Articles tagged with Lungs
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers found a strong association between chronic rhinosinusitis and non-cystic fibrosis bronchiectasis, with CRS diagnoses preceding bronchiectasis by an average of six years. Early treatment of sinus disease may offer therapeutic strategies for preventing bronchiectasis.
Scientists have constructed a detailed map of lung development after birth, providing insights into the genetic and epigenetic factors that affect lung health. The study used next-generation single-cell sequencing technologies to analyze over 80,000 human and mouse lung cells, revealing clues on how cell types communicate and develop.
Researchers found that combining durvalumab with novel agents like oleclumab and monalizumab increased major pathological response rates compared to solo durvalumab. The study also identified key immune cell signatures associated with treatment outcomes.
Researchers from Texas A&M University found that the absence of a functioning Nrf2 gene affects prenatal growth, especially when exposed to ultrafine particulate air pollution. This study highlights a possible mechanism by which ultrafine particles can impact placental function and prenatal health.
A team of University of Minnesota researchers has discovered the molecular properties of lung surfactants, which could lead to improved treatments for respiratory illnesses such as pneumonia and COVID-19. The study found that synthetic lung coatings can help premature infants and adults with respiratory problems breathe easier.
Scientists create nanoparticles coated in mannose to block production of scar-promoting protein in lung cells. The treatment holds promise for preventing severe lung scarring disease.
Researchers at the University of Pennsylvania School of Medicine have discovered a new type of cell in the human lung with regenerative properties. The cells, called respiratory airway secretory cells (RASCs), line tiny airway branches and can regenerate other cells essential for alveoli functioning.
A study published in The Lancet Respiratory Medicine found that astegolimab reduced exacerbation rates by 22% and improved quality of life in patients with moderate-to-severe COPD. Benefits were seen in those with specific inflammatory signals and genetic markers.
Researchers found no evidence that gelada monkeys' hemoglobin provides increased oxygen-carrying capacity, but discovered other physiological adaptations that enable them to thrive at high altitudes. The study sheds light on the mechanisms behind human adaptation and potential treatments for diseases associated with high altitude.
Researchers developed a method to identify aggressive early-stage lung cancers and target drugs to tumors likely to respond. They used genomics network models and identified signature genes associated with tumor invasiveness.
Researchers developed a novel drug to reduce airway mucus that exacerbates common lung diseases. The treatment works by blocking the secretion of mucins, which can block airways and cause life-threatening symptoms.
Researchers have identified a new family of proteins in blood vessels that prevent fluid from entering the lungs, offering a potential new avenue for treating acute respiratory distress syndrome. Stimulating these bitter taste receptors has been shown to provide protection against fluid leak into the lung.
Scientists at University of Illinois and Mie University develop monoclonal antibodies to prevent lung cell death in mouse models of idiopathic pulmonary fibrosis and acute respiratory disease syndrome. Non-invasive diagnostic tools also presented could aid in predicting disease progression and identifying patients at risk.
Researchers develop novel therapeutic approach for treating tuberculosis using phosphatase inhibitors, offering potential benefits for TB research and basic biology exploration. The discovery provides a promising alternative to traditional antibiotic-based treatments and has significant implications for combating antimicrobial resistance.
BGE-175 effectively prevents death in a mouse model of COVID-19 by reversing immune aging, suggesting its potential to protect elderly patients hospitalized with COVID-19. The drug restores the immune system to a more youthful state by blocking the PGD2-DP1 pathway.
Researchers have identified a unique population of memory CD4 T-cells that produce IL-9, which plays a key role in allergic memory responses. Blocking this cytokine may lead to reduced lung inflammation and improved treatment options for seasonal asthma.
A UC San Diego study found that excessive neuropeptide secretion by neuroendocrine cells in the lungs can lead to fluid buildup and poor oxygenation in both infant lung disease and COVID-19. Blocking these neuropeptides may be an effective treatment for conditions marked by excess lung fluid.
Researchers developed an inhalable vaccine called CoMiP that successfully induces an immune response against COVID-19 in the lungs of mice. The vaccine targets alveolar macrophages and elicits local immunity, potentially blocking SARS-CoV-2 transmission.
Researchers aim to understand why up to 80% of individuals experience temporary or lasting changes in their sense of taste after COVID-19. Preliminary data suggests ACE2 and TMPRSS2 are highly expressed in taste buds, which may explain why these are common targets for the virus.
The American College of Chest Physicians journal features cutting-edge original research on various chest medicine topics, including asthma, COPD, critical care, and sleep. The March issue includes a special series on nontuberculous mycobacterial pulmonary disease, offering insights into clinical epidemiology, risk factors, and diagnosis.
