Articles tagged with Mast Cells
Researchers developed a new mouse model of atopic dermatitis, revealing mast cells and Stat5 play critical roles in the disease. The study identified potential targets for eczema treatment based on links to human disease.
Researchers discovered that Salmonella protein tyrosine phosphatase (SptP) shuts down mast cell ability to release chemical signals without impacting other cellular functions. This leads to the failure of immune cells being recruited to the infection site, allowing Salmonella to multiply and spread unchecked.
Researchers have discovered a toxin produced by Staphylococcus aureus that causes immune-system cells in the skin to react and produce eczema-like rashes. The finding suggests a specific mechanism behind the link between staph bacteria and eczema, which could lead to new treatments.
Researchers show that mice injected with small dose of bee venom developed immunity to lethal dose, surviving three times longer than control mice. Protection depends on IgE signaling and mast cell activation, suggesting a positive evolutionary pressure for this type of defense.
Researchers at the University of Notre Dame have made progress toward a treatment for dangerous allergies by designing a special molecule that can out-compete allergens in their race to attach to mast cell receptors. The team has demonstrated the effectiveness of their inhibitor molecule on allergic reactions using animal models.
Researchers at Duke Medicine found a biomarker produced by mast cells can predict severe dengue cases. Asthma drugs targeting mast cells also showed effectiveness in limiting vascular leakage associated with dengue infections.
Researchers have identified two key compounds produced by mast cells that promote fibrogenesis, leading to pulmonary fibrosis. Introducing mast cells into mice lungs can reverse disease protection and cause pulmonary fibrosis.
Researchers show tRNA synthetases, essential in protein production, can also regulate transcription through a single chemical alteration, with implications for immune response and cancer. This transformation may lead to new treatments for allergies and cancer.
A team of scientists at Stanford University and the University of Bern have discovered a mechanism for destroying key allergy-inducing complexes using a new inhibitor called DARPin E2-79. This discovery could lead to rapid and potent interventions for acute allergic reactions, including anaphylactic shock.
A study by University of North Carolina at Charlotte researchers confirms the connection between metastatic breast cancer and autoimmune arthritis. Mast cells play a critical role in facilitating breast cancer metastasis, with SCF/Kit signaling inducing mast cell differentiation in arthritic conditions. This finding suggests a potentia...
Researchers discovered that mast cells release protein MCPT4, degrading Gila monster venom helodermin, reducing morbidity and mortality. This mechanism also applies to scorpion venom, providing a natural defense against deadly toxins.
A Stanford study has linked gamma-interferon, a key immune molecule, to the severity of asthma. High levels of gamma-interferon in children's blood may protect against asthma development, but severe asthmatics' lungs often have high concentrations.
Researchers at Duke-NUS Graduate Medical School have identified a new cell type that can sense and respond to the dengue virus, which is transmitted through mosquito bites. The discovery opens up new avenues for developing vaccines and treatments for the disease, which currently lacks effective therapies.
Researchers identified heparin as the underlying mechanism that initiates the production of bradykinin, contributing to swelling, anaphylactic, and inflammatory symptoms associated with aberrant mast cell activity. This discovery provides a new strategy for treating allergic diseases by blocking bradykinin or factor XII activity.
Researchers identified a previously unknown cellular switch that regulates both allergic and asthmatic responses in the body. This discovery suggests that at least some people with asthma and allergies have genes that prevent this switch from working properly, leading to medication development targets.
In a rat model of depression, fluoxetine inhibited mast cell ultrastructural alterations and de-regulated rMCP-1 expression. Treatment with fluoxetine suggested that SSRIs are an effective therapeutic agent for some gastroduodenal diseases caused by psychological factors.
UT Southwestern researchers found that tumors growing around nerves require cooperation from immune cells to grow. A new therapy targeting the immune system has shown promising results in treating previously untreatable tumors.
A recent study has found that anxiety levels in mice are directly influenced by the immune system, specifically through mast cells. Mice without mast cells showed reduced willingness to navigate open and high spaces, indicating lower anxiety levels.
Researchers at the Salk Institute have discovered that a protein called IKK2 plays a crucial role in regulating de-granulation, a process involved in allergic reactions. By targeting IKK2, scientists hope to develop acute inhibitors for treating allergies and potentially other diseases.
Researchers at NIH have successfully treated a patient with a rare disorder using cancer drug imatinib, which is also effective against systemic mastocytosis and chronic basophilic leukemia. The study's findings offer new treatment options for patients with these complex conditions.
Researchers discovered that mast cells in the lungs release renin, an enzyme that helps trigger bronchoconstriction, a hallmark of asthma. This finding suggests potential new targets for treatment against asthma and other respiratory diseases.
A study led by Monika Vig and Jean-Pierre Kinet found that calcium ion channels play a crucial role in triggering inflammatory responses, providing new insights into asthma and allergy symptoms. The discovery highlights the importance of CRACM1 calcium channels in mast cell activation.
