Articles tagged with Cancer Screening
Integrating magnetic resonance imaging (MRI) in prostate cancer screening pathways is associated with reduced unnecessary biopsies and overdiagnosis. MRI maintains clinically significant prostate cancer detection, reducing harm from overtreatment.
Global prostate cancer cases are projected to double from 1.4 million in 2020 to 2.9 million by 2040, with low- and middle-income countries seeing the highest increases. The number of annual deaths is predicted to rise by 85%, mainly in LMICs due to under-diagnosis.
Researchers at Mass General Cancer Center presented advancements in rapid nucleic acid detection for cervical cancer screening using CRISPR technology. They also showcased improvements to CAR T cell therapy for pancreatic cancer, highlighting the importance of dynamic functional control to enhance its efficacy.
A new study from the University of Miami Miller School of Medicine shows that community-based screening and treatment for Helicobacter pylori bacterium infection can identify and eliminate high-risk individuals. The approach aims to prevent gastric cancer in vulnerable populations, including Blacks, Asians, and Latinos.
A Mount Sinai study found that primary care physicians' approach to selecting patients with comorbidities for lung cancer screening is influenced by subjective clinical judgments. The researchers recommend streamlined protocols and clearer guidelines to increase adoption of lung cancer screening for this high-risk population.
New data suggest that blood-based colorectal cancer screening tests could lead to more cases and deaths than established methods, despite improving outcomes for unscreened individuals. The tests are predicted to be less effective and more costly, making them unsuitable replacements for current screening programs.
Primary care physicians struggle to balance harms and benefits of lung cancer screening in patients with multiple health issues, often relying on clinical judgment. Ultimately, the decision rests with the patient, who makes their own choice despite physician advice.
Researchers suggest a follow-up colonoscopy within defined periods after abnormal stool-based screening test results. The proposed measure aims to address low current performance rates and produce reliable results.
Patients with multimorbidity and limited life expectancy are often unaware of the potential harms of lung cancer screening. Despite this, many agree to undergo screening due to personal health goals, trust in their clinician, and anticipation of regret over not getting screened. Discussions between patients and clinicians about the ben...
Researchers at NTU Singapore have created a chip that can directly isolate blood plasma from a tube of blood in just 30 minutes, removing over 99.9% of blood cells and platelets. The device, called ExoArc, enables high-quality plasma for disease screening and research, improving diagnosis accuracy and reducing waiting times.
The study found that 90.98% of participants obtained a definitive result from colorectal cancer screening, with 31.71% being normal and 5.49% having non-neoplastic polyps. The results suggest the importance of primary care physicians in promoting secondary prevention and informing the population about the program.
A new study suggests that removing barriers to cervical cancer screening, surveillance, and diagnostic procedures can save lives and reduce disparities. If every eligible person gets the full screening and follow-up tests recommended, up to 23% fewer people would be diagnosed with cervical cancer and 20% fewer would die from it.
A study by Cancer Research UK reveals that mortality rates have dropped by 37% in men and 33% in women, with significant reductions in cervical cancer and lung cancer. However, cancer cases are on the rise overall, and researchers warn of an immense challenge ahead to maintain progress.
A clinical study published in the New England Journal of Medicine found that a blood test can detect colorectal cancer in 83% of people confirmed to have the disease. The test, which analyzes circulating tumor DNA, offers an alternative to current screening options for patients who may decline traditional methods.
A new study published in New England Journal of Medicine found that a next generation multi-target stool DNA colorectal cancer screening test detects 94 percent of colorectal cancers, outperforming other noninvasive tests. The test has the best detection rate for both colorectal cancer and advanced precancerous polyps.
Researchers create a technique using prime editing to quickly and easily screen cancer genes, revealing new information on p53 mutations. The method allows for the analysis of over 1,000 different mutations in the tumor suppressor gene p53, which are seen in more than half of all cancer patients.
A study found that up to 87% of childhood cancer survivors are not following recommended screening guidelines, leaving them vulnerable to late effects such as heart disease and certain cancers. The lack of awareness and barriers to adherence may contribute to this low rate, highlighting the need for improved support and education.
A new study finds that Latinx children with unreliable access to food at age 4 are nearly four times more likely to develop fatty liver disease later. The researchers recommend earlier screening for metabolic dysfunction-associated steatotic liver disease (MASLD) and ensuring public meal programs offer nutritious meals.
New research by Boston University School of Medicine found that while few clinicians have adopted the 2020 ACS cervical cancer screening guidelines, most are open to change if supported by scientific evidence and recommended by professional organizations. The study identified logistical issues and concerns about missed detection as bar...
A study from Florida Atlantic University identifies key social factors contributing to low breast cancer screening rates in the US. Socioeconomic status, access to healthcare, and insurance status are among the top influencers of breast cancer screening behavior.
