Articles tagged with Lungs
Researchers develop a new approach to treating lung metastasis by delivering chemokine CXCL10 via red blood cells, stimulating the immune system to attack tumors. Treatment with erythrocyte-anchored systemic immunotherapy (EASI) halts tumor growth and induces an immune response in mice.
Researchers at MUSC discover lysyl oxidase plays key roles in promoting fibrosis in scleroderma, and its levels can be used to monitor treatment response. The findings suggest LOX could be a promising biomarker for assessing fibrosis progression or regression.
A Vanderbilt University Medical Center study found that children are less likely to get infected or have severe symptoms due to lower levels of an enzyme called TMPRSS2. The research suggests that blocking this enzyme could potentially treat or prevent COVID-19 in older people.
A new study from the Chakrabarty lab found a strong linear association between long-term PM2.5 exposure and R0, which denotes the expected number of people each sick person can infect. The researchers also discovered that secondary inorganic components in PM2.5 increase the risk of COVID-19 transmission.
Cilia, tiny hairlike organelles, coordinate to push particles and fluid along, ensuring reproduction and defense against pathogens. Researchers identified mechanisms for effective cilia movement, which can inform diagnosis of diseases such as lung disease.
Researchers at La Jolla Institute for Immunology have discovered that blocking OX40L and CD30L, two key immune molecules, is crucial to preventing asthma attacks. The study shows how these molecules contribute to inflammation in the lungs during an allergic reaction.
A study published in Cancer Discovery found that patients with advanced-stage lung cancer had greater enrichment of oral commensals in the lung than those with early-stage disease, leading to decreased survival. The presence of specific bacteria was associated with tumor progression and activation of inflammatory pathways.
Researchers have developed two novel targeted therapies to slow down or stop fibrosis progression in people with idiopathic pulmonary fibrosis (IPF). These treatments aim to deliver potent drugs specifically to diseased cells, minimizing harm to healthy ones. The therapies will soon enter human clinical trials.
Researchers found that over half of e-cigarette users reported symptoms like cough and nausea, with those using flavored products and refillable devices more likely to experience severe symptoms. The study highlights the need for better understanding of e-cigarette risks among healthcare professionals and parents of youth.
Scientists from the University of Leeds monitored air quality during Bonfire Night events and found elevated concentrations of soot, which is around 100 times its normal level. The research highlights the potential health impacts of pollution on individuals with pre-existing health conditions.
Researchers at Helmholtz Munich have found a promising therapeutic approach against COPD by blocking lung epithelial cell death and triggering tissue regeneration. The novel treatment targets the lymphotoxin beta receptor signaling pathway, leading to improved lung function and reduced comorbidities.
Researchers found extensive lung damage and unique characteristics in COVID-19 patients, including fibrotic material and abnormal cell fusion. The study suggests the persistence of these 'abnormal cells' may explain long COVID symptoms like fatigue and shortness of breath.
Researchers found that SARS-CoV-2 attacks red marrow, damaging endothelium and regulating cell migration. This can lead to loss of functional cells, organ failure, and increased risk of secondary infections. The study analyzed lung samples from 79 patients who died from COVID-19.
Researchers found that CTAs were accurate in diagnosing COVID-19 with 83% accuracy when combined with patient feedback and symptoms. The study also identified 30 of the 57 patients as positive for COVID-19, and 20 had suspicious pneumonia on their scans.
A recent study published in ERJ Open Research reveals that NYC firefighters and emergency medical workers were significantly more likely to contract COVID-19 during the pandemic. The research found that workers with declining lung health were at a higher risk of severe infection and death.
A study estimates that long-term exposure to air pollution increases COVID-19 deaths by 15% globally, with higher proportions found in Europe and East Asia. Air pollution exacerbates health outcomes by aggravating co-morbidities and causing inflammation, leading to increased vulnerability to COVID-19.
A study published in the American Journal of Roentgenology found that spectral CT with electron density imaging can improve the assessment of lung lesion extent in patients with COVID-19. The results showed that lesion extent was easier to ascertain on electron density images, and ground-glass opacities were more conspicuous.
Researchers found that CBD increases apelin levels, which reduces inflammation and improves oxygen levels in the lungs. CBD treatment also normalized lung function and reduced physical damage caused by ARDS.
The study reveals that efavirenz alters the gene expression of important factors essential for genomic stability, particularly down-regulating S-phase and DNA replication genes. This suggests that efavirenz may be used in synergy with chemo/radiotherapy to treat lung cancer.
Researchers discovered that MG53 blocks inflammation and protects lungs from flu-induced death in mouse studies, offering a potential new therapy for the top-10 cause of global deaths. The treatment prevents excessive inflammation without affecting the virus itself.
