Articles tagged with Sars Cov 2
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A US clinical trial will assess the safety and efficacy of a nasal COVID-19 vaccine developed using technology from Washington University in St. Louis. The trial, sponsored by the National Institute of Allergy and Infectious Diseases, aims to evaluate the vaccine's ability to induce strong immunity in the nose and upper respiratory tract.
A new study found that COVID-19 infection is associated with faster growth of plaque in the coronary arteries, leading to an increased risk of cardiovascular events. The study also revealed a higher incidence of high-risk plaques and coronary inflammation among infected patients.
Researchers investigated ozonated water's impact on SARS-CoV-2 in saliva, discovering that protein concentrations like amylase and mucin decrease ozone stability and effectiveness. This study provides insights into the applicability of ozonated water for disinfection in real-world settings.
A study on six serodiscordant couples found that women who were immune to SARS-CoV-2 had elevated expression of the gene IFIT3 compared to their male partners. This suggests that overexpression of IFIT3 may offer protection against COVID-19 by inhibiting viral replication and preventing cell invasion.
Researchers developed a powerful tool to detect SARS-CoV-2 variants with high transmission potential, pinpointing exact mutations driving spread. The model focuses on spike protein and other parts of the virus, enhancing ability to bind human cells and evade immune systems.
Researchers from Osaka University found that Japan's state of emergency declarations led to increased hygienic behaviors and risk perception, which persisted even after the policy was lifted. However, older people became less fearful of COVID-19 and were less likely to wear masks.
A cohort study found COVID-19 to be associated with more severe disease outcomes compared to influenza and RSV during the 2022-2023 season. Vaccination attenuated these differences in severity and long-term mortality rates.
Researchers developed a nanoparticle-based vaccine that generates antibodies targeting conserved regions of sarbecovirus receptor-binding proteins, offering broader protection against multiple strains. The vaccine demonstrated strong antibody responses and protection in animal studies against diverse SARS-CoV-2 and other sarbecoviruses.
Researchers tracked nearly 1,000 people with post-COVID-19 syndrome, finding persistent physical and cognitive impairments that worsened with exercise intolerance. The study's findings support the inclusion of cognitive and exercise testing in clinical evaluation for patients with suspected post-COVID-19 syndrome.
A new method can detect tiny amounts of SARS-CoV-2 virus in blood, stool, and saliva from patients with acute COVID-19 infections. The technology has potential for guiding treatment of long COVID and monitoring viral loads for future infectious diseases.
A recent study published in JAMA Network Open found that females aged 40-55 years have the highest risk of developing long COVID, with a 31% higher associated risk compared to males. The research, part of the NIH RECOVER initiative, suggests that patients and healthcare teams should consider sex differences when treating long COVID.
A research team led by Jianyang Du, PhD, has received a grant to investigate the cellular and molecular mechanisms behind neurological disorders caused by long COVID-19. The study aims to provide insights into how SARS-CoV-2 alters neuronal activity, which could lead to effective therapeutic strategies.
A new study published in the Journal of General Internal Medicine found that COVID-19 infection significantly increases the rate of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) among COVID-19 survivors. Nearly eight times more people with ME/CFS were infected with SARS-CoV-2 than those without, according to the research.
Researchers identified a novel genetic risk factor for SARS-CoV-2 infection, linking a PTPN2 variant to increased ACE2 expression and susceptibility. The study suggests Tofacitinib may mitigate this risk, offering new treatment options for patients at higher genetic risk.
The NIH-funded RECOVER Initiative study reveals a significant association between SARS-CoV-2 infection and an increased incidence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), with 4.5% post-COVID participants meeting ME/CFS diagnostic criteria, compared to 0.6% non-infected participants.
Longidaza significantly reduced exertional desaturation and dyspnea, as well as improved distance walked during the six-minute walk test. The drug's effects on exercise tolerance were sustained for over 100 days after treatment.
Researchers at Indian Institute of Science discover that viruses like SARS-CoV-2 mimic host proteins to trigger excessive cell death and tissue damage in humans. In contrast, bats show mild symptoms despite harbouring similar viruses, highlighting species-specific responses to viral infections.
Researchers at University of Helsinki and colleagues have mapped the 'hijackome', detailing how SARS-CoV-2 variants exploit specific cellular pathways to spread and evade immune defenses.
Scientists at The Jackson Laboratory have identified the CAST/EiJ mouse as a highly susceptible model for studying severe COVID-19. This genetically pure background allows researchers to investigate the virus's impact without artificial receptor modifications, mirroring human responses. Initial trials using antiviral treatments show pr...
Dartmouth researchers propose a new way of thinking about masking and social distancing rules using game theory, considering them as two distinct actions. The study finds that people respond differently to these measures based on their perception of the disease's severity, trending towards masking or no protective action over time.
