A comprehensive molecular map of lung squamous cell carcinoma has identified potential new drug targets, including the gene NSD3, and highlighted immune regulation pathways that could help cancer evade immunotherapies. The study's findings have also revealed metabolic dysregulation and crosstalk between different cellular processes.
SourceBroad Institute of MIT and Harvard·JournalCell·TypeComputational simulation/modeling·DateAug 5, 2021
A new clinical trial will test a simple breathing exercise for adults with obstructive sleep apnea and hypertension. The study aims to reduce blood pressure and improve cardiovascular health through inspiratory muscle training.
SourceUniversity of Arizona Health Sciences·DateAug 5, 2021
A recent study published in Transplant Infectious Disease found that COVID-19 vaccination provides strong protection against the virus for solid organ transplant recipients, with an almost 80% reduction in symptomatic cases. The study examined data from over 2,150 transplant patients and showed that nearly 70% of vaccinated patients re...
SourceUniversity of California - San Diego·JournalTransplant Infectious Disease·DateAug 5, 2021
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers discovered a protein called CTRP9 associated with pulmonary function in scleroderma patients with interstitial lung disease. Patients with higher CTRP9 levels developed more severe lung disease, while low levels were linked to preserved function. The study suggests CTRP9 could help predict treatment needs for these patients.
SourceMichigan Medicine - University of Michigan·TypeData/statistical analysis·DateAug 3, 2021
The American College of Chest Physicians has released new clinical guidelines for venous thromboembolism (VTE) management, providing 29 recommendations on patient care and treatment. The guidelines update previous recommendations and offer strong guidance for clinicians managing patients with VTE.
SourceAmerican College of Chest Physicians·JournalCHEST Journal·DateAug 3, 2021
Researchers identified protein patterns in lung tissue from patients with end-stage bronchiolitis obliterans syndrome, revealing an epithelial/mesenchymal imbalance and increased stiffness in remodeled airways. This breakthrough study may help develop therapies to improve long-term outcomes for lung transplantation patients.
SourceElsevier·JournalAmerican Journal Of Pathology·TypeExperimental study·DateAug 3, 2021
Researchers at Hokkaido University created a lipid polymer that can carry genetic code into lung cells, potentially treating diseases such as acute respiratory distress syndrome and lung cancers. The delivery method bypasses the liver and targets specific lung cells without targeting ligands.
SourceHokkaido University·JournalMaterials Horizons·TypeExperimental study·DateJul 30, 2021
The European Respiratory Society has announced the press registration and program for its upcoming International Congress 2021. Over 4,000 presentations on various lung health topics will be presented during the event.
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers at UIC are developing a potential COVID-19 treatment using VT-109, which has shown promise in animal models by restoring lung function and reducing inflammation. The new funding will be used to conduct pre-clinical studies to determine efficacy, toxicity, and dosages before human trials.
A team of researchers identified a protein called FCHSD1 involved in COPD-related inflammation and cell death. Mice lacking FCHSD1 showed reduced inflammation and apoptosis, suggesting its inhibition as a potential therapy for emphysema.
SourceTokyo Medical and Dental University·JournalProceedings of the National Academy of Sciences·DateJul 19, 2021
A University of Alberta research team found that firefighters dealing with the massive 2016 Fort McMurray wildfire suffered from long-term lung damage, including increased bronchial reactivity and thickening. The risk of developing asthma was more than doubled compared to the general population.
SourceUniversity of Alberta Faculty of Medicine & Dentistry·JournalJournal of Occupational and Environmental Medicine·DateJul 19, 2021
Researchers discovered that cells sense and respond to mechanical forces based on the rate of force application, which can lead to cell stiffening or softening. The 'molecular clutch' model explains how this affects cellular behavior, particularly in cancer development and organ function.
SourceInstitute for Bioengineering of Catalonia (IBEC)·JournalNature Communications·DateJul 16, 2021
A subset of fibroblasts in lungs of people with idiopathic pulmonary fibrosis (IPF) produce a protein called meflin, which protects against cell aging and fibrosis. Further research could lead to novel therapies for lung fibrosis.
SourceNagoya University·JournalEuropean Respiratory Journal·DateJul 15, 2021
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
A TGen-led international study reveals that SARS-CoV-2 takes advantage of genetic changes in patients with pre-existing lung diseases, leading to more severe symptoms and poorer outcomes. The research identifies molecular characteristics associated with worse COVID-19 outcomes, highlighting the need for targeted treatments.
SourceThe Translational Genomics Research Institute·JournalNature Communications·DateJul 14, 2021
A recent study published in the American Journal of Roentgenology found that reduced-dose CT scans can detect greater than 90% of lung nodules in children and young adults with cancer. This could lead to a reduction in patient dose while maintaining high diagnostic accuracy.
