Articles tagged with Blood Samples
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A recent study published in Immunity reveals that human T-cell receptor genes exhibit unexpectedly high variability among individuals, with each person having a unique set of gene variants. The researchers identified 175 new gene variants originating from Neanderthals, which are present in up to 20% of modern humans in Europe and Asia.
A study by Johns Hopkins Medicine found that high doses of CBD may increase the adverse effects of THC in edible cannabis products. The study showed that CBD inhibits the metabolism of THC, resulting in stronger and longer drug effects.
A team of Brown researchers has developed a new, highly accurate method for detecting antidepressants in patients using liquid chromatography tandem mass spectrometry. The technique requires minimal biological samples and can be fully automated using liquid-handling robots.
Researchers evaluate an integrated NGS system, delivering accurate diagnoses in under 24 hours and expanding targeted treatments available to patients with myeloid neoplasms. The assay identified 80-92% of genetic variants, demonstrating promising results for accelerating precision therapies.
Researchers develop eRapid sensor technology to detect SARS-CoV-2 antibodies, enabling fast and multiplexed testing at the point-of-care. The device distinguishes between antibody types targeting different viral proteins with high sensitivity and specificity.
Researchers at Cedars-Sinai Cancer have developed a non-invasive test that can detect and profile prostate cancers in microscopic amounts. The test, known as the EV Digital Scoring Assay, has the potential to spare patients from unnecessary treatment-related side effects and direct them to effective therapies.
Researchers developed a novel CRISPR system to detect small amounts of cancer-related molecules in exosomes in plasma, effectively distinguishing between malignant and benign samples. The method has the potential to make cancer diagnosis and monitoring quicker and easier by analyzing blood samples.
A study by OHSU researchers found that immunity from COVID-19 gathers strength over time, indicating that vaccination should not be delayed. The study suggests that vaccine boosters can be spaced no more frequently than a year apart among healthy individuals.
Researchers have solved an 80-year-old medical mystery that causes kidney damage in children and can be fatal in babies. They discovered a gene mutation is the primary cause, but found that around 10% of patients without the mutation still experience symptoms.
Biomedical engineers at the University of Cincinnati are investigating the potential of interstitial fluid for early disease diagnosis and long-term health monitoring. The study proposes sampling interstitial fluid just under the skin using tiny microneedles, offering a more accessible and less painful alternative to blood testing.
Research from Brigham and Women's Hospital found that genetic analysis can identify up to 65% more A2 donors, increasing potential kidney transplants for recipient candidates with blood type B. This could improve availability and equity in kidney transplantation.
A new study by researchers at Florida Atlantic University explored the effects of resistance training on older adults' cellular level. The study found that resistance training did not significantly affect inflammatory proteins or redox balance markers, but showed a significant reduction in a specific protein ratio. This may support the...
A new study standardizes the use of optical genome mapping (OGM) for patients with blood cancers, demonstrating its potential as a frontline test for diagnosing hematologic malignancies. OGM outperforms existing tests in detecting cancer-causing gene variants and identifying additional information that can improve patient outcomes.
A study found that Tibetan Buddhist monks with long-term deep meditation practice had distinct gut microbiome profiles, associated with lower risks of anxiety, depression, and cardiovascular disease. Their gut microbiota was enriched with beneficial bacteria that may influence mental health.
Researchers have developed a novel blood-based biomarker, brain-derived tau (BD-tau), that specifically measures non-phosphorylated tau originating from the brain. This breakthrough addresses an unmet need for a blood test that tracks neurodegenerative changes in Alzheimer's disease but not in other dementias.
A new study published in PNAS Nexus reveals that children living near airports are exposed to toxic levels of lead from aviation gasoline. The researchers found a significant correlation between blood lead levels and proximity to the airport, with higher levels detected in East-facing directions.
Researchers at Texas A&M University are testing Raman spectroscopy as a diagnostic tool for Lyme disease, which shows promise in accurately identifying infected individuals. The new test could improve Lyme disease diagnosis and treatment outcomes for both humans and animals.
Researchers developed a blood test using circulating microparticle proteins to predict placenta accreta spectrum (PAS) cases as early as the second trimester. The study found five unique proteins that can distinguish PAS patients from control patients, enabling safe predication before delivery.
A new biomarker test, called BD-tau, can detect Alzheimer's disease neurodegeneration in blood samples with high accuracy. The test outperforms current methods and correlates well with CSF biomarkers, providing a valuable tool for improved diagnosis and clinical trial design.
Researchers developed a new epigenetic biomarker, GrimAge version 2, which leverages two DNAm-based estimators of plasma proteins to predict mortality risk. The study found that GrimAge 2 outperforms existing clinical biomarkers in predicting mortality across multiple racial/ethnic groups and associations with age-related conditions.