Researchers have developed a novel therapeutic approach using polypurine hairpins to inhibit the replication of SARS-CoV-2. The technique has shown promising results in laboratory animal models and Vero E6 cells, providing a potential new tool in the fight against COVID-19 and other viral diseases.
An experimental study in mice found that SARS-CoV-2 infection can damage the retinas, leading to long-term implications for vision. The virus caused widespread inflammation across the retinal pigment epithelium, including complement activation and increased production of inflammatory cytokines.
Researchers found that SARS-CoV-2 disrupts mitochondrial reactions, leading to immune sensor activation and a cytokine storm, which triggers multiple organ-damaging events. Autopsy samples revealed extensive inflammation and organ damage in organs such as the heart, lungs, and kidneys.
Researchers have discovered a monoclonal antibody capable of targeting multiple SARS-CoV-2 variants, including recent Omicron strains. K4-66's exceptional ability to adapt to the virus's frequent mutations makes it a promising candidate for vaccine and therapy development.
This study found that certain amino acid substitutions in four IFN-I antiviral pathway proteins can disrupt interactions, potentially aiding in determining SARS-CoV-2 transmission likelihood. Four proteins MDA5, NEMO, IRF3, and ISG15 were identified with potential domains or specific amino acids that may result in PPI disruption.
A study found stopping universal masking and SARS-CoV-2 testing led to a significant increase in hospital-onset respiratory viral infections compared to community cases. Restarting health care worker masks significantly reduced the risk of these infections.
Lysosomal TRAP effectively inhibits virus infection in cell, mouse, hamster, and human lung organoid models, including SARS-CoV-2 and influenza A. It outperforms current standard treatments and is not vulnerable to viral mutations.
Researchers have discovered that seemingly 'broken' genes in coronaviruses are retained due to their functional role beyond protein production. These extra genes help control the activity of other viral genes.
The Association for Molecular Pathology has published a joint consensus report on SARS-CoV-2 genomic surveillance, outlining key considerations for next-generation sequencing methods. The report provides guidance on pre-analytical, analytical, and post-analytical aspects of NGS-based surveillance programs.
Researchers discover SARS-CoV-2 hijacks three host proteins to shield itself from complement-mediated lysis, significantly impairing viral clearance. This may affect the course of acute and post-COVID-19 sequelae, deepening our understanding of immune evasion mechanisms.
Research highlights correlation between preeclampsia and COVID-19 in pregnant women, identifying biomarkers for differential diagnosis. The review article emphasizes the pathophysiological similarities between the two conditions, including shared pathways involving the renin-angiotensin system and ACE2.
A longitudinal cohort study found no significant associations between prenatal SARS-CoV-2 infection and child neurodevelopment outcomes in the first two years of life. Follow-up research is needed to determine if these effects persist into later childhood.
Researchers at Kumamoto University have developed a cutting-edge diagnostic tool, Intelli-OVI, to rapidly identify emerging SARS-CoV-2 variants. This system combines advanced DNA detection technology with computational algorithms to offer a quicker and more cost-effective method of monitoring viral mutations.
Researchers from the IBB-UAB have developed novel nanoparticles capable of trapping and neutralizing large quantities of SARS-CoV2 virus particles. These nanostructures could be used to manufacture antiviral materials such as wastewater and air filters, and develop new tests for early Covid-19 detection.
Researchers developed a new surveillance technique to track COVID-19 diversity using genomic data, predicting variant emergence with high accuracy. The software can forewarn public health officials of impending outbreaks, enabling timely responses and more effective disease monitoring.
Elevated body mass index (BMI) was associated with a significantly increased post-acute sequelae of SARS-CoV-2 infection risk. The study highlights the need for targeted care to prevent chronic conditions in at-risk children and young adults.
The novel coronavirus SARS-CoV-2 has an enzyme that counteracts the innate defense mechanism against viruses, allowing it to evade the innate immune system and become more infectious. Understanding this mechanism may lead to the development of new antiviral drugs and treatments.
A phase Ib clinical trial has shown that the MVA-MERS-S vaccine candidate is safe and effective in healthy individuals previously infected with SARS-CoV-2. The vaccine was tested in a placebo-controlled study with no serious vaccine-related side effects, indicating promising results.
A new study reveals that mild and asymptomatic SARS-CoV-2 infections can trigger immune responses in pregnant individuals, causing serious inflammatory responses in the developing fetus. The study also found that even without full infection, a pregnant individual's immunological response to infection may impact the fetus.
A retrospective cohort study of children and adolescents found a higher risk of developing type 2 diabetes after COVID-19 infection compared to other respiratory infections. The study suggests potential long-term effects on glucose regulation.