A clinical trial conducted by RCSI researchers found that administering alpha-1 antitrypsin to critically ill COVID-19 patients reduced inflammation after one week. The study's results are promising and may form the basis for a larger trial.
Research suggests that ECMO support for severe COVID-19 can result in exceptional early survival, with significant lung recovery and long-term outcomes. Patient selection and aggressive management strategies were key factors in improving outcomes, with 86.7% survival rate at median follow-up.
A new study suggests that persistent breathlessness after COVID-19 is linked to altered immune cell landscapes in the airways and signs of ongoing lung damage. While preliminary results indicate a possible improvement over time, further research is needed to confirm these findings and explore potential treatments.
A biodegradable nanoparticle has shown promise in reducing skin and lung scarring in mice with scleroderma. The treatment targets specific immune cells responsible for the disease's chronic inflammation and scarring.
The American Thoracic Society and European Respiratory Society have updated their technical standard for pulmonary function tests to address interpretation uncertainty and health inequity concerns. The new guidelines emphasize the importance of considering an individual's medical history, symptoms, and social circumstances when applyin...
A new study will measure the effectiveness of oral hygiene in preventing non-ventilator hospital-acquired pneumonia (NVHAP) among hospitalized patients. NVHAP is the most deadly and costly type of hospital-acquired infection, affecting approximately one in 100 hospitalized patients.
Researchers at UVA Cancer Center have made a groundbreaking discovery about the EP300 gene and its role in small-cell lung cancer. The study found that the gene makes a protein with properties that can both foster and prevent tumor formation, providing a new potential target for treatment.
The study reveals that asbestos minerals undergo changes that resemble self-defense when internalized by human lung cells. These changes include the formation of an iron-rich layer on the minerals, which may be a mechanism to protect the cell from toxicity.
A new study from the University of Gothenburg detects SARS-CoV-2 coronavirus particles in microscopically small fluid droplets exhaled by patients with COVID-19. The findings show that a few breaths are sufficient to detect viral RNA, offering potential for easy and convenient breath tests.
Researchers are exploring how bacteria form biofilms, which can be detrimental to health but also have potential uses in medicine and environmental cleanup. The study aims to understand the mechanisms behind microbial growth in biofilms and develop new materials and treatments.
The study defines the lung macrophage as a major target of IL-9, which promotes allergic lung inflammation. The researchers found a correlation between IL-9 and the diagnosis of asthma in patients, suggesting a potential therapeutic approach for treatment.
Scientists have devised a method to pinpoint active ingredients from traditional Chinese medicine formulations, revealing 4 analytes with significant anti-inflammatory activity. This breakthrough could improve quality control standards and lead to better herbal remedies.
A recent review of e-cigarette research highlights the significant health risks associated with vaping, including lung inflammation and injury. The study found that e-cigarettes can cause negative effects in multiple organs, from the brain to the bladder, and may even increase the risk of lung cancer.
Scientists at Tufts University create nanoparticles that carry genetic instructions to specifically target the lungs, reducing tumors in a preclinical model of a rare genetic lung disease. The breakthrough could lead to improved treatment options for patients with lymphangioleiomyomatosis.
A study found that using two cannulas to place newborns in respiratory failure on life-sustaining ECMO increases mortality rates. The safest path is a single cannula in the right internal jugular, which can remove oxygen-poor blood and add oxygen before returning it to the baby.
A new study suggests that incomplete lung cell repair may contribute to the development of chronic fibrotic lung disease in COVID-19 and non-COVID patients. The research proposes novel therapies to promote healthy regeneration and prevent scarring.
A new study suggests that small respiratory particles can remain moist and airborne for a longer time and greater distance than previously recognized. The mucus shell surrounding these particles likely reduces evaporation rates, keeping viral particles infectious for up to 30 minutes and traveling distances of up to 200 feet.
A new study by Dr. Brian Stansfield and Dr. Jessica Gancar found a clear linear relationship between mortality and red blood cell transfusion volume in newborns on ECMO, with a 14% decrease in survival chances for every transfusion. The study suggests that reducing transfusion volumes may improve outcomes.
Paczesny will explore biomarkers and a new type of immune cell to identify and regulate acute lung injury after BMT. She aims to improve understanding of signaling mechanisms in lung injury after BMT, particularly as they relate to idiopathic pneumonia syndrome.
Researchers found three risk factors linked to adult spirometric restriction: maternal nutritional problems during pregnancy, low birth weight, and below normal childhood weight. Infants with poor nutrition have a higher risk of developing lung restriction and comorbidities as adults.
Researchers have confirmed an inhaled vaccine provides long-lasting protection against SARS-CoV-2 and its variants by targeting the lungs and upper airways. The vaccine induces broad respiratory mucosal immunity, outperforming traditional injected vaccines in terms of efficacy and dose requirements.
