Articles tagged with Lungs
A West Virginia University study explores the link between pregnancy, sedentary behavior, and cardiovascular disease risk in women. The research aims to investigate whether physical activity can reduce or eliminate this accelerated risk development in women.
A RCSI study has found that babies born with Down Syndrome experience impaired changes in heart function and blood pressure in their lungs over the first two years of age. The research suggests that all babies with Down Syndrome should have their heart function monitored during childhood due to these common issues.
The new guideline provides evidence-based recommendations for managing patients on warfarin, DOACs, and antiplatelet drugs before and after surgeries. It aims to minimize preventable bleeding and thrombotic events by standardizing approaches and protocols.
A comprehensive analysis of interstitial lung disease diagnosis and treatment in patients who received an antibody drug conjugate known as T-DXd found that close monitoring and proactive management can reduce the risk of ILD. The study results suggest that patient awareness and ongoing education can aid in early detection.
The August issue of the CHEST journal features 47 articles on clinically relevant topics such as asthma, COPD, and pulmonary vascular disease. A highlighted article examines barriers to palliative care in interstitial lung disease.
Researchers at Aston University have developed a new approach to tackle one of the underlying causes of asthma, not just its symptoms. The treatment, which targets the structural changes made by asthmatic airways, shows promising results in mice, reducing symptoms within two weeks and returning airways to near normal.
A new combination drug therapy addressing the disorder's underlying defects has been found to be beneficial for primary school-aged children with cystic fibrosis. The study, conducted at Charité – Universitätsmedizin Berlin, confirmed that earlier treatment can slow disease progression and improve lung function and quality of life.
Researchers found that second primary lung cancer occurs in approximately 4% of lung cancer patients, with a higher rate of up to 8% among those undergoing surgery for early-stage disease. The study also revealed variations in incidence rates by treatment type and stage.
Researchers from Boston University School of Medicine have created functional lung epithelial cells from CF patients' blood cells, enabling the testing of effective treatments and potentially discovering novel therapies.
Researchers used Guardant NGS to analyze nearly 17,000 lung cancer samples and found MET amplification in 1.2% of cases, with 20.8% having overlapping oncogenic drivers. The study suggests that high gene copy numbers and smaller amplified regions can be used to enrich for the true MET-sensitive population.
A Nagoya University research group has developed an AI algorithm that can diagnose idiopathic pulmonary fibrosis with high accuracy, based on non-invasive examinations and medical data. The technology may revolutionize medical care by allowing doctors to request AI-assisted diagnoses instead of specialists.
A multicenter study found that preterm children with bronchopulmonary dysplasia who attend daycare are more likely to visit the emergency department, use systemic steroids, and experience chronic respiratory symptoms. The risk of these complications is highest in infants under 1 year old and may persist until 36 months of age.
A recent study published in the European Respiratory Journal found that children who grow up near green spaces have better lung function. The research suggests that increasing exposure to vegetation close to home can improve lung health, especially when combined with other factors such as physical activity and reduced air pollution.
A new study has found that testing for cyclin-dependent kinase inhibitor protein (p16) in biopsy tissue can help more accurately identify IPF. High expression of p16 is associated with worse outcomes and reduced survival, emphasizing the need for early treatment.
A UC Berkeley-led study identified specific human lung proteins that can promote or protect against SARS-CoV-2 infections. Researchers found that mucins, a key component of mucus in the lungs, help block the virus from entering cells, while other mucins may even promote infection.
Boston University researchers have discovered a key protein, ERG, connected to idiopathic pulmonary fibrosis (IPF), a disease characterized by progressive lung scarring. The study found that ERG plays a crucial role in the development of IPF, an aging-associated disease that causes respiratory failure and death.
A team of researchers at the University of Pittsburgh used computational modeling to investigate the immune response to avian flu. They found that the levels of interferon may be responsible for its more severe presentation and could hold the key to treating it.
Researchers identified common cellular mechanisms and dysfunctional processes driving post-COVID lung disease, similar to idiopathic pulmonary fibrosis. The study found shared gene expression patterns and endoplasmic reticulum stress as early triggers of both conditions.
A new study found outliers in influenza-negative ILI cases in global surveillance networks 13.3 weeks before the first reported COVID-19 peaks in 16 countries. This suggests undetected spread of COVID-19 and highlights the importance of strengthening disease surveillance networks.
The July issue of CHEST journal features 62 articles on clinically relevant topics, including asthma and COPD. The journal has received an Impact Factor of 10.262, an increase from 2020's Impact Factor of 9.410.
