Articles tagged with Stress Responses
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Research from the University of Portsmouth found that high impulsivity is linked to greater physiological reactions to boredom, including increased cortisol levels. The study suggests that targeting stress responses could lead to more effective coping mechanisms for psychiatric disorders.
Researchers discover PG3 activates p21, PUMA, and DR5 in cancer cells through ATF4 and ISR, independent of p53. The study provides insights into a novel mechanism by which PG3 induces cell death.
Researchers validated infrared thermal imaging as a non-invasive tool to assess reindeer stress during human interactions. Thermal imaging cameras detected temperature changes in the eye corner, indicating stress, without causing physical harm to the animals.
A study published in Nature Communications reveals a cellular signaling pathway that promotes heart cell survival. The Mst1-FoxO1-C/EBP-β interaction stimulates protective mechanisms in cardiac myocytes, potentially paving the way for new therapies.
Researchers investigate how hypernatremia affects microglial responses and evaluate potential therapies. Microglia's response to hyperosmotic stress is found to be associated with NFAT5 expression and NO production.
Researchers at Queen Mary University of London have identified a neurohormone responsible for triggering arm detachment in starfish. The team's discovery sheds light on the complex interplay of neurohormones and tissues involved in autotomy, a well-known survival strategy in the animal kingdom.
Kumamoto University researchers discovered HMGA2's crucial role in regulating stress responses in hematopoietic stem cells. The gene enhances blood cell production recovery under stressful conditions, such as chemotherapy and infections.
Researchers are working on a new approach to breeding corn that incorporates genomic selection and gene expression analysis to improve climate resilience. They aim to develop high-accuracy prediction models that can identify suitable genotypes for specific locations and future climates, reducing the need for trial-and-error approaches.
Researchers found that COVID-19 proteins can lower cortisol levels in the brain, leading to a heightened stress response and inflammation. The study suggests that this phenomenon may contribute to the neurological symptoms of Long COVID, including fatigue, depression, and memory problems.
A study from the University of California, Berkeley, shows that nematodes react to pathogenic bacteria by destroying mitochondria to protect against iron-stealing bacteria. This protective response suggests that humans may also respond to the smell of pathogens to prepare their gut for infection.
Researchers at Michigan State University discovered a protein pair, BAP2 and IRE1, that work together to regulate the response to ER stress in plants. This finding has significant implications for breeding crops more resilient to drought and heat conditions.
A new study at Tel Aviv University found that geckos experience a sharp increase in metabolic rates when exposed to rocket explosions, leading to energy depletion. The researchers hypothesize that this stress response may apply to many other animals in conflict zones.
A study found that dogs make more pessimistic choices when exposed to the smell of human stress, reflecting a negative emotional state. The researchers used an observational study with 18 dog-owner partnerships and found that dogs improved their learning about food presence in two trained bowl locations when exposed to stress smells.
Researchers at the University of Gothenburg have identified clear stress patterns among children undergoing dental treatment, particularly during anesthetic injections. The study used a sensor tool to monitor hand movements and sweating, revealing that invasive treatments were significantly more stressful for longer periods.
During its flyby, the Lucy spacecraft discovered a trough and ridge structure on Dinkinesh, revealing a complex history of sudden breakups and transformation. The asteroid's internal strength and dynamic evolution were also revealed, suggesting that it has significant cohesion, unlike some other asteroids.
Weo electrolyzed water (WEW) has been shown to attenuate cellular senescence in both normal fibroblasts and breast cancer cells. The study found that WEW modulated markers of cellular senescence, inflammation, and stress response genes in a cell type-dependent manner.
Recent research highlights how PM2.5 exposure triggers stress responses in digestive cells, leading to inflammation and damage in the liver, pancreas, and intestines. This can contribute to non-alcoholic fatty liver disease and type 2 diabetes.
A new study links interpersonal discrimination to changes at the molecular level, revealing a potential root cause of disparities in aging-related illness and death. Discrimination is consistently associated with accelerated biological aging, with everyday and major forms being linked to faster aging.
Scientists have discovered that aging clocks measure stochastic changes in cells, rather than damage accumulation. This finding suggests that aging can be predicted using the variation in cellular processes.
Researchers at Weill Cornell Medicine have discovered a way to boost protective effects of sphingolipids in blood vessels, slowing the development and progression of coronary artery disease. The study suggests revising current views on ceramides' role in the disease, instead finding that their levels remain stable in endothelial cells.
