Articles tagged with Stromal Cells
Researchers at Monash University discovered a tissue protein that acts as a central 'traffic controller' for immune cells, which can be hijacked by viruses to weaken immune responses. The study reveals that cytomegalovirus can block this system, derailing immune cell traffic and compromising the body's antiviral response.
Researchers at Sanford Burnham Prebys found that blocking macropinocytosis reshapes the tumor microenvironment, allowing more access to immune cells. This change made immunotherapy and chemotherapy more effective in treating PDAC tumors in mice.
A new study highlights the potential of natural Gal-3 inhibitor, modified citrus pectin, to restore treatment efficacy in pancreatic cancer. Gal-3 inhibition in combination with gemcitabine reduces tumor growth and reverses drug resistance.
Researchers have uncovered key tumor-stroma interactions that drive drug resistance in melanoma leptomeningeal disease. The study identifies a potential therapeutic target by inhibiting SERPINA3-mediated signaling.
New findings in The American Journal of Pathology indicate that periostin promotes esophageal squamous cell carcinoma progression by enhancing cancer and stromal cell migration in cancer-associated fibroblasts. Periostin may be a promising therapeutic target for treating ESCC.
Researchers at UC Riverside have discovered a new cell type in the thymus that is similar to M cells found in the gut and airways. The newly discovered cells are like gatekeepers, acting as antigen-delivery cells for the immune system in organs such as the intestine and lung.
Scientists have developed a synthetic extracellular matrix that can support the growth of mini endometria in a dish for at least two weeks. This allows researchers to study its role in healthy and diseased states, such as endometriosis, by extrapolating from patient samples.
A new single-cell study provides deeper understanding of the evolution of the tumor microenvironment in gastric cancer. Researchers identified six unique ecotypes, or collections of cell states, within the tumor microenvironment and discovered a potential new therapeutic target, SDC2.
Researchers have identified a novel approach to enhance anti-tumor immunity in bowel cancer by targeting sugar-coated molecules called sialoglycans on tumor-associated stromal cells. This strategy has shown promise in reversing T-cell mediated immunosuppression and improving treatment outcomes.
Cancer-associated fibroblasts (CAFs) are a type of cell that plays a crucial role in the tumor microenvironment. The authors suggest that understanding CAFs is essential for developing effective cancer therapies. Research targeting CAFs has shown promise, but challenges remain due to their complex nature.
A new study reveals a previously unrecognized level of heterogeneity and specialization of endothelial and mesenchymal cells in the bone marrow. By integrating single-cell gene expression data, researchers identified 14 endothelial and 11 mesenchymal subclusters, providing insights into blood stem cell self-renewal and differentiation
In a mouse model, stromal cells developed before weaning age promote the maturation of the intestinal barrier by forming a specialized niche. Absence of these cells induces defect in postnatal growth and increases susceptibility to intestinal inflammatory diseases.
Researchers have discovered a novel nano-therapy that prevents bronchopulmonary dysplasia (BPD) in premature babies. The therapy uses tiny particles released by mesenchymal stromal cells, which travel to the brain and lungs, reducing damage and improving lung and brain health.
Researchers create detailed 'atlas' of fallopian tube cells to better understand fertility and disease. The study identifies 10 epithelial cell subtypes and reveals new insights into ovarian cancer origins.
Researchers found that hyaluronic acid is not only present in pancreatic tumors but also serves as a nutrient source for cancer cells. This discovery indicates potential new treatments for pancreatic cancer by targeting the sugar scavenging pathway.
Researchers found that the therapeutic effects of MSCs are due to the recipient's immune cells responding to dying MSCs undergoing apoptosis, promoting anti-inflammatory effects. This understanding may lead to new therapeutic strategies targeting the responding immune cell population.
A new ex vivo drug delivery system has been shown to keep MSCs viable longer and reprogram the peripheral immune response toward organ repair. The study's results suggest that SBI-101 can impact a peripheral immune response that can be transmitted to local tissue damage in vital organs, including the kidney.
A study found that treating wounds with mesenchymal stromal cell secretions significantly reduced MRSA viability and stimulated the surrounding skin cells to build a defense. The treatment has potential as an alternative to antibiotics, reducing antibiotic resistance in both veterinary and human medicine.
Gastrointestinal stroma tumors (GIST) are rare cancers that can be problematic to detect and treat. Researchers have identified the mutational drivers for GIST in the stomach and found a potential drug therapy, temozolomide, which showed promising results in treating patients with specific mutations.
