Articles tagged with Parkinsons Disease
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Researchers developed a new approach to identify reliable blood biomarkers for Parkinson's disease, which may lead to early diagnosis and targeted treatments. The study found RNA signatures that correlate with the disease-causing mutations in the LRRK2 gene.
Researchers have developed a safe and effective therapeutic strategy for Parkinson's disease using mitomycin-treated embryonic stem cells. The treatment showed significant improvements in motor function and survival rate in mice, with no tumor formation detected.
Researchers found that inflammatory cells from the bloodstream play a key role in neurodegeneration in Parkinson's disease. CD95L-bearing immune cells cause damage to neurons, and blocking this molecule can prevent neurodegeneration in mice. This suggests that early treatment with drugs targeting CD95L might mitigate Parkinson's symptoms.
The Michael J. Fox Foundation is supporting research on a novel therapy for Parkinson's disease by Dr Bryce Vissel and Sandy Stayte at the Garvan Institute of Medical Research. The prototype drug targets kainate receptors to slow disease progression.
Patients with Parkinson's disease experienced improved or eliminated preoperative pain after eight years following subthalamic nucleus deep brain stimulation. However, new musculoskeletal pain developed in 75% of patients during the follow-up period.
Scientists at OIST Graduate University found that cell groups in the neostriatum do not communicate with each other and are less interconnected. The discovery has implications for studying diseases like Parkinson's, which affects motor control.
New research confirms GDNF is not necessary for maintaining dopamine neurons, contradicting previous findings. The absence of GDNF in mice did not cause significant damage to the midbrain dopamine system or trigger motor disorders.
Researchers discovered a new pathway in the brain's striatum where several areas communicate to make spatial decisions, such as estimating where to swing a bat or finding a car. This knowledge may lead to improved treatments for Parkinson's disease by strengthening damaged pathways.
Scientists develop peptide that binds to misshapen α-synuclein protein, stopping toxic fibril formation and brain cell death. The research offers a potential new approach for slowing Parkinson's disease progression.
Researchers discovered a skin test that can detect abnormal proteins associated with Alzheimer's and Parkinson's diseases. The study used skin biopsies to compare patients' protein levels, revealing seven times higher tau protein levels for those with both conditions.
A UBC study shows that Twitter is a valuable resource for healthcare professionals, with 25% of tweets about spinal cord injury coming from medical experts. The study also found that users discussing Parkinson's disease were more likely to share new research tools and methods.
Researchers have discovered a novel mechanism of neuronal death involved in neurodegenerative protein-misfolding diseases like Alzheimer's and Parkinson's. The study found that the loss of NAD+ is the primary cause of neuronal demise, and restoring it can rescue neurons.
Researchers at Karolinska Institutet found that eltoprazine significantly reduced Parkinson's disease patients' dyskinesia while maintaining anti-Parkinsonian effects. The treatment was well-tolerated and shows promise as a new therapeutic principle for treating L-dopa-induced dyskinesia.
A recent study published in JAMA found that creatine monohydrate treatment did not improve clinical outcomes for patients with early and treated Parkinson disease. The study, which followed 1,741 participants for up to 8 years, suggests that creatine may not be a viable treatment option for slowing disease progression.
Global sea ice has been decreasing at an average annual rate of 13,500 square miles since 1979, with the Arctic losing more than it gains in Antarctica. The Arctic ice decrease has accelerated over time, leading to increased absorption of solar radiation and further heating.
Researchers at UT Southwestern Medical Center developed a wearable sensor system to track gait, balance, and other movements in individuals with Parkinson's disease. The APDM Mobility Lab can effectively assess the severity of the disorder even when medications are used to reduce symptoms.
A new study by University of Cambridge researchers identified a critical threshold in alpha-synuclein protein levels that increases the chances of aggregation and neurodegeneration. The findings provide a mechanistic description of the initial molecular events leading to Parkinson's disease.
Researchers found that xanthohumol, a compound in hops, can protect neuronal cells from oxidative damage, potentially slowing the development of brain disorders like Alzheimer's and Parkinson's diseases. The study suggests xanthohumol could be a promising candidate for fighting neurodegenerative conditions.
A new study published by the American Academy of Neurology found that patients with Parkinson's disease experience improved motor skills when receiving an 'expensive' drug, even if it's just a placebo. The study suggests that harnessing the placebo response could enhance treatment benefits and reduce dosage needs.
Researchers at Scripps Research Institute have identified drug candidates targeting biological pathways involved in brain cell destruction in Parkinson's disease. The new compounds selectively inhibit JNK kinases, which play a central role in the disease, and show promise as potential therapeutics.
