Researchers have mapped cellular differences between two similar bowel diseases, identifying hidden immune activity that may explain why one carries a much higher risk of colon cancer. The study found that patients with PSC-associated IBD had a distinct microbiome and higher levels of immune activity even in the absence of inflammation.
A team of researchers at Kyoto University has reconstructed the family tree of blood cells over a 700-million-year span, revealing their evolutionary history. They found that early blood cells emerged around the same time as multicellular animals and were macrophage-like.
Researchers at WashU Medicine discovered that mast cells stand guard at tiny gates through which fluid waste leaves the brain, mounting a response when a pathogen is detected to close the gates and prevent invaders from entering. Enhanced mast cell activity before an infection reduced bacterial load.
Researchers have discovered a promising bioactive compound that can effectively reduce symptoms of conditions like asthma and migraine by blocking a receptor on certain defense cells. The compound is effective in eliminating life-threatening allergic reactions in mice and has shown promise for treating inflammatory conditions.
A rare case report highlights the association between systemic mastocytosis and severe osteoporosis in a young adult patient, emphasizing the importance of early diagnosis and consideration of SM as an underlying cause. The study aims to raise awareness about this underrecognized condition and its potential impact on bone health.
A new study explains how scratching aggravates inflammation and swelling in a type of eczema called allergic contact dermatitis. Scratching activates mast cells, which drive itchiness and inflammation, but also triggers the release of substance P, which protects against bacteria.
Researchers found that SYM2081 suppressed mast cell degranulation and proliferation in mouse models and human skin samples, paving the way for new topical treatments to prevent itching and inflammation. The study suggests that activating GluK2 could be a promising way to prevent rosacea and other inflammatory skin conditions.
A study by Trinity College Dublin researchers has linked rare mast cell types to treatment response in chronic spontaneous urticaria (CSU), a common skin condition characterized by recurring hives. The findings suggest that these cells may help predict who will respond well to anti-IgE therapies.
Researchers found that parents with high chemical intolerance scores were 5.7 times more likely to report a child with autism, highlighting the potential preventive role of avoiding toxic exposures. The study also suggests that reducing exposure prior to and during pregnancy could help prevention.
Scientists found that short-chain fatty acids produced by gut bacteria suppress allergic reactions by modulating mast cell activation and epigenetic modifications. This study provides new insights into the relationship between diet and immune system regulation, with potential applications in allergy treatment.
Scientists have created a new therapy using nanoparticles to target specific immune cells responsible for allergic responses. The approach, which combines an allergen with antibodies that selectively inhibit mast cells, has shown promising results in a mouse study, preventing allergic reactions without causing side effects.
A new study finds that people with antibodies to common foods like dairy and peanuts are at a higher risk of cardiovascular-related death. The research suggests that these subtle immune responses may lead to inflammation and contribute to heart disease over time.
A study by University of Texas Health Science Center at San Antonio researchers found that corticotropin-releasing factor (CRF) activates immune cells in the dura membrane under the skull, leading to pain signals. This discovery may lead to the development of a small-molecule drug therapy to inhibit CRF and MrgprB2 interaction.
Researchers found that mast cells act as sensors to avoid allergens in mice, protecting against health-threatening inflammatory reactions. The study suggests that both mast cells and IgE are necessary for antigen avoidance.
Researchers found histamine releases HMGB1 in vascular endothelial cells, leading to severe symptoms. Administering anti-HMGB1 antibody attenuated hypotension and improved recovery rates.
Research from UVA Cancer Center finds that an unhealthy gut microbiome can trigger changes in normal breast tissue, facilitating cancer's spread to other parts of the body. The study suggests that targeting the gut-mast cell relationship could help prevent breast cancer recurrence and metastasis.
An artificial intelligence model trained on histological images of surgical specimens accurately classified patients with and without Crohn disease recurrence. The model revealed previously unrecognized differences in adipose cells and mast cell infiltration, enabling stratification by prognosis for postoperative Crohn disease patients.
Researchers at Uppsala University found that allergic stimulation activates mast cell precursor cells, which can produce cytokine IL-13 contributing to asthma development. This challenges the idea that only mature immune cells are involved in immune reactions.
Researchers developed a 'frameshifting' therapy that alters mRNA to reduce mast cell tumor size and prevent organ infiltration. The treatment, targeting the c-KIT gene, shows promise in reducing KIT protein expression, signaling, and function.
The NIH is conducting a clinical trial to assess the risk of systemic allergic reactions to the Moderna and Pfizer-BioNTech COVID-19 vaccines in people with mast cell disorders or severe allergies. The study aims to identify potential genetic patterns that may predict who is at most risk for these reactions.
