburg found no correlation between post-COVID condition and ongoing viral infection or active brain damage. The study analyzed 25 participants with confirmed post-COVID condition, six without residual symptoms, and 17 control subjects, revealing undetectable SARS-CoV-2 antigens in all samples.
A new blood test called OvaPrint TM detects specific nucleic acids in the blood, distinguishing between cancerous and benign pelvic masses with high accuracy. The test has the potential to improve treatment outcomes by identifying the best surgical approach for patients with a pelvic mass.
A new study reveals that immunity to SARS-CoV-2 variants depends on previous exposure and vaccination history. The research found significant differences in immune responses to various variants, highlighting the need for personalized vaccine approaches.
Researchers developed statistical models using ultrasound measurements and protein levels to predict stillbirth, neonatal death, or extreme preterm delivery. The findings aim to identify suitable candidates for clinical trials testing novel treatments for fetal growth restriction.
Researchers at UMass Amherst are investigating the connection between PFAS chemicals and breast cancer. They will examine data from postmenopausal women to determine if PFAS concentrations are associated with less breast tissue involution, which may increase breast cancer risk.
A KAUST researcher has created a highly sensitive glucose detector based on a thin-film transistor that can measure glucose levels in saliva with high accuracy. The device uses an enzyme to oxidize glucose present in the saliva, producing electrons that indicate the glucose concentration.
A study by Cornell University researchers found that current methods for measuring malaria parasite multiplication rates vastly overestimate the actual rates, which has significant implications for vaccine efficacy and understanding of drug resistance.
Researchers develop a new technique to detect circulating tumor cells in blood, overcoming noise issues with existing methods. The dual-ratio approach enhances penetration range and accuracy, paving the way for quicker diagnosis of metastasis.
Researchers used proteomics and small RNA sequencing to analyze 103 human blood plasma samples, identifying 21 proteins and 315 small RNAs associated with aging. Combining protein and miRNA data improved age predictions (R2 = 0.70 ± 0.01), suggesting a broader range of age-related physiological changes.
Research reveals that chronic heart rate failure during exercise is a common reason for long-term exercise intolerance in Long COVID patients. The study also found a correlation between early post-COVID inflammation biomarkers and reduced exercise capacity, suggesting potential therapeutic targets.
Researchers developed an improved approach for people to collect their own blood samples to test for PFAS without being part of an academic research study. The new finger-prick method was found to be comparable to traditional blood draws, providing a more accessible and affordable option for individuals with elevated exposure.
A novel fluorescence probe successfully quantifies trace components like hydrogen sulfide in whole blood, overcoming autofluorescence interference. The probe uses a borodipyrromethene-based dye that quenches the interfering light, allowing for accurate measurements.
Researchers at USC Norris Comprehensive Cancer Center have identified a biomarker, CX3CR1, that can predict which patients with non-small cell lung cancer will respond well to chemoimmunotherapy. Elevated levels of the biomarker in T-cells after six to nine weeks of treatment indicate long-term benefits from the combination therapy.
MIT chemists develop rapid test to determine whether individuals have neutralizing antibodies against Covid-19, offering protection against future infections. The technique uses a fingerprint of sugar molecules to identify neutralizing antibodies in blood samples.
Researchers developed glass filters to capture tumor cells from blood samples, enabling more efficient culture of these cells. The optimized filter design enhances the accuracy of cancer detection, allowing for earlier treatment and improved patient health.
A study with 116 participants found associations between microRNAs in extracellular vesicles and mental health disorders such as depression and ADHD. While no biomarkers were identified, the results suggest genetic material can be non-invasively accessed through blood samples.
New Finnish studies show that short bouts of light or moderate exercise can increase the number of immune cells capable of destroying cancer cells in cancer patients. The exercises were enough as short as 10 minutes to boost the immune system, with a positive impact on quality of life and prognosis.
Researchers have discovered DNA methylation markers in newborn blood that may indicate a higher risk of developing schizophrenia later in life. The study, published in Molecular Psychiatry, used statistical analysis and compared results to adult brain samples to validate findings.
MIT researchers developed a miniature vacuum pump for portable mass spectrometers, overcoming design limitations of traditional pumps. The 3D-printed pump can create and maintain lower pressure vacuums, increasing the device's lifetime and enabling its use in remote locations and space exploration.
Researchers found that women with prediabetes after pregnancy had aberrations in their early pregnancy blood serum metabolomic profile, including higher concentrations of small HDL particles. These metabolic changes predicted prediabetes at postpartum and were associated with increased risk of type 2 diabetes.
Researchers developed an electronic biosensor using DNA aptamers to detect biomarkers in whole blood samples. The biosensor successfully detected clinically relevant levels of a marker protein for cardiovascular disease without further sample preparation.
A study by an international research team has found a mechanism that occurs in brown bears and paraplegics, preventing the formation of blood clots. The discovery could lead to new treatments for venous thromboembolism, a life-threatening condition.
A Danish study has validated a dried blood spot test that can detect HIV, hepatitis B, and hepatitis C from a single drop of blood. The test uses existing hospital equipment and is suitable for places where needle-based testing is not practical or feasible.
A new study has identified disrupted levels of molecular compounds in maternal blood and cord blood linked to later diagnosis of autism spectrum disorder. The findings shed light on the biological processes that give rise to ASD and could open the door to early diagnosis and treatment.
Researchers at Karolinska Institutet have discovered that a type of sugar molecule in blood is associated with the level of tau protein, a critical factor in severe dementia. Measuring blood glycan levels can predict Alzheimer's disease risk to 80% accuracy, almost a decade before symptoms appear.
Psychiatrists at Indiana University School of Medicine found deaths by suicide increased during the week of a full moon, especially in people over age 55. They also identified 3-4 p.m. and September as peak times for suicides.
A new case series study found that an 8-week methylation-supportive diet and lifestyle program reduced biological age by 4.60 years, with five of six participants exhibiting significant age reversal. The study suggests that this intervention may favorably influence biological age in both sexes.
Scientists have identified monocytes, a type of white blood cell, as a potential target for eliminating HIV infections. A new study found that monocytes can harbor stable HIV genomes, which may provide a new direction for efforts to improve therapies and eventually cure the disease.
A novel rare mutation in the ABCA12 gene was identified as a cause of Harlequin Ichthyosis through BGI genetic tests. The mutation leads to a severely dysfunctional protein responsible for the disease's serious phenotype.
Researchers discovered that telomere shortening is associated with early subjective depressive symptoms and cognitive complaints among healthy elderly individuals. The study also found a link between telomere shortening and increased interleukin-6 levels.
Researchers developed a new device that detects and analyzes cancer cells in blood samples, enabling doctors to avoid invasive biopsies and monitor treatment progress. The Static Droplet Microfluidic device uses metabolic signatures to differentiate tumour cells from normal blood cells.
Researchers examined three epigenetic age acceleration measurements and found inverse associations with lung cancer risk in men and younger participants. However, these findings did not support a positive association between epigenetic age measures and lung cancer risk in the study.