Articles tagged with Heat Shock
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The study reveals how heat shock chaperone proteins Hsp40 and Hsp70 bind each other and misfolded peptides, enabling the cellular machinery to work. The findings also identify a specific region of Hsp40 that handles protein handoffs, which could lead to therapeutic interventions for diseases.
Researchers identified Phaedra1 as a gene essential for stress-induced cell death in Drosophila melanogaster. The mTOR-Zeste-Phae1 pathway controls lethal stress-dependent individual death. Suppressing this pathway increases survival rates after exposure to lethal stress.
Researchers have discovered a novel cell-clearance pathway linked to diseases such as Chediak-Higashi Syndrome, which affects immune system function. The study used CRISPR/Cas9 gene-editing technology and live imaging to characterize this pathway and identify key genes involved.
Researchers identified a viable path to developing a novel therapy that would make opioids more effective and safer as a treatment for chronic pain. The study found that selective Hsp90 inhibitors amplified the pain-relieving effects of morphine, reducing tolerance and side effects.
A novel inhibitor HVH-2930 targeting heat shock protein 90 (HSP90) demonstrates efficacy against drug-resistant breast cancer cells. It selectively downregulates HER2 signaling, crucial for breast cancer progression, without triggering the heat shock response.
Kumamoto University researchers discovered HSF5's crucial role in the completion of meiosis and activation of genes essential for sperm formation under non-stress conditions. HSF5 is distinct from other Heat Shock Factors, which primarily regulate gene expression in response to stress.
A new study found that HSP10 treatment improved exploratory preferences, object contacts, and swimming time in aged mice, while also increasing proliferating cells and differentiated neuroblasts. The protein also mitigated age-related gene reductions and increased sirtuin 3 levels.
Cells employ a protective mechanism to preserve orphan ribosomal proteins during heat shock, allowing for rapid recovery once the stress subsides. This study uses lattice light sheet 4D imaging and pulse labeling with HaloTag dye to visualize these processes in real-time.
Researchers discovered a new mechanism underlying the heat shock response in Escherichia coli. IbpA suppresses σ32 translation, regulating Hsp expression and aiding cell protection under high temperatures. This finding sheds light on bacterial adaptation to harsh environments.
Researchers at the University of Chicago discovered that yeast cells use membrane-less compartments to drive high-level gene expression in response to environmental stress, mirroring a mechanism used by mammalian cells. This finding has implications for understanding human diseases such as cancer and neurodegeneration.
Plants respond to heat stress by activating a molecular defense pathway involving brassinosteroids, which increase heat stress resistance. Researchers at TUM discovered the role of transcription factor BES1 in this process.
Researchers from Nara Institute of Science and Technology discovered that plants can gain heat tolerance through an epigenetic memory mechanism involving JUMONJI proteins. This mechanism allows plants to adapt to future heat stress by 'remembering' how to deal with heat shock genes.
A new study reveals that human and mouse cancer cells use specific mechanisms to survive heat shock and regain their original function. The research, published in Molecular Cell, identified key genes involved in the process, including those related to autophagy and RNA processing.
Researchers from Iowa State University have discovered that two seemingly unrelated responses in corn plants work together to mitigate damage caused by heat stress. The unfolded protein response and heat shock response, which operate in different parts of plant cells, collaborate to protect the crop from stress.
Researchers from Kazan Federal University and the Institute of Cytology have detailed novel non-trivial intramolecular interactions for small heat shock protein (sHSP) from Acholeplasma laidlawii. This discovery could help uncover new strategies to combat mycoplasma infections in crops.
A new model simulates and understands flow transitions in hypersonic vehicles, revealing points of transition from smooth to turbulent flows. This research has the potential to inform safer vehicle design and improve overall performance.
Aggressive breast cancer cells exploit the natural stress protector heat shock protein 70 (HSP70) to thrive and evade cell death, says a new study. The finding highlights how cancer cells manipulate tumor necrosis factor alpha (TNFα), which normally promotes self-destruction, to aid their survival.
Researchers discovered a gene called heat shock factor is co-opted by the sleeping chironomid to survive desiccation. The gene's activation leads to the synthesis of heat shock proteins protecting cells from misfolding, allowing the insect to regain life.
Researchers uncover genetic mechanism behind insect's ability to revive after drying up. Heat shock factor plays key role in activating genes that protect cells from dehydration damage.
Researchers have discovered how heat shock factor 1 (HSF1), a master transcriptional regulator, is activated and controlled by the on/off switch HSP70 and phosphorylation. This finding could lead to treatments for cancer and neurodegenerative diseases.
Heat shock proteins collide with protein complexes, generating a force that breaks apart damaged or dysfunctional proteins. This study provides new insights into the role of heat shock proteins in maintaining proper protein function and preventing disease.
Researchers at the University of Würzburg have developed a new fluorescence probe to visualize the motions of Hsp90, an essential chaperone that assists numerous proteins. The technique reveals synchronized structural changes within the protein, shedding light on its healing powers and potential connection to diseases.
Researchers at TUM have identified how small heat shock proteins interact with other proteins in Alzheimer's disease. They found that these proteins can bind to both amorphous and amyloid forms of beta-amyloid, preventing clumping and potentially developing new agents.
A new study has found that protein aggregates formed after heat exposure are fully reversible and resume normal cellular functions after returning to normal temperatures. The research sheds light on the biological nature of protein aggregates, which were previously considered toxic dead-end products.
Researchers found a molecular clue to aging in transparent roundworm C. elegans, discovering that adult cells begin their downhill slide when an animal reaches reproductive maturity. The study suggests that a genetic switch is responsible for turning off cell stress responses, starting the decline of adult animals.