Research suggests that psychological distress during pregnancy may be linked to a heightened risk of asthma and poorer lung function in children. The study found that mothers' overall psychological distress was associated with a 45-92% increased risk of current asthma in their children, while fathers' symptoms had no association.
Researchers propose endotracheal aspirates as an attractive alternative to invasive bronchoalveolar lavage for diagnosing ventilator-associated pneumonia. The study revealed that ETA is functionally diverse and highly enriched in proteins involved in immunity, suggesting its potential to detect lung infection earlier and more accurately.
A machine learning program using neural networks analyzes 1.4 million data points to predict which babies and children are most likely to suffer brain injury after Extracorporeal Membrane Oxygenation (ECMO) treatment, outperforming human clinicians.
Researchers have generated a single-cell atlas of mouse innate lymphoid cells in the lung, discovering a pool of local progenitors that can generate mature ILC2s. The study reveals the complexity of ILC2 functions and their developmental relationships, shedding light on how they contribute to immune defense and inflammatory diseases.
Scientists at Boston University's NEIDL and CReM developed living human lung cells from stem cells to study COVID-19's impact on the lungs. They found that NFkB pathway activation triggers deadly levels of lung inflammation, leading to a search for new therapeutics.
A portable device has been created to mimic the placenta's oxygenation role for pre-term newborns in respiratory distress. The artificial lung uses a fine membrane to release carbon dioxide and uptake oxygen while protecting blood from infection, improving survival rates and reducing brain damage.
A study by Children's Hospital of Philadelphia researchers has identified a cellular pathway that can be targeted with a naturally occurring drug to stimulate lung tissue regeneration. The findings could lead to better therapies for patients with lung diseases, including acute respiratory distress syndrome (ARDS) due to COVID-19.
Researchers found significant lung injury from e-cigarette devices with nickel-chromium alloy heating elements, even without nicotine or other additives. The switch in devices occurred when the team's original eC device went off market, revealing severe respiratory distress and lung lesions.
A new international study found that ECMO significantly improves survival rates for critically ill COVID-19 patients. The study analyzed data from over 200 hospitals worldwide and showed that ECMO can be a life-saving option for those who are failing ventilators and other care.
Researchers at La Jolla Institute for Immunology report that protein TL1A drives fibrosis in several mouse models, triggering tissue remodeling and making it harder for lungs and airways to function normally. This discovery suggests potential targets for therapeutics aimed at reducing fibrosis and tissue remodeling.
A Mayo Clinic study reveals that lung transplant patients who receive antifungal preventive medications have a significantly lower risk of death within the first year posttransplant. The study analyzed data from 667 patients and found that mortality risk was about twice as high in those not receiving treatment.
A team of researchers at Boston University has found that SARS-CoV-2 initially suppresses the lung cells' ability to activate the immune system, triggering a deadly inflammatory pathway. This activation leads to an influx of immune cells and an increase in inflammation in the lungs.
Research from King's College London found COVID-19 can be diagnosed using emergency stroke scans. The scans capture lung images showing 'ground glass opacification,' which predicts increased mortality and informs PPE use, triage, and contact tracing.
Research suggests that conditions related to obesity, such as inflammation and leaky gut, leave lungs more susceptible to COVID-19. Additionally, high levels of ACE2 receptors in obese individuals can lead to a higher viral load, exacerbating disease severity.
Researchers have developed an accelerated platform to identify and test potential treatments for early-stage lung cancer using 'organoids' created from lung cells. The studies revealed reduced expression of genes that are markers of mature lung alveolar cells, and increased expression of genes involved in early lung development.
The article reviews mechanisms linking obesity and diabetes to COVID-19 severity, suggesting that bacterial conditions work with the virus to increase disease severity. A combined deficiency in ACE2 caused by COVID-19 leads to impaired gut barrier function, allowing bacteria and toxins to leak into the circulation.
A team led by West Virginia University researcher Larissa Casaburi is developing an AI model that predicts COVID-19 patient outcomes based on factors such as lung conditions, smoking history, and coal mining. The model has the potential to provide more accurate diagnoses and tailor treatment plans to individual patients.
Researchers at Washington University School of Medicine have developed an experimental imaging agent called Galuminox that detects inflammation via positron-emission tomography (PET) scans. The agent has shown promise in imaging inflammation in the lungs of mice with acute lung injury, and its potential uses include cancer treatment an...
Researchers detected significant amounts of NETs in Covid-19 patients' lungs, contributing to severe disease complications. NET-targeting pharmacological approaches may improve patient conditions, while understanding the mechanisms behind these toxins is crucial for preventing further complications.
A new study reveals that autistic individuals are 1.5 to 4.3 times more likely to have chronic physical health conditions, including low blood pressure, arrhythmias, asthma, and prediabetes. Autistic females also face increased risks of these conditions, depending on their biological sex.
