A new study published in JAMA Neurology finds ecopipam to be effective in suppressing tics in patients with Tourette syndrome. The medication was well-tolerated and showed no significant adverse effects over a period of up to 24 weeks.
A Kobe University study reveals a neuronal connection between the motor cortex and insular cortex that regulates tics in Tourette's syndrome. The discovery suggests a new pathway for treating the condition, potentially involving non-invasive therapies like ultrasound neuromodulation.
A study published in Neurology found that female individuals with Tourette syndrome are less likely to be diagnosed, take longer to receive a diagnosis, and are diagnosed at an older age than males. The study also showed that symptoms started earlier in females with persistent motor or vocal tic disorder.
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Behavioral therapies are proven to be the most effective treatment for Tourette syndrome, teaching patients how to manage tics using behavioral strategies. The therapies train patients to recognize early signs of an upcoming tic and implement strategies to reduce tic severity.
SourceKennedy Krieger Institute·JournalPsychiatric Clinics of North America·DateNov 18, 2024
A new study suggests that ecopipam, an experimental drug, may improve tic severity in children and teens with Tourette syndrome. After three months, the group taking ecopipam had fewer and less severe tics, with a 30% decrease in motor and vocal tic severity scores.
Researchers have replicated and expanded on previous work to show that tics associated with Tourette syndrome have a fractal pattern, which can predict disease severity. This discovery could lead to a diagnostic tool for doctors to analyze tic patterns and diagnose patients with Tourette's
SourceWashington University in St. Louis·JournalJournal of The Royal Society Interface·TypeComputational simulation/modeling·DateFeb 23, 2022
A team of researchers from Charité – Universitätsmedizin Berlin has identified a neural network that generates tics, which could lead to improved treatment of people with Tourette syndrome. The study found that targeting this network via deep brain stimulation can alleviate symptoms in patients.
SourceCharité - Universitätsmedizin Berlin·JournalBrain·DateJan 20, 2022
A study published in Neurology found that strep throat exposure was associated with an increase of about 20% in ADHD symptoms of hyperactivity and impulsiveness in children with chronic tic disorders. However, researchers did not find a link between strep exposure and worsening tics or symptoms of OCD.
SourceAmerican Academy of Neurology·JournalNeurology·DateFeb 10, 2021
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Researchers at Osaka University developed an oral device that effectively reduces motor and vocal tics in Tourette syndrome patients. The study found that the oral splint improved tic symptoms for both children and adults, with long-lasting effects.
SourceOsaka University·JournalMovement Disorders·DateSep 9, 2019
A Yale study has trained adolescents with Tourette Syndrome to control their tics through real-time fMRI, achieving significant symptom reductions. The technique, called rt-fMRI-NF, involves monitoring brain activity in real time and adjusting it towards healthier patterns.
SourceYale University·JournalBiological Psychiatry·DateAug 21, 2019
A meta-analysis of multiple studies identifies hundreds of gene variants contributing to Tourette's syndrome, with more severe symptoms associated with increased risk variants. The study suggests a continuous spectrum of tic disorders and raises the possibility of predicting TS development in children with mild tics.
SourceMassachusetts General Hospital·JournalAmerican Journal of Psychiatry·DateMar 1, 2019
A new study found that 35% of young singers in an elite choir exhibited tics during a performance. This discovery may indicate a relation between ticcing and exceptional motor skills, potentially leading to a reevaluation of the perception of tics as a disorder.
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A new computational model simulates the role of the brain in Tourette syndrome, suggesting that motor tics arise from interactions between multiple brain areas. The model predicts how dysfunctions in neural circuits can lead to an increased number of tics, which could aid in identifying new treatment targets.
SourcePLOS·JournalPLOS Computational Biology·DateMar 30, 2017
GABA's role in dampening hyperactivity has led researchers to believe that increased production during adolescence improves symptoms for the majority of people with TS. This finding could offer a new approach to treatments targeting GABA levels in brain areas controlling motor function.
SourceUniversity of Nottingham·JournalTrends in Cognitive Sciences·DateOct 1, 2015
A study by researchers at the University of Montreal found that cognitive behavioral therapy can alter brain function in people with Tourette syndrome, reducing tics and improving brain activity. The therapy helped normalize brain activity in areas affected by the disorder.
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A study by University of Nottingham researchers found that higher levels of GABA in the supplementary motor area (SMA) help dampen down hyperactivity, allowing stronger signals to produce movement. This could lead to targeted approaches controlling tics using transcranial direct-current stimulation (tdcs).
SourceUniversity of Nottingham·JournalCurrent Biology·DateSep 25, 2014
Scientists at the University of Nottingham have discovered a mechanism controlling tics in children with Tourette Syndrome. The study found that brain changes can alter excitability ahead of voluntary movements, suggesting a potential therapy to help young people overcome tics.
SourceUniversity of Nottingham·JournalJournal of Neuropsychology·DateDec 11, 2013
A comprehensive behavioral therapy program has been shown to be effective in reducing tic severity in adults with Tourette syndrome. The study found that 38% of participants who received the treatment showed significant symptom improvement, compared to 6% of those receiving a control treatment.
