Articles tagged with Umbilical Cord
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Researchers used umbilical cord blood to analyze genetic changes linked to metabolic dysfunction in children. The study found multiple regions of altered DNA associated with metabolic issues later in childhood.
A retrospective analysis of over 2,600 patients found that Black children were more likely to suffer severe graft-versus-host disease but overall survival rates improved across all racial groups. The study suggests that cord blood transplants are a vital lifeline for many patients and improve care for those without a matched donor.
A clinical trial with PeriCord, a new tissue engineering product derived from umbilical cord and pericardium stem cells, confirms its feasibility in repairing damaged heart tissues after a heart attack. The therapy has demonstrated excellent biocompatibility and anti-inflammatory properties.
A new study discovered microplastics in the placentas of Hawaiʻi mothers between 2006 and 2021, with increasing presence found each year. The researchers believe microplastics may be ingested through food or inhaling dust particles, raising concerns about their impact on fetal health.
Research suggests delaying cord clamping by two minutes can significantly reduce mortality rates among premature babies. This allows blood to flow from the placenta, easing breathing transitions and potentially saving lives.
Two systematic reviews and meta-analyses found that delaying umbilical cord clamping by at least two minutes can reduce the risk of death in premature babies. The studies included over 10,000 babies from 60 studies and showed a significant reduction in mortality rates for deferred clamping compared to immediate clamping.
Researchers analyzed 48 TV episodes of popular UK programs, finding that midwives and doctors clamping the umbilical cord were shown inaccurately or dramatized in a third of cases. The study highlights the need for safety warnings to inform viewers about outdated practices.
Scientists have developed a platform to enhance the innate ability of white blood cells from umbilical cord blood to treat various types of solid and blood cancers. Pre-clinical studies showed that these cells, known as gamma delta T-cells (GDT), possess antiviral and antitumour properties.
A new method to cure HIV using umbilical cord blood stem cells has yielded long-term successful results for a middle-aged mixed-race woman with leukemia and HIV. The approach broadens the opportunities for people of diverse ancestry to attain cures.
A retrospective study found associations between vitamin D levels and fine motor development delays, as well as thyroid hormones with cognitive development. Certain metals were also linked to language, cognitive, or motor skill development.
A water birth significantly reduces the use of epidurals, injected opioids, episiotomy, pain, and heavy bleeding after birth, while increasing mothers' satisfaction levels and the odds of an intact perineum. A water immersion also increases the likelihood of an intact perineum and reduces episodes of umbilical cord breakage.
A comprehensive quality-improvement initiative in a NICU reduced death and severe brain bleeding in extremely preterm infants from 27.4% to 15%. The program introduced evidence-based practices, including electronic order sets, improved monitoring of blood carbon dioxide and pH levels, and standardized delivery room practices.
Researchers found delaying cord clamping reduces a child's relative risk of death or major disability in early childhood by 17 percent, including a 30 percent reduction in mortality before the age of two. In addition, fewer infants in the delayed-clamping group needed blood transfusions after birth.
Severe PES is characterized by high fever, rash, diarrhea, and increased transplant-related mortality. A study revealed that monocytes derived from cord blood produce proinflammatory cytokines, leading to PES. Tocilizumab treatment significantly controlled clinical symptoms and reduced mortality in patients with severe PES
A clinical trial found that non-altered stem cells from umbilical cord connective tissue increased the survival of critically ill COVID-19 patients by 2.5 times. The treatment also showed a fourfold increase in survival for patients with chronic health conditions.
A large study found that giving antibiotics after C-section umbilical cord clamping is equally safe as before, with no increase in surgical site infections. The results challenge the current WHO recommendation of administering antibiotics before incision.
Researchers at University College London have developed a new way to increase the functionality of umbilical cord blood stem cells, making them more suitable for transplantation. This breakthrough could improve treatment options for patients with blood cancers and other blood disorders.
A study funded by NIH found that umbilical cord milking may increase the risk of severe intraventricular hemorrhage in extremely preterm infants. The study, halted due to safety concerns, compared cord milking to delayed cord clamping and found a higher rate of brain bleeding in the former group.
A randomized clinical trial compared maternal blood loss with immediate and delayed umbilical cord clamping, finding no significant difference. The study included 113 women who had a scheduled cesarean delivery at term, with results suggesting that delaying cord clamping may not impact maternal bleeding.
Joanne Kurtzberg, MD, has been awarded the 2019 Bernard Sanberg Memorial Award for her groundbreaking work in pediatric hematology and regenerative medicine. The award recognizes her clinical trials that have led to positive results in treating adult ischemic stroke patients with cord blood therapy.