A study by researchers at the University of Rochester Medical Center found that vaping and smoking are linked to an increased risk of COVID-19 in young people. The research team is investigating the role of ACE2 receptors in this connection, which may help identify vulnerable individuals who can be better monitored.
A study published in European Respiratory Journal found that COVID-19 patients developed pneumothorax at a 0.91% incidence rate. Survival rates were higher among younger patients, while older patients and those with acidosis had poorer outcomes.
Researchers followed 150 COVID-19 patients for six, 12, and 24 weeks to track lung and heart damage. Symptoms improved significantly between visits, with lung damage decreasing from 88% at six weeks to 56% at 12 weeks.
Researchers found that mucosal-associated invariant T (MAIT) and invariant natural killer T (iNKT) cells were reduced in the blood of severe COVID-19 patients but increased in their airways. Highly activated MAIT and iNKT cells were associated with better outcomes, suggesting a beneficial role during severe COVID-19.
A study published in the European Respiratory Journal found that children with accelerated weight gain before age four have higher lung function at age seven, but also exhibit airflow limitation. The research suggests that early childhood growth patterns can be a useful tool for identifying respiratory health issues.
Research presented at the European Respiratory Society International Congress shows that babies exposed to levels of air pollution within EU standards develop poorer lung function as children and teenagers. Long-term exposure to air pollution is also linked to a higher risk of developing asthma in adults, according to a second study.
Researchers at UIC have discovered that blood vessel cells play a crucial role in programming macrophages to reduce inflammation and promote tissue repair. The study found that Rspondin3, a protein released by blood vessels, helps guide the programming of macrophages.
Researchers found that patients with acute respiratory distress syndrome (ARDS) have lower fungal diversity in their lungs, leading to more severe disease outcomes. This is because fungi can activate and regulate the immune system, contributing to inflammation and organ failure.
A new study suggests that COVID-19 is causing significant dilation of the lung's blood vessels, contributing to low oxygen levels and unusual respiratory behavior. The dilation was detected using a non-invasive ultrasound technique, and its correlation with oxygen levels may help explain why some patients experience 'happy hypoxia.'
A new tool for diagnosing COVID-19 has been developed by LSU Health New Orleans, using 3D digital models created from CT scans of patients with severe respiratory symptoms. The tool allows clinicians to visualize the distribution of the virus in the lungs and may help identify false negatives in RT-PCR testing.
New research shows that nitrate improves diaphragm function by increasing power, which could help elderly individuals clear lungs more effectively. This finding is significant, especially in the context of COVID-19, as the diaphragm plays a crucial role in breathing and coughing.
A new study finds that oxygen therapy can disrupt the balance of bacteria in the lungs, contributing to lung injury. The researchers used mice and found that high concentrations of oxygen led to an increase in oxygen-tolerant bacteria, which are more likely to cause infections.
The WVU toxicologist aims to improve health and well-being in susceptible populations by studying the impact of air pollution on lung regeneration. He plans to identify adverse outcomes of carbon black and ground level ozone inhalation, and study mechanisms leading to lung injury and impairment of lung regeneration.
A team of researchers at McMaster University has discovered that the ACE2 receptor is present in very low levels in human lung tissue, suggesting alternative infection pathways. This finding challenges existing knowledge about SARS-CoV-2 entry into cells and may lead to better diagnostic devices and treatment strategies.
A study published in Annals of the Rheumatic Diseases identified a genetic variant associated with an increased risk of interstitial lung disease among Japanese rheumatoid arthritis patients. The variant, located in the RPA3 gene, is linked to fibrosis and triggers complications in RA patients.
A pre-clinical study led by Cincinnati Children's Hospital demonstrates that barasertib reverses fibroblast activation, stopping dangerous scar tissue build-up in lungs of IPF patients. The drug targets AURKB activity, slowing disease progress and improving lung function.
Researchers at EPFL have developed a synthetic inhibitor of coagulation factor XII that efficiently blocks blood clotting without causing bleeding side-effects. The inhibitor has high potency and selectivity, but its short retention time requires constant infusion to achieve sustained thrompobrotection.
The American Thoracic Society and its collaborators have developed new clinical practice guidelines for diagnosing hypersensitivity pneumonitis, a condition that manifests as interstitial lung disease. The guidelines aim to standardize clinical care and facilitate research by providing a framework for clinicians to make accurate diagno...
A randomized clinical trial using dornase alfa, a cystic fibrosis treatment, aims to reduce inflammation and mucus production in patients with severe COVID-19 pneumonia. The study's main goal is to monitor the number of patients alive and ventilator-free 28 days after treatment.
A two-year observational pilot study found that remote monitoring of post-operative lung transplant patients significantly reduced hospital stays and readmissions by 44% and 66%, respectively. The study also showed a significant reduction in hospital costs, with an average savings of $132,000 per patient per year.