Articles tagged with Amino Acids
Researchers created nanoparticles using ultraviolet light crosslinked amino acids, loaded with doxorubicin and coated with tannic acid complex. The nanoparticles exhibited superior stability and drug release under different pH conditions, showing excellent anticancer activity in tumor-bearing mice.
A new framework has been established for standardized imaging of diffuse gliomas using amino acid PET, enabling the evaluation of treatment success and improving therapies. The RANO group has developed criteria that enable reliable imaging of tumor activity and extent.
Researchers from Osaka University have discovered a link between the rare D-form of the amino acid alanine and the circadian clock's influence on glucose metabolism in the kidney. The study found that D-alanine regulates gluconeogenesis, a process that creates new glucose to maintain energy levels, and is mediated by the protein Cry2.
Cysteine is sensed by a protein called Pib2 and binds with it to activate TORC1, promoting cell proliferation. The study found that all 20 amino acids differently affect TORC1 using two pathways: Pib2 and Gtr.
Researchers at Politecnico di Milano have designed a hydrogel with specific characteristics using supramolecular chemistry and crystallography. The study showed that the interactions between an amino acid and bioactive molecules can be identical in both solid and aqueous states.
The ATLIGATOR software and its web extension, ATLIGATOR web, enhance protein interaction analysis through a graphical user interface providing pre-generated atlases, pocket collections, and visual interaction data. The web platform offers tools for practical application, including pocket grafting and rational design.
Scientists discovered that malate decarboxylase CsNADP-ME2 mediates the balance of carbon and amino acid metabolism in cucumber fruit. The enzyme plays a crucial role in promoting the production of soluble sugars and starch, while down-regulating its expression leads to increased malate accumulation.
University of Alberta researchers have identified taurine as a key player in predicting poor clinical outcomes and treating long COVID. A predictive test and proposed supplement trial aim to minimize symptoms and improve patient outcomes.
A new AI tool provides fully automated, easy-to-use evaluation of brain tumors using amino acid PET scans. The deep learning-based segmentation algorithm assesses treatment response with quality comparable to that of an experienced physician.
A recent clinical trial found that creatine supplementation significantly reduced post-COVID-19 fatigue and improved related symptoms such as loss of taste and breathing difficulties. Creatine levels in leg muscles and the brain also increased after 6 months of intake.
A recent policy analysis highlights gaps in Canadian regulation of muscle-building dietary supplements, including whey protein and creatine monohydrate. The lack of consistent manufacturing site and product safety testing poses significant health risks to young people.
A novel study found that consuming two oz-eq portions of animal-based versus plant-based protein foods results in different EAA bioavailability. The study, conducted by scientists at Purdue University, included young and older adults, with no differences in EAA bioavailability between age groups.
A HKUST research team has developed a novel technique to self-assemble a thin layer of amino acids with ordered orientation, demonstrating high piezoelectric strength. The technique enables the production of biocompatible and biodegradable medical microdevices, such as pacemakers and implantable biosensors.
A recent study published in GeroScience found that a moderate-protein diet (25% and 35%) improved metabolic health in both young and middle-aged mice. The researchers also observed reduced blood glucose concentrations and lipid levels in liver and plasma. A balanced diet with moderate protein intake may promote metabolic health in huma...
Scientists conducted computational simulations to clarify the origin of life on Earth. The study suggests that chiral asymmetry may have originated in space through CP Lyman-α emission line, influencing the production of biological amino acids.
Researchers have successfully created bacteria that can produce an unnatural amino acid, para-nitro-L-phenylalanine (pN-Phe), which has potential applications in vaccine development. The discovery was made using genetic code expansion methods and metabolic engineering techniques.
A recent meta-analysis shows that amino acid PET can accurately differentiate between recurrent brain metastases and treatment-related changes. This technology has the potential to reduce unnecessary invasive procedures and overtreatment in patients with cancer.
Researchers have identified a new group of mitochondrial viruses confined to arbuscular mycorrhizal fungi Glomeromycotina, which may represent an ancestral lineage of mitoviruses. These large duamitoviruses possess distinct characteristics and are globally distributed in ecological niches occupied by glomeromycotinian fungi.
A new study published in the journal Life suggests that solar particles may have formed amino acids and carboxylic acids, the basic building blocks of proteins and organic life, through chemical reactions in Earth's early atmosphere. The experiments replicate the Miller-Urey experiment, but with a focus on solar particles instead of li...
Researchers from Tokyo Institute of Technology discovered that amide-to-ester substitutions can significantly improve cyclic peptides' membrane permeability, making them suitable for clinical and therapeutic applications. The study used enhanced sampling molecular dynamics simulations to unravel the mechanism behind this effect.
