Articles tagged with Parkinsons Disease
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A study published in JAMA Neurology found that inosine treatment increases blood and cerebrospinal fluid urate levels in early Parkinson disease patients, suggesting a potential strategy to slow disability progression. The treatment was also shown to be safe and tolerable, with minimal serious adverse events.
Patients with Parkinson's disease struggle to recognize emotions in facial expressions and speech prosody. After surgery for deep brain stimulation, they show difficulty recognizing disgust and sadness, but this impairment is only temporary.
The study involved 23 people with deep brain stimulators and 21 without stimulators, who completed driving tests in a simulator. Those with stimulators performed better on driving tests, especially when the device was turned on.
The Parkin enzyme activates a signal pathway that protects neurons from damage, increasing the expression of protective factors. This process may provide novel therapeutic targets to halt or delay neurodegeneration in Parkinson's disease.
Scientists have identified a biological pathway linking Gaucher disease and Parkinson's disease. The connection is attributed to the accumulation of defective proteins, leading to an overload of cellular machines that dispose of defective proteins. This cascade triggers cell death in dopamine-producing cells, resulting in PD symptoms.
Researchers explore the connection between pesticides and Parkinson's disease, discovering two genetic mutations linked to increased risk in pesticide-exposed individuals. The study highlights the complexity of the disease and the need for further investigation into pesticide exposure and its potential effects on human health.
A review of subthalamic nucleus deep brain stimulation effects on Parkinson's disease patients reveals that while it improves motor features, social maladjustment and certain aspects of quality of life can be negatively impacted. Effective strategies are needed to mitigate these adverse effects and improve patients' overall well-being.
A new study shows that telemedicine consultations can effectively manage Parkinson's symptoms and improve quality of life. Virtual house calls enable individuals with the condition to live independently while receiving specialized care.
Researchers used RNA interference to identify dozens of genes that may regulate mitochondrial disposal, opening new drug targets for Parkinson's and related disorders. Four helper genes were found to enhance or inhibit tagging of damaged mitochondria.
Scientists at UCLA and Emory University have identified a biochemical signal in the blood associated with the faster-progressing form of Parkinson's. The researchers discovered that N8-acetyl spermidine is significantly elevated in rapid progressors, suggesting its potential as an early biomarker for the disease.
Researchers found that a volatile organic compound emitted by fungi, 1-octen-3-ol, attacks genes responsible for dopamine transport and packaging, leading to Parkinson's-like symptoms in fruit flies. The study suggests a potential link between fungal exposure and the degeneration of dopamine-producing neurons.
Researchers developed a simple dot test called the Triplets Learning Task (TLT) to assess dopamine loss in Parkinson's disease. The test shows promise as a non-invasive way to evaluate dopamine deficiency and may lead to new ways to improve treatment for PD patients.
A study published in Neural Regeneration Research found that Parkinson's patients with psychosis had greater white-matter fiber injury than those without psychosis. This difference may explain why psychosis often occurs in Parkinson's disease patients.
A new algorithm developed at Northwestern University can accurately track physical activity no matter where a patient carries their phone. The study's findings are crucial for improving the health of patients with Parkinson's disease, who may carry their phones in different locations throughout the day.
A study using voxel-based magnetic resonance morphometry found significant gray matter volume loss in Parkinson's disease patients compared to healthy controls. This loss was particularly pronounced in temporal, occipital, parietal, frontal, insular, and cerebellar regions.
A new drug, pimavanserin, has shown significant improvement in reducing psychotic symptoms in Parkinson's disease patients. The study found a 37% improvement in psychotic symptoms compared to placebo, with no worsening of motor symptoms reported.
A study led by TGen found that reduced SMG1 expression may contribute to alpha-synuclein pathology in Parkinson's disease and dementia. The researchers identified SMG1 as a regulator of alpha-synuclein aggregation, suggesting potential new therapeutic targets for treatment.
Researchers have identified a novel Parkinson's disease drug target and a compound capable of repairing neurons derived from human stem cells. Using a discovery platform combining yeast cells with human stem cells, scientists found that the compound reversed alpha-synuclein toxicity in yeast cells and partially rescued neurons in anima...
Researchers at University of Luxembourg's LCSB have published an interactive Parkinson's disease map, allowing scientists to systematically study the disease through a clearer understanding of existing knowledge. The map facilitates the identification of gaps in current understanding and establishes new research hypotheses.
NYSCF and PPMI collaborate to develop stem cell lines from patients, enabling researchers to study Parkinson's disease progression. The partnership aims to identify biomarkers and accelerate treatment development.
A study published in Neurology found that alpha-synuclein, a protein associated with Lewy bodies, is elevated in the skin of people with Parkinson's disease. This could lead to the development of a biomarker for early diagnosis and improved treatment options.
