Articles tagged with Placebos
A study published in JAMA found that inhaling nitric oxide gas for up to 3 days did not shorten the time to resolution of painful crises in patients with sickle cell disease. The treatment, which had shown promise in small trials, failed to demonstrate significant benefits in reducing pain duration or hospitalization length.
A study found that nitroglycerin ointment increased bone mineral density and decreased bone resorption in postmenopausal women. The researchers also observed increases in bone-specific alkaline phosphatase and decreases in urine N-telopeptide, markers of bone formation and resorption.
Researchers found that rescue therapy was effective in reducing asthma exacerbations and treatment failures, with linear growth not affected. The study suggests using rescue inhaled corticosteroid as a step-down alternative for mild persistent asthma.
The SCAST study found that candesartan did not reduce the risk of vascular death, stroke, or heart attack in patients with acute stroke and high blood pressure. In fact, it increased the risk of poor outcomes and low blood pressure-related symptoms.
Researchers found no reduction in preterm delivery or neonatal morbidity in twin pregnancies treated with 17-hydroxyprogesterone. The study, presented at the Society for Maternal-Fetal Medicine's annual meeting, involved over 240 mothers and 480 babies.
A study published in JAMA Network found that escitalopram significantly reduced the frequency and severity of menopausal hot flashes in healthy women. The medication was associated with a 47% decrease in hot flash frequency compared to placebo, making it a nonhormonal option for treating menopausal hot flashes.
Researchers at the Children's Hospital of Pittsburgh found that antibiotics are more effective than a placebo in relieving symptoms of middle-ear infections in young children. The study, funded by the National Institute of Allergy and Infectious Diseases, involved 291 children between 6 and 23 months old with acute middle ear infections.
A pair of clinical trials found that two weeks of rifaximin treatment significantly reduced IBS symptoms, including bloating and abdominal pain. The benefits persisted for 10 weeks after treatment was stopped, suggesting a potential underlying cause of IBS: alterations in gut bacteria.
Researchers have found that placebos work even when administered honestly, leading to improved symptoms for patients with irritable bowel syndrome. The study suggests that the performance of medical ritual may hold significant benefits, independent of patient knowledge.
A new study found that placebos are effective in treating irritable bowel syndrome (IBS) symptoms even when patients are informed they are taking a placebo. The study involved 80 patients who received either a real treatment or a placebo, with nearly twice as many experiencing symptom relief with the placebo.
A new study published in Clinical Infectious Diseases found that cranberry juice had no significant effect on reducing the recurrence of urinary tract infections. Among participants who suffered a second infection, those who drank cranberry juice showed a higher recurrence rate compared to those who received a placebo.
A new study suggests that fat-derived stem cells can safely improve heart function after a heart attack by reducing damaged tissue, increasing blood flow, and boosting the heart's pumping ability. The treatment was found to be effective in patients with severe heart attacks, but further research is needed to confirm its efficacy.
A randomized phase 2 study found that combining sorafenib with doxorubicin improved median overall and progression-free survival in patients with advanced liver cancer. The study showed a significant reduction in the risk of death and progression, with median overall survival increasing to 13.7 months
A randomized trial with over 600 patients found that high-dose prescription omega-3 did not reduce the recurrence of atrial fibrillation. The treatment had no significant impact on the rate of symptomatic AF or flutter events in either group, suggesting that previous findings may be due to small sample sizes.
A new study shows that bihemispheric transcranial direct current stimulation (tDCS) coupled with physical and occupational therapy significantly improves motor function in stroke patients. The therapy rebalances brain activity on both sides of the brain, enhancing recovery.
A randomized controlled trial of DHA supplementation in individuals with mild to moderate Alzheimer's disease found no beneficial effect on cognitive and functional decline. The study included 402 participants who received either DHA or a placebo for 18 months. No significant difference was observed in the rate of brain atrophy, ADAS-c...
A study published in Annals of Internal Medicine questions the foundation of placebo-controlled trials, citing a lack of standardization and regulation for placebo ingredients. The researchers found that only 10% of cases disclose the makeup of placebos, leading to potential biases in study results.
Researchers found that people with periodontal disease are at high risk for cardiovascular disease and that invasive dental procedures may raise this risk. However, studies have not consistently shown a link between these procedures and cardiovascular events. Meanwhile, peer support programs improved diabetes management in patients, su...
A study found that buprenorphine implants significantly reduced opioid use over 16 weeks, with 65.7% of patients remaining in the study for 24 weeks and fewer withdrawal symptoms. The implants also showed promise in decreasing non-medical opioid use.
Postmenopausal women taking estrogen therapy are at a higher risk of developing kidney stones, according to a study. The research found a significant increase in kidney stone development, with a fivefold greater risk in women with a history of kidney stones.
