Articles tagged with Cellular Immunity
Researchers discover enzyme ANKIB1 crucial for innate immune signalling, driving type I and type III interferon induction. This finding solves a long-standing puzzle in innate immunity and provides opportunities for new therapies for devastating diseases.
A novel vaccination approach cleared harmful gut bacterium Clostridioides difficile (C. diff) in an animal model of infection. The experimental vaccine protected against illness, death, tissue damage and infection recurrence through mucosal immunization.
Researchers compared four flu vaccines and found varying cellular immune responses across different age groups. The Fluzone High-Dose vaccine outperformed others in older adults, while Flucelvax excelled in younger adults.
A study published in Aging Cell suggests that hormone replacement therapy (HRT) can help reverse changes in the immune system caused by menopause, leading to a healthier immune profile. Women taking HRT showed fewer inflammatory monocytes and stronger infection-fighting ability compared to age-matched controls.
Three young scientists received top honors at the 2025 Blavatnik National Awards for Young Scientists, each receiving a $250,000 prize for their innovative work on critical global issues. The awards recognize exceptional scientific achievement and innovation by U.S.-based researchers under 42 years old.
Researchers at CU Anschutz discovered a genetic program within lymphatic endothelial cells that enables storage and archival of antigens, helping the immune system remember infections. This understanding could lead to improved vaccines and therapies by fine-tuning immune memory.
Researchers at the University of Chicago discovered that random fluctuations in gene expression enable certain cells to express genes from other tissues, promoting immune system training and tissue repair. This 'epigenetic noise' can also contribute to cancer development by allowing cancer cells to access a broader range of genes.
Scientists discovered that certain bacteria can trigger their own cell death as a defense mechanism against viruses, utilizing components of the bacterial immune system. This phenomenon could be exploited to develop novel antimicrobial treatments and fight drug-resistant infections.
Researchers developed a new vaccine platform that provides robust, long-lasting protection against multiple flu strains and COVID-19. The vaccine boasts 100% survival rates in vaccinated mice following challenge with either virus.
Researchers at the University of Melbourne have identified a rare type of immune cell, called stem-like T cells, that holds the key to maintaining powerful, long-term immune responses. ID3+ T cells have the remarkable ability to resist burnout and maintain a powerful immune response over time.
Gut bacteria that cross a weakened intestinal barrier induce epigenetic changes in bone marrow, generating trained immune cells primed to respond more efficiently to infections. However, this amplified immune response also contributes to the development of inflammatory diseases such as cardiovascular and neurodegenerative conditions.
A new longitudinal study has provided unprecedented insights into human papillomavirus (HPV) infection dynamics. The study found that non-persistent infections exhibit a plateau in viral load before rapidly declining, while chronic infections show a strong correlation between immune cells and virus production. This research could infor...
Researchers at McGill University have discovered that pregnancy enhances the body's natural immunity to block severe flu infection. By activating a powerful molecule in the nasal cavity, pregnant women may benefit from stronger antiviral defenses against the Influenza A virus.
Researchers found impaired PD-1 activity can significantly reduce antibody diversity and quality in memory B cells. This may explain the increased rates of infection reported in patients with cancer receiving checkpoint inhibitor therapy.
Researchers created a spatial atlas of the developing human thymus, revealing key differences in immune cell development and function. The study's findings could inform new T cell engineering therapies for cancer treatments, autoimmune conditions, and regenerative immune therapies for older adults or those with compromised immune systems.
Researchers at POSTECH have identified GLUT3 as essential for the suppressive function of regulatory T cells in tumor microenvironments, which can be targeted for cancer immunotherapy. The team's findings highlight the critical role of GLUT3 in regulating protein modifications that sustain immune suppression within tumors.
A recent study published in Stem Cell Reports has found that brief exposure to certain 'danger signals' can prime the body's innate immune system, leading to a long-term hyperreactive and inflammatory state. This mechanism can help fight infections but also increases the risk of cardiovascular disease.
A new study suggests that berry-flavored vapes can weaken the lungs' natural defences, making it harder for the body to fight off infections. The research adds to growing evidence on how added flavourings in vaping solutions exacerbate dangers.
Scientists at St. Jude Children's Research Hospital found that nutrient availability affects T cell development and mitochondrial activity, inhibiting T cell formation in lysosomes. The study highlights the crucial role of organelle signaling, such as mitochondrial and lysosomal function, in shaping tissue immunity.
A new study published in Nature has found that the type 2 immune response is positively correlated with long-term cancer remission, contradicting previous theories that it promotes tumor growth. The research used samples from pioneering clinical trials and revealed a statistically significant correlation between type 2 immune factors a...
A new long-term study found that memory T cells can be established and maintain key features to fight off subsequent infections of newer strains, providing potential insight into rapid recovery from COVID. The study's findings are important for understanding how the body responds to COVID-19.
A team of researchers from Osaka University has pinpointed the B cells responsible for boosting COVID-19 immunity after vaccination. They found that activated atypical B cells are the main responders to mRNA vaccines, providing a new way to assess vaccine response and underlying biology.
A new vaccine created by Mizzou researchers protects cattle from bovine anaplasmosis, a devastating tick-borne disease causing hundreds of millions of dollars in economic losses. The vaccine has been proven to give immunized cattle protection for at least a month and is being discussed with industry partners for future distribution.
A new mRNA derivative, comb-structured RNA, has been developed to enhance anti-cancer activities by activating immune cells and demonstrating high tumor effects in mice models. The study shows the potential of this novel cancer mRNA vaccine as a safe and effective treatment.
Researchers found that severe herpesvirus infections can strongly activate host cellular immunity, leading to a therapeutic effect on refractory adult T-cell leukemia/lymphoma. This activation may play an important role in the survival of patients with this intractable disease.
A recent study published in Immunity found that skipping breakfast can lead to a decline in immune cells and an increased risk of heart disease. The research showed that fasting triggers a stress response in the brain, which negatively affects immune cells.
Researchers developed a new blood test that can indicate cellular immunity to SARS-CoV-2 within 48 hours. The test distinguishes between post-infection and post-vaccination immunity, enabling quick diagnosis for patients unable to produce antibodies. Long-lasting T-cell responses may protect against severe disease in re-infections.
Researchers found that current COVID-19 vaccines provide robust protection against severe disease caused by the Omicron variant through induced cellular immunity. The study showed that CD8+ T cell responses were over 80% cross-reactive with the original strain, suggesting a key role in vaccine protection.
The L452R mutation of the SARS-CoV-2 spike protein evades human immune response via HLA-A24, a common allele in East/Southeast Asian populations. This mutation also enhances viral infectivity and replication efficiency.