Researchers have identified a new potential treatment for neuroblastoma by targeting the ALT mechanism, which is responsible for chemotherapy resistance. The study found that activating ATM kinase at telomeres promotes chemotherapy resistance in ALT neuroblastoma and suggests a cancer-specific approach to treating this disease.
SourceTexas Tech University Health Sciences Center·JournalScience Translational Medicine·TypeExperimental study·DateAug 23, 2021
A University at Buffalo-led study found that photobiomodulation therapy sped up recovery from burns and reduced inflammation in mice by activating endogenous TGF‐beta 1, a protein controlling cell growth and division. The findings may improve therapeutic treatments for burn injuries worldwide.
SourceUniversity at Buffalo·JournalScientific Reports·DateAug 6, 2021
Researchers use X-rays to activate opsins in neurons, allowing for remote control of neural function and behavior. Scintillators emit visible light in response to X-ray irradiation, enabling the technique without tissue damage.
SourceFujita Health University·JournalNature Communications·TypeExperimental study·DateJul 28, 2021
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
The new CRISPR 3.0 system allows for simultaneous activation of up to seven genes at once, demonstrating high accuracy and efficiency. This multiplexed gene activation system has significant potential for crop breeding and enhancement, enabling the discovery and translational science in plants.
SourceUniversity of Maryland·JournalNature Plants·DateJun 24, 2021
Researchers from Kanazawa University found that gasdermin D forms pores in the cell membrane, allowing factors to flow in and activating IL-1® maturation. This study provides insight into the essential functions of the human immune system and the regulation of immune function.
SourceKanazawa University·JournalCell Reports·DateJun 18, 2021
Researchers at Nagoya University identified a key enzyme that activates nitrate uptake mechanisms in plants responding to nitrogen starvation. The CEPH protein plays a critical role in activating the high-affinity transport system, which enables rapid nitrate uptake from the environment.
SourceNagoya University·JournalNature Plants·DateMay 31, 2021
Researchers have identified the activation mechanism of SHP2, a key player in cancer development. The study reveals that flexible beta sheets, not previously thought to be crucial, open in the presence of a peptide, triggering SHP2 activation.
SourceSaarland University·JournalProceedings of the National Academy of Sciences·DateApr 23, 2021
A recent study published in Cell Reports reveals that DNA supercoiling is involved in regulating gene expression, rather than being just collateral damage. The researchers found that specific genes are massively activated in response to stimuli, and topoisomerase TOP2A plays a crucial role in this process.
SourceCentro Nacional de Investigaciones Oncológicas (CNIO)·JournalCell Reports·DateApr 13, 2021
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
A team of researchers at Tokyo Institute of Technology has identified a critical protein segment responsible for activating the MRN complex, a key player in DNA repair. The discovery reveals a conserved function across species, with implications for genetic disorders and gene editing applications.
SourceTokyo Institute of Technology·JournalProceedings of the National Academy of Sciences·DateMar 10, 2021
Researchers at Ruhr-University Bochum have developed a method to control the direction of nerve fiber growth using magnetic nanoparticles. The team successfully implanted functionalized nanoparticles into model neurons, allowing them to guide axon growth and potentially promote regeneration in Parkinson's patients.
SourceRuhr-University Bochum·JournalScientific Reports·DateJan 18, 2021
Researchers at University of Texas M. D. Anderson Cancer Center discovered NIK protein essential for T cell metabolic shift during activation, regulating anti-tumor immunity. Elevated NIK activity in T cells may improve adoptive therapy efficacy.
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalNature Immunology·DateJan 4, 2021
Researchers identified two inflammatory pathways involving complement and the inflammasome that promote abnormal blood vessel formation in wet AMD. Blocking these pathways, including essential proteins of the inflammasome, may lead to improved therapies for this common blinding disease.
Researchers at the Buck Institute have identified chronic inflammation as a driver of NAD+ decline, a key metabolite central to an efficient and healthy metabolism. Senescent cells activate CD38, which degrades NAD+, leading to age-related diseases. Blocking CD38 activity may offer a new target for therapeutic interventions.
SourceBuck Institute for Research on Aging·JournalNature Metabolism·DateNov 16, 2020
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Biologists developed fluorescent mice to visualize protein kinase A (PKA) activation in the retina. They found that light stimulation activates PKA for nearly 15 minutes in rod cells, which are essential for night vision.
A new study found that coronaviruses use mimicry to trick human immune proteins, including those controlling blood coagulation and complement activation, which may drive pathology in infected patients. The researchers discovered over 150 protein mimics used by coronaviruses, including many involved in severe COVID-19 disease.