A new clinical study reveals that treatment with mesenchymal stromal cells reduces inflammation in patients with chronic obstructive pulmonary disease (COPD). The study provides insights into the therapeutic potential of MSCs as a novel treatment for COPD, which is a leading cause of morbidity and mortality worldwide.
Researchers found adenovirus vectors generate strong and sustained populations of killer T-cells by targeting long-lived stromal cells in tissues, effectively creating 'training grounds' for these immune cells. This understanding helps explain the prolonged effects of adenovirus vaccines on human immunity.
The device was used to culture two maternal endometrial cell types, revealing the effects of glucose and insulin level alterations on uterine environment. High levels of glucose altered protein expression and secretion, while insulin changes triggered quantitative changes in protein secretion without significant gene transcription.
A new gelatin-based microcarrier offers significantly higher harvest rates of cells grown with over 90% compared to traditional standards. The microcarrier facilitates expansion of mesenchymal stromal cells used to treat various ailments, including heart attacks and immune system rejection.
Researchers at Institute for Basic Science have identified new subsets of gut connective cells crucial for lymphatic growth and fat digestion. The discovery sheds light on the mechanisms that impair lacteal regeneration and reveal a link between intestinal environment and cell interactions.
Researchers found that removing CAVIN1 from stromal cells allows prostate cancer cells to feed on lipids, fueling growth and spreading. This leads to aggressive tumor behavior, including invasive and metastatic behavior.
Researchers have developed a novel method to induce regulatory T-cells from mesenchymal stromal cells, which could lead to new treatments for various chronic inflammatory diseases. The study found that MSCs can produce an abundant replacement for naturally occurring T-cells, increasing the count and frequency of Treg-like cells.
Researchers developed an off-the-shelf artificial cardiac patch that improves cardiac repair after myocardial infarction in rats and pigs, reducing scarring and boosting cardiac function. The patch is cell-free, easy to store, and offers a clinically feasible alternative to traditional cell-based cardiac patches.
New research from Penn Medicine suggests blocking the Wnt pathway can make chemotherapy more effective against glioblastoma. The study found that targeting stromal cells, which act like stem cells and promote tumor growth, may be an effective way to overcome treatment resistance.
Researchers at the University of Melbourne discovered striking differences in male and female immune systems that may explain why men are more susceptible to obesity. The study found a novel type of stromal cell that communicates with Treg cells and is specific to males, leading to a sex-specific chain of events.
A team of researchers has created a detailed cell atlas of an entire salivary gland tumor in a mouse model, revealing that the tumor is composed of various cell types, including cancer stem cells. The study uses single-cell RNA sequencing technologies to identify these cells, which make up less than one percent of the tumor population.
Researchers propose a new path forward for adipose-based cell therapies in reparative medicine, focusing on patient safety and evidence-based medical practice. The FDA argues that autologous cellular therapies need to demonstrate safety and efficacy before marketing.
Researchers discover that mature bone marrow stromal cells can transform into regenerative cells after an injury, providing an alternative source for bone healing. This breakthrough suggests that these cells could be generated through transformation of readily available mature stromal cells.
New study finds liver mesenchymal stromal cells have immunoregulatory qualities making them more effective than similar cells derived from bone marrow and fat tissue. The discovery could lead to better treatment options for diseases like organ rejection, inflammatory bowel disease, and autoimmune disorders.
A brief disruption to a molecular pathway in mice before birth compromises adult immunity to rotavirus, preventing antibody responses and interfering with gut cells that support antibody production.
A study of 16 participants found that women with endometriosis secrete higher levels of lactate than those without the condition. Exposure to dichloroacetate reduced lactate secretion and cell proliferation in human cell-culture models.
Researchers found that specialized proresolving mediators can help heal injured tendon cells by attacking inflammation, offering a new approach to treat chronic tendon injuries. The study suggests these mediators may target diseased cells and promote resolution of tendon inflammation.
Researchers have uncovered a new mechanism for tooth repair by identifying a new population of mesenchymal stromal cells that contribute to dentin formation. These cells send signals to control cell production through the molecular gene Dlk1.
Researchers found that gut microbes stimulate antiviral signals in non-immune lung cells to protect against the flu virus during early stages of infection. Enhanced baseline type I interferon signaling reduced flu virus replication and weight loss in mice.
A study found that pancreatic cancer cells can behave differently based on their surroundings, with some responding better to chemotherapy and radiation. The stroma of tumors consists of connective tissue cells that contribute to tumor growth and spread.
A Russian scientist has received funding to analyze the tumor microenvironment and develop new cancer therapies. The project aims to create targeted treatments with minimal side effects, building on gene and cell technologies.