A study published in Neurology found that people with depression are three times more likely to develop Parkinson's disease than those without depression. Researchers analyzed 4,634 individuals with depression and 18,544 without depression over a 10-year period.
Researchers found significant cortical thinning and subcortical atrophy in Parkinson's patients with mild cognitive impairment, indicating faster neurodegeneration. This pattern may serve as a predictor of dementia in PD patients in the future.
A University of Houston researcher has won a $330,000 NSF grant to develop signal-processing techniques that interpret electrical activity recorded by deep brain stimulation probes. This technology aims to provide real-time feedback to neurosurgeons, allowing them to guide probe placement and perform surgeries faster and more accurately.
Scientists at University of Wisconsin-Madison discover that zinc ions play a crucial role in maintaining protein stability. A shortage of zinc can cause proteins to misfold and clump together, leading to cell death. Researchers identify a 'protein chaperone' called Tsa1 that prevents protein aggregation and maintains cellular balance.
Researchers discovered a mechanism by which damaged mitochondria signal their own destruction, allowing cells to thrive. The 'eat me' signal involves cardiolipins and a protein called LC3, opening doors to potential research into cures for Parkinson's disease.
Researchers have identified distinctive epigenetic modifications associated with Parkinson's disease that can be easily analyzed in blood samples. These changes replicate the epigenetic status of brain tissue cells, potentially simplifying early diagnosis of the disease.
Mayo Clinic researchers have discovered a genetic mutation that alters lipid metabolism in Parkinson's patients, leading to higher levels of ceramides and glucosylceramides in the blood. This biomarker is associated with severe cognitive impairment and dementia in Parkinson's disease.
A study of residents in Olmsted County, Minn., over 15 years found the incidence of dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD) to be higher among older adults. The study also identified age-related increases in both DLB and PDD rates.
A study found a link between early-onset Parkinson's disease and a genetic deletion on chromosome 22, shedding light on molecular changes that lead to the disease. The deletion is associated with abnormal protein accumulations in the brain and may delay diagnosis by up to 10 years.
Researchers have taken detailed images and measurements of a brain protein thought to play a role in Parkinson's disease. The protein morphs from its globular shape into 'protofibril' strands that assemble into pore-like rings.
Scientists at the University of Sheffield have identified a synthetic drug, ursodeoxycholic acid (UDCA), that may slow down Parkinson's progression by making faulty mitochondria work normally again. This breakthrough discovery has the potential to improve symptoms and possibly halt disease progression.
Researchers analyzed cerebrospinal fluid biomarkers in patients with early-stage Parkinson's disease (PD) and healthy controls. Lower levels of Alzheimer's beta-1-42 and tau proteins were found in PD patients, associated with motor severity. The study suggests that these biomarkers have prognostic potential for early-stage PD.
Researchers at the University of Pennsylvania School of Medicine have developed a comprehensive test for protein biomarkers in spinal fluid that shows prognostic and diagnostic value in early stages of Parkinson's disease. The study found that patients with lower levels of tau and alpha synuclein had greater motor dysfunction, while th...
Researchers have identified a new biological target for combating Parkinson's disease by discovering a compound that eases symptoms in mice. The study found that a protein called AIMP2 activates a self-destruct pathway, leading to cell death, but also triggered the activation of PARP1 and PAR, which can be targeted by existing compounds.
Researchers at WashU Medicine found that corrupted proteins spread in the brain through a specific type of receptor called heparan sulfate proteoglycans (HSPGs). Blocking this receptor may aid treatment of Alzheimer's and Parkinson's diseases, potentially unifying understanding and treatment of multiple neurodegenerative conditions.
A UCSF team discovered that a chemical found in an anti-wrinkle cream can increase mutant PINK1 enzyme activity to near normal levels, reversing cell death caused by Parkinson's-disease mutations. This finding suggests potential for new treatment strategies and raises hope for combatting other diseases, including diabetes and cancer.
A new study published in Neural Regeneration Research suggests that X-linked methyl-CpG binding protein 2 (MeCP2) may be a promising therapeutic target for treating Parkinson's disease. Researchers found that overexpressing MeCP2 in damaged human cells reduced apoptosis and increased tyrosine hydroxylase levels, indicating potential be...
A study published in Nature Neuroscience reveals that genetic mutations linked to Parkinson's disease can cause problems with mitophagy, a process essential for eliminating damaged cells. The research suggests that targeting this pathway could lead to the development of more effective drug treatments.
Researchers analyzed data from over 30,000 patients to determine if Parkinson's disease and Alzheimer's disease share a common genetic risk factor. The study found no evidence of such overlap.