A study published in International Journal of Molecular Sciences suggests a link between corticotropin-releasing hormone (CRH) and increased expression of mast cells in the nasal cavity, exacerbating allergic reactions. The research offers promising therapeutic potential with CRHR1 inhibitors and SCF neutralizing antibodies.
Researchers discover that serotonin release from mast cells contributes to airway hyperresponsiveness in asthma, revealing a new mechanism for this common respiratory disease. The study uses a mouse model of asthma to demonstrate how mast cells react to methacholine, leading to increased airway constriction.
A team of scientists discovered that mast cells orchestrate the recruitment of neutrophils through a molecular mechanism involving tumor necrosis factor. Mast cells position themselves around blood vessels and release TNF, which activates surface proteins on neutrophils, allowing them to migrate into tissues.
KU Leuven researchers discovered a biological mechanism connecting food antigens to mast cell activation and digestive intolerance in people with IBS. The study found that certain foods like gluten, wheat, and soy can trigger local immune reactions in the gut, leading to abdominal pain.
A new humanized mouse model has revealed a central role for mast cells in immune checkpoint inhibitor resistance in melanoma. The study found that depleting mast cells improves treatment responses to anti-PD-1 therapy, suggesting a potential new approach for treating this type of cancer.
A new humanized mouse model has revealed that tumor-infiltrating mast cells are connected to immune checkpoint inhibitor resistance in melanoma. Combining anti-PD-1 therapy with small molecule inhibitors able to deplete mast cells caused complete regression of tumors and prolonged survival in mice.
Researchers found that maternal antibodies can cross the placenta and trigger allergic reactions in foetal mast cells, leading to lifelong allergies. The study suggests a potential new intervention strategy to limit such transfer and reduce the incidence of neonatal allergies.
A new study by Michigan State University researchers connects specific hormones present before and after birth with immune response and lifelong immunological disease development. Females are at increased risk for common diseases like asthma, allergies, and irritable bowel syndrome due to their perinatal hormone levels.
Researchers found that mice with mild skin infections develop adaptive immunity against bacteria, granting increased resistance to severe secondary infections. This discovery suggests that the 'allergy module' has an important biological function in defending against toxin-producing pathogens.
A team of researchers has identified a crucial ion channel protein in mast cells that regulates calcium levels, which are essential for the activation of many types of immune cells. This discovery has significant implications for the treatment of allergies and autoimmune diseases.
Researchers at UC San Diego discovered the critical gene ZNF263, which regulates heparin biosynthesis in human cells. This breakthrough could enable the production of heparin in well-controlled cell culture, providing a safer and more sustainable alternative to current methods.
Activated platelets attach to vessel walls and interact with mast cells, triggering a powerful inflammatory response that can lead to organ damage and death after heart surgery. Inhibiting platelet activation may prevent or minimize this response, according to a study published in Science Advances.
Researchers at the University of Birmingham are exploring how mast cells play a role in DVT, a condition that affects tens of thousands of people in the UK each year. By studying mast cells in mice and humans, they hope to develop new medicines that can reduce the risk of bleeding while preventing the condition.
Researchers have identified a key mechanism underlying atopic dermatitis, a chronic inflammatory skin disease affecting 20% of children and 5% of adults. The study reveals that mast cells and sensory neurons interact in 'sensory neuroimmune units' to detect allergens, triggering inflammation.
A team of researchers from Charité - Universitätsmedizin Berlin has identified a new endogenous mechanism that enables the skin to actively kill bacteria. The discovery involves mast cells and interleukin 6, which stimulate the release of antimicrobial peptides that target bacteria.
Research suggests that scratching the skin can lead to allergic reactions to foods, including anaphylaxis, in children with eczema. The study found that mechanical skin injury expands and activates intestinal mast cells, promoting anaphylactic reactions.
Researchers found that scratching the skin triggers a series of immune responses culminating in increased activated mast cells in the small intestine. This skin-gut communication helps illuminate the relationship between food allergy and atopic dermatitis.
A study by Duke-NUS Medical School researchers has identified a key player in the early fight against dengue virus infection: an interaction between two types of immune cells. The discovery sheds light on how the immune system recognizes viruses and could lead to the development of better vaccines for this and similar diseases.
Researchers used mouse models to track the immune cell triggering during anaphylactic shock, revealing a previously unknown mechanism in which dendritic cells mine blood vessels for allergens and rapidly deliver them to mast cells. This finding opens innovative lines of attack against deadly allergic reactions.