Long-term finasteride use has been shown to reduce disease progression and improve urinary tract symptoms associated with benign prostatic hyperplasia. The treatment also reduces the risk of acute urinary retention and surgical intervention, making it an effective option for men with moderate to severe lower urinary tract symptoms.
A new Cochrane Systematic Review found that vitamin D supplements have no effect on bone density in healthy children. However, children with low levels of vitamin D may benefit from supplementation.
Researchers found that rufinamide significantly reduced total partial seizure frequency compared to placebo, with a notable 50% reduction in responder rate and total partial seizure frequency. The study also showed efficacy for complex partial seizures, simple partial seizures, and secondarily generalized partial seizures.
A recent study published in Arthritis & Rheumatism found that abatacept failed to prevent disease flares in patients with non-life threatening systemic lupus erythematosus (SLE). The medication was administered to 175 patients, but it did not show significant therapeutic benefits over placebo.
A new study found that taking a placebo improved symptoms in about one-third of women with low sexual arousal, with the most improvement occurring during the first four weeks. The key predictor of symptom change was an increase in satisfying sexual encounters, suggesting a need to investigate behavioral factors more closely.
A recent study found that opening a new line of communication about sex can have a positive effect on many women with low libidos. Fifty women were given a placebo instead of a drug treatment for low sexual arousal, and on average, one in three showed an overall improvement.
Adding albuterol to a treatment for multiple sclerosis improves functional status and reduces inflammation by decreasing interleukin-12 levels. The study suggests that combining glatiramer acetate with albuterol is well-tolerated and enhances clinical response in patients with relapsing-remitting MS.
A pilot study suggests pioglitazone is well-tolerated and may be a promising treatment for Alzheimer's disease. Peripheral edema was the main adverse event, but no significant treatment effect on clinical efficacy was observed.
A study suggests that current treatment theories need to be expanded to account for a more dynamic quitting process. Successful quitters can achieve abstinence despite periods of smoking before the end of treatment. Continued cessation treatments without interruption may increase 'real-world' quit rates for motivated smokers.
The SHIFT study found that ivabradine significantly reduced cardiovascular death and hospitalization for worsening heart failure when added to standard treatment in patients with a high heart rate. Lowering heart rates with ivabradine was also associated with improved clinical outcomes, including an average reduction of 15 bpm.
A study published in The Lancet Neurology found that memantine showed significant benefits for patients with mild to moderate dementia with Lewy bodies (DLB), with improvements in global clinical status and behavioral symptoms. However, no significant differences were found in patients with Parkinson's disease dementia (PDD).
A new hepatitis E vaccine has demonstrated 100% efficacy in preventing infection, with protection offered across all age and sex subgroups. The vaccine is safe and can be used in both rich and poor countries, as well as for tourists, making it a crucial development in outbreak control.
The CRESCENDO study found that rimonabant increased gastrointestinal, neuropsychiatric, and serious psychiatric side-effects compared to placebo. The primary endpoint of cardiovascular death, myocardial infarction, or stroke occurred at similar rates in both groups.
A large trial found that B vitamin supplements did not reduce the risk of subsequent vascular events in patients who had a recent stroke or ischemic attack. Despite lowering homocysteine levels, B vitamins were not effective in preventing non-fatal strokes, heart attacks, or vascular deaths.
Individuals with Parkinson's disease who were told they had a higher chance of receiving an active drug showed a stronger neurochemical response to placebo. The expectation of symptom improvement is associated with the release of dopamine in patients with Parkinson's disease and can affect motor performance.
A combination treatment of naltrexone and bupropion, along with diet and exercise, has been shown to reduce body weight by 5% or more in people with obesity. The study found that patients who received the treatment experienced significant weight loss, with those in the highest dosage group losing up to 6.1kg over 56 weeks.
A completed clinical trial found that MDMA-assisted psychotherapy significantly improved symptoms of posttraumatic stress disorder (PTSD) in patients who had failed traditional treatments. Eighty percent of trial participants no longer met the diagnostic criteria for PTSD, with notable improvements in workability and emotional regulation.
A randomized controlled trial found that patients with chronic low-back pain and degenerative lumbar osteoarthritis who took glucosamine for six months showed no significant difference in pain-related disability, pain, or quality of life compared to those who received a placebo. The study suggests that further research is needed to det...
A new non-surgical treatment for uterine fibroids, ulipristal acetate (UPA), has shown promising results in reducing total fibroid volume and menstrual bleeding. Patients taking UPA experienced improved quality of life, fertility, and reduced symptoms.
A new diabetes drug, dapagliflozin, has been shown to improve blood sugar control in patients who have inadequate control with metformin. The drug acts independently of insulin, promotes excretion of glucose in the urine, and is associated with weight loss and low risk of hypoglycaemia.