A new study by Rush University Medical Center researchers found that a sudden decrease in testosterone levels may cause Parkinson's-like symptoms in male mice. Testosterone supplementation reversed the pathology in the mice. The study suggests that preserving testosterone levels may be important to prevent Parkinson's disease.
Research in Taiwan found a link between stopping cholesterol medication and an increased risk of developing Parkinson's disease. Fat-soluble statins were associated with a reduced risk, while hydrophilic statins showed no such correlation.
Researchers at Scripps Research Institute discover that parkin enzyme loss leads to reduced levels of protective protein Fbw7β, causing neuronal stress and death. Targeting Fbw7β may offer a new neuroprotective strategy for Parkinson's disease and other neurodegenerative disorders.
Researchers at Banner Sun Health Research Institute and Mayo Clinic are working together on a diagnostic test to identify early Parkinson's disease in patients. They believe that transcutaneous submandibular gland biopsy may provide the needed accuracy, as they look for a protein in the cells from patients with early Parkinson's disease.
This study examines how Parkinson's disease affects the health-related quality of life in northeastern Sicily, Italy. The researchers applied the ecological model to investigate the individual and social environmental factors impacting patient outcomes, including depression, cognitive impairment, coping strategies, and family size.
A recent Penn study found a significant association between cerebrovascular disease and dementia, particularly in younger patients with Alzheimer's disease. The researchers suggest that early management of vascular risk factors and healthy lifestyles may delay or prevent the onset of dementia due to Alzheimer's and Parkinson's disease.
Researchers found two distinct strains of alpha-synuclein that promote different patterns of misfolding, leading to unique sets of symptoms in neurodegenerative disorders. The study suggests that different structural shapes of the protein may contribute to co-occurrence of synuclein and tau accumulations in certain brain diseases.
Researchers have discovered that a single protein, alpha-synuclein, can exist in two different structural shapes, or 'strains', which promote misfolding of other disease proteins commonly found in Alzheimer's and Parkinson's. This finding has significant implications for the development of therapies for neurodegenerative diseases.
Researchers propose a new motion test that examines various walking features in healthy and clinical populations, identifying critical changes in mobility. The study uses advanced mathematical computations to extract data from accelerometer signals, showing significant differences between healthy and clinical groups.
Lauren Sciences LLC has received a second grant from the Michael J. Fox Foundation to further develop its V-Smart therapeutic platform for treating Parkinson's disease. The grant will investigate the efficacy of V-Smart vesicles in delivering GDNF to brain regions affected by PD.
Researchers at Scripps Research Institute design a dual inhibitor attacking leucine-rich repeat kinase 2 (LRRK2) and c-jun-N-terminal kinase (JNK) enzymes, two proteins closely linked to Parkinson's disease development. The compound may offer a more effective treatment by eliminating complications of individual inhibitors.
Researchers have found that diapocynin, a synthetic antioxidant molecule, protects neurobehavioral function in mice with Parkinson's Disease symptoms. The treatment prevented expected deficits in motor coordination, suggesting potential therapeutic benefits.
Researchers at Tel Aviv University found that mannitol prevents clumps of α-synuclein protein from forming in the brain, a process characteristic of Parkinson's disease. Mannitol has been shown to reduce aggregates of α-synuclein in genetically-altered flies and mice.
A new University of Florida study suggests a brain-imaging technique can help diagnose movement disorders. The diffusion tensor imaging technique was used on 72 patients with movement disorder diagnoses, with high accuracy achieved in separating the patients into disorder groups.
Scientists at the Vienna University of Technology have observed and explained the dance of atoms on iron-oxide surfaces. They found that carbon monoxide is the partner responsible for rapid motion, which leads to clustering and reduces the effectiveness of catalysts. A hydroxyl coating of the surface can suppress this effect.
A new surgical technique for deep brain stimulation (DBS) has been developed, allowing for more accurate placement of brain electrodes and reducing complications. The procedure is safer and faster than traditional DBS surgery, making it a promising treatment option for various medical conditions beyond Parkinson's disease.
The IUPUI research collaboration used advanced mathematical models and laboratory testing to examine the effects of simulated drug addiction on neural circuits. The study found that recurrent stimulant injections caused neurons to lose their ability to engage supervisory control over brain function and behavior.
A new study found that increased serum iron levels are associated with a 3% relative reduction in the risk of developing Parkinson's disease. The research used a Mendelian randomization approach to investigate the link between iron levels and Parkinson's disease risk.
A meta-analysis of over 100 studies found exposure to pesticides, weed killers, and solvents is associated with a higher risk of developing Parkinson's disease. The research suggests that the risk increases in a dose-response manner as length of exposure to these chemicals increases.
Scientists develop new animal model to study Parkinson's disease, tracing protein spreading in brain regions. The experiment reveals clues on mechanisms underlying pathological progression.