Scientists at TUM have characterized a small heat shock protein essential for embryonic development in nematodes, which may have implications for human health. The Sip1 protein regulates itself via pH value and prevents clotting of important proteins.
A new study found that a cellular defense system against protein misfolding can overreact in chronic cases, worsening disease symptoms and reducing therapeutic effectiveness. Inhibiting this response with certain drugs showed promise as a treatment approach.
Researchers found that heat shock factor-1 (HSF-1) stabilizes the cell's cytoskeleton, preventing misfolded proteins from accumulating in the brain. This discovery expands opportunities for therapies to prevent neurodegenerative diseases such as Alzheimer's and Parkinson's.
Research suggests that heat shock protein (HSP90) overexpression contributes to dopaminergic neuronal death and muscle abnormalities in PD. Exercise training has been shown to inhibit HSP90 overexpression, making it a potential therapeutic target for treating PD-related skeletal muscle issues.
Researchers at Technical University of Munich used FRET methodology to observe interaction between Hsp90, P23 and ATP. They found that P23 strengthens ATP bonding, increasing energy production. This breakthrough reveals the importance of cooperation in cellular energy generation.
Researchers found exercise training significantly reduces HSP90 overexpression in PD rats, suggesting a potential therapeutic target for skeletal muscle abnormalities. This study supports the use of HSP90 inhibitors as a new treatment option for PD-related muscle issues.
Researchers uncover an entire network of cellular helpers to mitigate damage, identifying new regulatory mechanisms for the heat shock response. The study's findings may also offer insights into neurodegenerative diseases such as Alzheimer's and Parkinson's.
Researchers have uncovered a complex emergency program designated to save single cells and thus the organism itself when exposed to life-threatening conditions. The protein HSF1 plays a central role in coordinating this process.
Researchers have identified a new therapeutic target by linking protein translation to heat shock response in cancer cells, which slows tumor growth and makes drug-resistant tumors vulnerable to other therapies. A compound called Rohinitib disrupts this link, normalizing metabolism and killing cancer cells.
Researchers have identified a mechanism by which small heat shock proteins collaborate with other molecular chaperones to disassemble amyloid fibers. This activity could lead to the development of therapeutic applications for neurodegenerative disorders, such as Parkinson's disease.
A study published in PLoS Biology describes a way to break apart beneficial amyloid fibers that can play protective roles in the brain. Human cells have the necessary machinery to clear these fibers, which could lead to new treatments for neurodegenerative diseases.
Researchers found that high levels of heat shock factor 1 (HSF1) in ER-positive breast cancer tissue are associated with poorer outcomes, including increased mortality. Elevated HSF1 levels also correlate with larger and more aggressive tumors.
Female mosquitoes produce heat shock proteins to protect themselves from stress caused by hot blood meals, helping them digest the meal and maintain egg production. Tests on other insects also showed a similar response.
Scientists believe that molecular chaperones, which help make and manage proteins, are crucial in both cancer and Alzheimer's. Disabling these molecules may lead to effective treatments for both diseases. Researchers are also exploring the potential of increasing their activity to halt disease progression.
Researchers at Cornell University found that enzyme RNA polymerase II assembles at the site of an activated gene, regardless of its position. This challenges the traditional view of 'transcription factories' and provides new insights into the gene transcription mechanism.
Researchers found that alcohol activates a stress-linked pathway in neurons to release key genes that can influence the health and activity of brain cells. The study sheds light on how this process occurs and may help scientists understand alcohol-linked disorders such as chronic alcoholism and fetal alcohol syndrome.
Targeted overexpression of HSP25 protects salivary gland function by maintaining gland weight, salivary flow rate, and salivary fluid composition. HSP25 also preserves expression of aquaporin 5, crucial for water transport in salivary glands. These findings suggest a novel radioprotective strategy against radiation-induced salivary gla...
Researchers discovered a critical regulatory link between hypoxia and heat shock responses, with HIF-1 at the center. The gene's activity was found to be crucial in both normal and pathological changes, making it a promising target for health promotion and cancer treatments.
Researchers have identified a potential new treatment target for children's muscle disease, where heat shock protein HSP60 plays an active role in controlling inflammation. This discovery could lead to therapies aimed at expanding T-cells with regulatory capacities reacting to HSP60, potentially contributing to disease remission.
A recent study in Nature explores the role of the protein CHIP in cell response to stress. The research found that when proteins are misfolded during stress, a complex process is triggered to remove them.
Researchers found that elevated molecular chaperones promote longevity in C. elegans, a roundworm whose biochemical environment is similar to humans. This suggests that brief exposure to environmental and physiological stress can have long-term benefits to cells by unleashing molecular chaperones.
Researchers have discovered that heat shock proteins from deep ocean vent microbes can increase the sensitivity of DNA tests by up to ten times. These unique proteins also enable genetically modified bacteria to survive at higher temperatures.
A team of researchers from Imperial College London has identified a protein called HSP27 that could help reduce cell death in the brain, potentially slowing down neuro-degenerative diseases. The study used transgenic mice with high levels of HSP27, which showed reduced mortality and neuronal cell death.
Scientists have identified a powerful combination of heat shock proteins that can restore aggregated proteins to their functional states. The Hsp104-Hsp40-Hsp70 trio helps stabilize proteins during aggregation and refolding, providing essential protection against denaturation and promoting cell survival.
Researchers at Northwestern University have identified a new regulatory molecule, HSBP-1, that regulates the production of heat shock proteins in response to stress. This finding may lead to new insights into cell death associated with aging and diseases such as heart disease and stroke.