Articles tagged with Cancer Screening
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Scientists at Nagoya University have discovered a reliable cancer marker, stromal cell-derived factor 4 (SDF-4), that detects gastric cancer with high accuracy. The protein is found in high levels even in patients with stage I gastric cancer, suggesting its potential for early detection.
Researchers have identified 451 genetic variants associated with prostate cancer risk through a comprehensive analysis of nearly 950,000 men. The findings improve the accuracy of genetic risk scores and may lead to personalized screening recommendations for men at higher risk.
A Mayo Clinic study found patients with lower extremity lymphedema had twice the risk of developing skin cancer, including basal cell carcinomas and squamous cell carcinomas. Regular skin cancer screenings are crucial for these patients as early detection is critical.
A study published in Cell Host and Microbe found that gender-neutral HPV vaccination is effective in preventing cervical cancer by inducing a stronger herd immunity. The vaccine protects against high-risk HPV types 16 and 18, which cause 70% of all HPV-related cervical cancers, and also provides cross-protection against low-risk types.
The HPV vaccine effectively clears most cancer-causing strains, but a new equilibrium of lower-risk HPV types emerges, suggesting a change in screening approaches. Vaccinating boys and girls may be necessary to clear all cancer-causing HPVs.
A new study published in Radiology shows that patients diagnosed with lung cancer via CT screening have a 20-year survival rate of 81 percent, significantly higher than the average five-year survival rate for all lung cancer patients. Early detection through routine screening can lead to a cure if found early.
A large-scale study found that low-dose CT screening increases the 20-year survival rate of lung cancer patients from 18.6% to 81%, with Stage I cancers having an even higher long-term survival rate of 95%. Early detection through annual screening can effectively cure lung cancer in the long term.
A study found that physicians who presented treatments for obesity as good news and an opportunity were more successful in helping patients lose weight. Patients who received counseling with a positive and optimistic tone had significantly higher weight loss outcomes compared to those who received neutral or negative advice.
Researchers found that Black men are more likely to have prostate cancer than white men, regardless of PSA level. This highlights the importance of earlier and more frequent screening for Black men to reduce health disparities.
Researchers at the University of Surrey have developed new, tissue-equivalent curved organic X-ray detectors that are cheaper, more flexible, and sensitive than traditional detectors. These detectors have the potential to improve accuracy in cancer treatment and reduce radiation risk.
The study demonstrates that concurrent DNA and RNA sequencing improves the detection of novel variants in individuals undergoing hereditary cancer testing, expanding identification of those with hereditary cancer predisposition. This advancement enables personalized therapeutics and surveillance for these individuals.
A recent study published in JAMA Oncology found that false-positive mammography results may significantly increase the risk of developing breast cancer. The risk varies depending on individual characteristics and follow-up, highlighting the need for personalized screening strategies after a false-positive result.
Researchers found a significant long-term increased risk of breast cancer among women with false-positive mammography results. The risk is highest in women aged 60-75 and those with low breast density, facing a 60% increased risk over the subsequent 20 years.
Thyroid cancer incidence is significantly higher in more affluent areas of São Paulo State, Brazil, compared to less developed regions like Barretos. The study suggests overdiagnosis may be responsible for this trend, with mortality rates remaining similar across socioeconomic groups.
Researchers found that presenting adults between 76 and 85 with personalized information about the benefits and harms of colon cancer screening decreases excess screening. The study involved 431 older adults who received either standard or personalized care, with no significant differences in screening orders between the two groups.
Research by George Mason University found that women with physical disabilities have lower cervical cancer screening rates, highlighting the need for improved access to preventive health services. The study's findings also reveal disparities in screening rates among different types of disabilities.
The TMIST breast cancer screening trial is expanding to Thailand, aiming to improve outcomes for Black and Hispanic women. The trial, led by the ECOG-ACRIN Cancer Research Group, is comparing 3-D and 2-D mammography in 128,905 women to better inform tailored future screenings.
A clinical trial in Spain found that only 1 in 3 family members of patients with colorectal cancer participate in screening, missing opportunities for early detection. The study used fecal testing and colonoscopy to screen first-degree relatives, but uptake was low.
Researchers developed a blood test to detect cancer earlier in individuals with Li-Fraumeni syndrome, an inherited condition with a high risk of developing cancer. The study provides a proof-of-principle framework for detecting specific cancers earlier, paving the way for further clinical trials and improved patient care.
A new multitarget stool RNA test, ColoSense, has been shown to detect colorectal neoplasia with high sensitivity and comparable specificity to existing molecular diagnostic tests. The test also demonstrated significant improvement in sensitivity relative to the fecal immunochemical test.
