Articles tagged with Menopause
Scientists have discovered a rare sequence variant in the CCDC201 gene that causes primary ovarian insufficiency, leading to an average of nine years earlier menopause. Women carrying two copies of this variant experience almost half of carriers having children after age 30.
The Menopause Society launches a new monthly series to address the limited education on menopause, aiming to improve healthcare professionals' ability to guide patients. The Menopause Step-by-Step resource provides evidence-based guidance on recognizing and managing common clinical issues during the menopause transition.
Elinzanetant, a selective neurokinin-1,3 receptor antagonist, demonstrated significant reductions in vasomotor symptoms frequency and severity vs placebo in postmenopausal individuals with moderate to severe VMS. The treatment also improved sleep disturbances and menopause-related quality of life, with a favorable safety profile.
A new non-hormonal hot flash treatment has been shown to significantly reduce symptom frequency and severity within weeks, while also improving sleep quality and overall well-being. The investigational drug elinzanetant was found to have a favorable safety profile with mild side effects.
Researchers discovered that blocking Cxcr4 in mice reduced white fat tissue, while estrogen therapy could be effective with lower doses. The study offers promising avenues for understanding healthy and unhealthy fat tissue development.
A new study published in Menopause suggests that severe menopause symptoms such as hot flashes can negatively affect cognitive function in postmenopausal women. The study found a link between hot flashes and cognitive impairment in memory, attention, and executive function.
Researchers found that symptom-triggered testing can pick up early-stage aggressive ovarian cancer in 1 in 4 of those affected. The UK's protocol for picking up early-stage disease is an effective way to diagnose even early-stage ovarian cancer, with complete surgical removal possible in more than three quarters of women.
A study by the University of Gothenburg finds that removing Fallopian tubes during laparoscopic sterilization results in marginally more surgical complications than cutting them. The procedure may help protect against future ovarian cancer, a serious disease with limited early symptoms.
A recent study published in The Journal of Clinical Endocrinology and Metabolism found that women who underwent menopause before age 46 were nearly twice as likely to develop breast cancer as other women of similar ages. Relatives of these women were also more likely to have breast, prostate, or colon cancer.
A new study suggests that more than one-third of women do not recognize postmenopausal bleeding as a key symptom, and many healthcare professionals lack adequate education on the subject. The findings highlight the need for improved patient counseling about abnormal uterine bleeding as an early warning sign of endometrial cancer.
A new study published in Menopause suggests that a longer reproductive lifespan is associated with a lower prevalence of multimorbidity in postmenopausal women. The study found that women with longer reproductive lifespans had lower risks of cardiovascular disease, osteoporosis, and other chronic diseases.
Research highlights the need for further study on the impact of sustained heat exposure on hormone release and action. Heat exposure is associated with decreased fertility, increased risks of pregnancy complications and menopause symptoms, as well as worsened conditions like thyroid disorders and diabetes mellitus.
Researchers found that when given accurate information about the anti-Mullerian hormone test, women had less interest in taking the test compared to those who viewed misleading online claims. The study highlights the importance of providing evidence-based information to women seeking fertility treatment.
A study by Dr. Takanori Sekito and colleagues reveals a strong association between vaginal pathogenic Escherichia coli and recurrent cystitis in postmenopausal women, suggesting that targeting both the urinary bladder and vagina is crucial for effective treatment.
A team of scientists from Max Planck Institute found that extremely long-lived proteins in the ovary play a crucial role in preserving fertility. These proteins, known as chaperones, help maintain cellular processes and prevent misfolded proteins from aggregating.
A yearlong randomized controlled trial found that daily prune consumption slowed bone loss connected to osteoporosis. Participants who ate at least four to six prunes every day maintained bone density and bone strength.
Researchers found that women who had their ovaries removed before menopause experience reduced white matter integrity in multiple brain regions. This reduction may contribute to an increased risk of cognitive decline and dementia later in life.
A new brain imaging study led by Weill Cornell Medicine researchers found that estrogen receptors in the brain increase with age during menopause, affecting cognitive and mood symptoms. The study pioneers PET imaging as a tool to track estrogen activity in the brain, revealing potential predictors of common menopause-related issues.
A new study published in Menopause suggests a significant association between chronic kidney disease and tooth loss in postmenopausal women. The study found that lower kidney function is linked to fewer teeth, indicating the need for attention to both oral and bone health in this population.
Hormonally.org provides free-to-access, evidence-based resources on women's hormonal health, empowering women to seek care, treatment, and support. The nonprofit addresses stigmas and misinformation surrounding women's hormonal issues, fostering a supportive online community for connection and shared decision-making.