A Johns Hopkins study finds activating a specific protein on immune cells can reduce allergic reactions and asthma attacks. By targeting this protein, researchers hope to develop new treatments for allergies.
A protein called RGS13 has been found to suppress allergic responses in mice, including severe anaphylaxis. Researchers believe RGS13 may be a target for developing new drugs to treat certain allergic diseases.
Researchers found mast cells with mutated cell surface receptor in patients with idiopathic anaphylaxis, suggesting a genetic trigger. The mutation may predispose people to idiopathic anaphylaxis and respond to inhibitors targeting the mutated cell surface receptor.
New research on glutaric acidemia type I reveals that young mice are more susceptible to brain damage due to lysine uptake, which can be mitigated with a novel treatment strategy. Mast cells play a role in abdominal aortic aneurysm development, and blocking LAG-3 might enhance cancer vaccine effectiveness.
A new study reveals that mast cells not only cause allergic reactions but also help reduce skin damage and inflammation from sun exposure or poison oak. The discovery opens up new possibilities for treating allergies and other conditions.
In a breakthrough study, researchers found that neutrophils in the lungs produce histamine in response to infection, contradicting the long-held assumption that mast cells are the primary source. This discovery has implications for asthma and bronchitis treatments, suggesting antihistamines may be a viable therapeutic option.
Researchers at VCU University have identified a new therapeutic target for asthma, allergies, and cancer by uncovering the transport mechanism of bioactive molecule S1P out of mast cells. The study may lead to the development of new treatments for these conditions.
Researchers at Karolinska Institutet found that mast cells can contribute to diseases like psoriasis and cancer through a previously unknown activation mechanism. The study suggests that the CD30 protein stimulates mast cell release of proteins regulating inflammatory cell recruitment.
Researchers have found that mast cells play a crucial role in regulating the immune system, particularly in maintaining tolerance to transplanted skin. The study revealed that mast cells mediate immune suppression by interacting with regulatory T cells.
Researchers at Stanford University School of Medicine found that mast cells in the immune system can break down and neutralize certain types of snake venom, enhancing resistance to its toxicity. This counterintuitive discovery challenges the long-held assumption that the immune system exacerbates snakebite symptoms.
Researchers at VCU demonstrated that a cytokine called interferon gamma can induce the death of developing mast cells in a mouse model system. This finding may lead to the development of new treatments for allergy and inflammatory responses in diseases such as arthritis, multiple sclerosis, and heart disease.
In a breakthrough discovery, Stanford researchers have found that mast cells can provide protection from sepsis by destroying a molecule that contributes to the pathology and death associated with this bacterial infection. The study reveals a new role for mast cells in limiting damage caused by endothelin-1.
A study by Dr. Bart Vanhaesebroeck and his team found that inactivating p110delta in mast cells significantly reduces the allergic response seen in mice. Current therapies targeting symptoms rather than mast cell activation are insufficient, highlighting the need for targeted treatments.
Researchers found that mast cells are required for experimental oral allergen-induced diarrhea, which is dependent on serotonin and platelet-activating factor signaling. Blocking these pathways could lead to new treatments for gastrointestinal allergy.
Researchers at Duke University discovered that mast cells trigger both the innate and adaptive immune responses by releasing TNF, which recruits infection-fighting T-cells and induces antibody production. This finding redefines how the immune system functions and may lead to new therapeutics for disease protection.
A new study has identified a special type of idiopathic hypereosinophilic syndrome (HES) that can be diagnosed with a tryptase blood test and treated successfully with imatinib. The disease, characterized by an overabundance of white blood cells called eosinophils, can cause severe organ damage and is often fatal.
Pattern recognition receptors on mast cells play a crucial role in triggering an immune response and modulating inflammation. This receptor activation leads to the release of histamine and other pro-inflammatory mediators, contributing to various diseases such as allergic reactions and asthma.
Scientists at Uppsala University have identified a gene that regulates mast cell survival upon allergic activation, providing hope for a novel therapy to treat allergies. Inhibition of this gene, A1, leads to the death of mast cells, decreasing their numbers and alleviating allergic symptoms.
Scientists have identified a novel family of peptide antibiotics, Piscidins, isolated from the tissues of hybrid striped bass and found in mast cells. These potent compounds show broad-spectrum activity against various bacterial pathogens, including multi-drug-resistant strains.
Researchers from North Carolina State University isolated a new peptide antibiotic from hybrid striped bass mast cells, which could fight important bacterial pathogens in both fish and mammals.
Researchers at Emory University have uncovered a significant connection between mast cells and the development of multiple sclerosis. Mast cells, previously only studied in respiratory tract diseases like hay fever and asthma, are now linked to nerve damage in MS.
Researchers found that mast cells recognize harmful bacteria and alert the immune system to destroy them, clearing up a mystery about their role. Mast cells can also boost the immune system in people with weakened immune systems.