A study of 5,435 adolescents and young adults with cancer found that those receiving specialty palliative care experienced a decrease in pain severity. However, the intervention did not affect other symptoms, highlighting the need for new interventions targeting other symptoms during treatment.
Researchers documented a steady increase in cervical cancer incidence and death rates in Appalachian Kentucky from 2000 to 2019. The region's cervical cancer death rate is now twice the national average, with distant-stage cancers increasing by 5.5% per year.
Researchers found that polygenic risk scores identify only 11% of individuals who develop disease and generate 5% false positives. The scores contribute little health benefit while adding cost and complexity to healthcare systems.
TTUHSC researchers received funding for pilot studies on photothermal tumor therapy, clear cell renal cell carcinoma, and colorectal cancer screening in underserved areas. The grants support the purchase of a cell sorter and address regional health disparities.
A new blood test called OvaPrint TM detects specific nucleic acids in the blood, distinguishing between cancerous and benign pelvic masses with high accuracy. The test has the potential to improve treatment outcomes by identifying the best surgical approach for patients with a pelvic mass.
A multilevel intervention combining automated reminders and patient outreach improved follow-up rates for patients with overdue abnormal cancer screening results. The study found that such interventions can enhance patient outcomes through earlier diagnosis and treatment.
Researchers discovered the STAT3 signaling pathway as a potential target for treating H3K27M-mutant diffuse midline gliomas (DMGs), a uniformly lethal central nervous system malignancy. The current standard of care, including palliative radiation and chemotherapy, remains ineffective in this disease.
A recent study compared using health information exchange (HIE) data with patient self-reported data as a means of gathering intelligence on cancer screening uptake. HIE data provided more information about laboratory screening tests, while patient self-reports offered more details about cancer screening procedures.
A multilevel primary care intervention, including electronic health record reminders and patient outreach, improved timely follow-up of overdue abnormal cancer screening test results for breast, cervical, colorectal, and lung cancer. The intervention was found to be effective in reducing missed screenings.
A new study found that an alternative model to identify patients with lung cancer eligible for screening was more accurate than the currently used method based on the United States Preventive Services Task Force (USPSTF) criteria. The PLCOm2012 models had higher sensitivity and identified more people with lung cancer eligible for scree...
The study developed a highly accurate AI model for fully automated cancer detection, including small and difficult-to-detect tumors. The model could detect visually imperceptible cancer from normal-appearing pancreases substantially early before clinical diagnosis, with a median of 438 days.
Researchers found that short-form videos on TikTok can inform and encourage women to get regular pap tests, particularly when created by doctors. The studies also showed that autonomy-supportive messages improved attitude toward the message and engagement intention.
A machine learning model developed by researchers can predict lung cancer risk with an 83.9% sensitivity, identifying those who need screening for the disease. The model uses just three predictors: age, smoking duration, and pack-years of smoking, making it a simplified approach to determine high-risk populations.
Researchers from The University of Queensland and The Alfred hospital in Melbourne have identified gene variants associated with a higher risk of nodular melanoma. The study found that four genes with rare DNA variants were linked to the aggressive subtype, which accounts for most melanoma deaths.
A new poll found that 62% of people aged 50-80 disagree with using life expectancy as a factor in determining cancer screening guidelines. The majority also believes that some older adults should still receive cancer screenings even if guidelines don't recommend them.
The report found that new diagnoses of six major cancer types declined sharply in early 2020, coinciding with the start of the COVID-19 pandemic. Cancer screenings and other procedures were also significantly reduced, likely due to medical care interruptions.
A new editorial paper highlights the importance of including older patients in lung cancer clinical trials, where they are often undertreated due to age-related factors. The paper emphasizes the need for increased collaboration among stakeholders to enhance enrollment and retention of older cancer patients.
A scoping review identified four key themes: everyday language, thorough information, adequate discussion time, and a trusting relationship. The study also highlighted the impact of racism on Black men's medical interactions. Researchers suggest strategies to support men's communication preferences.
Clinician staff perspectives on implementing Adverse Childhood Experience (ACE) screening in Los Angeles County Pediatric Clinics revealed that screening can elicit important patient information and build trust. However, challenges arise from insufficient time for screening, inadequate training, and limited referral resources.
A new Canadian guideline aims to promote health equity among marginalized groups by providing 16 preventive care recommendations. The guidelines focus on removing barriers to healthcare, prioritizing people from disadvantaged groups, and improving access to essential screenings and interventions.
