Articles tagged with Controlled Trials
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A two-dose Ebola vaccine regimen has been found to be safe, well-tolerated, and produce a strong immune response in people over 1 year old. The study also supports the use of this regimen for Ebola virus disease prevention in children and adults.
A randomized controlled trial found that facility-based and home-based multidomain interventions improved cognitive function and retention rates among participants aged 60-79. The programs showed indicators of efficacy and feasibility, with potential benefits through inactivation of the HPA axis and enhanced brain plasticity.
Researchers compared the accuracy of two types of fecal tests for detecting colorectal cancer, finding that both types are reliable when thresholds are adjusted. The study suggests that health providers should select the best type of test based on specific demands in screening settings.
A new study published in the Journal of Consulting and Clinical Psychology found that a six-week progressive muscle relaxation program significantly improved grief severity and yearning in widows and widowers. This approach was more effective than mindfulness training, which also showed improvements but not to the same extent.
A systematic review found evidence that non-invasive brain stimulation can reduce smoking frequency in nicotine-dependent smokers. High-frequency repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex was associated with the greatest reduction in smoking frequency.
A new app called selfBACK has been developed to help people deal with back pain in a better way. The app uses artificial intelligence and draws on other people's experiences with back pain to provide tailored advice and feedback.
Researchers found that startups using A/B testing are more successful, with improved performance by 30-100% and higher product innovation rates. The study also found that smaller firms without financing can benefit the most from A/B testing, but use it least.
A new trial found that remdesivir and hydroxychloroquine have no impact on viral clearance in hospitalized COVID-19 patients. Despite not affecting mortality, the treatment groups showed a decrease in SARS-CoV-2 load within the first week.
A new study analyzing 1,200 RCTs found that reporting of adverse effects has only improved slightly over the past 17 years. Researchers argue that many trials focus on benefits rather than harms, and selective reporting can misinform clinical decisions.
Despite widespread use, many common joint procedures like hip replacements and shoulder repair surgery have limited high-quality evidence to support their clinical effectiveness. The analysis highlights the urgent need for research and definitive trials to evaluate these interventions.
New CONSORT-AI extension addresses limitations in AI study reporting, promoting standardization and improving the validity of AI studies in dentistry. With the growth of AI in clinical trials, standardized reporting is crucial to gauge methodology, bias, and replication.
Training stroke survivors to walk at a faster speed can help improve the brain function that enables people to walk and perform another task simultaneously. Advanced brain imaging found changes in the brain consistent with adaptations necessary for controlling gait in complex environments, supporting the findings.
The study found large, statistically significant reductions in mortality, time to recovery, and viral clearance for COVID-19 patients treated with ivermectin. Ivermectin significantly reduces the risk of contracting COVID-19 when used regularly.
School-based interventions, particularly peer-assisted instruction and small-group teaching, have positive effects on reading and mathematics for students with academic difficulties. These targeted interventions can substantially boost skills in these students.
Researchers found that adolescents with autism exhibit greater brain activity during proactive executive control tasks, suggesting a unique approach rather than impairment. The study also revealed enhanced connectivity between regions associated with reactive control processes in individuals with autism.
Researchers at George Mason University are conducting two studies on adaptive interventions for emotion regulation in the workplace. The first study evaluates the effectiveness of three cognitive reappraisal Just-in-Time Adaptive Interventions (JITAIs) in achieving proximal emotion and performance outcomes.
A randomized controlled trial found that Congressional offices with targeted support reported increased value of scientific evidence for understanding legislative issues. The intervention group introduced around 23% more bills using research evidence language and reported a 7% greater value of using research evidence compared to controls.
A new toolkit developed by Brigham and Women's Hospital has significantly reduced falls and fall-related injuries among hospitalized patients. The toolkit, which engages patients and families in fall prevention strategies, was associated with a 15% reduction in falls and a 34% reduction in injurious falls.
A randomized controlled trial found that vitamin D supplementation improved clinical outcomes for children with severe atopic dermatitis. The study involved 86 patients who received either oral daily vitamin D or placebo for 12 weeks.
A two-drug combination of dapagliflozin and exenatide continues to effectively control patients' glucose levels without losing efficacy over a two-year period. The study also revealed significant improvements in blood pressure and weight, contributing to overall health.
The TARGET FFR trial found that a physiology-guided incremental optimization strategy (PIOS) reduced the proportion of patients with a final post-PCI FFR ?0.80, while also improving mean Coronary Flow Reserve. The study's results suggest potential benefits for PCI outcomes.