A study by ISGlobal found that a higher omega-6:omega-3 ratio in umbilical cord plasma is associated with an increased risk of ADHD symptoms in children. The research suggests that maternal diet during pregnancy plays a crucial role in shaping the child's brain development and may impact their future health.
Researchers at Duke University Medical Center have developed a technique to expand umbilical cord blood stem cells, which appears safe and restores blood count recovery faster than standard cord blood transplant in adults with blood cancer.
Researchers at Kazan Federal University used gene and cell therapy to treat spinal cord injuries, improving motor functions and tissue structure. The approach, which uses umbilical cord blood cells to transport therapeutic genes, has potential applications for other demyelinating diseases like multiple sclerosis.
Researchers at Indiana University discovered banned flame retardants, like PBDEs, are passed from mother to baby through the umbilical cord. The study found higher levels of these chemicals in infant blood compared to their mothers.
A new biomarker has been identified that can predict the risk of lung disease and death in extremely preterm infants. The biomarker is related to endothelial mitochondrial function, which can be measured using umbilical cord cells collected at birth.
Researchers at UF Health have found a way to expand and preserve certain cord-blood cells, known as Tregs, which modulate the immune system and prevent autoimmune diseases like Type 1 diabetes. This discovery has important implications for patients with the disease and could potentially be used as a treatment or preventive measure.
In two studies, researchers compared the cryopreserved human umbilical cord patch to acellular dermal matrix and conventional suturing methods for in-utero spina bifida repair. The results showed improved spinal cord function with decreased meningeal scar formation and better preservation of spinal cord tracts.
A two-year study of over 37,800 live births in Zambia found that chlorhexidine washes did not reduce neonatal mortality, contradicting previous results in south Asia. The study suggests that the treatment may not be effective in lower mortality settings with more facility-based deliveries.
Infants of obese mothers exhibit impaired expression of genes regulating cell energy and metabolism, correlating with higher levels of metabolically deleterious lipids in their blood. This study may pave the way for improved healthcare and early interventions for children at risk of obesity.
Researchers at UTHealth have developed a patch made from cryopreserved human umbilical cord that may treat spina bifida in utero. The patch utilizes natural material with regenerative properties to promote local tissue growth, reducing the need for future surgeries.
A new study found that children whose mothers used selective serotonin reuptake inhibitors (SSRIs) during pregnancy had longer umbilical cords than other newborns. The lengthening of the umbilical cord may indicate increased fetal activity and movement in the uterus.
Researchers compared two patches, human umbilical cord and biocellulose film, in a rat model of spina bifida. The study found that the umbilical cord patch promoted cellular migration with minimal inflammation, suggesting a potential regenerative material for antenatal spina bifida repair
Researchers at Duke University have discovered that umbilical cord tissue-derived cells produce molecules that promote the growth, connection, and survival of retinal neurons. The study identifies thrombospondins as key players in this process, with potential therapeutic applications for degenerative eye diseases.
Research from Nationwide Children's Hospital found that delayed umbilical cord clamping in extremely preterm infants led to higher blood pressure readings and reduced need for red blood cell transfusions. The study, which examined 40 infants between 22-27 weeks gestation, showed no immediate safety concerns.
A technique called cord milking increases blood flow from the umbilical cord to the infant's circulatory system, improving blood pressure and red blood cell levels in preterm infants delivered by Cesarean section. This study found benefits only in Cesarean-delivered infants, while vaginal births showed no difference.
A study published in Pediatrics reveals that late clamping of the umbilical cord increases antioxidant capacity and reduces inflammatory effects in newborns. This research led by the University of Granada found a beneficial effect on newborn development after delaying clamping by two minutes.
A new technology grows cord blood stem cells in a lab before transplant, increasing survival rates by 9.6% compared to traditional methods. Patients who received the StemEx transplants engrafted faster and were less vulnerable to infections and bleeding.
The study, published in the journal Blood, shows that 12 adult patients underwent successful umbilical cord blood transplantation for leukemia or lymphoma. The treatment, 16,16 dimethyl prostaglandin E2, improved blood formation and reduced complications.
A systematic review found that delaying umbilical cord clamping after birth improves newborn iron levels and overall health. Babies with delayed cord clamping had higher haemoglobin levels and were less likely to be iron-deficient.
Researchers at the University of Toronto have found that Human Umbilical Cord PeriVascular Cells (HUCPVCs) are more effective than bone marrow cells in restoring heart function after a heart attack. The study demonstrates that HUCPVC cell therapy is twice as effective at repairing damage to heart tissue than no treatment.