A secondary analysis of the CARDIA Lung study found that a substantial proportion of middle-aged adults with normal spirometry findings had emphysema on CT scan. Race-specific interpretations of spirometry may underestimate respiratory symptom burden and risk for death in Black adults, perpetuating structural racial inequities.
A Colorado State University study found that brass instruments produce 191% more aerosols than woodwinds during play. Male performers and louder playing of brass instruments were associated with higher emissions. Bell covers can reduce particle spread, but not achieve N95 level protection.
A University of Essex study found that three-quarters of professional footballers experienced general fatigue for 37 days and muscle fatigue for 38 days after recovering from COVID-19. Despite no drop in lung capacity, GPS data showed a four per cent decline in match performance.
New research found that coinfection with influenza A virus can significantly suppress SARS-CoV-2 replication in the lung. This effect can persist even after clearance of influenza A virus, suggesting potential factors that restrict SARS-CoV-2 growth.
A UC Riverside study reports that switching from combustible cigarettes to electronic cigarettes does not restore the nasal epithelium to that of a non-smoker. The researchers found alterations in gene expression profiles associated with cigarette smokers, indicating potential harm from prolonged EC use.
The Heart and Lung Research Institute (HLRI) at the University of Cambridge will bring together over 380 researchers and clinicians to tackle cardiovascular and respiratory diseases. The institute aims to deliver high-impact research to drive breakthroughs in prevention, early diagnosis, and treatment of these diseases, which represent...
A study found that rates of serious complications associated with shoulder surgery are low, but one in 26 patients need further surgery within a year. The effectiveness of some shoulder procedures is doubtful at best, according to experts.
Researchers developed an inhalable COVID-19 vaccine that targets the lungs specifically and effectively, allowing for self-administration via an inhaler. The vaccine prototype, RBD-Exo, elicited production of antibodies specific to the SARS-CoV-2 spike protein in rodent models, offering a promising solution to improve vaccine delivery.
Researchers have discovered a unique biochemical profile in severe asthmatic patients, which could lead to more effective treatments. The study found a decrease in carnitine metabolism in severe asthmatics, playing an important role in cellular energy generation and immune responses.
Researchers will develop and test new beacon molecules and imaging equipment to improve the detection and removal of non-small-cell lung cancers, aiming to reduce unnecessary tissue removal. The goal is to enhance surgical outcomes and improve patient care.
Scientists locate highly effective memory B cells in the lungs, which can boost the efficacy of vaccines used to protect against viral respiratory diseases. The discovery suggests a promising avenue for increasing vaccine effectiveness.
A novel single-cell RNA sequencing technique, TAS-Seq, has been developed to provide higher-precision data than current methods. The new method detects more genes and identifies highly variable genes, making it a sensitive high-throughput scRNA method.
This volume of Oncotarget features groundbreaking research on various cancers, including breast, lung, colorectal, and neuroblastoma, as well as novel drug targets for bladder cancer. The studies also delve into the role of BRCA in breast and colorectal cancers.
A recent study published in Environment International found that young adults exposed to higher levels of ambient and household air pollution had poorer lung function. Household air pollution from unvented biomass stoves was particularly detrimental, causing a significant decrease in lung capacity.
The American Heart Association warns that e-cigarette use in adolescents can lead to stunted lung development and altered cardiovascular systems, increasing the risk of heart disease over time. Long-term exposure to e-cigarette aerosols has been linked to increased blood pressure, impaired blood vessel function, and arterial stiffness.
A new study reveals that inhaled fine particles can take a direct route from lungs to brain through blood circulation, potentially contributing to brain disorders. The particles were found to stay longer in the brain than in other organs, raising concerns about the long-term effects of air pollution on cognitive function.
A recent study published in the Journal of Cardiac Surgery found that lung transplant recipients have a standardized mortality rate approximately five times higher than nonhospitalized adults. The main causes of death include rejection of the new organ, pneumonia, and infections.
A new analysis by University of Pittsburgh scientists demonstrates that institutional racism, rather than race-based biology, worsens asthma severity in Black people. The study links discriminatory lending practices from the 1930s to long-term environmental and health inequities, particularly in historically redlined neighborhoods.
A study from Cincinnati Children's Hospital Medical Center found that early antibiotic use disrupts the developing immune system of newborns, increasing risks of severe pneumonia and life-long health issues. Fecal transplants may offer a solution to mitigate these effects.
Researchers identified immune endothelial cells promoting inflammation and developmental endothelial cells supporting cell development, regeneration, and proliferation. The study's findings may lead to targeted treatments for lung infections and acute respiratory distress syndrome.
Researchers at the University of Birmingham have identified a 'cellular brake' protein that may help prevent autoimmune responses in lung cancer patients undergoing immunotherapy treatment. This finding could enable clinicians to closely monitor high-risk patients and develop preventative strategies.