SourceColumbia University Irving Medical Center·JournalCell Systems·DateOct 27, 2020
Researchers analyzed 113 patients' immune responses to COVID-19, identifying common patterns that predict severe outcomes. High levels of alpha interferon and inflammasome activation were linked to poor outcomes.
Acalabrutinib improved oxygenation levels and decreased molecular markers of inflammation in most patients with severe COVID-19. The treatment showed promise in reducing the severity of the disease, particularly among those on mechanical ventilation.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience Immunology·DateJun 5, 2020
Researchers discovered that helper proteins Swi5-Sfr1 and Rad51-related helpers collaborate to activate Rad51 in DNA repair. Mutations in Swi5-Sfr1 compromised activation, but yeast cells lacking Rad51-related helpers still repaired DNA, suggesting a compensatory role.
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
A recent study published in Science Advances found that physical forces alone can activate genes in human cells, leading to increased gene expression. The researchers discovered that histone proteins play a key role in determining which genes are responsive to stretching forces.
SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalScience Advances·DateApr 1, 2020
Researchers at MIT discovered that the waves produced on an egg's surface during fertilization are similar to those found in ocean and atmospheric circulations, as well as quantum fluids. The study reveals a universal wave pattern that helps organize cell division and formation of an organism.
SourceMassachusetts Institute of Technology·JournalNature Physics·DateMar 23, 2020
A new study led by the University of Pennsylvania School of Medicine reveals that the pioneering protein FoxA2 simultaneously binds to chromosomal proteins and DNA, opening gates for gene activation. This discovery helps untangle mysteries of embryonic stem cell development into organs, moving regenerative medicine forward.
SourceUniversity of Pennsylvania School of Medicine·JournalNature Genetics·DateMar 18, 2020
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers discovered autophagy's selective degradation of protein liquid droplets but poor performance with aggregated proteins. This study used yeast and a test tube system to reconstitute the Ape1 isolation process, revealing the role of Atg8 and receptor proteins.
SourceJapan Science and Technology Agency·JournalMolecular Cell·DateFeb 13, 2020
Researchers at the University of Zurich have identified a new target for treating incurable leukemia in children by analyzing the molecular causes of the disease. They found that an abnormal protein activates genes at the wrong time, triggering the formation of malignant white blood cells and causing leukemia.
SourceUniversity of Zurich·JournalCancer Cell·DateNov 25, 2019
Researchers identify protein CaVbeta1E that promotes muscle mass maintenance via GDF5 signaling, counteracting sarcopenia. The study opens a new field of activity in developing therapeutic strategies against muscular decline associated with aging.
SourceAFM-Téléthon·JournalScience Translational Medicine·DateNov 6, 2019
Researchers at Washington State University have identified a new therapeutic target for the treatment of gout, a common type of arthritis that causes episodes of painful and stiff joints. Blocking the signaling molecule TAK1 can suppress inflammation caused by gout, according to the study.
SourceWashington State University·JournalCellular and Molecular Immunology·DateOct 29, 2019
A research team at the University of Colorado School of Medicine has identified BRD4 as a central regulator of cardiac fibroblast activation. Chemical inhibitors of BRD4 potently block cardiac fibroblast activation, providing a potential therapeutic target for heart failure treatment.
SourceUniversity of Colorado Anschutz Medical Campus·JournalCirculation Research·DateSep 17, 2019
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers create a novel method using magnetic tweezers to study the mechanical forces that activate proteins like VWF, which initiates blood clots. The technique reveals the unfolding of VWF dimers under low forces, shedding light on the first step in blood coagulation.
SourceLudwig-Maximilians-Universität München·JournalProceedings of the National Academy of Sciences·DateSep 4, 2019
LMU biologists have identified a general alarm signal that activates the Unfolded Protein Response (UPR) in mitochondria, ensuring protein degradation and restoring normal cell function. The signaling pathway is triggered by a decline in mitochondrial membrane potential and involves transcription factor ATFS-1.
SourceLudwig-Maximilians-Universität München·JournalCell Reports·DateAug 28, 2019
A new strategy for designing light-sensitive proteins has been developed by researchers at Ruhr-Universität Bochum. They combined computer-aided and experimental methods to create a more targeted approach, enabling the manipulation of protein building blocks without impairing function.
SourceRuhr-University Bochum·JournalChemBioChem·DateAug 2, 2019
Researchers discovered two proteins that act like a 'clutch' in cells to activate the immune response. These protein condensates guide the movement of contents inside cells, much like switching gears in a car. The study sheds light on control mechanisms for immune activation and could lead to designing T cells with specific functions.