A new study published in Neurology found that low-frequency deep brain stimulation at 60Hz significantly improves swallowing dysfunction and freezing of gait in Parkinson's patients. This treatment is more effective than standard high-frequency DBS at alleviating these symptoms, which can lead to disability and mortality.
Laurie Sanders, a Pitt assistant professor of neurology, will receive the William N. & Bernice E. Bumpus Foundation Innovation Award. The award supports her research on unrepaired mtDNA damage and its role in Parkinson's disease development.
Researchers discovered a protein in E. coli that inhibits the accumulation of toxic amyloids, a key feature of Parkinson's disease. The finding could lead to a new therapeutic approach for treating Parkinson's.
Researchers at UCSD have identified a specific region of the alpha-synuclein protein where mutations can lead to the creation of ring oligomers, causing cell death. This discovery could lead to the development of compounds that target this region to prevent or treat Parkinson's disease.
Researchers at University of Gothenburg tested portable stimulator on 10 Swedish Parkinson's patients, showing improved balance and combined symptoms. The active noise stimulation improved the patients' balance and symptoms when unmedicated, and may lead to new treatment in the next five years.
A study published in Neurology found that exercise programs can reduce falls and improve mobility in people with Parkinson's disease, particularly those with less severe symptoms. Participants who exercised showed a 70% reduction in falls and better overall mood and quality of life compared to those who did not participate.
Researchers found that methamphetamine users are three times more likely to develop Parkinson's disease than non-users, with women facing nearly five times the risk. The study suggests long-term effects of meth use may manifest years after initial use, leading to increased incidence in women.
Parkinson's patients, medics, and carers identified top 10 research priorities for managing the condition. The list includes balancing treatments for falls and improving sleep quality, as well as addressing stress, anxiety, and dyskinesias.
Researchers at IRCM have discovered a mechanism that regulates dopamine levels in the brain, which could lead to new treatments for Parkinson's disease. The Rgs6 gene plays a crucial role in preventing excessive dopaminergic signalling and cellular stress.
Researchers found a link between gut microbiota and Parkinson's disease, with patients having lower levels of Prevotellaceae bacteria and higher levels of Enterobacteriaceae family in their intestines. The study suggests that intestinal dysfunction may be part of the pathology and potentially related to the progression of the disease.
Researchers found no evidence of asymptomatic myocardial dysfunction or deterioration of systolic function in patients taking pramipexole and ropinirole. This suggests that non-ergot derived dopamine agonists may be safe for the heart, contradicting previous concerns about an increased risk of heart failure.
Drs. Alim Louis Benabid and Mahlon DeLong developed deep brain stimulation (DBS) for treating Parkinson's disease, improving motor function and quality of life for thousands of patients. Their groundbreaking research has led to the use of DBS in other disorders, benefiting over 110,000 patients worldwide.
A new study found that Parkinson's patients' brain activity improves equally in response to real medication and placebo treatment, highlighting the power of expectations to drive changes in the brain. The research suggests that dopamine-rich areas in the brain are activated when patients believe they have received medication, offering ...
Parkinson's patients experience changes in body weight due to non-motor disorders, worsening their quality of life. Research highlights the role of depression, cognitive impairment, sensory disturbances, and motivation towards food consumption in altering eating habits.
A new study published in Brain: A Journal of Neurology found that a medium amount of physical activity can lower the risk of Parkinson's disease. Participants who spent more than six hours per week on household and commuting activities had a 43% lower risk of developing the disease.
Researchers found that Parkin triggers 'cellular suicide' in damaged nerve cells, depending on the degree of damage, and may help weed out faulty neurons. This discovery could lead to a new understanding of how Parkinson's disease arises.
Researchers created a cellular model of Parkinson's disease using human stem cells from identical twins with the disease. The study found that dopamine-producing neurons had reduced activity and higher levels of α-synuclein protein, which can be targeted for therapy.
Transplantation of stem-cell-derived dopamine neurons restores motor function in a rat model of Parkinson's disease, suggesting a viable alternative to existing treatments. The therapy demonstrates efficacy and potency similar to fetal neurons, paving the way for human clinical trials.
Researchers have discovered that inhibiting a particular mitochondrial fission protein could reverse Parkinson's Disease symptoms by reducing cell death and dopamine release deficits. This study offers exciting potential for an effective treatment and paves the way for future studies in this field.