A new study from Ohio State University suggests that childhood stress can contribute to mood disorders later in life by altering brain development through mast cell activity. Chronic stress was found to increase mast cell activity in the brain of stressed rats.
Researchers discovered that mast cells release histamine from the gut, triggering the formation of oleoylethanolamide, which stimulates ketogenesis and supports brain and muscle function during prolonged fasts or intense exercise. This finding challenges the long-held assumption that mast cells are solely responsible for allergic respo...
Researchers from CNRS and INSERM identify 'primitive mast cells' generated in yolk sac during embryonic development. These cells play a crucial role in shaping the body's immune response, contradicting previous theories on mast cell origin.
Research reveals testosterone promotes a protective immune response in male mice by increasing IL-33 production, reversing symptoms in female mice with similar autoimmune disease. Sex differences in immune responses may underlie gender disparities in MS and other autoimmune diseases.
A recent study published in Journal of Leukocyte Biology found that stress receptors can control immune cells' defense mechanisms, leading to allergic diseases. Mice with disabled stress receptors showed reduced disease symptoms and were protected against stress-related illnesses.
A new study identified CRF1 as a master regulator of mast cell activity during stressful challenges, including psychological stress and anaphylaxis. The study showed that mice lacking CRF1 expression were protected against disease, suggesting a potential therapeutic target for treating stress-related diseases.
Researchers at NIAID found that some patients' seemingly inexplicable anaphylaxis was caused by an uncommon allergy to a molecule found naturally in red meat. Six study participants tested positive for an allergy to galactose-a-1,3-galactose, or alpha-gal, and experienced no anaphylaxis after implementing diets free of red meat.
La Jolla Institute researchers find Histamine-Releasing Factor (HRF) exacerbates both asthma and food allergies. Inhibiting HRF may prevent allergic reactions, offering a new treatment avenue.
Researchers at Karolinska Institutet and Uppsala University have discovered that mast cell development does not depend on stem cell factor. Instead, factors like interleukin 3 and 6 play a crucial role in their formation.
Research reveals mast cells can contribute to severe dengue disease by increasing vasculature permeability, providing insights into pathogenesis and potential treatments. Mast cell activation mechanisms also affect local immune responses during dengue transmission.
A proof-of-principle study found that imatinib improved airway hyperresponsiveness and decreased mast cell presence in patients with severe asthma. Treatment also showed a small improvement in airway function.
A study published in Biology of Sex Differences found that females are more vulnerable to certain stress-related and allergic diseases due to distinct differences in mast cells, a type of white blood cell. Mast cells play a key role in stress-related health issues common in women like IBS, migraines, and autoimmune diseases.
Researchers developed a method to stop allergic reactions by removing a key receptor from mast cells and basophils, targeting the immune system's response. The approach has implications for treating skin allergies and asthma, with potential benefits over current therapies.
Scientists have discovered a new target to combat severe and fatal allergic reactions by identifying a molecular motor that controls the release of inflammatory factors. Researchers found that depleting this motor reduces mast cell granule transport and release, potentially leading to new treatment options for anaphylaxis.
A University of Cincinnati study found that gut bacteria influences intestinal mast cells' activation and fat absorption. The research suggests a novel role for the gut microbiome in promoting lipid absorption.
A global trial of midostaurin reveals that the drug can produce partial or complete resolution of organ damage in 60% of patients with advanced systemic mastocytosis. Patients treated with midostaurin experienced improved liver function, fewer signs of malabsorption, and increased survival rates.
Researchers identify ADGRE2 gene mutation responsible for vibratory urticaria, a rare inherited disorder causing hives and allergic symptoms upon vibration. The study reveals a key role of the mast cell response to physical stimuli in disease development, offering new insights into immune system functions.
Kolltan Pharmaceuticals presents substantial tumor shrinkage with KTN0158 in dogs with spontaneous mast cell tumors, with favorable results from non-clinical toxicology studies. The company plans to file an IND for the drug candidate in oncology this year.
Researchers found that repeated exposure to stimuli can lead to recurring mast cell degranulation and long-term pathological eye changes. Inhibiting this release with substances like disodium cromoglycate may offer new ways to treat serous retinal detachment.
A study published in the Journal of Leukocyte Biology found that histamine plays a role in protecting tumors from the immune system. By blocking histamine production, researchers were able to interrupt a process promoting melanoma growth.
Researchers developed a new mouse model of atopic dermatitis, revealing mast cells and Stat5 play critical roles in the disease. The study identified potential targets for eczema treatment based on links to human disease.