A recent study has identified common and unique cellular processes in six neurodegenerative diseases, providing new insights into the underlying causes of these conditions. The research used machine learning analysis to compare RNA markers in whole blood samples from patients with distinct diseases, revealing eight shared themes across...
Researchers developed a method to estimate seroprevalence using blood donation samples, offering insights into the first year of the COVID-19 epidemic in Brazil. The study found significant differences among regions and subgroups, highlighting the need for real-time tracking and forecasting of future waves.
A study found that antibodies to common antibiotic gentamicin are associated with an increased risk of progression to type 1 diabetes in children already genetically at risk. The researchers also identified an association between the FUT2 gene and the production of these antibodies, which may be compounding risks for type 1 diabetes.
A new diagnostic pathway for prostate cancer reduces the number of harmless tumors found during screening, halving the risk of overdiagnosis. This strategy involves using MRI to guide targeted tissue sampling, reducing the need for unnecessary biopsies and associated complications.
Researchers developed an efficient engineered pathogen capture method to quickly identify infectious microbes in tiny blood samples. This advanced technology could significantly improve clinical outcomes for children with bloodstream infections and sepsis.
A study conducted in Brazil reveals that only 75.8% of under-fifteen children in São Paulo have antibodies against measles, falling short of the ideal 94% target to prevent outbreaks. The finding is a warning sign that Brazilian children are not achieving herd immunity, making them susceptible to infection.
A post-pandemic outbreak of a drug-resistant fungus in Brazil was linked to the misuse of medications and full ICUs. The study found that 90% of infected patients had strains resistant to fluconazole and echinocandins, leading to high mortality rates.
A new AI-powered blood test, DELFI, has been developed to detect liver cancer with high accuracy. The test detected over 80% of liver cancers in a study of 724 individuals, with an overall sensitivity of 88% and specificity of 98%.
Researchers measured phycotoxin concentrations in bull sharks caught in the Indian River Lagoon, finding multiple toxins widespread or persistent in the environment. The study highlights dietary exposure as a key mechanism of toxin transfer to bull sharks.
A study by Leiden University Medical Center found six proteins in blood samples that were altered one to two years before a breast cancer diagnosis. The researchers believe these proteins could be used to develop a blood test for early detection of breast cancer in high-risk women.
Researchers found that female tiger sharks that frequently visit Tiger Beach in the Bahamas are larger and have higher hormone levels than other individuals. The study suggests possible effects of mass tourism on these sharks, with females having better nutritional states and more omega-3 in their blood.
Scientists at Ural Federal University have developed a sensor device that determines cholesterol levels without using enzymes. The system uses copper chloride, making the process cheaper, easier, and faster than traditional methods.
Researchers found that liquid biopsies can detect clonal haematopoiesis, a condition placing patients at higher risk of developing myelodysplastic syndrome or acute myeloid leukaemia. The study suggests that these patients should be referred for further evaluation to uncover actual risk and identify potential diagnostic pathways.
Researchers found lower serum TDP-43 levels in patients with C9orf72 repeat expansion or motoneuron disease, distinguishing them from other FTD subtypes. This study suggests TDP-43 as a potential biomarker for diagnosing specific FTD subtypes, enabling patient-specific interventions.
A study reveals that BA.2.75.2, a new Omicron sublineage, largely evades neutralizing antibodies and is resistant to several monoclonal antibody treatments, posing an increased risk of SARS-CoV-2 infections this winter.
A new study suggests that impaired autophagy may contribute to the development of post-partum depression in pregnant women. The researchers found lower levels of messenger RNA associated with autophagy in blood samples from women who went on to develop PPD.
Researchers analyzing over 3,000 blood samples from Alzheimer's patients and healthy individuals to identify reliable biomarkers. They investigate how well blood tests can diagnose Alzheimer's disease and predict its progression.
A WVU biomedical engineer is working on a rapid diagnostic tool that can detect tick-borne infections such as Lyme disease via a blood sample on a single chip. The tool uses dielectrophoresis and machine-learning to detect diseases within one to two weeks after onset, reducing the risk of hospitalization and chronic conditions.
Researchers at Hokkaido University have developed a biosensing technology to detect amyloid β build-up in the brain from biomarkers in blood samples. The Digital ICA TM technology can detect Aβ-binding exosomes in mice, increasing with age and disease progression.
Researchers at La Jolla Institute for Immunology have discovered a rare T cell defect tied to the risk of developing MAC disease. People with this defect have fewer specialized Th1* cells, which robs them of an effective immune response to MAC bacteria.