A research group has developed a family of eco-friendly glass fabricated from biologically derived amino acids or peptides. The proposed glass is biodegradable and biorecyclable due to its unique combination of functional properties, including excellent optical characteristics and good mechanical properties.
Researchers at the University of Nebraska-Lincoln have discovered that the orientation of a single amino acid in peptides can direct activation to specific neurons, influencing communication among brain cells. This finding has far-reaching implications for understanding and regulating signaling processes in the brain.
A Keck School of Medicine study found exposure to PFAS, known as 'forever chemicals,' disrupts key biological processes in children and young adults, increasing risk of diseases such as developmental disorders, cardiovascular disease, and cancer. The study highlights the importance of regulating PFAS as a class of chemicals.
Researchers discover abiotic peptide chain formation from glycine in space conditions, shedding light on the origin of life. The study shows that small clusters of glycine molecules exhibit polymerization upon energy input.
Researchers found that metabolites associated with the Mediterranean diet may serve as an objective measure to assess adherence among pregnant individuals. The study identified several key metabolites linked to maternal physiology and outcomes, including gestational diabetes and chronic diseases.
Researchers developed a 'scanning and direct derivatization' method to target polymyxin, an antibiotic of last resort, for treating diseases resistant to conventional drugs. The method generated hundreds of peptide derivatives with varying effects, accelerating drug development.
A new study from the University of Copenhagen suggests that combining proteins and antioxidants in foods like coffee with milk may have an anti-inflammatory effect in humans. The researchers found that immune cells treated with this combination were twice as effective at fighting inflammation as those with only polyphenols.
Researchers at Iowa State University have identified a metabolic switch that can be modified to control fat production, which could lead to more effective treatments for childhood obesity and cancer. The discovery involves altering the acetylation levels of fatty acid synthase, an enzyme critical to de novo lipogenesis.
Researchers recreated interstellar cloud and asteroid conditions to understand how carbonaceous chondrites acquired amino acids, finding that interstellar cloud conditions are resilient to asteroid processing but influence the amount of amino acids present.
A study by researchers from the University of Tsukuba found that treating cabbage leaves with multiple amino acids can prevent disease caused by Pseudomonas cannabina pv. alisalensis, a bacterium that causes blight in brassica crops. The amino acids trigger stomatal closure, reducing bacterial entry and disease symptoms.
Researchers found that gamma rays can catalyze the formation of amino acids in early meteorites, which could have contributed to the origin of life on Earth. The study provides evidence for a possible mechanism by which life's building blocks were delivered to our planet.
Researchers discovered three essential amino acids - leucine, valine, and tryptophan - as potential metabolic biomarkers for HCC. The study used metabolomics to analyze the differences in tumor and non-tumor tissue metabolomes, revealing striking differences that could aid in diagnosis.
Researchers found reduced levels of D-amino acids in patients with severe COVID-19 and IAV infection, suggesting they could be used as biomarkers. Supplementation with D-alanine improved survival rates and clinical outcomes in mouse models of both infections.
A recent study from the University of Copenhagen reveals that Mars was once covered in a 300-metre-deep ocean, filled with water and icy asteroids carrying biologically important molecules. This finding suggests that conditions allowing the emergence of life were present on Mars long before Earth.
A research group at Kobe University has successfully synthesized α-amino acid N-Carboxyanhydrides (NCAs), a crucial precursor for artificial polypeptides, using the photo-on-demand phosgenation method. This new synthesis method eliminates the use of toxic phosgene and is considered safe, inexpensive, and simple.
Researchers found that short bursts of activity after meals can improve the body's ability to use amino acids from food to build muscle proteins. Breaking up prolonged sedentary periods with brief activity 'snacks' may help maintain muscle mass and quality, according to a University of Toronto study.
Researchers at Leibniz-Institut für Lebensmittel-Systembiologie an der TU München discovered that casein digestion produces peptides with a satiating effect, stimulating gastric acid secretion via bitter receptors. This mechanism may help regulate food intake and maintain a healthy body weight.
Researchers found a way for peptide-forming reactions to occur in water, solving a decades-long puzzle about early Earth chemistry. The process requires rapid reactions on the margins of water droplets, where amino acids can transform into life's building blocks.
Researchers at Tokyo Institute of Technology have developed a novel method for detecting protein phosphorylation using phosphate's electrical signature. The technique boasts 95% accuracy and 91% specificity, offering new avenues for clinical diagnosis and pharmaceutical applications.
Researchers have found that amino acids in saliva can help identify patients with severe Covid-19 cases. The study collected saliva samples from 75 individuals and found that amino acids changed the most between patients with low and high severity of Covid-19.