A study of routine fecal occult blood testing found a significant decrease in colorectal cancer mortality in Sweden. The association between screening and reduced mortality is expected to be higher due to co-existing testing and delayed diagnoses.
Researchers developed scSNV-seq to investigate genetic changes affecting gene activity and disease development. The technique accurately assesses the impact of thousands of DNA mutations in cells, providing crucial insights for developing targeted therapies.
A statewide genomic screening program enrolls first 20,000 participants, providing information on genetic risk factors for diseases such as hereditary breast and ovarian cancer. The program aims to empower communities to understand the value of research and increase participation rates among underrepresented groups.
Three Virginia health systems are part of a new NIH research network studying emerging cancer screening technologies, aiming to reduce cancer-related illnesses and deaths. The network will evaluate the benefits and harms of multi-cancer detection tests, which screen for multiple types of cancers simultaneously.
A study published in JAMA Oncology revealed a significant decline in US cancer incidence during the first 10 months of the pandemic. The research found 134,395 potentially undiagnosed cancer cases between March and December 2020, highlighting an unusual drop in all-site cancer incidence.
Men with low sperm count or none have a higher risk of developing cancer, including at younger ages, compared to fertile men. Families of azoospermic men have a significantly increased risk of five cancers, while families of oligozoospermic men have a higher risk of colon, bone and joint, and testicular cancers.
The UNC Lineberger Comprehensive Cancer Center has been selected as a national research site for the National Cancer Institute's Cancer Screening Research Network. The network will conduct large-scale studies using emerging cancer screening technologies to identify effective and accurate methods for early detection and prevention. The ...
Researchers identified a putative paclitaxel response predictive biomarker for glioblastoma and breast cancer using the whole genome CRISPR knockout screen. The biomarker candidate was validated in two independent breast cancer patient cohorts that received taxane treatment.
A new screening tool has been developed to catch endometrial cancer cases earlier, saving lives. The partnership between Pennington Biomedical's Metamor Institute and the LSU School of Medicine has already screened over 2,000 women and found abnormal bleeding in many cases.
Researchers found that Inuit residents in Nunavik had shorter survival rates for lung cancer compared to Montreal residents, despite similar disease stages. The study attributes this disparity to chronic under-resourcing of healthcare services and lack of Inuit representation in healthcare provision.
A new study published in Radiology found that annual breast cancer screening beginning at age 40 and continuing until 79 results in the highest mortality reduction. The study analyzed Cancer Intervention and Surveillance Modeling Network (CISNET) estimates and showed that annual screening reduces breast cancer deaths by 41.7%.
A recent study reveals the lack of colorectal cancer screening programs in low-middle-income countries, but successful implementation in high-middle-income Latin American nations. High-middle-income countries achieved high uptake of screening, with over 75% receiving colonoscopies following positive stool test results.
A new hand-held device screens for breast cancer biomarkers from a tiny spit sample, offering quick and efficient results. The portable tool distinguishes between healthy tissue, early cancer, and advanced cancer in a small group of women.
A study co-led by Prof. Kelly Metcalfe finds risk-reducing mastectomies significantly reduce breast cancer risk and death probability in women with a BRCA1 or BRCA2 genetic variant. The procedure reduces the risk of breast cancer by 80% and decreases mortality to less than 1%.
A new study found that lockdown-induced delays in diagnosing melanoma led to over 100,000 years of life lost across Europe and £6.1 billion in costs, mainly due to loss of productivity. The research emphasizes the importance of considering unintended side effects in pandemic planning.
Researchers have developed a hand-held biosensor that can detect breast cancer biomarkers from saliva with high accuracy and efficiency. The device is portable, reusable, and cost-effective, making it an excellent choice for communities or hospitals without access to advanced technologies like MRI.
Researchers have developed a new urine-based test for early detection of ovarian cancer using nanopore sensing technology. The method can simultaneously identify multiple peptides, including those derived from LRG-1, and shows promise for improving 5-year survival rates by up to 75%.
A new stool test, multitargetFIT-test (mtFIT), detects cancer precursors more effectively than the current FIT test, predicting a reduction in new cases of colorectal cancer and mortality. The new test yields more true-positive results without an increase in 'false-positive' results.
A novel imaging technique, low-dose positron emission mammography (PEM), shows promise in transforming breast cancer detection by providing high sensitivity and low false positive rates. PEM could potentially decrease healthcare costs and reduce unnecessary procedures for patients with dense breasts.
Researchers at Northwestern University found a significant decrease in screenings for prostate cancer and urinary tract infections after implementing point-of-care alerts. The study showed a 9% reduction in PSA screenings and a 5.5% reduction in urine testing, with minimal changes in overtreatment of blood sugar.