A Johns Hopkins Medicine study found that COVID-19 booster shots are essential for maintaining long-term immunity against infection, particularly among older adults. The results support the CDC vaccination guidelines recommending COVID-19 boosters and highlight the importance of continued research on factors affecting immunity.
A recent study published in Nature Communications has found a strong connection between the gut microbiome and certain blood metabolites. The research, led by Uppsala University, analyzed fecal and blood samples from over 8,500 participants in the SCAPIS study, identifying novel associations between gut bacteria and plasma metabolite s...
Researchers developed a faster, more affordable method to analyze serological data and predict COVID-19 wave behavior. The study showed that vaccination boosted immunity, with hybrid immunity producing higher protection levels. Antibody levels rose quickly after the first dose, especially in cities where case numbers were highest.
A new study from OHSU reveals that breakthrough infections following vaccination can provide a potent immune response against COVID-19, with increased protection for those 65 and older. The research found an equally strong immune response among people who received a third vaccine booster dose three months prior.
A team of scientists from SMART and NTU Singapore has developed a rapid point-of-care test kit that measures antibodies against SARS-COV-2 and its variants, offering personalized vaccination strategies. The test kit requires just 10 minutes to show results and has up to 93% accuracy.
Researchers found higher total and non-HDL cholesterol levels associated with GenX exposure in a new study. Legacy PFAS chemicals like PFOS and PFNA were most strongly linked to elevated cholesterol, particularly in older participants.
A study of NASA astronauts found DNA mutations associated with spaceflight, increasing the risk of cardiovascular disease and blood cancer. Regular screening is recommended to monitor astronaut health.
Researchers at Brain Chemistry Labs have developed a new blood test for ALS using microRNA sequences, which accurately discriminated between patients and healthy individuals. The test works even with varying environmental conditions, offering hope for rapid diagnosis and improved patient outcomes.
A new study suggests that members of the public want to know if their health information or samples from their bodies will be used in research or to help develop new biomedical products. The study found that patients are more likely to want notification about research use of their health information than biospecimens.
A new test developed by MIT researchers measures neutralizing antibodies in a blood sample to predict COVID-19 immunity. The easy-to-use test could help people decide on necessary protections and may be particularly useful for those with weakened immune systems.
Researchers from Keck School of Medicine found a strong association between PFOS exposure and liver cancer risk, with the strongest link seen in the top 10% of PFOS exposure. The study suggests that PFOS may disrupt normal liver function, leading to non-alcoholic fatty liver disease and increased risk of liver cancer.
Researchers have developed a smartphone clip-on instrument that can rapidly detect Zika virus in whole blood using spatial RT-LAMP technology. The device is sensitive, accurate, and easy to use, making it ideal for point-of-care clinics and controlling the spread of infectious diseases.
A new study published in JAMA Internal Medicine found that an alert about a shortage of blood test tubes led to a significant reduction in unnecessary blood clotting tests. The study suggests that similar interventions could reduce low-value care and promote wise use of medical tests.
A 20-year study found that Black adolescents living in poverty showed accelerated immune cell aging and higher insulin resistance at ages 25-29. The researchers also found associations between childhood poverty, perceived life chances, and premature immune cell aging.
A study by Goethe University Frankfurt found that antibodies against Omicron variants BA.1 and BA.2 decline rapidly, even after a second vaccination or booster shot, offering limited protection against infection.
Researchers found that highly specialized T cells, designed to eliminate infected cells, remained active in the blood of all previously SARS-CoV-2-infected patients for at least 20 months. These T cells did not disappear or wane even at long follow-up, suggesting a vital aspect of protective immunity that persists years after COVID-19.
Researchers developed a new blood test that can indicate cellular immunity to SARS-CoV-2 within 48 hours. The test distinguishes between post-infection and post-vaccination immunity, enabling quick diagnosis for patients unable to produce antibodies. Long-lasting T-cell responses may protect against severe disease in re-infections.
Researchers at Massachusetts General Hospital have developed a blood test that can detect multiple mutations associated with brain cancer, including EGFRvIII. The test showed high sensitivity and specificity, making it a powerful tool for diagnosing gliomas and monitoring tumor progression.
A study found that pharmacogenomic testing can help providers avoid prescribing antidepressants with undesirable outcomes. The test, which analyzes genes related to drug metabolism, resulted in a significant improvement in depression symptoms compared to usual care.
Researchers analyzed stored blood samples from infected men and found significant age acceleration in DNA epigenetic measures and telomere shortening. The study demonstrates HIV's substantial impact on the body's aging processes within two to three years of infection.