Articles tagged with Genome Wide Association Studies
Researchers analyzed DNA haplotypes associated with hereditary prostate cancer (HPC) and found that one mutation increased risk by 22-fold. The study identified 183 variants linked to HPC at genome-wide significance, shedding light on the genetic factors contributing to disease.
Researchers created H-MAGMA, a computational tool that links non-coding genetic variants to their target genes in brain disorders. The study found that genes associated with psychiatric disorders are typically expressed early in life, while neurodegenerative disorder-associated genes are expressed later.
A systematic review of 149 studies has identified 24 genetic variants that increase the risk of endometrial cancer by up to 3.16 times. The study provides a polygenic risk score for personalized risk assessment, facilitating targeted screening and prevention strategies.
Researchers Alyssa Johnson and Adam Bohnert have discovered a new class of lysosomes, dubbed 'tubular lysosomes,' which can form complex networks that affect aging, disease, and stressors. Their findings could lead to medical therapies and treatments to extend health and longevity in humans and animals.
A genome-wide association study found nine gene locations associated with eating certain foods, including tofu, cheese, and tea. The study identified six genetic variants linked to at least one disease phenotype, including several types of cancer and type-2 diabetes.
A large genetic risk study found that adoptees had a slightly elevated genetic risk for depression, schizophrenia, and neuroticism. The adoption process did not increase the impact of this genetic risk, suggesting that both environment and genetics play a role in mental health problems.
The exposome represents the cumulative health effects of environmental exposures. A review article in Science calls for a coordinated international effort to characterize the exposome at scale, accounting for non-genetic risk factors and potential preventable exposures.
A University of Miami study has found that the profiles of genes influencing cognition are similar across people with schizophrenia, bipolar disorder, and the general population. This discovery could lead to more effective therapies for improving cognitive function in patients with severe mental illness.
A new study published in Science Advances identifies several common genetic pathways linked to compulsive behavior and addiction, including those related to heavy alcohol consumption. The research used genome-wide association studies and model organisms to pinpoint the genes responsible for high levels of alcohol intake.
A large-scale study of over 100,000 people revealed new genetic targets for a variety of diseases, including autoimmune disorders and cancer. The research also identified potential repurposing of existing drugs to target these conditions.
Researchers at MLU and Georg August University Göttingen discovered a gene responsible for tyloma, an interdigital hyperplasia affecting up to 60% of German cattle. The disease can lead to tears in skin, bacterial infections, and shortened lifespans.
A team of CHOP researchers has discovered a genetic signature that can help diagnose adult-onset 'type 1.5' diabetes, which shares characteristics with pediatric-onset type 1 diabetes. The finding could lead to more effective diagnostic methods and improve treatment outcomes for adults.
A recent study from the University of Alberta suggests that many cancers, diabetes, and Alzheimer's diseases have a genetic contribution of no more than 5-10%. The research highlights the importance of metabolites, chemicals, proteins, or the microbiome in determining disease risk rather than genes.
A new study from the University of York found that parents' socioeconomic status and children's inherited DNA differences are powerful predictors of educational achievement. Children with high genetic propensity for education but poor backgrounds had limited access to higher education, while those with low genetic propensity but afflue...
A study published in the Journal of Allergy and Clinical Immunology identified over 300 genes and 200 CpG sites associated with reaction severity. The research suggests that neutrophil-mediated immunity plays a prominent role in peanut allergy reactions, offering potential new targets for treatment.
Researchers linked genetic variation in fruit fly mitochondrial genomes to changes in food intake, providing a new tool for studying human metabolic traits. The study used the Drosophila Genetic Reference Panel and identified specific haplotypes associated with increased food consumption.
A study by Duke-NUS Medical School researchers has uncovered new insights into how individual cell types in the brain contribute to Alzheimer's disease progression. The study found distinct gene expression profiles and networks across different cell types, providing potential druggable targets for future drug development.
Patients with inflammatory bowel disease are more likely to develop Parkinson's disease due to shared underlying inflammation. While the risk is small, early detection and intervention may be crucial in slowing or stopping PD progression.
A new study by UNC researchers found that using a polygenic risk score (PRS) improves psychosis risk prediction in persons meeting clinical high-risk criteria. The PRS, developed from genome-wide association studies (GWAS), discriminates persons with schizophrenia from unaffected individuals and predicts future psychosis.
Researchers found that 44% of colonies of the invasive species Didemnum vexillum are formed by gene chimera, which could promote genetic diversity and colonization success. The creation of chimera may also be a mechanism to increase adaptive success in new environments.