SMART researchers develop a nanosensor that selectively detects salicylic acid in live plants, vital for stress response. The sensor combines sensors for H₂O₂ and salicylic acid, enabling simultaneous monitoring of plant hormones and aiding in early diagnoses to improve crop resilience.
Researchers teach two dogs to recognize the scent of trauma reactions on human breath, achieving 90% accuracy in discriminating between stressed and non-stressed samples. The study suggests that dogs may be able to detect stress VOCs linked to PTSD symptoms, potentially allowing them to interrupt episodes at an earlier stage.
A new study found that people with high genetic stress sensitivity are more likely to experience heart attacks during stressful periods, such as holidays and elections. Those who also have anxiety or depression are at even higher risk, with their likelihood tripled.
Research reveals a mechanism by which daughter cells safeguard themselves against UV-damaged RNA inherited from mother cells. DHX9 stress granules, a special type of stress granule, trap and neutralize damaged RNA to prevent harm.
The Wim Hof method has been found to increase epinephrine levels and decrease pro-inflammatory cytokines, indicating a potential anti-inflammatory response. However, its impact on exercise performance is less clear, with some studies showing benefits and others finding no significant difference.
A long non-coding RNA called lncREST has been identified as a crucial component of the stress response during DNA replication. Its absence leads to impaired stress signalling, resulting in severe DNA defects and cell death. The discovery opens up new avenues for developing anti-tumour therapies.
Researchers at Aarhus University discovered that RNA modification N4-acetylcytidine (ac4C) plays a key role in stress granule formation and function. Acetylated transcripts are localized to stress granules, regulating their assembly and dispersal.
A study published in Nature Cardiovascular Research reveals that a dynamic synergy between cell types facilitates cardiac renewal, challenging existing paradigms. Targeting the microenvironment rather than specific cell types is key to healing injured hearts.
Researchers discovered that aggregates prevent silencing of stress response in brain cells, leading to cell death. A new treatment involves administering a drug to turn off the stress response and keeping SIFI turned on to clean up protein aggregates.
Researchers identified mechanisms that cause ponatinib to harm the heart and found a promising treatment that could reverse this process. The treatment protects heart cells without diminishing the tumor-fighting efficacy of the drug.
Plants use their circadian clocks to regulate responses to changes in water and salinity levels, offering a new avenue for creating drought-resistant crops. The discovery of the ABF3 feedback loop reveals a delicate balance between boosting stress tolerance and maximizing growth and yield.
A team of researchers at the University of Cologne has discovered a protein complex called C/EBP heterodimer that directs cells towards a dormant state in response to faulty gene expression. This mechanism, known as cellular senescence, can protect tissues from damage but also promote disease and ageing.
A new study by UCL researchers found that financial stress is detrimental to biological health, disrupting the communication between immune and neuroendocrine systems. This can lead to disease, including cardiovascular disease, depression, and schizophrenia.
Repeated sexual rejection in fruit flies causes social stress, leading to increased aggression and reduced resilience to starvation and toxic herbicide exposure. The response is mediated by the brain's neuropeptide F signaling system, which also plays a role in reward- and stress-responses in other organisms.
Researchers at UC Riverside have identified a crucial protein that controls plant responses to stress and aging. The discovery reveals the importance of Golgi bodies in maintaining cellular health and highlights their potential role in human aging.
Researchers from Staffordshire University developed a cognitive-behavioral intervention to help young athletes manage stress. The program taught them to view stress as an enhancing factor for performance, rather than a debilitating one, leading to improved wellbeing and performance.
A new UCLA Health study found that hormonal contraceptive pill users processed stress differently at the molecular and psychological level. They also reported a more negative emotional response to stress compared to non-users.
Eating fatty foods during stressful periods can reduce brain oxygenation and cause poorer vascular function in adults. Consuming low-fat food and drinks may help mitigate this effect.
Researchers have identified a new mechanism for removing RNA-protein crosslinks induced by aldehydes, which can damage cellular function. This discovery sheds light on the effects of aldehydes on human cells and may be particularly important for maintaining cell function in older individuals.
Researchers are exploring new ways to fight metastasis, including the use of bacteria to activate a defensive response against cancer. Stress and changes in circadian rhythms have also been linked to metastasis, suggesting that these factors may be targets for prevention or treatment.
A new study found that residents of neighborhoods with more greenspace tend to have longer telomeres, indicating better cellular health. However, the positive impact of greenspace is not enough to compensate for other environmental challenges like air pollution and racial segregation.