A new study led by Penn State researchers found that daily consumption of beetroot juice may improve blood vessel function and reduce future heart disease risk in postmenopausal women. Beetroot juice contains high levels of nitrate, which helps blood vessels expand and improves circulation.
Research from the University of Illinois has found a link between per- and polyfluoroalkyl substances (PFAS) and cardiovascular diseases in postmenopausal women. The study reveals how PFAS chemicals interact with pro-inflammatory pathways, providing potential explanations for the increased risk.
Research links early menopause to higher risks of breast and ovarian cancer in women. Second-degree relatives also show increased risks for colon, prostate, and testicular cancers.
Research reveals a three times greater risk for metabolic-dysfunction-associated steatotic liver disease in women with moderate-to-severe vasomotor symptoms compared to those with mild symptom severity. The study highlights the importance of addressing hot flashes and night sweats to assess cardiovascular health.
A new study published in Menopause suggests that acute increases in physical activity and temperature may contribute to the experience of hot flashes in midlife women. Researchers found that performing greater amounts of moderate physical activity than usual was related to more subjectively reported hot flashes.
A large-scale Finnish study discovered a significant link between premature menopause and increased mortality risk. Women with spontaneous premature ovarian insufficiency were more than twice as likely to die of any cause or heart disease, but hormone replacement therapy reduced this risk by half for those using it for over six months.
A new study finds that fezolinetant significantly reduces the frequency and severity of hot flushes in menopausal women for up to 24 weeks without serious side effects. The drug, approved by the FDA and EMA, works by blocking a brain protein involved in regulating body temperature.
A new study suggests that premature surgical menopause can lead to increased muscle disorders, including musculoskeletal pain and sarcopenia. Women experiencing premature menopause are more likely to develop these conditions due to significant hormone deficiency, including decreased estrogen and testosterone levels.
Menopausal hormone therapy is appropriate to treat vasomotor symptoms in early menopause without contraindications. WHI evidence does not support routine supplementation with calcium plus vitamin D or a low-fat diet for preventing fractures and breast/colorectal cancer, respectively.
A new study published in the Journal of Affective Disorders found that women in the perimenopausal stage are significantly more likely to experience depression. The meta-analysis of seven studies involving over 9,000 women from around the world reveals a 40% increased risk of depressive symptoms during this life-stage.
A study published in the Canadian Association of Radiologists Journal shows an increase in breast cancer diagnoses among females in their Twenties, Thirties, and Forties. Younger women are more likely to be diagnosed at later stages and with more aggressive cancer.
A new study from the University of South Australia explores female experiences with pelvic pain and identifies key concepts for effective pain management. The study found that women value learning about the biological explanation for persistent pain, which can help change outcomes and reduce stigma.
A new study suggests that the benefits of hormone therapy for women over 65 years old differ greatly depending on the type, route, and dose prescribed. The use of estrogen monotherapy beyond age 65 was associated with significant risk reductions in mortality, breast cancer, and other health issues.
A new study published in Neurology found that earlier menopause and higher cardiovascular risk are associated with increased risk of thinking and memory problems later. Women who experienced earlier menopause had lower cognitive scores compared to their male counterparts, especially those with high cardiovascular risk.
A study shows post-menopausal women experience a steep rise in heart problems due to reduced estrogen levels, accelerating plaque buildup and cardiovascular risk. Researchers highlight the importance of recognizing early warning signs and increasing screening for coronary artery calcium.
A new study found that postmenopausal women exhibit smaller cortical surface areas in certain brain regions, reduced thalamic subnuclei volumes, and decreased functional connectivity, suggesting a link between menopause-related symptoms and brain changes.
Researchers found that chlorogenic acid enhances osteoblast proliferation and differentiation, while inhibiting RANKL-induced osteoclastogenesis. Administration of chlorogenic acid antagonizes ovariectomized-induced bone loss in rats.
Female whales of certain species experience menopause, living up to 40 years longer than their peers by prioritizing family care over breeding. This unique trait allows them to support their offspring and grandchildren without overlap with their daughters' reproductive cycles.
A new study found that women who enter menopause early experience poorer work ability and reduced working life participation. Healthcare professionals and employers are advised to address menopause symptoms to support women's quality of life and productivity in the workforce.
Research highlights significant security, privacy and safety issues in female-oriented technologies, including period-tracker apps and fertility smart devices. The study found inadequate regulations and industry practices in data collection and sharing, posing a potential threat to users' sensitive information.