A recent study published in Nature Genetics has identified short tandem repeats, also known as eSTRs, which impact nearby gene expression in the human genome. The researchers found over 28,000 eSTRs associated with various complex traits, including schizophrenia, inflammatory bowel disease, and intelligence.
Researchers have identified a link between certain gut bacteria and an increased risk of bowel cancer. The study found that individuals with a specific type of bacteria from the Bacteroidales group had a slightly higher risk of developing the disease, with risks ranging from 2-15%.
Researchers found thousands of genes affected within ten minutes after water hitting a leaf, leading to strengthened defense hormones. The study also discovered a regulatory network that affects how plant defence hormones are strengthened by mechanical stimulation.
Researchers at NYU Abu Dhabi's Center for Genomics and Systems Biology have developed an improved assembly of the date palm genome using long-read sequencing technology. This will help advance research and inform propagation practices for this essential MENA region food source.
A new study developed genetic-based epilepsy risk scores that can accurately distinguish between healthy patients and those with epilepsy, as well as between patients with generalized and focal epilepsies. These scores have the potential to identify high-risk patients earlier and guide precision treatment.
Broadening diversity among participants enhances genomic studies' potential to uncover disease causes and treatments. The Psychiatric Genomics Consortium provides guidance on analyzing diverse data, highlighting opportunities, challenges, and solutions.
A new study identifies a clear biological basis for PTSD, finding that genetics accounts for between five and 20 percent of the variability in PTSD risk following a traumatic event. The study also found significant overlap with other mental disorders, including depression, schizophrenia, and neuroticism.
Researchers developed a new approach to identify plant genes that control traits, enabling more efficient breeding of affordable and sustainable crop varieties. The method is valuable for global food security and human nutrition, particularly for crops such as maize, vegetables, fruits, and grains.
A large genome-wide association study has identified 183 genetic loci associated with high serum urate levels, a major risk factor for gout. The study also found that these loci can be used to predict gout risk in independent populations.
Researchers at the University of Helsinki have identified 35 genetic loci associated with plasma lipid species levels, revealing a significant heritable component in cardiovascular disease risk. The study also highlights the potential of lipidomics to improve cardiovascular risk prediction and treatment.
A new UCL-led study found that some genes predicting high cholesterol don't apply to people from Uganda as they do in European populations. The researchers investigated genetic variants affecting blood fat levels and found that only 10% of markers were implicated in cardiovascular risk factors among Ugandan participants.
Children with Down syndrome are 10-20 times more likely to develop Acute Lymphoblastic Leukemia (ALL) than children without the condition. Researchers at Baylor College of Medicine have made breakthroughs in understanding this risk, identifying genetic variants associated with increased ALL susceptibility.
Researchers have uncovered 16 genetic regions linked to diabetic kidney disease, which may help identify potential targets for prevention and treatment. The study provides insights into the pathogenesis of DKD and could lead to new therapeutic strategies.
A study has identified TCF4 as a master regulator of schizophrenia during early human brain development. The gene is believed to play a crucial role in the disease's underlying genomic biology. Researchers hope that this discovery will pave the way for new treatments and precision medicine approaches.
A recent genome-wide association study involving over 470,000 participants found no meaningful link between genetic variants and same-sex sexual behavior. Instead, thousands of genetic variants with small effects contribute to individual differences in predisposition to the trait.
A large-scale study has identified a robust new signal and fine-mapped previously reported genetic variants associated with childhood obesity. The findings suggest that genetic influences on obesity operate across the lifespan and provide valuable insights into potential treatments.
A genome-wide association study found specific genetic links to re-experiencing trauma symptoms in US veterans with PTSD, highlighting the role of brain cells in stress response. The study identified eight distinct genetic regions associated with PTSD vulnerability, providing potential targets for drug treatments.
A study of over 165,000 US military veterans has identified multiple genetic locations associated with the risk of re-experiencing traumatic memories, a hallmark symptom of post-traumatic stress disorder. The research also found genetic overlap with conditions such as hypertension and psychiatric disorders.
A new study has found that the Nunavik Inuit population in Canada's Arctic have a distinct genetic profile, which may predispose them to brain aneurysms. Researchers analyzed the genetic characteristics of 170 Inuit volunteers and identified unique variants correlated with a higher risk of this condition.
A global genome-wide association study identified eight genetic variants linked to anorexia nervosa, revealing a complex interplay between metabolic and psychiatric factors. The research suggests that integrating metabolic information may help clinicians develop better treatment approaches for this potentially lethal illness.