Researchers found that human placenta-derived endothelial colony-forming cells (ECFCs) are more proliferative and better at forming new blood vessels than those derived from umbilical cord blood. The study, published in Cell Medicine, suggests that the placenta could be an abundant source of ECFCs for therapeutic use.
Two studies suggest that cleansing umbilical cord with chlorhexidine solution during and after birth can reduce sepsis and mortality in babies in rural parts of Sindh province, Pakistan. The interventions showed a significant reduction in infections and mortality risk, with no effect seen from handwashing alone.
A study led by Johns Hopkins researchers found that chlorhexidine umbilical cord cleaning can save lives, with a 20% reduction in mortality rates. The simple, safe, and inexpensive intervention has the potential to avert an estimated half a million neonatal deaths per year.
Researchers at Penn School of Medicine have developed a technique to expand immune cells in umbilical cord blood prior to transplants, leading to quicker immune system rebuilding and lower risk of infections. The method paves the way for future salvage therapy options and increased use of public cord blood banks.
Researchers have discovered that mesenchymal stem cells from umbilical cord blood can suppress inflammation and attenuate collagen-induced arthritis. The study suggests a new potential therapy for rheumatoid arthritis, which currently has limited long-term drug-free remission options.
The University of Colorado Cord Blood Bank has received a $6.3 million grant to collect and bank umbilical cord blood from minority groups, increasing genetic diversity and matching rates for minority patients. The bank will support an additional 5,000 cord blood units and expand collections to Arizona.
Researchers found that approximately half of increased umbilical cord IgE levels were due to maternal IgE transfer. This discovery challenges the use of umbilical cord blood for assessing allergy risk in infants.
A new study aims to investigate whether delaying the clamping of a newborn's umbilical cord for two minutes after birth can improve their recovery from corrective heart surgery. The study hopes to determine if this practice can decrease the need for blood transfusions in critically ill babies.
A University of South Florida-led study finds that mannitol boosts the therapeutic effectiveness of human umbilical cord blood cells in treating cerebral palsy. Mannitol helps open the blood-brain barrier to facilitate entry of beneficial cells and promote neurotrophic factor effects.
USF researchers recommend delaying umbilical cord clamping to increase the transfer of stem cells, which may help prevent anemia and other health problems in newborns. The study suggests that this delay can be beneficial for pre-term infants and those born in areas with limited access to healthcare.
Researchers at the University of Pittsburgh School of Medicine have found that umbilical cord tissue contains a plentiful supply of stem cells that could be used to treat various muscle and bone disorders. The study reveals that these cells can be easily harvested from the tissue, expanded in number, and are remarkably stable.
UCSF researchers found private cord blood banking to be cost-effective only for families with high likelihood of needing a stem cell transplant. The analysis revealed that the process is more expensive than expected, with an additional $1,374,246 per life-year gained.
Researchers have successfully grown human-like tissue in the lab using umbilical cord blood stem cells to create functional heart valves. The tissue-engineered valves exhibited properties similar to those of natural human valves, including collagen and elastin production.
Researchers have found that human umbilical cord blood cells can improve liver damage and function in rats with hepatitis. The study provides an alternative to bone marrow transplants for hepatic regenerative medicine, offering hope for patients suffering from terminal hepatic failure.
Researchers at Rush University Medical Center present pre-clinical data on a CD26 Inhibitor that increases the efficiency and responsiveness of umbilical cord blood for bone marrow transplants. The technology may improve treatment outcomes for blood cancer patients who require stem cell transplantation.
StemCyte's move to New Jersey is driven by collaboration with Rutgers and a desire for proximity to groundbreaking research. The company will house its executive management and therapeutics team at the new office, which will support its northeast US operations.
A new study found that human umbilical cord blood cell therapy reduced amyloid-ß plaques by 62% and cerebral amyloid angiopathy by 86% in mice with Alzheimer's-like disease. The treatment targeted the pathogenic inflammatory response associated with CD40-CD40L activity.
Researchers found that human umbilical cord blood cell therapy significantly reduced amyloid-β and β-amyloid plaques in mice with Alzheimer's-like disease. The treatment modulates the immune system by suppressing CD40-CD40L activity, offering potential for targeting inflammatory responses associated with degenerative conditions.
A recent study has found that umbilical cord blood transplants can be a successful treatment option for children with inherited metabolic disorders, offering improved outcomes compared to bone marrow transplants. The procedure has shown advantages in terms of availability and reduced risk of complications.
Scientists have found distinct gene expression signatures in the umbilical cords of premature infants who developed bronchopulmonary dysplasia, a fatal lung disorder. These signatures were associated with chromatin remodelling and histone acetylation pathways, providing a potential proxy for predicting disease risk.