Scientists identify CXCL12-expressing mesenchymal stromal cell niches as a strategy to target and eliminate treatment-resistant leukemic stem cells in chronic myelogenous leukemia. The study reveals that these niche interactions control quiescence of leukemic stem cells.
Human cells can now travel more than five times faster than previously documented by slingshotting themselves forward, according to University of Michigan researchers. This new method of cell movement could be involved in the spread of cancer and potentially harnessed for tissue repair therapies.
A new study reveals that diabetes impairs the antibacterial activity of multipotent stromal cells (MSCs), leading to diminished capacity to fight off bacterial infections. This finding has significant implications for the use of MSCs as a therapeutic strategy in treating diabetes and other autoimmune disorders.
Researchers identified VISTA on immune cells infiltrating pancreatic tumors, which resisted immune checkpoint blockade drugs. The study highlights the importance of stroma and found higher expression of VISTA in pancreatic tumors compared to melanoma.
Researchers create 3D models of breast cancer tumors using stromal cells, which play a major role in cancer growth and progression. The study aims to introduce stromal cells as new therapeutic targets, offering potential treatments for triple-negative breast cancer.
Researchers used single-cell transcriptomics to characterize stromal cells in fat tissue and discovered a subpopulation called Aregs that suppresses adipogenesis. These findings provide potential new avenues for treating metabolic diseases like type-2 diabetes.
Researchers successfully restored cartilage tissue and eliminated pain syndrome in a patient using cell technology-based regenerative medicine. This treatment promises to prolong the lives of natural joints by addressing limited regenerative potential of knee cartilage injuries.
CNIO researchers have identified a subpopulation of cancer-associated fibroblasts that foster tumour growth and discovered the Saa3 gene as a key player. Eliminating this gene reprograms the cells, losing their pro-tumour properties, opening a new avenue for therapeutic strategies.
Researchers have developed a method to selectively mark multipotent stromal cells in mice using the CD73 gene, allowing for the analysis of their distribution pattern and function in living organisms. This breakthrough enables the study of these stem cells in their original state, providing insights into their role in regenerative medi...
Scientists at Newcastle University have developed a coating that allows individual stromal cells to detach from the surface, enabling continuous cell growth. This innovation can produce up to a billion cells per week, making it ideal for cell-based therapies requiring large numbers of cells.
Researchers have discovered that structural and connective cells in the lymphatic system called stromal cells are major players in priming donated immune cells to attack the host's body. Disrupting a critical signaling pathway during the first 48 hours can provide long-term protection against graft-versus-host disease.
A new study reveals that non-blood cell forming stem cells in human bone marrow play a crucial role in maintaining the hematopoietic microenvironment and retain self-renewal potential after primary and secondary transplantations. The findings suggest an alternative to traditional hematopoietic stem cell transplantation.
Research by Institute for Basic Science reveals that aging compromises the survival of naïve T cells by degrading the supportive environment within the lymph nodes. The study found that the production of a key protein responsible for attracting T cells to the lymph nodes declined with age, resulting in reduced effective immune response.
A study found that freeze-thawing and intravenous infusion affect mesenchymal stromal cell gene expression, which may impact their therapeutic use in reducing inflammatory responses. The lung microenvironment also influences MSC gene expression, highlighting the need for careful characterization.
Scientists developed a new technology to isolate 100% pure tumor and stromal cell populations from minute formalin fixed paraffin embedded specimens. This allows for downstream analysis of tumor genetic characteristics via next generation sequencing with unprecedented precision.
A new adipogenic cocktail D&R has been developed to induce functional mature adipocytes from MSCs. This cocktail improves energy homeostasis by inducing cells with characteristics of a mature adipocyte, including fat droplets and sensitivity to insulin.
A study reveals that thymus atrophy may stem from a decline in its ability to protect against DNA damage from free radicals. Common dietary antioxidants may slow thymus atrophy and represent a promising treatment strategy for protecting older adults from infections.
Researchers developed a high-throughput screening method to characterize and select multipotent cells from adipose-derived stromal cells (hASCs) using flow cytometry. This approach can identify specific cell types advantageous for regenerative medicine and tissue engineering applications.
Researchers at Duke University have discovered that stem cells from bone marrow can alleviate neuropathic pain in mice by increasing levels of the anti-inflammatory protein TGF-β1. The treatment remained effective for several weeks, outlasting traditional painkillers and offering new hope for chronic pain conditions.
Indiana University researchers found that restoring missing microRNA-29 in pancreatic cancer stromal cells reduced the viability and growth of cancerous cells. The study suggests that miR-29 could be a potent therapeutic agent against pancreatic cancer by targeting reactive tumor stroma.