A five-year exercise training trial found no correlation between physical activity and increased longevity among elderly participants. Researchers suggest that current guidelines for moderate-intensity exercise may be sufficient for reducing mortality risk in older adults.
A new randomized control trial found that gamifying mobile mental health intervention content improved resilience and reduced attrition. The study showed significant benefits in both resilience and anxiety measurements after five weeks, with the game group retaining 21% more participants than other groups.
The EAST-AFNET 4 trial found that early rhythm control therapy reduces cardiovascular complications and death in patients with atrial fibrillation. Rhythm control therapy delivered soon after diagnosis can improve outcomes, including reduced risk of severe cardiovascular complications.
A new meta-analysis of published studies on hydroxychloroquine for COVID-19 treatment finds no mortality benefit, while combining it with azithromycin is associated with a 27% increased risk. The study supports current clinical recommendations against using these drugs for COVID-19 patients.
A new study found that texting intervention as an add-on to mental health treatment programs improved symptoms and increased participant engagement. The research team developed a text-messaging-based psychotherapy tool that was clinically promising, safe, and feasible for people with serious mental illness.
A new study published in Psychological Science found that improving subjective well-being through online and in-person interventions had positive effects on self-reported physical health. Participants who received the intervention reported increasing levels of happiness and fewer sick days compared to control participants.
A new study published by The Endocrine Society found that cinnamon supplementation lowered abnormal fasting glucose levels and improved response to eating carbohydrates. Cinnamon was well-tolerated without adverse effects.
The study found that focusing on subjects less likely to remain in the program, such as smokers and those with negative low-dose CT exams, improves cost-effectiveness and maximizes societal benefits. Adherence increased progressively with higher Lung-RADS categories, and having smoked previously was a significant predictor of adherence.
In a multicenter randomized controlled trial, crossover patients who received renal denervation due to elevated ambulatory blood pressures experienced significant reductions in daytime ambulatory systolic BP. The blood pressure lowering effect was consistent with primary RADIANCE-HTN SOLO results.
A recent randomized controlled trial found that landiolol hydrochloride administration reduced the incidence of postoperative atrial fibrillation after esophagectomy for esophageal cancer. However, this did not impact overall survival in patients with esophageal cancer.
A randomized trial found that rituximab reduces the risk of relapse by 64% compared to azathioprine, with fewer severe adverse events. The study suggests that rituximab may be a superior treatment option for patients with ANCA-associated vasculitis, particularly those with history of relapses.
A randomized controlled trial found that intra-articular hypertonic dextrose injections significantly reduced knee pain in patients with moderate to severe osteoarthritis. The study, conducted at the Chinese University of Hong Kong, involved 76 patients who received either the hypertonic dextrose or normal saline injection therapy.
A small observational study of 29 Italian patients with severe COVID-19 and hyperinflammation found that high-dose intravenous anakinra was associated with respiratory improvements and reduced signs of cytokine storm in 72% of patients. The treatment was generally safe, but more research is needed to fully understand its effectiveness.
A study of randomized controlled trials found that consuming green tea led to a significant decline in body weight and body mass index. However, the analysis did not reveal any notable changes in waist circumference after supplementation.
A George Mason study found that alternate light source detects bruises 5 times better than white light on diverse skin tones, addressing the disparity in bruise detection for people of color. The research aims to improve medical and legal outcomes for victims of violence.
A randomized clinical trial in 60 urban workplaces in China found that a wellness program with hypertension management component significantly improved blood pressure control among employees. The program reduced systolic blood pressure by 3.5 mmHg and diastolic blood pressure by 2.5 mmHg compared to usual care.
A new randomized controlled trial found that the guided self-help intervention SH+ significantly reduced psychological distress and improved functioning, depression, and wellbeing among South Sudanese female refugees. The intervention was highly acceptable to participants, with 80% attending all five sessions.
A randomized controlled trial found that the ACE method was as effective as a specialist stop smoking service in quitting smoking. The study's results suggest that ACE may offer a viable cost-effective alternative for public-funded healthcare settings.
Researchers found no depression or anxiety from dementia screening in older adults. The study also showed that screening did not reduce emergency department visits and hospitalizations. Dementia screening provides awareness for patients and families to take action, including advance care planning.
A newly released special issue examines the prevalence of null findings in randomized control trials, highlighting their expected and valuable role in evaluation research. Key articles propose frameworks for defining and interpreting null results, exploring context and implementation fidelity as factors influencing outcomes.