A team of researchers from Ritsumeikan University in Japan has elucidated the mechanism behind the liquid-solid phase transition of FUS protein that leads to ALS. They discovered a new therapeutic target, arginine, which suppresses FUS aggregation and could delay ALS progression.
Researchers at Scripps Research have discovered a new set of chemical reactions that generate amino acids and orotic acids from common early earth molecules. This discovery sheds light on the origins of life on Earth and has potential applications in manufacturing processes.
The study found that supplementing diet with taurine can increase levels of the antioxidant enzyme superoxide dismutase and reduce oxidative stress. Taurine supplementation showed modest effects on markers of oxidative stress and mineral levels, suggesting potential benefits for anti-aging therapy.
Researchers discovered a mechanism by which plants stabilize protein molecules during folding, even in low-oxygen conditions. The study found that the redox potential of supporting proteins plays a critical role in disulfide bridge formation and protein folding.
Researchers at Tokyo University of Science have developed a fast and facile synthesis method for antibacterial amino acid Schiff base copper complexes using microwave irradiation. The new technique produces high-purity products with promising antimicrobial activity, overcoming the challenge of long synthesis times.
Liu's three-year grant will pursue protein-derived cofactor studies to improve understanding of amino acids and their role in metabolism. The research aims to gain a quicker and more thorough understanding of amino acid function and purpose.
The Biofinder instrument has successfully detected bio-residue in ancient fish fossils from the Green River formation, confirming that biological residues can survive millions of years. The device's capabilities make it an ideal tool for future NASA missions to detect signs of past life on other planetary bodies.
A new study by the University of Colorado Anschutz Medical Campus explores the effects of multiple mutations in SARS-CoV-2 variants. The findings suggest that certain mutations work together to improve virus fitness, making it challenging for antibody treatments to neutralize new variants.
Researchers at DTU Compute and DIKU have developed a machine learning model that can map the potential of proteins, enabling the biotech industry to accelerate the development of new proteins. The model generates a picture of how proteins are linked, allowing for the identification of closely related proteins with desirable properties.
A new study published in Scientific Reports reveals that regular high-intensity interval training exercise can significantly decrease fasting glucose levels and waist circumference, while improving oxygen consumption rates in patients with non-alcoholic fatty liver disease. Exercise also modifies amino acid metabolism in adipose tissue...
Researchers studied peptide bond formation between tRNA molecules and a ribosomal RNA segment, revealing the potential for minihelices to bind to the primordial peptidyl transferase center. The study suggests that functional interactions between tRNA and PTC could have been 'revised' in evolution.
Researchers at University of Bonn identified a key enzyme, RIM1, that maintains synaptic homeostasis and prevents excessive brain activity. The discovery has implications for understanding diseases such as epilepsy, schizophrenia, and autism.
Researchers developed a MOF-based system for delivering DNA into target cells, overcoming challenges in gene therapy. The tiny structures protected genetic cargo and helped ferry it into the nucleus, where gene activity takes place.
Researchers developed a compound consisting of insulin bound to an antioxidant group, improving glucose consumption and brain function in mice with type 1 diabetes. The combination therapy showed better cognitive performance than individual treatments alone.
A team of scientists successfully investigated the electronic structure of tautomeric mixtures using inelastic X-ray scattering (RIXS) at BESSY II. They can now experimentally separate the signal of each individual molecule, providing detailed insight into their functionality and chemical properties.
Researchers from the University of Tsukuba found that D-serine controls tissue pocket formation, allowing for successful tail regression in marine sea squirts. The study's findings provide insight into epidermal homeostasis and evolutionary perspectives on D-amino acid function.
Researchers found that bilobalide, an active ingredient in Ginkgo biloba extract, protects the heart from ischemic injuries by preserving ATP generation and enhancing metabolic flux. The study suggests that bilobalide may provide a new herbal therapy for treating myocardial ischemia.
A dietary supplement combining 5-aminolevulinic acid and sodium ferrous citrate helps slow down aging-related muscular decline in fruit flies. The study reveals improved muscle architecture and mitochondrial function, offering a potential therapeutic option to address age-related muscle health.
Scientists have characterized thousands of small molecules in coral reef ecosystems, providing insights into food web dynamics and chemical ecology. The study found that corals and seaweeds release diverse compounds that influence nutrient concentrations and availability in the ecosystem.
Researchers developed a novel polymeric nanoparticle that selectively binds to fibrinogen in human plasma, offering a simpler and less expensive way to manufacture fibrinogen concentrate. This breakthrough could lead to the creation of more efficient fibrinogen-specific affinity reagents for drug development.