SourceAmerican Roentgen Ray Society·JournalAmerican Journal of Roentgenology·DateJul 9, 2021
A new study finds that over 37% of coal miners suffer from major depressive disorder, with 11.4% considering suicide in the last year. The researchers urge increased mental health support and further study of potential contributors to this crisis.
SourceUniversity of Virginia Health System·JournalJAMA Network Open·DateJul 8, 2021
A new study found that lung metastases from triple-negative breast cancer contain a more diverse array of cancer cells compared to liver metastases. The researchers identified specific genes responsible for this difference, which may inform targeted therapies for breast cancer treatment.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience Advances·DateJul 7, 2021
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Researchers have identified DAF as a receptor that increases damage to the lungs in mice infected with influenza A virus. The study highlights an immune evasion strategy by the virus and stresses the importance of a balanced immune response to viral infections.
SourceInstituto Gulbenkian de Ciencia·JournalPLOS Pathogens·DateJul 2, 2021
The NIH-funded program provides comprehensive training in lung biology and pulmonary sciences, with a focus on integrating basic science with clinical applications. Researchers will benefit from mentorship in grant writing, science communication, and career development.
SourceBoston University School of Medicine·DateJul 1, 2021
Researchers discovered fundamental differences in T-cell responses between patients who recover from and die from severe COVID-19. They found that dying patients harbor more lung-homing T cells, which contribute to extensive lung deterioration, while survivors have a growing number of Th1 T cells, important fighters of viral infection.
SourceGladstone Institutes·JournalCell Reports·DateJul 1, 2021
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Immunologists at McMaster University have identified a 'spider web' mechanism that traps pathogens like influenza and SARS-CoV-2 in neutrophils, creating a sticky tangle to kill viruses. This discovery could lead to new aerosol and nasal spray vaccine technologies to prevent infections before they spread.
SourceMcMaster University·JournalProceedings of the National Academy of Sciences·DateJun 29, 2021
Research from Thomas Jefferson University found that e-cigarette vapor increases levels of the coronavirus receptor ACE-2 in lung tissue of mice, making them more susceptible to infection. Male mice were found to have a greater increase in ACE-2 when exposed to nicotine, highlighting a potential sex difference in vaping-related risks.
SourceThomas Jefferson University·JournalJournal of Investigative Medicine·DateJun 29, 2021
A recent study has made a breakthrough in understanding the process that leads to pulmonary embolism, a condition that kills over 2,000 people in the UK each year. Researchers have identified a protein called fibrin as crucial in stabilizing clots and preventing fragments from breaking loose.
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Type II alveolar cells, a major cell type infected by SARS-CoV-2, possess high levels of MHC-II and play a role in improving the outcome of respiratory viral infections. AT2 MHC-II expression is unique and triggers an immune cascade that activates helper T cells.
SourceChildren's Hospital of Philadelphia·JournalNature Communications·DateJun 28, 2021
Researchers have identified a novel virulence trait of Streptococcus pneumoniae that increases the severity of S. pneumoniae superinfection following flu. The surface protein PspA, previously known to have several other virulence mechanisms, now functions as an adhesin to dying lung epithelial cells. This finding provides further expla...
SourceUniversity of Alabama at Birmingham·JournalCell Reports·DateJun 24, 2021
A previously validated blood gene profile that predicts idiopathic pulmonary fibrosis mortality has been repurposed to assess the likelihood of COVID-19 survival. The study found a high-risk gene profile associated with greater ICU admission, mechanical ventilation, and in-hospital death.
SourceUniversity of South Florida (USF Health)·JournalEBioMedicine·DateJun 21, 2021
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
A Phase 2 trial showed that combining doxycycline with TB treatment reduces lung cavity size and increases markers of recovery in pulmonary TB patients. This discovery has promise for preventing long-term complications and improving outcomes for those affected by the disease.
SourceNational University of Singapore, Yong Loo Lin School of Medicine·JournalJournal of Clinical Investigation·DateJun 19, 2021
Researchers develop nanodecoys made from human lung spheroid cells that bind to and neutralize SARS-CoV-2, accelerating viral clearance and reducing lung injury. The therapy could be effective against emerging variants of the virus.
SourceNorth Carolina State University·JournalNature Nanotechnology·DateJun 17, 2021
Researchers at UNC School of Medicine developed an improved oligonucleotide therapy strategy that can correct gene defects underlying cystic fibrosis. The approach has shown promising results in both human cells and mice, with potential applications for treating other pulmonary diseases.