The Lancet Respiratory Medicine published a series of papers on cystic fibrosis treatment, including new CFTR modulator drugs showing promise and improving patient outcomes. Additionally, a three-in-one inhaler therapy was found to improve lung function and reduce asthma attacks in patients with severe asthma.
A new triple-therapy inhaler combining a steroid preventer, long-acting bronchodilator, and muscarinic antagonist significantly improved lung function and reduced moderate to severe asthma attacks. Patients with uncontrolled asthma who used the inhaler saw increased airway obstruction clearance and fewer exacerbations.
A major Canadian-led study has found that most adults can continue to eat red and processed meat without significant impacts on heart disease, diabetes, or cancer. The researchers concluded that a small reduction in risk was associated with reducing meat consumption by three servings per week.
Researchers conducted a randomized controlled trial in New Haven, Connecticut, where police officers made community policing visits to residents' homes. The study found that positive interactions improved public trust and cooperation with police, especially among black individuals and those with strong negative views towards the police.
The Lancet published several studies on cardiovascular disease, including a new risk chart for 21 global regions and a trial on percutaneous coronary intervention versus coronary artery bypass grafting. Additionally, the journal presented findings on sirolimus-eluting stents versus durable polymer everolimus-eluting stents in patients ...
A study found that providing current medical research to patients and visitors in waiting rooms increases interest by 30 percent. The trial, conducted in North Queensland, Australia, showed that age and gender also play a role in public interest.
A randomized clinical trial and meta-analysis found intensive blood pressure control to be more effective than standard control in reducing stroke recurrence risk. Patients who received intensive blood pressure control had a lower risk of stroke compared to those on standard control, suggesting potential benefits for stroke prevention.
A new Phase III clinical trial will assess the efficacy and safety of thrombectomy procedure in patients with larger ischemic strokes. The trial aims to determine if thrombectomy is safe and effective for this population, which has limited treatment options.
A Mount Sinai study found improved asthma control and quality of life in older patients, with a significant reduction in emergency department visits. The study tested a patient-tailored self-management support intervention, which targeted social determinants of health and achieved meaningful improvements.
Two new trials show oral semaglutide is more effective than subcutaneous liraglutide in treating type 2 diabetes, with the latest trial showing it's also safe for patients with moderate renal impairment. Another trial found that insulin degludec plus liraglutide is a durable therapy option for type 2 diabetes.
The Lancet journals present research on improving stroke outcomes, including effects of antiplatelet therapy and robotic training for upper limb rehabilitation. Papers also explore extending thrombolysis and stenting for symptomatic vertebral artery stenosis.
A randomized, controlled trial found that ultra-processed diets led to higher calorie consumption and weight gain compared to unprocessed diets. Participants consumed an average of 508 calories more per day on the ultra-processed diet, resulting in a two-pound weight gain.
A digital parent training intervention with telephone coaching was successfully implemented in primary health care, reducing discontinuation rates by nearly half. The programme improved parenting skills and satisfied parents, highlighting the potential of web-based interventions to facilitate better access to mental health services.
A meta-analysis of randomized controlled trials found that diets with high-quality protein sources from plants like legumes and nuts lower cholesterol levels and blood pressure compared to those with red meat. This study provides evidence for the benefits of plant-based diets in reducing cardiovascular disease risk factors.
A six-week mindfulness-meditation training program significantly reduced subjective distress and life dissatisfaction in mildly stressed adults. The effects were mediated by a reduction in perceived stress, supporting the theory that mindfulness facilitates acceptance of internal reactions to stressors.
Researchers will conduct the first randomized controlled trial of a peer-based recovery intervention for patients at high risk of overdose. The study aims to compare the effectiveness of a single session with a social worker versus a four-year peer-led recovery program.
A systematic review found that serotonin-noradrenaline reuptake inhibitors can cause withdrawal symptoms when discontinued, with venlafaxine showing higher prevalence rates. These symptoms typically occur within a few days of stopping the medication and can last several weeks.
Studies present new approaches to treating small coronary artery disease with drug-coated balloons, reducing the need for stents. Radial access is associated with lower rates of adverse events compared to femoral access in patients with acute coronary syndrome.
A recent randomized controlled trial found that consuming red raspberry drinks improved flow-mediated dilation, an established biomarker of cardiovascular disease risk. Ellagic acid and urolithin metabolites correlated with FMD improvements in some participants.