A study using PET/CT revealed that residual COVID-19 symptoms can be attributed to ongoing lung inflammation. Treatment with steroids and antifibrotic drugs significantly decreased inflammatory activity.
Scientists have proven that inhaled aerosol vaccines provide stronger immune responses and better protection from respiratory infections compared to nasal sprays. This method delivers vaccine droplets directly into the airway, inducing a broader protective response.
A new study found that patients with long COVID have virus-specific T cell levels over 100 times higher than those who recovered from the disease. The research team's findings suggest hidden viral reservoirs may be causing long-term symptoms, guiding future treatments towards vaccines and antiviral medications.
The American College of Chest Physicians' flagship journal CHEST published its June issue featuring 58 articles on various chest medicine topics, including asthma and COPD. The journal is set to expand with two new open-access journals, CHEST Pulmonary and CHEST Critical Care.
Researchers at Cedars-Sinai have discovered that zinc, a common mineral, plays an important role in reversing lung damage and improving survival for patients with idiopathic pulmonary fibrosis (IPF). By identifying a molecular pathway involving zinc, the team hopes to develop new therapies to reverse IPF-related lung damage.
African Americans with chronic obstructive pulmonary disease (COPD) are more likely to experience flare-ups due to inadequate sleep, which may boost their risk by up to 95%. The study, published on June 6, 2022, suggests that poor sleep quality may partially explain why African American patients tend to fare worse than white patients. ...
The NIH has launched a clinical trial testing dupilumab, an approved treatment for moderate-to-severe asthma, in children with poorly controlled allergic asthma living in low-income urban neighborhoods. The study aims to define the activity levels of gene networks associated with asthma attacks and improve lung function.
New research reveals that age-induced changes in lung fibroblasts reactivate dormant melanoma cells, promoting growth and metastasis. The study found that WNT5A signaling pathway regulates tumor cell dormancy and metastasis initiation, with increased sFRP1 secretion facilitating reactivation in the aged lung.
Researchers found that inhibiting caspase 11 reduced inflammation, tissue injury and blood clots in lung tissue of infected mice. This suggests potential therapeutic targets for treating severe COVID-19 symptoms.
A recent study published in Pharmaceutics suggests that berberine can suppress the proliferation of lung cancer cells, reduce airway inflammation, and modulate genes involved in inflammation. The researchers used liquid crystalline nanoparticles to enhance safety and effectiveness.
A recent study reveals that 91% of athletes display dysfunctional breathing patterns, which can lead to increased risk of musculoskeletal injuries. The study emphasizes the importance of screening and addressing these patterns through targeted interventions and breathing training protocols.
Researchers at Aston University have developed a new antibiotic combination that successfully treated a cystic fibrosis patient's deadly lung infection. The combination of imipenem/relebactam with amoxicillin eradicated the infection, enabling the patient to receive a lifesaving lung transplant.
A study published in Nature Communications reveals that the type of macrophage present in a person's body may determine how likely they are to develop severe inflammation in response to COVID-19. The research found that an aggressive subset of macrophages, known as M1 macrophages, can cause a cascade of events leading to multi-organ fa...
Researchers have found that light-based therapies such as photobiomodulation and photodynamics can effectively treat a range of post-COVID complications, including muscle and joint damage. The studies, conducted in Brazil, utilized laser irradiation, negative pressure, and other technologies to improve symptoms and promote healing.
A study suggests that lung ultrasounds performed by primary care physicians can accurately diagnose community-acquired pneumonia with high specificity. This could allow for direct antibiotic prescribing, saving time and money for patients and reducing X-ray radiation.
A new computer-aided diagnostic tool, Deep-Lung Parenchyma-Enhancing (DLPE), uses artificial intelligence to reveal signs of pulmonary fibrosis in COVID long-haulers, helping to explain respiratory symptoms and improve disease management.
A study by researchers at UCSF found that e-cigarette use costs the US $15 billion annually in healthcare expenditures, with each user paying around $2,000 extra per year compared to non-users. The study, published in Tobacco Control, highlights the growing concern over health care costs associated with e-cigarette use.
Researchers linked dietary cholesterol to exacerbation of viral infections in mice, showing that high levels of cholesterol made mice sicker when infected with influenza. The study found that dietary cholesterol increased the number of cytokine-producing immune cells in the lungs, contributing to excessive inflammation.
Researchers discovered that adaptive immune response against TB matures over time, with key players in immunity becoming activated by three months after infection. The emergence of these activated T cells is inversely correlated with the number of granuloma-contained live bacteria, suggesting they play critical roles in bacterial control.