Articles tagged with Parkinsons Disease
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Researchers found an association between weight loss and rapid disease progression in Parkinson's patients. Those who lost weight showed a greater increase in symptoms, while those who gained weight had the smallest annual increase.
Researchers found that alpha-synuclein spreading in Parkinson's disease is triggered by enhanced expression and trans-neuronal passage of monomeric and oligomeric forms, rather than prion-like seeding. This new insight sheds light on the pathogenesis of Parkinson's disease.
A nationwide study in Taiwan found that people with hepatitis C virus were nearly 30% more likely to develop Parkinson's disease than those without. The study involved over 49,000 participants and followed them for an average of 12 years.
Researchers used a portable device to compare brain activity in people with Parkinsonian syndromes and healthy adults. The study found that those with Parkinsonian symptoms demonstrated higher prefrontal cortex oxygenation levels to maintain stability while standing, and this difference relates to their performance in maintaining balance.
Researchers at Michigan Technological University have developed new probes to measure surface hydrophobicity in proteins. These sensors show significant improvements over existing commercial tools, with up to a 60-fold increase in detection strength.
A team of researchers has identified a unique gait pattern among top Russian officials, including President Vladimir Putin and Prime Minister Dmitry Medvedev. The experts link this 'gunslinger's gait' to military or intelligence training, specifically KGB instruction on keeping the weapon close to the chest while walking.
Scientists at the University of Nottingham have discovered a small molecule called nicotinamide mononucleotide (NMN) that causes a chain reaction of destruction within neuron cell processes. This finding may lead to new therapies for age-related neurodegenerative disorders such as Parkinson's and Alzheimer's disease.
A study published in Neurology found an association between pesticide heptachlor epoxide and reduced brain cells in nonsmokers who drank more than two cups of milk daily. Researchers discovered residues of the pesticide in 90% of participants with high milk consumption, but note that the study does not show cause-and-effect.
Researchers at UC San Diego are investigating DNA methylation in the blood as a potential signature for Parkinson's disease. The study, funded by the Michael J. Fox Foundation, aims to improve early diagnosis and treatment of the chronic movement disorder.
Researchers at Case Western Reserve University School of Medicine received NIH grants to study Parkinson's disease, investigating gliptins for effective treatment. They also explored regenerating stem cells to heal the brain after a stroke and targeting brain tumor stem cells to develop new therapy strategies.
A study at Thomas Jefferson University has successfully increased the production of GM1 ganglioside in mice with Parkinson's disease. The researchers used an enzyme to convert naturally occurring ganglioside molecules into GM1, providing neuronal protection similar to direct GM1 injection.
Biologists at the University of York have created a reliable method to detect Parkinson's disease by analyzing fruit flies' visual responses. The study used adapted methods from human vision research and found increased neuronal activity in 'young' flies with Parkinson's mutations, leading to an 85% accurate classification rate.
Scientists measured dopamine signals in Parkinson's patients during brain surgery, revealing rapid dopamine release encodes information crucial for human choice. The findings have widespread implications for neurological and psychiatric disorders, including depression and addiction.
Researchers have uncovered a mechanism that helps repair damaged synapses, enabling optimal neuronal communication. This discovery highlights the importance of microautophagy in breaking down cellular debris and may lead to new treatments for neurodegenerative diseases like Alzheimer's.
A new approach has been discovered to reduce uncontrolled movements caused by levodopa, a common Parkinson's disease medication. By boosting the functioning of a specific brain receptor, scientists have found that side effects such as dyskinesia can be dramatically reduced.
A new diagnostic criteria for Parkinson's disease has been developed, aiming to improve diagnosis and treatment, especially in early stages. The criteria incorporate motor and non-motor symptoms, genetic factors, and propose a stage classification to focus on early detection.
Researchers have discovered a potential link between Parkinson's treatment and protection against age-related macular degeneration (AMD), the most common form of blindness. The study suggests that patients taking L-DOPA as Parkinson's treatment may be less likely to develop AMD, with delayed or prevented disease progression.
A new study from Lund University suggests that unwanted blood vessel formation may be behind intractable walking and balance difficulties associated with Parkinson's disease. The researchers used cerebrospinal fluid samples from 100 patients and found clear connections between angiogenesis markers and symptoms.
The article reviews lessons learned from Alzheimer's disease research to advance the development of screening and diagnostic algorithms for Parkinson's disease. It explores MCI-AD research, clinical trials incorporating biomarkers and genetics, and emerging therapeutic strategies targeting specific biological mechanisms.