A study of 12,064 survivors of heart attack found that folic acid and vitamin B12 supplementation did not lower the risk of heart attack, coronary death, or stroke. The researchers also found that folic acid supplementation did not increase the risk of cancer.
A new study reveals that oral micronized progesterone relieves hot flashes and night sweats in postmenopausal women, with a 56% improvement rate. The natural hormone form offers an effective alternative to estrogen for those who cannot or prefer not to use it.
A study published in The Lancet found that low-dose combination therapy of rosiglitazone and metformin can stop people progressing to type 2 diabetes, with a relative risk reduction of 66% compared to placebo. This strategy could target populations at-risk of diabetes.
PSD502 demonstrates significant time to ejaculation and ejaculatory control improvements, with a 5.5-fold increase in IELT, compared to placebo. Men treated with PSD502 experience reduced premature ejaculation symptoms and increased satisfaction.
Researchers found that extended-release injectable naltrexone (XR-NTX) decreases the brain's craving response when presented with alcohol cues. XR-NTX works by blocking opioid receptors in the brain and was approved for treating alcohol dependence in 2006.
A large trial found that adding misoprostol to standard uterotonics did not reduce post-partum blood loss, but was associated with increased shivering and body temperature. WHO's withdrawal of support for misoprostol use in low-income settings has been criticized.
Boehringer Ingelheim announces new data on flibanserin in pre-menopausal women with Hypoactive Sexual Desire Disorder (HSDD), showing significant improvements in sexual desire and overall functioning. The study found that 48.3% of women receiving flibanserin reported feeling very much improved, compared to 30.3% on placebo.
Researchers tested bosentan for idiopathic pulmonary fibrosis and found no significant improvements. In contrast, two-day neuromuscular blocking agent therapy improved survival in patients with severe acute respiratory distress syndrome (ARDS). Oral iloprost showed promise in preventing lung cancer among former smokers.
Researchers found MP-376 reduced P. aeruginosa density and improved lung function in CF patients, with the highest dose showing the most significant effect. The treatment was well-tolerated and showed a 79% reduction in need for other antimicrobials.
A recent study has found that high-dose vitamin D supplementation is associated with an increased risk of falls and fractures in older women. The research, published in the Journal of the American Medical Association (JAMA), revealed that women who received a single annual high dose of vitamin D had a higher rate of falls and fractures...
Children and adolescents with cystic fibrosis who received azithromycin did not experience improved lung function compared to those receiving placebo. However, they showed a significant reduction in pulmonary exacerbations and weight gain.
A study published in Annals of Internal Medicine found that human growth hormone (HGH) improves sprint capacity in healthy recreational athletes, with effects nearly doubled in men who also received testosterone injections. The researchers also noted significant reductions in fat mass but no increase in muscle mass.
SE5-OH containing natural S-equol significantly reduced frequency of hot flushes in postmenopausal women. The compound had no effect on reproductive hormones E2 and FSH, suggesting its potential as a critical component in reducing menopausal symptoms.
A study found that consuming a non-spicy pepper analog increased fat oxidation and boosted metabolism, potentially aiding in weight loss. The research suggests that eating peppers could be a simple way to enhance weight loss efforts.
A randomized trial found that high-dose B-vitamin therapy accelerated kidney function decline and increased cardiovascular events in patients with type 1 or 2 diabetes. The study suggests that B-vitamin therapy may not be an effective treatment for slowing disease progression, and potentially poses risks for these patients.
A Phase 2 study demonstrated that BOTOX provides a clinically meaningful benefit for idiopathic OAB patients with urinary urgency incontinence. The study found that doses of 100U-150U provided the optimal balance between efficacy and safety, with significant reductions in symptoms and increases in PVR at higher doses.
A German study found that high dose UDCA was not superior to placebo in treating NASH, but showed promise in a subgroup of mildly overweight male patients. This result is significant as the incidence of NASH is increasing with rising obesity levels.
A new study found that statins can reduce the incidence of new brain lesions in patients with multiple sclerosis by 55.3% compared to a placebo group. This could be meaningful for patients as new lesions are reliable correlates of future clinical attacks.
New data from the RECOVER study showed that Neupro (Rotigotine Transdermal System) effectively improved both motor and non-motor symptoms of Parkinson's disease, including sleep quality, mood, cognition, and pain. The treatment also translated into significant improvements in quality of life for patients.
Two clinical trials found SE5-OH with Natural S-equol to be safe and well-tolerated in both pre- and post-menopausal women, with no significant impact on reproductive hormones or menstrual cycle length. The supplement showed promise in reducing hot flashes in post-menopausal women.