A new study aims to identify genes that are unique to African Americans and contribute to hereditary breast cancer. The research will analyze large datasets of over 18,500 African American women, including those with diagnosed and cancer-free individuals.
A large-scale genetic study of diverse populations found that genetic mutations contributing to chronic diseases like diabetes vary across ethnicities. The research highlights the importance of including diverse populations in genetic studies to develop effective treatments for debilitating diseases.
A recent multicenter analysis found that including diverse populations in large-scale genomic studies is critical for reducing health disparities and accurately representing genetics-related disease risks. The study identified 27 new trait-variant associations, furthersing our understanding of the genetic architecture of traits.
A study published in the Journal of Neuromuscular Diseases reveals four clinical characteristics associated with secondary modifying genes in CMT1A. The researchers identified significant genomic loci containing candidate genes that could explain disease variability and potentially predict natural course of disease.
A genetic study found that genes regulating iron metabolism are responsible for excess liver iron in populations of European ancestry. The research suggests a systemic and not organ-related problem, with implications for treatment and therapy.
Researchers from Joslin Diabetes Center have identified a genetic factor linked to the development of diabetic peripheral neuropathy. The study suggests that people carrying a specific variant in a sodium channel may be protected from the complication, providing a potential target for pharmacological therapy.
A study of ancient DNA from Siberia, Alaska, and Canada found that a significant genetic contribution from Paleo-Eskimos shaped the modern populations in the region. The researchers discovered that Paleo-Eskimos interbred with southern Native peoples and influenced the spread of Na-Dene languages.
Researchers analyzed 41 ancient sub-Saharan Africans, revealing a multi-stage model for the spread of food production into Kenya and Tanzania. The study found that Stone Age herders across East Africa had closely related genomes, despite cultural differences, and that genes for lactose digestion were rare in first East African herders.
A genome-wide association study has identified five new genetic risk loci for harmful alcohol use, confirming one previously identified locus. The study provides insight into the role of genetics in this behavior and highlights the importance of habitual alcohol use on various health and behavioral traits.
Scientists from Sanford Burnham Prebys have revealed a new mechanism for ALS' pathogenesis and suggest that modulating membralin has potential in ALS therapy. A membralin-boosting gene therapy extended the survival of mice with ALS-like symptoms, providing an important new perspective into the disease.
A large international consortium analyzed protein-coding genes from nearly 46,000 people, linking rare DNA alterations to type 2 diabetes. The study identified four genes with rare variants that affect diabetes risk, providing potential targets for new medicines and guiding researchers to better understand the disease.
Researchers describe an effective, unbiased method for choosing the best algorithm for prioritizing GWAS results, called Benchmarker. Combining multiple strategies often gives the best results and certain algorithms perform best when looking for genes for specific traits.
A new mutation in the ADAMTS3 gene is associated with breathing difficulties in bulldogs and Norwich terriers. Swelling from edema in the airways can cause respiratory disease, independent of face shape. Screening for this mutation could help identify at-risk dogs and inform breeding practices.
A genome-wide test suggests that bitter and sweet beverage preferences are related to the psychoactive properties of these beverages, not genetic variations in taste genes. People prefer certain drinks due to their emotional and psychological impact.
Researchers identified 20 new genetic associations with bipolar disorder in a massive study of over 50,000 subjects across 14 countries. The findings highlight the complexity of the disease and its overlap with other psychiatric disorders.
A recent genome-wide association study found that childhood-onset asthma is associated with nearly three times as many genes as adult-onset asthma. The study identified 61 independent asthma-related genes, with most being specific to childhood onset. The findings suggest different mechanisms cause the inception of asthma in childhood c...
A new study published in Genome Biology identified key genomic features that may have enabled the domestication of corn and soybeans. The research found that these crops occupy a middle ground in their willingness to mutate, with higher mutation rates in modern varieties compared to their wild relatives.
A new genetic test, known as the Obesity Genome-wide Polygenic Score (GPS), has been developed to predict an individual's risk of developing severe obesity. The test uses a genetic score based on over 2 million variations in a person's genetic code and shows high predictive power.
Researchers have developed a scoring system based on genetic markers to predict an individual's inborn risk for obesity. The score accurately predicted BMI and obesity in over 300,000 individuals, with those in the top 10% being 29 pounds heavier on average and 25 times more likely to develop severe obesity.
A large GWAS study identified novel loci associated with asthma susceptibility, including the gene IL1RL1 and HLA-DQA1, in four major ethnic groups. The study suggests unique biological pathways contribute to asthma susceptibility across different ethnicities.