Articles tagged with Parkinsons Disease
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Researchers have identified the key cellular mechanism behind antipsychotic-induced parkinsonism, which includes involuntary movements and tremors. By targeting dopamine D2 receptor blockade in specialized neurons, a new approach to designing novel antipsychotics without side effects may be possible.
A large-scale study of 246,557 patients found no significant association between gadolinium exposure and parkinsonism, a degenerative disorder of the central nervous system. Researchers observed a similar incidence of incident parkinsonism among those exposed to gadolinium-enhanced MRIs as those who received non-gadolinium-enhanced MRIs.
A new biomarker, phosphorylated protein kinase LRRK2, has been found in patient urine samples and correlates with the presence and severity of Parkinson's disease. Elevated levels of this biomarker predict the risk for onset of Parkinson's disease and may be a promising guide for future clinical treatments.
Researchers found that c-Abl activation accelerates α-synuclein accumulation and motor deficits in Parkinsonian mice. This suggests a potential role for c-Abl in promoting neurodegeneration in Parkinson's disease.
Researchers at Johns Hopkins Medicine discovered that blocking the enzyme c-Abl prevents Parkinson's disease symptoms in specially bred mice. The study also found that a chemical tag on the protein α-synuclein may signal the disorder's presence and progression. The findings suggest both a promising target for drug research and a potent...
A team of scientists has discovered that two genes associated with Parkinson's disease are key regulators of the immune system, providing direct evidence linking Parkinson's to autoimmune disease. The study found that proteins produced by these genes can prevent cells from being detected and attacked by the immune system.
Researchers found that neurodegeneration in Parkinson's disease stems from endoplasmic reticulum stress rather than mitochondrial failure. ER stress prevents neurons from producing vital proteins, leading to their death. By blocking ER stress, scientists were able to prevent neurodegeneration in mutant flies.
Researcher Erika Geisbrecht is studying the connection between a gene called clueless (clu) and genes that cause Parkinson's disease in fruit flies. She aims to understand how muscles develop and maintain themselves throughout a fruit fly's life to apply this knowledge to humans.
A study of Minnesota patients found a possible increase in Parkinson's disease and parkinsonism cases between 1976 and 2005, particularly in older men. The trends may be associated with decreased smoking rates over the decades.
The study found a significant increase in Parkinson's disease incidence, particularly among men aged 70 and older. Environmental and lifestyle factors may contribute to this trend, warranting further research to identify potential causes.
A preliminary clinical trial suggests that n-acetylcysteine improves dopamine levels and cognitive function in patients with Parkinson's disease. The study used brain imaging studies to track changes in dopamine levels and found significant improvements in both measures.
Researchers at UCLA discovered that people with Parkinson's disease have impaired decision-making, particularly when sensory information is weak. This finding suggests that the neurological factors underlying Parkinson's may be more complex than previously thought and could lead to earlier detection strategies.
Researchers found that eliminating α-synuclein protein protects zebrafish from ziram-induced dopamine loss and provides potential treatment for pesticide-exposed Parkinson's patients. This study supports the approach of targeting α-synuclein to slow or stop disease progression in most people with Parkinson's.
Pittsburgh researchers uncover a major reason why alpha-synuclein, a key protein in Parkinson's disease, is toxic to neurons. They found two ways to prevent the toxicity: gene therapy and a protein that blocks alpha-synuclein from sticking to mitochondria.
Researchers discovered mutations in TMEM230, a new gene linked to Parkinson's disease, in patients from North America and Asia. The gene produces a protein involved in dopamine packaging in neurons, which is crucial for movement disorder diagnosis.
Researchers discovered a novel gene, TMEM230, associated with Parkinson's disease that affects neurotransmitter trafficking between neurons. This new link may lead to novel treatments and better understanding of neurodegenerative diseases.
Researchers found that myricitrin can help maintain two key functions of mouse neurons exposed to neurotoxicity, including enzymatic activity and rapamycin complex 1 activation. The study suggests that myricitrin could have a role in preventing neuronal degeneration in Parkinson's disease.
A dietary supplement containing 30 natural ingredients has shown promise in preventing and reversing massive brain cell loss in mice. The supplement was found to completely eliminate severe brain cell loss and abolish cognitive decline in mice with widespread brain damage.
Researchers at the Buck Institute identified a new target for treating sporadic Parkinson's disease, which accounts for 95% of all cases. The study showed that increasing PGC-1alpha expression restored mitochondrial function and prevented degeneration of dopaminergic neurons.