Scientists have created a low-cost imaging device suitable for endoscopic screening programs, offering excellent contrast between healthy and malignant tissue. The new system uses ultraminiature spatial frequency domain imaging technology to detect cancerous lesions with high specificity and sensitivity.
A study of 18,000 women found those diagnosed with polycystic ovary syndrome (PCOS) were 8 times more likely to attempt suicide compared to control group. This increased risk is attributed to higher likelihood of psychiatric conditions such as depressive disorders and anxiety disorders associated with PCOS. Researchers emphasize the ne...
Researchers mapped changes in tumor-related bacteria to uncover potential strategies to combat the rise of young-onset colorectal cancer. Unique bacterial signatures were found in tumors from younger patients, including Akkermansia and Bacteroides, which are more likely to have left-sided, rectal, and advanced stage tumors.
Screening rates for blood pressure, cholesterol, and common cancers were lower in 2021 than 2019, particularly among Asian adults. The study of 89,000 adults highlights the need for public health efforts to increase preventive health screenings among eligible adults across racial and ethnic groups
A systematic analysis by MedUni Vienna's Center for Public Health found that people experiencing homelessness are twice as likely to develop cancer due to increased exposure to risk factors. Key barriers include lack of access to preventive services, inadequate support from healthcare systems, and traumatic experiences.
Researchers have developed an AI-driven test that accurately diagnoses ovarian cancer in women clinically classified as normal, improving detection of early-stage disease. The test uses machine learning and blood metabolite information to assign a probability of disease presence or absence, offering a more clinically informative approach.
A study found that the 21-gene breast recurrence score test may underestimate chemotherapy benefits for young Black women with estrogen receptor-positive breast cancer. The researchers recommend lowering the test's cutoff point to ensure accurate treatment recommendations for all patients regardless of race or ethnicity.
Experts predict a significant increase in bowel cancer death rates among young adults in the EU and UK, driven by rising obesity and heavy alcohol consumption. Death rates are predicted to rise by 26% in men and nearly 39% in women in the UK, with similar increases seen in Italy and other European countries.
A new study funded by NIHR has led to the UK government approving digital pathology for cancer screening samples. This technology enables faster reporting and improved care for patients with bowel, breast, lung, and cervical cancers. The use of digital pathology will help reduce risk of sample loss or damage and allow pathologists to r...
A study found rectal examinations offer no advantages over PSA blood tests for detecting prostate cancer. The research analyzed data from 85,738 participants and concluded digital rectal examination alone or with PSA is not more effective than the PSA test.
A new diagnostic kit allows dentists to screen for oral squamous cell carcinoma with a simple brush biopsy, detecting genetic signals of the disease with over 90% accuracy. The non-invasive test is less complicated than surgical biopsies and can be performed in under a minute without numbing required.
A Stanford Medicine-led study found that advances in treating metastatic breast cancer are responsible for nearly one-third of the decrease in annual deaths from breast cancer between 1975 and 2019. This decline is attributed to improved treatments, which have enabled women with metastatic disease to live longer than ever.
Researchers developed a training curriculum for community health workers to enhance cancer genetic screening in Black women. The 10-module program, KEEP IT, improved genetic knowledge and competencies among CHWs, who are trusted members of their communities.
A survey of low-income adults showed a significant decrease in food insecurity, from 20.6% in 2019 to 15.5% in 2021. The findings highlight the importance of financial relief and nutritional benefits for vulnerable populations during the pandemic.
A new study from the University of Pennsylvania School of Medicine found that mailing signed orders to patients with cirrhosis led to a significant increase in liver cancer screenings. The study involved over 500 patients and showed that 55% completed their screening within six months, compared to just 27% in the control group.
Researchers identified Benidipine as a compound promoting the death of cigarette smoke-induced senescent lung cells, improving lung emphysema. The dihydropyridine family of calcium channel blockers constitutes a new class of senolytics that could improve lung diseases.
The IASLC Early Detection & Screening Committee published a perspective outlining key components of LDCT screening regimens. The report emphasizes the need for data-driven management systems, quality assurance assessments, and multi-disciplinary clinical management to maximize benefits of early detection and treatment.
Researchers found that colon cancer screenings reduce cancer rates by about 0.5 percent, doubling previous estimates of a quarter of a percentage point. This effect is twice the impact of just being invited to screen, suggesting that actual screening rather than just the offer makes a difference.
A study published in the Journal of Thoracic Oncology found that adopting a lung nodule program can increase early lung cancer detection for patients not eligible for traditional screening. The study revealed significant differences in stage at diagnosis and overall survival rates between young, elderly, and screened cohorts.
Researchers found that patients who scheduled their own mammograms through an online patient portal had a 13 percentage point increase in screening completions. This simple intervention doubled the number of mammogram completions, resulting in approximately 4,500 more people getting screened.