SourceNational Centre for Biological Sciences·DateJul 22, 2019
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers discovered two adaptor proteins that act as a 'clutch' to activate the immune response by moving protein condensates towards the center of cells. This discovery sheds light on the control mechanisms for immune response activation and could lead to designing immune cells to combat specific problems.
Researchers found that methylmercury increases cardiac fragility by removing an inhibitory brake on Drp1, a protein involved in mitochondrial fission. Treatment with a polysulfide group-releasing compound reversed this effect, suggesting a possible strategy to mitigate cardiotoxicity.
SourceNational Institutes of Natural Sciences·JournalScience Signaling·DateJun 25, 2019
Yale scientists identify two proteins P300 and Brd4 as essential for activating the zebrafish genome after fertilization, allowing embryonic development to proceed. The discovery provides new insights into how life begins at a molecular level.
SourceYale University·JournalDevelopmental Cell·DateJun 17, 2019
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
A study has revealed the structure of FoxM1 protein in its inactive state, which could lead to the development of new cancer treatments by stabilizing the protein. This understanding also provides insight into how transcription factors function and switch between active and inactive states.
SourceUniversity of California - Santa Cruz·DateMay 28, 2019
Scientists have discovered a previously unknown mechanism by which cells sense proteasome dysfunction and respond by editing the amino acid sequence of a key sensing protein. This finding has important applications for treating cancer, aging, and neurodegenerative diseases.
SourceMassachusetts General Hospital·JournalCell·DateApr 18, 2019
A team of biologists has discovered new rules governing cell decision-making in genetics, revealing how genes are activated under specific conditions. The study found that a protein called Zelda strengthens Dorsal activity, allowing cells to make decisions about gene activation based on their environment.
SourceNew York University·JournalCurrent Biology·DateApr 11, 2019
A new study reveals that BAX, a crucial driver of apoptosis, is activated by transient interactions with BH3-only proteins at two distant sites on the protein. This 'hit-and-run' interaction initiates the conversion of BAX into a lethal protein for cells.
SourceWalter and Eliza Hall Institute·JournalCell Reports·DateApr 9, 2019
A study published in Science Signaling reveals that the coralberry plant extract FR900359 can slow down aggressive uveal melanoma by targeting and inhibiting activated Gq proteins. The substance effectively stops cell division activity and suppresses cancer cell proliferation.
SourceUniversity of Bonn·JournalScience Signaling·DateMar 20, 2019
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers have developed a new live-imaging technique that detects short-lived leaks in epithelial tissues and reveals an active repair mechanism involving the protein Rho. This discovery could provide insights into diseases targeting the epithelial barrier, such as those caused by microbes, allergens, and cancers.
SourceUniversity of Michigan·JournalDevelopmental Cell·DateFeb 14, 2019
Researchers at The Wistar Institute found that the S100A14 protein is expressed at higher levels in these individuals than control donors, activating natural killer cells to defend against HIV. This discovery may lead to novel approaches for prevention of HIV infection by manipulating host immune defense.
SourceThe Wistar Institute·JournalJAIDS Journal of Acquired Immune Deficiency Syndromes·DateNov 13, 2018
Researchers at Scripps Research Institute have discovered the molecular mechanisms of protein talin's activation of integrin on the cell membrane. This process is essential for cell adhesion and plays a crucial role in cancer progression and metastasis.
SourceScripps Research Institute·JournalProceedings of the National Academy of Sciences·DateOct 10, 2018
Scientists will investigate necroptosis, a form of programmed cell death, as a key contributor to neuronal loss in Alzheimer's. The goal is to develop therapeutics capable of blocking the necroptosis pathway and slowing or arresting cell death characteristic of the disease.
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
Medical researchers from MSU propose a new targeted cancer therapy by increasing the activity of wild-type p53, which supports genetic stability and prevents malignant tumor formation. The study reveals that p53 also regulates metastasis formation through various programmed cell death pathways.
SourceLomonosov Moscow State University·JournalCancers·DateAug 1, 2018
Researchers have identified P38 alpha as a crucial protein in activating brown fat cells to burn excess fat and eliminate the risk of obesity and related diseases. The study found that mice genetically modified to lack P38 alpha were protected against obesity, diabetes, and fatty liver disease.
SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournalPLOS Biology·DateJul 18, 2018
Researchers at Kyoto University have discovered that MTSS1 controls the branching of neurons by activating one pathway and inhibiting another. This protein plays a dual role, regulating actin filaments to facilitate efficient and uniform coverage of the surrounding environment.
