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Cancer diagnoses and deaths are declining in Appalachia but remain significantly higher compared to other US regions

Researchers found that cancer incidence and death rates are decreasing in Appalachia, but people in the region are more likely to be diagnosed with and die from cancer compared to other areas of the US. The disparities are attributed to limited access to care, historical occupational risks, and higher poverty rates.

SourceAmerican College of Surgeons·JournalJournal of the American College of Surgeons·TypeData/statistical analysis·DateFeb 6, 2025

Human papillomavirus infection kinetics revealed in new longitudinal study

A new longitudinal study has provided unprecedented insights into human papillomavirus (HPV) infection dynamics. The study found that non-persistent infections exhibit a plateau in viral load before rapidly declining, while chronic infections show a strong correlation between immune cells and virus production. This research could infor...

SourcePLOS·JournalPLOS Biology·TypeObservational study·DateJan 21, 2025

Large-scale TMIST breast cancer screening trial achieves enrollment goal, paving the way for data that provides a precision approach to screeninge

The Tomosynthesis Mammographic Imaging Screening Trial (TMIST) has successfully enrolled over 108,000 women worldwide for a randomized controlled trial comparing 2D and 3D mammography. The study aims to determine whether 3D mammography is more effective in reducing advanced breast cancer risk.

SourceECOG-ACRIN Cancer Research Group·TypeRandomized controlled/clinical trial·DateJan 15, 2025

Travel distance to nearest lung cancer facility differs by racial and ethnic makeup of communities

A cross-sectional study found that American Indian/Alaska Native populations are significantly farther away from lung cancer screening centers than non-Hispanic White populations. The researchers recommend increasing access to lung cancer services through mobile units and imaging locations to address these disparities.

SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeNews article·DateJan 13, 2025

AI can improve ovarian cancer diagnoses

A new study published in Nature Medicine shows that AI-based models can accurately identify ovarian cancer in ultrasound images, achieving an accuracy rate of 86.3%. The models also reduce the need for expert referrals and misdiagnosis rates by 63% and 18%, respectively.

SourceKarolinska Institutet·JournalNature Medicine·DateJan 2, 2025

Cardiovascular disease and breast cancer stage at diagnosis

A case-control study found a link between advanced breast cancer stage and prevalent cardiovascular disease, with hormone receptor-positive and ERBB2-negative disease being more affected. Future studies are needed to confirm these findings and investigate interventions to improve patient outcomes.

SourceJAMA Network·JournalJAMA Network Open·DateJan 2, 2025

New method could improve cervical cancer screening

A new study from Karolinska Institutet and Queen Mary University of London has developed a method to divide HPV-positive women into three risk groups, based on the variant of the HPV virus and the amount of virus present in the self-test. This method could enhance cervical cancer screening for high-risk women.

SourceKarolinska Institutet·JournalPLOS Medicine·DateDec 13, 2024

Artificial intelligence improves mammography-based risk prediction

Artificial intelligence is enhancing breast cancer risk prediction through mammographic analysis, uncovering key features that predict breast cancer risk. These AI-generated features may inform personalized screening strategies, such as more frequent or less frequent screenings for women at high or low risk of breast cancer.

SourceCell Press·JournalTrends in Cancer·TypeCommentary/editorial·DateDec 12, 2024

UNC researchers awarded up to $10M to leverage data science to accelerate cancer diagnosis and optimize delivery of precision oncology

A team of UNC-Chapel Hill researchers will develop an oncology health learning system using AI-ready data to generate real-time identification of new cancer cases and support personalized treatments. The project aims to improve cancer diagnosis, care equity, and quality by creating accessible tools for health providers.

Using race and ethnicity to estimate disease risk improves prediction accuracy but may yield limited clinical net benefit

A cross-sectional study found that including race in disease risk models improves prediction accuracy, but the clinical net benefit is smaller than expected. The researchers provide a widely adaptable framework for deciding whether to include or exclude race from disease risk predictions.

SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeNews article·DateDec 2, 2024

Home testing kits and coordinated outreach substantially improve colorectal cancer screening rates

A new study shows that mailing at-home fecal immunochemical testing kits and providing coordinated follow-up led to a tripling of screening completion rates compared to usual care. The intervention increased screening rates by 30% within six months and 34.6% by 12 months.

SourceUniversity of North Carolina Health Care·JournalJAMA Network Open·TypeRandomized controlled/clinical trial·DateNov 25, 2024

Gut dysbiosis and fecal microbiota transplantation in pancreatic cancer: Current status and perspectives

Research highlights the role of gut dysbiosis in pancreatic ductal adenocarcinoma (PDAC), with specific microbial profiles associated with PDAC. Fecal microbiota transplantation (FMT) is proposed as a potential adjunct therapy to improve patient outcomes through microbiome modulation and immune system recalibration.

SourceXia & He Publishing Inc.·JournalCancer Screening and Prevention·DateNov 7, 2024

Cancer genetic risk assessment guidelines expand to meet growing understanding of hereditary risk

The National Comprehensive Cancer Network has updated its guidelines for genetic/familial high-risk assessment, incorporating the latest scientific research and expert recommendations to enhance screening practices and treatment options. The expanded guidelines cover various cancer types and provide guidance on genetic testing, heredit...

First steps towards national screening for Barrett's esophagus

Researchers found that using a multi-step strategy with less-invasive devices can identify patients with Barrett's oesophagus before an endoscopy. This approach is promising for cost-effective screening, which could lead to earlier diagnosis and treatment of oesophageal cancer.

SourceFlinders University·JournalJournal of Gastroenterology and Hepatology·TypeComputational simulation/modeling·DateOct 29, 2024

Human papillomavirus type 16 based L1, L2, E6, and E7 peptide microspheres induce encapsulated peptide mixture specific cytotoxic T lymphocytes and tumor regression in a murine model of cervical cancer

Researchers developed HPV16 peptide microspheres to induce specific cytotoxic T lymphocytes, leading to tumor regression in cervical cancer models. The approach combines peptide-based vaccinations with microsphere technology to enhance immune responses and eliminate tumor cells.

SourceXia & He Publishing Inc.·JournalCancer Screening and Prevention·DateOct 28, 2024

Researchers using $3.3M NCI grant to develop more accurate, comfortable breast cancer screening technology

College of Medicine – Tucson researchers are using a $3.3 million grant to test advanced breast computed tomography (CT) scans that create high-resolution 3-D images without physical compression, aiming to enhance early cancer detection and diagnosis for women with dense breasts. The technology has the potential to detect more breast c...

Disparities in gastric cancer screening worldwide

Gastric cancer is the sixth most common cancer globally, with high incidence rates in Asia, Latin America, and parts of Europe. Screening programs focusing on H. pylori eradication and early detection have shown promise in reducing mortality rates. Emerging research explores serological markers for pre-screening tools and vaccination a...

SourceXia & He Publishing Inc.·JournalCancer Screening and Prevention·DateOct 9, 2024