SourceMassachusetts General Hospital·JournalArchives of General Psychiatry·DateAug 6, 2012
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A new study published in Pediatric Neurology reveals that tics are a common disorder affecting approximately 16.86% of schoolchildren in Spain, with boys being more frequently affected than girls. The study found that while severe tics were previously thought to be rare, most cases are actually mild and have no functional impact.
SourceSpanish Foundation for Science and Technology·JournalPediatric Neurology·DateSep 8, 2011
A new study found that cognitive-behavioral therapy can reduce tics and brain activity in patients with Tourette syndrome, potentially leading to improved treatment options. The therapy was shown to have a measurable impact on brain activity linked to symptom improvement.
SourceUniversity of Montreal·JournalInternational Journal of Cognitive Therapy·DateApr 14, 2011
Research finds that Tourette's brains exhibit structural and functional changes that enable greater cognitive motor control, allowing individuals to suppress tics more accurately. This discovery may lead to new treatments, such as brain training approaches, to help individuals manage symptoms without medication.
A recent study found that anxiety/panic disorder is the most disabling psychiatric condition associated with Tourette syndrome (TS), contributing significantly to psychosocial and occupational disabilities. The study identified motor tics as a primary factor in disability, especially in adults whose tics persist into adulthood.
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A multisite study found comprehensive behavioral intervention for tics (CBIT) significantly reduced chronic tics and tic-related problems in children. CBIT was compared to supportive counseling and education, showing similar improvement rates as anti-tic medication studies without side effects.
SourceUniversity of California - Los Angeles·JournalJAMA·DateMay 18, 2010
A study of 15 patients with severe Tourette syndrome found that deep brain stimulation reduced tic frequency by 52% on average and improved OCD symptoms. The treatment showed no significant effect on thinking abilities.
SourceAmerican Academy of Neurology·JournalNeurology·DateOct 27, 2009
Researchers used magnetization transfer imaging to visualize alterations in cerebral architecture of Tourette's patients and found correlations with symptom severity. They identified changes in the frontal lobe that may be responsible for the syndrome's pathology.
SourceBMC (BioMed Central)·JournalBMC Neuroscience·DateMay 11, 2009
A new study from University Hospitals Case Medical Center found that Deep Brain Stimulation (DBS) can reduce tic frequency and severity in some adults with refractory Tourette Syndrome, improving quality of life. The treatment was safe and showed promising results in a double-blind clinical trial.
SourceUniversity Hospitals of Cleveland·JournalJournal of Neurosurgery·DateNov 12, 2007
A study found that children with Tourette's syndrome are quicker at processing certain mental grammar skills, including rule-governed language tasks. They showed superior performance compared to typically developing children in producing grammatically correct past tense forms.
SourceGeorgetown University Medical Center·JournalNeuropsychologia·DateJul 12, 2007
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Researchers found that individuals with Tourette's syndrome make fewer error responses than neurologically normal peers, while responding just as fast to task demands, suggesting a compensatory change in cognitive control. This study challenges the widely held view that TS results from a failure of cognitive control mechanisms.
A four-year study will investigate the effectiveness of two behavioral interventions for adults with Tourette syndrome, with a focus on tic severity. The study complements an existing research program that explores similar treatments in children, funded by NIH.
Researchers have made significant strides in understanding the brain circuits responsible for tics in Tourette's syndrome. Studies suggest an imbalance in the basal ganglia's inhibitory function may lead to the disorder's characteristic symptoms. Increased activity in certain regions, such as the ventral striatum, and altered neuronal ...
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A study of 1,596 children in Rochester, NY, found that 8% had Tourette's and 27% had some tic disorder, with mild symptoms being more prevalent. Research suggests that tics can be an indicator of a subtle brain developmental disorder.
SourceUniversity of Rochester Medical Center·JournalNeurology·DateOct 31, 2001
Researchers found that 27% of special education students had tics, compared to 20% of regular students. Early recognition and treatment can improve performance and social development for affected children.
SourceAmerican Academy of Neurology·JournalNeurology·DateOct 22, 2001
Researchers found that plasma exchange and IVIG relieve neuropsychiatric symptoms in children with tics and obsessive-compulsive disorder, with symptom improvements lasting up to a year. The study suggests these treatments may be effective for a subgroup of children with strep-triggered disorders, but not all cases.
SourceNIH/National Institute of Mental Health·JournalThe Lancet·DateSep 30, 1999
Research suggests Tourette's syndrome is not a simple motor disorder, but rather a condition affecting the brain's circuits that control planning and decision making. The study found that individuals with Tourette's can anticipate and adjust to their tics, indicating intentional movement.
SourceNew Scientist·JournalThe New Scientist·DateSep 8, 1999
Researchers found that low doses of Tacrine hydrochloride reduced motor and vocal tics in adults with Tourette syndrome. The study also showed dose-related improvement in comorbid symptoms such as attentional difficulties, hyperactivity, and obsessive thinking.
SourceEmory University Health Sciences Center·DateJun 5, 1999
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