The fellowship program will provide postgraduate training in regulatory science to optimize clinical trial design and support approval of novel therapies for Parkinson's disease. A mentored researcher will work with experts from academia, industry, and the FDA to investigate aspects of Parkinson's research design.
A recent study found that genetic modifications, such as differential gene expression and alternative splicing, contribute to the development of Parkinson's disease. The research identifies specific genes implicated in the disease, suggesting new avenues for diagnosis and treatment.
A retrospective analysis suggests that regular laxative use can stabilize Parkinson's disease rigidity, pointing to potential modifications in underlying disease processes. Further research is planned to confirm the mechanisms involved.
Researchers developed a new technique to control dopamine-producing cells' activity in the brain. They identified the exact signalling pathway that causes involuntary movements, known as dyskinesia, and found a way to reduce side effects.
Researchers have developed detailed digital models of organs that can accurately monitor and outcome measurements for clinical trials. These models can enable more effective monitoring of the impact of new drugs and treatments, reducing the need for invasive tests.
Researchers at Lund University have proven that transplanted nerve cells can survive and function in the human brain for many years, restoring normal dopamine production. A study followed a Parkinson's patient whose nerve cells survived for nearly a quarter of a century after transplantation.
Researchers found that a JAK/STAT pathway inhibitor, AZD1480, reduces neuroinflammation and neurodegeneration in Parkinson's disease rat models. The study suggests that Jakinibs may be an important new approach to slow the progression of the disease.
Researchers studied Parkinson's-affected cells before symptoms appear, finding declines in dopamine neuron function and electrical activity. The study aims to understand the root cause of the disease and develop a therapy to arrest its progression.
Stanley Fahn, a pioneer in the field of movement disorders, will receive the 2016 Jay Van Andel Award for Outstanding Parkinson's Disease Research. He has made significant contributions to the development of rating scales for Parkinson's and other diseases.
A lab-based study led by University of Leicester researchers has found a way to 'reverse' symptoms of neurodegenerative diseases like Parkinson's and Alzheimer's using genetic and pharmacological approaches. The study utilized fruit flies to explore the role of specific metabolites in the kynurenine pathway, which can help alleviate sy...
Researchers identified a compound that reverses symptoms of Alzheimer's and Parkinson's diseases in genetically altered fruit flies. The study suggests that the treatment could work for humans by targeting a specific enzyme involved in disease progression.
Caltech researchers have mapped out a circuit of neurons that control motor impairment in patients with Parkinson's disease. The study used two laboratory techniques to identify the pathways of cholinergic neurons in the brainstem, revealing their role in both locomotion and reward-based behaviors.
Researchers found that unexpected events activate the same brain system responsible for interrupting movement, leading to impaired working memory and disrupted trains of thought. The study focuses on the subthalamic nucleus (STN), a key player in Parkinson's disease treatment.
Researchers found a genetic variation linked to slower Parkinson's disease progression, lower alpha-synuclein levels, and tremor-dominant symptoms. The 'good' GG genotype was associated with better outcomes for patients, including slower physical decline and lower dementia risk.
Common Parkinson's disease medications can cause impulse control disorders such as pathological gambling, compulsive buying and binge eating in some patients. Alternative treatment strategies include adjusting medications, deep brain stimulation and cognitive behavioral therapy.
Researchers at Temple University Health System found that disturbances in circadian rhythm exacerbate motor and learning deficits in Parkinson's disease. Altering circadian rhythm through daily light exposure can accelerate cell death and worsen neuroinflammation, potentially speeding disease progression.
A new Parkinson's disease study has found significant variability in brain signaling that could serve as a predictive marker for identifying patients at highest risk of dementia. Measuring brain signal variability may help identify the best patients to include in trials of new neuroprotective drugs.
Chemists at the University of Illinois have identified the complex chemical structure of alpha-synuclein, a protein that forms long fibrils in the brains of Parkinson's disease patients. This knowledge will help researchers identify specific targets for diagnosis and treatment.
A Danish population study found patients with rosacea had a higher risk of new-onset Parkinson's disease compared to the general population. The study also suggests that tetracycline use may reduce PD risk, but further studies are needed for confirmation.
A recent study found that antipsychotic drug use is associated with higher mortality among all Parkinson's disease patients, not just those with dementia. The researchers compared records of over 15,000 patients and found a significant increase in mortality rates among those who took antipsychotics.
A study on Bengalese finches found that dopamine levels in a specific region of the brain are crucial for correcting vocal errors. The research suggests that dopamine plays a vital role in sensory-motor learning, which underlies skills such as speaking and singing.