A qualitative study explores the challenges transgender people face when sharing health information with clinicians, including risk of substandard care. The authors argue that improving medical culture, policies, and data collection tools are necessary to enhance quality and safety of clinical care for transgender individuals.
Researchers have identified 11 genes associated with aggressive prostate cancer, which could lead to more effective treatments and earlier detection. The findings come from a large-scale study of over 17,500 patients and may help personalize care for individuals with the disease.
Researchers have identified new genetic markers to detect Lynch syndrome-associated colorectal cancer with 92% accuracy. The discovery could lead to a non-invasive screening option using stool samples, reducing the need for annual colonoscopies and invasive tests.
Breast milk from breast cancer patients contains tumour DNA that can be detected through liquid biopsy, offering a potential new tool for early diagnosis. The study found that ctDNA was detectable in 13 of 15 breast milk samples collected from breast cancer patients, outperforming detection in blood samples.
The study found significant reductions in breast cancer screening volume and uptake globally during the 2020 COVID-19 pandemic. The analysis of 26 studies from 13 countries revealed a decline in screening volumes ranging from 13% to 61%, and screening uptake rates varying by up to 43.5%.
Researchers advocate for accessible breast cancer screening services for individuals with disabilities, highlighting physical barriers such as equipment accessibility and fragrance-free policies. They stress the need for social and procedural barriers removal through comprehensive training and resources.
A large-scale international study of childhood cancer survivors found that women who received high-dose doxorubicin chemotherapy without chest radiation have a significantly increased risk of breast cancer before age 40. The researchers are calling for broadening guidelines for breast cancer screening in these patients.
A large study found that people with an evening chronotype were more likely to engage in unhealthy lifestyle behaviors such as smoking, poor sleep, and physical inactivity. These individuals had a 72% higher risk of developing diabetes compared to those with a morning chronotype.
Scientists at Montefiore Einstein Cancer Center have developed a novel HPV test that detects cervical adenocarcinoma and its precursor lesions with high sensitivity. The test assesses methylation levels in cervical tissue samples, offering a more accurate detection method for this common type of cancer.
Researchers found decreased in situ and invasive melanoma diagnoses during the pandemic, which may reflect reduced skin cancer screening. Thick melanomas increased primarily due to a decrease in thin melanomas, rather than an absolute increase in thicker ones.
Researchers found that an AI algorithm comparable to human readers demonstrated high sensitivity and specificity in detecting breast cancer. The study utilized a large dataset of mammographic exams and compared the performance of AI with human readers, finding no significant difference between the two.
A systematic review and meta-analysis of 18 clinical trials involving 2.1 million individuals found no significant lifetime gain from common cancer screening tests. However, colorectal cancer screening with sigmoidoscopy may have a potential benefit, according to the study.
Researchers have been awarded $600K each to lead projects improving healthcare access for underserved populations, including Black women and rural/minority communities. These projects will use innovative strategies such as at-home blood pressure monitoring and telemedicine-assisted testing to address health disparities.
A new study finds that integrating longitudinal tobacco cessation care into lung cancer screening improves quit rates and enhances the benefits of screenings. Researchers recommend incorporating behavioral treatment and medication into the screening process to help smokers quit.
A Swedish study revealed that including all eleven associated genes in the screening test doubled the proportion of women with genetically confirmed hereditary breast cancer. The study included 4759 individuals and found that around 85% of women investigated for suspected hereditary breast cancer had a genetic abnormality.
A new AI tool predicts certain forms of esophageal and stomach cancer at least three years prior to diagnosis. The K-ECAN tool uses basic EHR data to identify high-risk patients, who may benefit from earlier screening and preventative measures.
A new study estimates that cancer screenings have saved the US at least $6.5 trillion and led to 12 million more years of life, with significant economic impact from breast, colon, cervical, and lung cancer screenings.
A promising molecular diagnostic tool uses a single biomarker to detect primary bladder cancer in patients with hematuria, showing high sensitivity and accuracy. The noninvasive test offers advantages such as shorter turnaround time and efficient analysis of results.
A machine learning model found that background parenchymal enhancement (BPE) on breast MRI is an indicator of breast cancer risk in women with extremely dense breasts. Women with dense breasts are at a higher risk of developing breast cancer compared to those with fatty breasts.
A recent study published in Annals of Internal Medicine found that continued breast cancer screening after age 70 is associated with a greater incidence of cancer that likely would not have caused symptoms. Researchers estimate up to 47% of breast cancers found among women aged 74-84 were overdiagnosed.