Pulmonary lymphangioleiomyomatosis (LAM) is a rare cancer affecting up to 1 in 1 million women worldwide, characterized by uncontrolled tumor cell growth. Researchers aim to identify new therapeutic targets using extracellular vesicles, with the goal of developing new therapies for LAM patients.
A recent study found that protracted inflammation following COVID-19 is strongly linked to long-term changes in lung structure and function. Monitoring patients for signs of inflammation after infection may help identify those at risk of long-term lung problems.
Researchers found that disulfiram protected rodents from immune-mediated lung injury in models of SARS-CoV-2 coronavirus infection and TRALI, a rare lung failure syndrome. Disulfiram blocks NETs formation, which can cause lung damage and blood clots.
Scientists sequenced the gene expression profiles of more than 170,000 individual cells to shed light on a key mystery: the role of Type I Interferons (IFN) during viral infections. The study reveals interferon plays a crucial role in clearing the virus by alerting immune cells, such as macrophages, to search and destroy infected cells.
Researchers have discovered disulfiram prevents the formation of toxic webs known as neutrophil extracellular traps (NETs) that contribute to acute respiratory distress syndrome (ARDS). Disulfiram's ability to block NET formation may lead to a new treatment for severe COVID-19 and other lung injuries.
Researchers at Medical University of Vienna discovered that certain microbiome profiles following lung transplantation can provide prognostic information for future changes in lung function. Machine Learning analyzed multiomics data, including the microbiome, lipidome, and metabolome, to predict lung function deterioration.
A recent study published in Developmental Cell reveals that Kras mutation causes chromatin rearrangement, leading to stem-like cell regeneration and tumor onset. The team discovered a protein complex called AP-1 as the mediator of this process, which can be targeted with small-molecule drugs.
Researchers at Rosalind Franklin University have identified a new therapeutic approach for treating cystic fibrosis. The treatment uses antisense oligonucleotides to restore CFTR function by removing stop mutations. This strategy has shown promise in treating CF patients with class I mutations and similar types of mutations.
Research from the Dunedin Multidisciplinary Health and Development Study finds that prolonged cannabis use leads to over-inflated lungs and increased airway resistance, impairing oxygen extraction. This effect is distinct from tobacco use and may reflect early signs of a severe form of emphysema.
A combined treatment strategy targeting SARS-CoV-2 symptoms and severe lung tissue injury is essential to minimize lung sequelae. Researchers are exploring therapy using lung epithelial stem and progenitor cells to mitigate virus-induced inflammatory storm and promote tissue regeneration efficiently.
Researchers found that higher monocyte counts are linked to early signs of injury and scarring on lung imaging among community-dwelling adults. This suggests that hyperactive monocytes may contribute to lung injury at the early stages of interstitial lung disease.
Dr. Edward Y. Lee, MD, MPH, receives the highest distinction from North America's first radiological society for his contributions to pediatric thoracic imaging and education. The ARRS Gold Medal honors his tireless efforts to advance radiology globally.
A national analysis of lung transplantations performed in the US between August 2020 and September 2021 shows that 7% of lung transplants were performed to treat COVID-19-related lung damage. The study suggests that lung transplantation may be a safe option for select patients with severe, irreversible lung damage.
A large data analysis reveals that primary ciliary dyskinesia (PCD) is more common than initially estimated, with a prevalence of 1 in 7,500 people globally. The study also found ethnic heterogeneity in PCD-causing gene variants, with African descent and non-Finnish European groups showing higher rates.
Researchers discovered that lunge-feeding whales have an 'oral plug' in their mouths, which seals off the upper airways during feeding. This mechanism prevents water from entering their lungs and allows them to gulp down large amounts of krill without drowning.
A newly developed decoy protein has been found to be highly effective in preventing death and lung damage in humanized animal models of severe COVID-19 disease. The treatment works by competing for the spike protein of SARS-CoV-2, thereby neutralizing the virus before it can bind and enter cells.
A study published in MBio found that removing the NS2 protein from Respiratory Syncytial Virus (RSV) allows the human body's immune response to destroy the virus before exaggerated inflammation begins. This discovery could lead to new therapeutics targeting this protein for other respiratory viruses like influenza A and SARS-CoV-2.
Researchers from Karolinska Institutet have discovered that lung macrophages develop in two different ways, with fetal precursor cells dividing faster to remove microorganisms early on. The study's findings can help limit organ damage and promote new treatments for lung diseases.
A large-scale international study found that simple health assessments can identify people with chronic lung conditions like COPD. The screening tools were effective in diverse low- and middle-income settings, highlighting a pressing need for global awareness and early diagnosis.