A new study published in Menopause reveals that aggregate exposure to neighborhood poverty is associated with increased levels of antimullerian hormone, potentially causing greater ovarian follicle loss over time. This finding highlights the potential effect of early life adversity on reproductive health.
A new approach to menopause is needed, focusing on empowering women with high-quality information and empathic clinical care. The experience of menopause varies for each person, and an individualised approach can help women navigate this life stage.
A new review paper from Brigham and Women's Hospital concludes that menopause does not uniformly elevate the risk of depression and other mental health conditions. Certain groups, such as those with a history of depression or severe sleep disturbances, are more likely to experience depressive symptoms during menopause.
A meta-analysis of 30 studies involving 3,501 women found that cognitive behavioural therapy (CBT) and mindfulness-based interventions significantly improved anxiety, depression, memory, and concentration difficulties. CBT was also the most cost-effective option for menopause management.
A new study suggests that hormone therapy can improve not only hot flashes but also depressive symptoms commonly associated with menopause. Researchers found a high prevalence of depression among women undergoing the menopause transition, and that hormone therapy was effective in managing both hot flashes and mood-related symptoms.
A new study found that women with migraines and long-term hot flashes or night sweats are at increased risk of heart disease and stroke. However, the research suggests that focusing on prevention and correcting unhealthy habits can help most women mitigate this risk. Women who have experienced both migraines and vasomotor symptoms for ...
A new study suggests that women experiencing both migraine and persistent hot flashes are at a higher risk of cardiovascular disease. The research found that these women were 1.5 times more likely to develop heart disease and 1.7 times more likely to have a stroke compared to those without both symptoms.
A new mathematical model predicts that ovarian tissue freezing can potentially delay or eliminate menopause in healthy women. The study, led by Yale University's Kutluk Oktay, uses data from hundreds of previous procedures to estimate the maximum number of years menopause can be delayed, with younger women showing greater promise.
Middle-aged women exposed to toxic metals have fewer eggs in their ovaries as they approach menopause, according to a new study. The researchers found that higher levels of heavy metals such as arsenic and cadmium are associated with lower Anti-Müllerian hormone levels, indicating diminished ovarian reserve.
Menopausal women who regularly swim in cold water report significant improvements to their anxiety, mood swings, low mood, hot flushes, and menstrual symptoms. The study found that cold water swimming relieves these symptoms through physical and mental effects.
Researchers developed a mathematical model that predicts menopause can be delayed by implanting ovarian tissue back into the body, potentially preventing health issues associated with menopause. The model suggests that certain conditions, such as age and primordial follicle count, influence how long menopause is delayed.
A recent study from Drexel University explored an art therapy intervention to address the health needs of overweight, postmenopausal women. The integrated approach showed significant improvements in psychosocial wellbeing, quality of life, and body image, with participants also experiencing decreases in BMI and blood pressure.
Scientists in Brazil have developed a method to obtain a substance similar to estrogen from soy isoflavones, which may help alleviate menopause symptoms. The researchers extracted equol from soybean oil production residue and found it to be more bioavailable than glycosylated forms.
A recent study published in Lancet Oncology has found that measuring blood hormone levels can identify post-menopausal women who are most likely to benefit from anastrozole, a medication used to prevent breast cancer. The study suggests that inexpensive blood tests could be used to personalize preventive therapy for these women.
A new study suggests that a longer reproductive life span is associated with a decreased risk of low handgrip strength in postmenopausal women. The findings, published in Menopause journal, also indicate that this trend continues even after controlling for other variables such as household income and level of education.
Research published in BMJ Open found that women spending 6+ hours/day on sedentary activities may double their risk of uterine fibroids before menopause. The study linked sedentary behavior to increased oestrogen levels, a known risk factor for the condition.
A new study highlights how perimenopausal women's periods may become unpredictable, heavy, and cause worse premenstrual symptoms. The research suggests that improved education and support are needed to manage these changes, including extra support in the workplace, emotional support from loved ones, and access to support groups.
Researchers created an immunodeficient mouse model of physiological ovarian aging, mirroring female fertility decline with age. The study found decreased oocyte quality, impaired follicle activation and growth, and increased mitochondrial dysfunctions in Old mice.
The 2023 Practitioner’s Toolkit for Managing Menopause offers updated guidance on assessing and treating women with menopausal health issues. The toolkit includes new advice on hormone therapies, bone health, and treatment guidelines, aiming to improve care for women globally.
A study of wild chimpanzees in Uganda's Kibale National Park found that females can experience menopause and postreproductive survival. The research challenged the long-held assumption that this trait is unique to humans, suggesting it may be a species-typical trait in chimpanzees.