SourceUniversity of North Carolina Health Care·JournalNucleic Acids Research·DateJun 16, 2021
A new study reveals that coronaviruses induce substantial apoptosis in host cells, enabling their internal spread. Targeting this process with PERK inhibitors reduces viral pathogenesis and lung damage.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience Advances·DateJun 16, 2021
Researchers have identified seven genes responsible for excessive inflammation and damage to the lungs in tuberculosis. A new drug treatment, doxycycline, has shown promise in reducing lung damage and accelerating recovery in patients with pulmonary TB.
SourceUniversity of Southampton·JournalJournal of Clinical Investigation·DateJun 15, 2021
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
A University of California, San Diego study uses AI to analyze gene expression patterns associated with pandemic viral infections. The analysis reveals two telltale signatures that help define patients' immune responses and measure disease severity. These findings provide a map for predicting patient outcomes and testing therapies.
SourceUniversity of California - San Diego·JournalEBioMedicine·DateJun 11, 2021
Researchers developed a nanoparticle delivery system to stimulate blood vessel growth in the newborn lung, improving survival rates from 70% to 35%. The treatment involves delivering an engineered nanoparticle carrying a STAT3 gene vector, which prompts blood vessel growth and improves lung function.
SourceCincinnati Children's Hospital Medical Center·JournalCirculation·DateJun 11, 2021
Researchers found that metformin prevents pulmonary inflammation, a major factor in COVID-19 severity and mortality, by inhibiting inflammasome activation and reducing IL-1β production. Metformin may have therapeutic potential for treating severe COVID-19 and other forms of acute respiratory distress syndrome.
SourceUniversity of California - San Diego·JournalImmunity·DateJun 10, 2021
A new physiological measurement of heart function, PAPP, has been shown to identify high-risk patients with systolic heart failure or pulmonary hypertension. This monitoring technology can reduce the risk of death by 46% annually in patients with low PAPPs.
SourceUniversity of Virginia Health System·JournalHeart Lung and Circulation·DateJun 8, 2021
Scientists at Brookhaven National Laboratory have developed an atomic-level model of the SARS-CoV-2 envelope protein bound to a human lung-cell-junction protein. The findings reveal how the virus causes extensive lung damage by hijacking cell-junction proteins, leading to a cytokine storm and promoting viral spread.
SourceDOE/Brookhaven National Laboratory·JournalNature Communications·DateJun 8, 2021
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Researchers from UNC School of Medicine discovered that MUC5AC is more reliably associated with COPD manifestation than another mucus protein, revealing a possible biomarker for disease initiation and prognosis. Elevated levels of MUC5AC in non-smokers who developed COPD suggest it could predict disease progression.
SourceUniversity of North Carolina Health Care·JournalThe Lancet Respiratory Medicine·DateJun 3, 2021
Abbreviated lung ultrasound protocols show similar diagnostic sensitivity to 28-zone studies, suggesting they can efficiently diagnose volume overload. Researchers found no mortality differences between patients with mild and moderate-to-severe pulmonary congestion.
SourceNational Kidney Foundation·JournalAmerican Journal of Kidney Diseases·DateJun 3, 2021
Researchers at the University of Münster discovered that platelet-white blood cell interactions resolve lung inflammation by secreting anti-inflammatory substances and eliminating excess neutrophil granulocytes. This finding has implications for developing new therapy concepts to combat acute respiratory failure.
SourceUniversity of Münster·JournalJournal of Experimental Medicine·DateJun 2, 2021
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers analyzed 430 lung squamous tumors and identified mutations in genes such as TP53, CDKN2A, and FGFR1. The study found that 13.5% of patients with druggable mutations had lower median overall survival.
SourceImpact Journals LLC·JournalOncotarget·DateJun 2, 2021
A nationwide clinical trial found no benefit from antibiotics in preventing hospitalization or death for patients with idiopathic pulmonary fibrosis. The study collected biological samples that will advance the understanding and treatment of the disease.
SourceUniversity of Virginia Health System·JournalJAMA·DateJun 2, 2021
Researchers discovered that antibody-secreting cells are formed in lung tissue after a respiratory infection, producing antibodies that fight microbes. These localized antibodies may play a key role in determining who becomes severely ill or experiences mild symptoms when infected.
SourceBoston University School of Medicine·JournalJournal of Clinical Investigation·DateJun 1, 2021
Scientists discover that inhalable nanobodies targeting the spike protein of SARS-CoV-2 can prevent and treat severe COVID-19 in hamsters. The treatment showed impressive results, reducing infectious virus particles by a million-fold and preventing weight loss associated with severe infection.
SourceUniversity of Pittsburgh·JournalScience Advances·DateMay 26, 2021
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
The VOYAGE study found that dupilumab reduced asthma exacerbations by 59.3% in children with uncontrolled moderate-to-severe asthma. The treatment also improved lung function within two weeks, an effect sustained for up to 52 weeks.