Researchers at the University of Copenhagen found that a high-fat diet can postpone signs of brain aging in mice with a defective DNA repair system. This could lead to new treatment possibilities for children with Cockayne syndrome and patients with Alzheimer's and Parkinson's disease.
Researchers have developed a method to deliver drugs more effectively for Alzheimer's and Parkinson's using micro and nanoparticles. Encapsulated growth factors have been found to be much more effective than traditional oral medications in animal trials, improving symptoms and healing damaged zones.
Researchers found that deacetylase inhibitors can fully restore movement problems caused by the LRRK2 Parkinson's mutation in fruit flies. This study provides compelling evidence for a direct link between defective transport and movement problems, suggesting a potential therapy for people with this specific mutation.
The Braak hypothesis suggests that Parkinson's disease begins in the digestive tract and spreads to the brain. Researchers at Lund University have now found direct evidence of this process, tracking the spread of alpha-synuclein protein from the gut to the brain in rat models.
Researchers have made a groundbreaking discovery about the similarities and differences between two neurodegenerative diseases, progressive supranuclear palsy and Parkinson's Disease. The study reveals that individuals with PSP experience more severe cognitive impairments than those with PD early on.
Researchers at UCLA have discovered that the drug AT2101 improves motor function, stops inflammation, and reduces alpha-synuclein levels in mouse models of Parkinson's disease. This finding suggests that further investigation into the compound's potential for treating Parkinson's is warranted.
Researchers have observed a significant increase in Antarctic sea ice extent, reaching a new record high. This upward trend is an exception to the overall decline of sea ice globally.
University of Michigan scientists are launching a five-year effort to better understand the cause of falls in Parkinson's patients and find new options based on brain science. The Udall Center of Excellence will focus on the cholinergic system, which helps regulate attention and balance.
Sok Kean Khoo, a GVSU researcher, has received a $110,000 grant from the Michael J. Fox Foundation to study molecular biomarkers for Parkinson's disease. The goal is to develop a blood test for early detection and potentially improve treatment options for the incurable neurological disorder.
Researchers at Beth Israel Deaconess Medical Center identified brain networks that can help guide site selection for brain stimulation therapies. The findings suggest that stimulating sites in the same connected brain network can improve treatment outcomes across multiple neurological and psychiatric disorders.
A new study finds that people with middle-age migraines are more likely to develop Parkinson's disease and other movement disorders. Those with migraine with aura face a higher risk, with women also being more prone to a family history of the condition.
Research suggests that a high-fat diet can accelerate neurological symptoms in mice genetically predisposed to Parkinson's disease. This diet also causes damage in the brain and affects glucose and insulin regulation.
Baicalin inhibits iron accumulation after substantia nigra injury by down-regulating divalent metal transporter 1 and increasing ferroportin 1 expression. This study suggests baicalin as a potential therapeutic agent for Parkinson's disease prevention.
A recent study analyzing data from over 1,700 patients found that the complication risk of deep brain stimulation (DBS) is similar for both older and younger Parkinson disease patients. The results suggest that age should no longer be a rigid exclusion criterion for DBS candidates.
Researchers at Duke Medicine report that implanting deep brain stimulation devices poses no greater risk of complications to older patients with Parkinson's disease. In a study analyzing over 1,750 patients, the team found that increasing age did not significantly affect overall complication rates.
A new Penn Medicine study found that dopamine replacement therapy is associated with an increase in impulse control disorders and excessive daytime sleepiness in newly diagnosed Parkinson's disease patients. In contrast, fatigue improved with dopamine therapy, but depression remained undertreated.
Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease by modulating neurotransmitter signaling in the corpus striatum. This finding suggests a potential new treatment for this debilitating condition.
Researchers at Max Planck Institute show that supplying D-lactate or glycolate, two products of the gene DJ-1, can restore mitochondrial activity and prevent neuron degeneration in Parkinson's disease. These substances may also have a general role in protecting cells from decline.
Researchers found that naltrexone reduced symptoms of compulsive gambling and other behaviors in PD patients. The medication may help alleviate these issues due to dopamine agonist treatment, not necessarily a result of the disease itself.
Researchers analyzed data from over 18,000 patients to find more than two dozen genetic risk factors involved in Parkinson's disease, including six previously unknown. The study confirms that the more variants a person has, the greater their risk of developing the disorder.
Researchers at Emory University School of Medicine found that XPro1595 can protect vulnerable neurons and reduce motor deficits in a rat model of Parkinson's disease. The drug targets tumor necrosis factor, a critical inflammatory signaling molecule, and showed benefits when administered by subcutaneous injection.