Researchers found that exposure to the aggregation pheromone 4,8-dimethyldecanal reduces death-feigning duration in red flour beetles, allowing them to save time and increase survival chances. Sex-related differences in death feigning behavior were also observed, with males exhibiting longer durations.
A small molecule drug improved the fitness of hematopoietic stem cells used in cell transplants, potentially enhancing the success of procedures like ex vivo gene therapy. The study found that targeting extracellular vesicles relieved stress on cells outside the body, improving their performance when transplanted back in.
Researchers found that beta-blockers can revive exhausted killer T cells, making them better cancer fighters. The study discovered a link between the sympathetic stress response and immune system response to cancer.
Research found alterations in proteins that can affect autophagy, a self-eating process of damaged cells. Healthy newborns showed individual responses to prenatal exposure to air pollution, with some more vulnerable than others. The study aims to understand the impact on breathing problems during infancy and childhood.
A new study found that high-stress caregivers had higher klotho levels and longer telomeres in specific immune cells, which may provide protection against aging. In contrast, low-stress caregivers showed no significant associations between klotho levels and telomere length.
A KAIST research team has identified excessive astrocyte-mediated synapse removal as the cause of mental diseases induced by childhood abuse trauma. This mechanism is linked to stress hormones and can lead to abnormal neural networks and complex behavioral abnormalities.
A team of researchers from Goethe University Frankfurt has discovered a central switch point in the mitochondrial signaling chain under misfolding stress. The mitochondria send two chemical signals to the cell when protein misfolding stress occurs, triggering a protective response that reduces misfolded proteins and stabilizes membranes.
Integrated Biosciences announces a drug discovery platform that enables precise control of the integrated stress response, a biological pathway activated by cells in response to various pathological conditions. The new platform uses optogenetic technique to study the ISR in live cells without physical or chemical damage.
A new study reveals that preoperative hydroxyprogesterone administration can improve disease-free and overall survival in patients with node-positive breast cancer by modulating cellular stress response and negative regulation of inflammation. Non-coding RNAs, such as DSCAM-AS1, play a regulatory role in this process.
A new study published in Aarhus University found that women using birth-control pills do not exhibit the same reduced stress hormone levels as those who are not on the pill. The researchers measured ACTH levels before and after social activities to observe rapid changes in the body's stress response.
Researchers have discovered that rattlesnakes can modulate each other's stress responses when in the presence of a companion, similar to human behavior. This phenomenon, known as social buffering, was observed in wild-caught snakes in Southern California and persisted even after hibernation or mating.
Scientists at Karolinska Institutet have identified a group of nerve cells involved in creating negative emotional states and chronic stress. The neurons, which are sensitive to oestrogen levels, were mapped using advanced techniques such as Patch-seq, Neuropixels, and optogenetics.
A study by Juntendo University researchers reveals that p62 bodies control redox-independent NRF2 activation through phosphorylation of ULK1, enabling the antioxidative stress response. The finding provides new insights into the role of phase separation in stress responses and its physiological significance.
A recent study by researchers at UNICAMP found that low-load with many repetitions and high-load with fewer repetitions both promote similar muscle growth. Muscle activation patterns were different, but metabolic stress was the same in both groups.
Researchers discover that senescence-associated secretory phenotype (SASP) can induce neuroendocrine transdifferentiation (NED) in breast cancer epithelial cells, promoting tumor progression and aging-related features. SASP's dual role in cancer involves both antitumoral and tumorigenic effects.
A recent study published in Cell Metabolism found that biological age increases with stress from surgery, pregnancy, and severe COVID-19, but can be reversed upon recovery. The study used 'biological clocks' to measure the health of cells and tissue, revealing a dynamic relationship between stress and biological aging.
A recent study published in Brain found that stress increases Alzheimer's risk in female mice by elevating amyloid beta levels, while male mice do not exhibit this effect. The researchers identified a cellular stress response pathway in brain cells that is active in females but not males.
A study found that biological age in humans and mice increases rapidly in response to diverse forms of stress, only to reverse after recovery. The researchers used DNA methylation clocks to measure changes in biological age, revealing transient changes in response to stressful stimuli.
Researchers uncover the critical link between cellular energy levels and mitochondrial damage through protein FNIP1. The study reveals that FNIP1 enables communication between AMPK and TFEB, instructing genes to remove damaged mitochondria and create new ones.