SourceKyoto University·JournalCell Reports·DateJul 3, 2018
Researchers link abnormal TOR activity to oxidative stress and degeneration in both muscle cells and neurons. This discovery has broad implications for understanding diseases such as Alzheimer's, cancer, and HSP, and may lead to new therapeutic targets.
Researchers at Texas Tech University Health Sciences Center identified a specific amino acid residue responsible for inverting potassium channel communication. The study paves the way for developing novel and safer therapeutic drugs to correct illnesses associated with potassium channel dysfunction.
SourceTexas Tech University Health Sciences Center·JournalProceedings of the National Academy of Sciences·DateJun 20, 2018
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Research reveals that E. coli infection can induce delirium in aging rats by reducing levels of brain-derived neurotrophic factor (BDNF), a protein essential for long-term memory formation. The study suggests that immune system activation, such as after surgery or infection, may contribute to cognitive decline in the elderly.
SourceSociety for Neuroscience·JournaleNeuro·DateMay 29, 2018
The researchers have identified a gene called Ankrd16 that prevents the production of harmful protein aggregates in neurological disorders such as Alzheimer's and Parkinson's disease. Elevating levels of Ankrd16 protects specific neurons from dying, while removing it leads to widespread buildup of abnormal proteins.
SourceUniversity of California - San Diego·JournalNature·DateMay 16, 2018
Cadm1 protein interacts with Kaposi's sarcoma viral proteins to promote inflammation and cancer growth in KSHV-infected cells. This discovery could lead to a new therapy targeting human protein CADM1 in viral-mediated cancers.
Researchers at Stanford University School of Medicine have found that young neural stem cells store large protein aggregates in lysosomes. Clearing these aggregates rejuvenates the cells' ability to activate and makes new neurons. The study highlights the importance of maintaining precise control over protein production and disposal.
Researchers studying a rare skin disorder called DEB found that loss of collagen VII affected the cellular microenvironment, leading to abnormal mRNA and protein turnover. Meanwhile, another study used novel proteomics to characterize changes in O-GlcNAc modification sites on proteins involved in T cell activation.
SourceAmerican Society for Biochemistry and Molecular Biology·JournalMolecular & Cellular Proteomics·DateMar 12, 2018
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Researchers provide foundational understanding of myostatin activation mechanism, shedding light on tolloid enzyme's role in generating active myostatin. The study's findings hold promise for developing novel therapies targeting specific structural states of myostatin.
SourceThe Yates Network·JournalThe EMBO Journal·DateJan 23, 2018
The structure of chloride channel TMEM16A has been determined, revealing a unique activation mechanism that could restore hydration of the mucus layer in cystic fibrosis patients. Researchers believe that activating this channel could compensate for the defect in chloride ion secretion, paving the way for novel therapies.
A computer model developed by InSysBio scientists suggests that activating beta-amyloid degradation is key to preventing protein plaques in the brain. The model found that starting treatment at age 60 can lead to relative normalization of indices, highlighting the importance of early intervention.
SourceInSysBio LLC·JournalCPT Pharmacometrics & Systems Pharmacology·DateSep 28, 2017
Researchers have discovered that membrane lipids can activate the unfolded protein response (UPR), leading to increased protein production but also heightened sensitivity in cells. This new understanding may provide insights into various diseases, including those caused by viral infections and tumor growth.
SourceSaarland University·JournalMolecular Cell·DateAug 4, 2017
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers have discovered how Rice Stripe Virus (RSV) reproduces in small brown planthoppers, a key step in controlling the spread of devastating crop diseases. By studying interactions between proteins and compounds, they found that RSV activates the JNK signaling pathway to promote replication.
A University of Pennsylvania study found that social isolation in fruit flies leads to sleep loss, which causes cellular stress and activates the unfolded protein response (UPR). Chronic activation of UPR is linked to aging and age-related diseases such as Alzheimer's and diabetes.
SourceUniversity of Pennsylvania School of Medicine·JournalSLEEP·DateJun 26, 2017
Researchers find that members of the DUX family of proteins, specifically DUX4, trigger gene expression program in human embryos. DUX4 stimulates expression of genes induced during zygotic genome activation by binding to their regulatory regions.
SourceEcole Polytechnique Fédérale de Lausanne·JournalNature Genetics·DateMay 1, 2017
A recent study published in eLife provides a deeper understanding of p38α's structure and activation mechanism. The research reveals novel conformations that could be used to uncover new inhibitors, as well as important electrostatic interactions that may allow for alternative activation pathways with increased specificity.
SourceInstitute for Research in Biomedicine (IRB Barcelona)·DateApr 27, 2017