Research reveals individual corals have varying capacities to adapt to changing ocean conditions brought about by climate change. The study found that some corals are more protective of their partner algae in harsh environmental conditions, suggesting a greater capacity to respond to climate change.
Researchers developed a method to deliver drugs across the blood-brain barrier using nasal mucosal grafting, showing neuroprotection in Parkinson's mouse models. The technique has potential to treat various brain disorders, including neurodegenerative diseases and psychiatric conditions.
Researchers at King's College London have identified a new gene, HIFalpha, that regulates nerve signals from damaged mitochondria in fruit flies. Switching off the HIFalpha gene restores nerve function and prevents early failure of nerve cells caused by mitochondrial damage.
A small phase I clinical trial found that an FDA-approved leukemia drug improved cognition, motor skills, and non-motor function in patients with Parkinson's disease and Lewy body dementia. The drug, nilotinib, also reduced toxic proteins linked to disease progression.
Researchers led by Assia Shisheva found a novel interaction partner of the ArPIKfyve-Sac3 complex in the brain, which binds Synphilin-1 and prevents its aggregation. This discovery may lead to new therapeutic approaches for reducing cytoplasmic aggregates in Parkinson's disease.
A new study found that people with Parkinson's disease psychosis who took antipsychotic medication were four times more likely to die than those who didn't. The treatment also led to serious health issues such as cognitive decline and worsening of Parkinson's symptoms.
A new study has found a potential treatment for Parkinson's disease by targeting specific nerve cells, showing promising results in rats. The technique could lead to less invasive and more precise treatment options for patients.
Scientists at UNC Eshelman School of Pharmacy created macrophages that deliver glial cell-derived neurotrophic factor (GDNF) and teach neurons to produce the protein. The treatment has shown promise in reversing Parkinson's disease progression and promoting neuron survival.
Researchers at Columbia University Irving Medical Center discovered that long-term use of L-DOPA leads to dyskinesia due to striatonigral neurons becoming less responsive to GABA. This suggests that modulating these neurons could prevent or delay dyskinesia.
Researchers found that external brain stimulation, specifically transcranial direct current stimulation (tDCS), can compensate for the loss of dopamine in people with Parkinson's disease by decreasing the effort the brain has to put into getting its motor neurons to fire. This correction improves some patients' motor symptoms.
Researchers at Massachusetts General Hospital found that urate stimulates astrocytes to activate an antioxidant pathway believed to have a role in several neurodegenerative disorders. A phase 3 trial of a urate-elevating drug, led by Dr. Michael Schwarzschild, is planned to enroll 270 patients with early-stage Parkinson's disease.
A new study published in Restorative Neurology and Neuroscience reports that repetitive transcranial magnetic stimulation can reduce gait freezing in Parkinson's patients. The treatment, involving high-frequency rTMS, improved motor skills and continued to show benefits even after the intervention was stopped.
Researchers have identified a new type of prion causing Multiple System Atrophy (MSA), a neurodegenerative disorder with similarities to Parkinson's disease. The discovery raises concerns about treatments and research involving contact with brain tissue from MSA patients.
Protein misfolding diseases are rising in incidence and seeing increasing financial and healthcare burden. Recent advances in understanding these disorders provide fresh ideas for their future therapy.
Brain cells in Parkinson's disease are vulnerable due to high energy consumption, which can lead to exhaustion and cell death. This discovery may lead to new treatment strategies for reducing energy consumption or improving energy production in neurons.
Researchers at Rockefeller University have identified two proteins, SATB1 and ZDHHC2, that appear to protect neurons from degeneration in Parkinson's disease. These proteins were found to be more abundant in dopamine-producing neurons in the substantia nigra pars compacta region, which is less affected by the disease.
Researchers discover UDCA, a decades-used liver treatment, may slow Parkinson's disease progression by rescuing damaged mitochondria. Studies confirm beneficial effects on nerve cells and genetic animal models of the condition.
Researchers at Scripps Research Institute will explore therapeutic potential of proteins regulating human health and associated diseases like Parkinson's and arthritis.
Researchers found that low-dose lithium reduced involuntary motor movements in Parkinson's disease mice, boosting dopamine synthesis via inhibition of calpain-1. This study adds to evidence that low-doses of the psychotropic drug could benefit patients suffering from the incurable condition.
A new study published in PLOS Medicine suggests that taking diabetes medication glitazones may lower the risk of developing Parkinson's disease by 28%. Researchers analyzed data from over 160,000 diabetes patients and found a significant association between glitazone use and reduced incidence of Parkinson's.
Researchers found that activating Nurr1, a class of proteins in the brain, protects dopamine neurons and improves motor control. The study suggests that existing anti-malaria drugs could be repurposed to treat Parkinson's disease.