Researchers at Brigham and Women's Hospital found that people with wide-ranging long COVID symptoms were twice as likely to have SARS-CoV-2 proteins in their blood compared to those without long COVID symptoms. This persistent infection could explain some of the long COVID sufferers' symptoms, suggesting a potential treatment target.
Researchers at the University of São Paulo developed a synthetic peptide that mimics the ACE2 receptor, blocking SARS-CoV-2 invasion and reducing inflammation in human lung cells and mice. The peptide could be customized for every variant, offering a fast-acting molecular shield against the virus.
Researchers developed a modular click chemistry method to synthesize catechol derivatives, which showed potent inhibitory effects against SARS-CoV-2 3CL pro with low cytotoxicity. The study demonstrates the feasibility of this approach for natural-product-based structural modifications in antiviral drug discovery.
Researchers at La Jolla Institute for Immunology have developed six lines of humanized mice to study human cases of COVID-19, shedding light on SARS-CoV-2's movement through the body and varying symptoms. The models help understand how different genetic backgrounds influence disease progression.
A new method combines confocal fluorescence microscopy with microfluidic laminar flow to detect nanoparticles and viruses quickly and accurately. The approach uses a 3D-printed Brick-MIC setup for sensitivity and specificity improvements, potentially changing virus detection in clinical settings.
Researchers have identified a novel small-molecule inhibitor of SARS-CoV-2 using chemical genetics. The compound, designated 172, demonstrates broad-spectrum antiviral activity against multiple human pathogenic coronaviruses and different SARS-CoV-2 variants of concern.
Treatment-emergent nirmatrelvir resistance mutations were commonly detected in immunosuppressed individuals, but at low frequencies and transient nature. The study suggests a low risk for the spread of nirmatrelvir resistance in the community with current variants and drug usage patterns.
The study reveals how SARS-CoV-2 ORF10 exploits the ubiquitination pathway by mimicking Gly/N-degrons to bind CUL2 ZYG11B, leading to degradation of IFT46 and dysfunctional cilia. This mechanism offers a promising target for developing PROTAC-based drugs to combat COVID-19.
Long COVID patients face numerous barriers and frustrations in receiving care, yet express a desire for collaborative treatment planning. The study highlights the need for improved communication and collaboration between patients and healthcare professionals.
A recent cohort study found that prenatal exposure to COVID-19 during pregnancy did not increase the risk of autism screening in toddlers. The research suggests that maternal SARS-CoV-2 infection and pandemic-related exposure had no significant impact on autism positivity rates.
A new study provides further evidence that SARS-CoV-2, the virus responsible for COVID-19, likely originated from animals sold at the Huanan Seafood Market in Wuhan, China. The analysis of genetic data found that wildlife species such as raccoon dogs and civet cats were present at the market and may have carried the virus.
A new international study provides a list of wildlife species present at the Huanan Seafood Wholesale market where SARS-CoV-2 likely arose. Genetic material from raccoon dogs, civet cats, and other species was found in samples from market stalls.
Researchers isolated drug-resistant strains of SARS-CoV-2 from immunocompromised individuals who received antiviral treatments. The virus variants showed resistance to Paxlovid and remdesivir, highlighting the need for combination therapy to treat COVID-19 in highly vulnerable patients.
A new long-term study found that memory T cells can be established and maintain key features to fight off subsequent infections of newer strains, providing potential insight into rapid recovery from COVID. The study's findings are important for understanding how the body responds to COVID-19.
Researchers identified an antibody that assists some variants of the virus in infecting cells while blocking others, a dual-role effect. The study highlights the complexity of developing treatments as viruses evolve, but notes this phenomenon has not been observed in humans.
Researchers developed artificial lymphoid organ-chips to recreate human immune system's response to booster vaccines. The technology could potentially be used to evaluate the likely effectiveness of new protein and mRNA-based booster vaccines for COVID-19 and other infectious diseases.
Researchers developed a monoclonal antibody called SC27 that targets multiple parts of the SARS-CoV-2 spike protein, including conserved sections. The antibody shows promise against various COVID-19 variants and related coronaviruses, potentially benefiting immunocompromised patients
A study published in Nature found that immune cells called CD8+ T cells prevent lung healing and repair post-infection, leading to pulmonary fibrosis. This discovery may lead to new therapeutic treatment options for patients with long COVID.
This study found modestly increased risks of inflammatory bowel disease and bullous skin disorders in hospitalized patients infected with the Omicron variant. Booster vaccination mitigated long-term autoimmune sequelae risk.
A recent study by University of Missouri researchers found that giving nurses massages during their shifts can reduce physical aches and pains while improving mental rejuvenation. The study's lead researcher aims to create a healthier work environment where nurses are excited to remain in the profession long-term.