Research presented at the ATS 2021 International Conference found that cumulative tobacco smoke exposure during pregnancy and childhood is associated with decreased lung function in children. Even small amounts of secondhand smoke exposure can have detrimental effects on children's lung function.
Research presented at the ATS 2021 International Conference found that patients with idiopathic pulmonary fibrosis (IPF) living in poor neighborhoods experience poorer outcomes, including increased mortality and reduced odds of receiving a lung transplant. The study highlights the impact of environmental factors on disease progression.
A new study has confirmed that UK children with cystic fibrosis have poorer lung function than their US peers, suggesting differences in treatment patterns may be the cause. The research also found that children in the US received more aggressive mucolytic therapy earlier in life.
SourceUniversity of Liverpool·JournalThorax·DateMay 14, 2021
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers found that individuals with asthma living in historically redlined neighborhoods have lower lung function than those in non-redlined areas. This association was independent of race and co-occurring diseases, suggesting that environmental factors play a significant role in worsening asthma outcomes in these communities.
Researchers have developed a novel nanotechnology that can improve the effectiveness of the CF antibiotic Tobramycin, increasing its efficacy against Pseudomonas aeruginosa lung infections. The technology has shown to eradicate infections in as little as two doses, providing new hope for people living with cystic fibrosis.
SourceUniversity of South Australia·JournalSmall·DateMay 13, 2021
Researchers at Boston University School of Medicine have identified a panel of genes that are active in smokers and ex-smokers who experience faster loss of lung function. These genes may be useful to predict which people are most at risk for smoking-related decline in lung function, offering hope for early diagnosis and treatment.
SourceBoston University School of Medicine·JournalThorax·DateMay 11, 2021
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
A new study reveals that while most COVID-19 patients fully recover, approximately one-third still experience persistent lung changes and reduced oxygen transfer efficiency. Women are more likely to suffer from these effects.
SourceUniversity of Southampton·JournalThe Lancet Respiratory Medicine·DateMay 6, 2021
A team of researchers has created a molecular catalog of cells in healthy lungs and those affected by cystic fibrosis. The study reveals new subtypes of cells and sheds light on the cellular changes that occur in the airways, providing potential targets for future genetic therapies.
SourceCedars-Sinai Medical Center·JournalNature Medicine·DateMay 6, 2021
A team of researchers has developed a molecular catalog of cells in healthy lungs and those with cystic fibrosis, revealing new subtypes of cells and how the disease alters their composition. This discovery could help scientists identify prime targets for future genetic therapies.
SourceUniversity of California - Los Angeles Health Sciences·JournalNature Medicine·DateMay 6, 2021
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
A new study found that repeat vape aerosol exposure had little impact on lung tissue, unlike combustible cigarette smoke, which caused significant biological responses in lung cell models.
SourceImperial Brands·JournalCurrent Research in Toxicology·DateMay 5, 2021
Researchers have developed a new model of NTM lung infection and found that human mesenchymal stem cells (hMSCs) are effective in treating this condition. The study identified donor-specific hMSC potency against NTMs, which could lead to improved treatment outcomes for patients with chronic NTM lung disease.
SourceAlphaMed Press·JournalStem Cells Translational Medicine·DateMay 4, 2021
A team of scientists created a cell atlas using autopsy samples from COVID-19 patients, revealing how infected cells and lungs responded to the virus. The study found repeated attempts by the lungs to repair themselves failed due to viral-induced changes in cellular programs.
SourceBroad Institute of MIT and Harvard·JournalNature·DateApr 30, 2021
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers created a detailed cell atlas of COVID lungs, revealing a trifecta of detrimental effects: runaway inflammation, direct destruction, and impaired regeneration of lung cells involved in gas exchange. This study provides leads on why survivors experience long-term respiratory complications due to lung scarring.
SourceColumbia University Irving Medical Center·JournalNature·DateApr 29, 2021
A new treatment has shown promising results in reducing the severity of acute respiratory distress syndrome caused by the flu in mice. The therapy, based on natural molecules, improves lung function and prevents progression of disease in infected animals.
SourceOhio State University·JournalAmerican Journal of Respiratory Cell and Molecular Biology·DateApr 27, 2021
A Phase 3 trial to test the safety and efficacy of Zyesami and remdesivir for life-threatening cases of COVID-19 has begun enrolling patients. The trial aims to provide additional protection for lung cells and increase treatment options for critically ill patients.
SourceNIH/National Institute of Allergy and Infectious Diseases·DateApr 22, 2021
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
A recent study from West Virginia University reveals that rural e-cigarette users are more likely to develop severe respiratory failure and require critical care. The study found a high correlation between lung injury and toxic volatile organic compounds in e-liquids, particularly in those produced by garage labs.
SourceWest Virginia University·JournalHospital Practice·DateApr 20, 2021