The study reveals that protein misfolding in the brain can be toxic, even before visible amyloid fibrils form. Researchers used super-resolution microscopy to observe how alpha-synuclein proteins interact and found that excess soluble protein can cause toxic effects.
A study published in Neurobiology of Disease found that neurons with a defective DJ1 gene experience oxidative stress and immune response imbalances due to disrupted glutamine and serine metabolism. This knowledge could lead to novel therapeutic strategies by targeting affected metabolic pathways.
A study using molecular simulations suggests that polyunsaturated lipids can alter the binding rate of dopamine and adenosine receptors, affecting cell function in neurodegenerative diseases. This discovery could lead to new therapeutic pathways for regulating receptor binding.
Seven major pharmaceutical companies have signed up to a groundbreaking Parkinson's consortium aimed at accelerating the development of safe and effective therapies. The consortium will share data, expertise, and resources with leading academics and industry members to promote and develop new treatments for Parkinson's.
A stem cell study published in Stem Cell Reports has discovered that the GBA1 mutation creates problems with protein processing and recycling in cells, leading to an accumulation of alpha-synuclein. This excess protein is released into the brain, contributing to Parkinson's spread and symptoms.
A study published in The Journal of Physiology found that neurons in the thalamus can be conditioned to respond to placebos in Parkinson's patients. When apomorphine was administered before a placebo, it increased thalamic neuronal activity and clinical improvement. The response lasted up to 24 hours.
A new study published in PLOS Medicine found that Parkinson's patients experience a higher risk of injurious falls and hip fractures up to 30 years before diagnosis. This suggests early signs of balance issues may be an indicator of the disease.
Research found patients with PD were more likely to have had a hip fracture or injurious fall in the years preceding their diagnosis. Individuals who suffered injurious falls were also at higher risk of being diagnosed with PD in following years.
Researchers at EPFL create cellular and mouse models that accurately reproduce the evolution of Parkinson's disease, using insights into protein clumps called Lewy bodies. The new models can propel research and drug development, offering a powerful tool for rapid screening of molecular pathways involved in the disease.
Researchers at Mayo Clinic have developed a saliva gland test that can detect early Parkinson's disease. The test involves taking a biopsy of the submandibular gland, which has been shown to be effective in detecting the abnormal protein associated with the disease in 14 out of 19 patients.
Researchers at Gladstone Institutes uncover a neural circuit that controls walking and find a new target for treating Parkinson's disease. Dopamine depletion disrupts movement by miscommunicating between the basal ganglia and thalamus, leading to an imbalance between go and stop pathways.
Scientists have identified a protein called Tet3FL that acts as a 'guardian' against neurodegenerative diseases like Parkinson's. Tet3FL removes molecules called methyl groups from specific genes, keeping them active and maintaining cellular 'trash removal' processes.
A large clinical trial conducted on patients with mild to moderate Parkinson disease found no clinically meaningful benefits from physiotherapy and occupational therapy. The study included over 762 patients who were randomly assigned to receive these therapies or no treatment.
Researchers from the University of Birmingham conducted a trial finding that physiotherapy and occupational therapy do not improve 'activities of daily living' in patients with mild to moderate Parkinson's disease. The study suggests that resources should be reallocated towards more effective treatments.
Ongoing aerobic exercise has been shown to enhance factors that potentially have a protective effect on the brain, counteracting brain shrinkage and improving connections in individuals with Parkinson's disease. Aerobic exercise can also help manage symptoms such as rigid muscles, slowed movement, and impaired posture and balance.
Men with high urate levels have a lower risk of developing Parkinson's disease, according to a study published in Neurology. The study found that men with the highest urate levels were nearly 40% less likely to develop the disease.
A team of researchers at Boston University School of Medicine has discovered a previously unknown cellular defect in patients with idiopathic Parkinson's disease. The findings suggest that the cells' dysfunction of calcium homeostasis can determine whether certain neurons live or die.
A study published in The Lancet Neurology found that people with Parkinson's who took the oral drug rivastigmine were 45% less likely to fall and steadier when walking. This breakthrough treatment has the potential to improve quality of life for millions worldwide.
Researchers found an association between weight loss and rapid disease progression in Parkinson's patients. Those who lost weight showed a greater increase in symptoms, while those who gained weight had the smallest annual increase.
A clinical trial is underway to investigate the use of cholesterol-lowering drug Simvastatin in treating Parkinson's disease. The study, funded by several organizations, aims to explore its potential neuroprotective effects and could lead to new treatments for the condition.