A pilot study in Parkinson's disease suggests that remote recruitment and conduct of research visits is feasible and well-received by participants. The study leverages direct-to-consumer genetic testing and telemedicine to diagnose and treat diseases, potentially increasing participation in clinical research and accelerating diagnosis.
The UK Parkinson's Excellence Network is a multi-disciplinary effort bringing together patients, healthcare professionals, and social care experts to develop patient-centered care. The network aims to improve treatment and raise awareness of the need for better care, with a focus on education and service development.
A study found that compounds in New Zealand blackcurrants increased mental performance indicators such as accuracy and attention, while also reducing the activity of monoamine oxidase enzymes. This may lead to potential benefits for brain health and managing symptoms of disorders like Parkinson's disease and depression.
Researchers found that patients who had undergone vagotomy were protected against developing Parkinson's disease, with a risk halved after 20 years. The study suggests that Parkinson's disease begins in the gut and spreads via the vagus nerve to the brain.
Researchers at the University of Pittsburgh School of Medicine have developed a gene therapy that reduces production of brain protein α-synuclein, preventing Parkinson's disease progression in an animal study. The therapy targets mitochondria and α-synuclein interaction, showing promising results in protecting dopamine neurons.
Researchers will investigate mTOR's role in brain function and regulation using various techniques. Understanding its function in the striatum could lead to new therapies for neurodegenerative diseases.
Researchers discover that different shapes of alpha-synuclein aggregates cause distinct neurodegenerative diseases, including Parkinson's disease and Multiple System Atrophy. The study suggests new possibilities for treating brain diseases with a drug that counteracts aggregate development.
Scientists have identified a new neural circuit in the brain that tracks movement speed and delivers this information to spatial memory systems. This discovery has important implications for understanding movement-related symptoms associated with Parkinson's disease and improving spatial memory.
Researchers found that older adults' cycling speed improved while completing cognitive tasks without sacrificing cognitive performance. The study suggests combining physical activity with mental tasks may encourage more vigorous exercise.
Researchers have discovered a novel biomarker that tracks Parkinson's progression in the brain, providing a new tool for diagnosis and treatment. The study uses MRI-based diffusion imaging to measure changes in brain tissue fluid levels, which can inform treatment decisions and identify promising new therapies.
A large study found that people with depression were 3.2 times more likely to develop Parkinson's disease within a year after diagnosis. The link between depression and Parkinson's disease remained even when adjusting for other conditions related to depression.
A large study found that people with depression are more likely to develop Parkinson's disease, with a threefold increased risk within the first year. The link between depression and Parkinson's disease holds true even after adjusting for other related conditions.
The American Comparative Literature Association honored Lois Parkinson Zamora for her pioneering studies on hemispheric American studies and modern Latin American literature. Her work has been recognized nationally, with numerous publications and awards, including the John and Rebecca Moores Distinguished Professorship.
A team of neuroscientists found that misfolded a-synuclein can activate microglia, leading to chronic inflammation. They also identified specific receptors on microglial cells that respond to the protein and tested drugs to reduce inflammation.
A recent study by Ludwig Institute for Cancer Research has made a significant breakthrough in understanding the molecular mechanisms behind Parkinson's disease. The researchers discovered that disruption of a developmental mechanism, Lmx1b, leads to the death of dopamine-producing neurons, resulting in the symptoms of PD.
Researchers have made significant progress in cell transplantation therapy, demonstrating improved outcomes for patients with complete spinal cord injury and potential treatments for Parkinson's disease. Studies also show that human pluripotent stem cells hold promise for treating the disease.
A new approach has reversed Parkinson's-like symptoms in rats by delivering dopamine via biodegradable nanoparticles that crossed the blood-brain barrier without side effects. This breakthrough could lead to a new treatment for human patients.
Researchers found that serum glucocorticoid kinase 1 (SGK1) protects brain cells by blocking pathways involved in neurodegeneration and alleviating mitochondrial dysfunction. Increasing SGK1 levels offers a potential therapeutic approach for Parkinson's disease, as naturally occurring levels are not sufficient to promote cell survival.
Researchers discovered that deep-brain stimulation (DBS) reduces excessive synchronization of brain activity in the motor cortex, a region governing body movements. This reduction leads to improved symptoms and facilitated movement in patients with Parkinson's disease.
A new study by McGill University researchers found that a 12-week tango course improved balance and functional mobility in 40 Parkinson's patients, while also showing modest benefits in cognitive functions. The dance style's social interaction and physical activity may have therapeutic value for PD patients.