Articles tagged with Research Impact
A Rutgers Health study found that abdominal fat depots are related to lower cognitive functioning and brain volumes in middle-aged males at high Alzheimer's risk, but not females. The study challenges the use of BMI as a primary measure for assessing obesity-related cognitive risks.
Researchers found GZ17-6.02 alone and in combination with standard-of-care agents was effective in killing MF cells, activating key pathways including ATM, AMPK, NFκB, and macroautophagy. The compound's unique multi-factorial mechanism suggests potential for treating mycosis fungoides.
A recent study by Binghamton University researchers found that 90% of commercial tattoo inks in the US market contain major discrepancies between their actual and labeled contents. The study analyzed 54 inks from nine manufacturers and discovered unlisted polyethylene glycol, propylene glycol, and other contaminants.
A national multicenter survey found that up to one-third of children who were hospitalized due to COVID-19 did not fully recover and experienced persistent symptoms. Children who had not recovered were more likely to have neurological symptoms, including headache and weakness.
Researchers have discovered a previously unknown neurochemical mechanism behind human tendency to make decisions based on social context. The study reveals the dynamic interactions of dopamine and serotonin in the brain's substantia nigra area, which contribute to our brain's overall assessment of value during social interactions.
Calls to US poison centers involving psilocybin among teens and young adults tripled and doubled, respectively, after decriminalization, leading to alarming concern over potential long-term consequences. Most calls involved intentional consumption, with adverse reactions including hallucinations, agitation, and heart rate issues.
A new study found that mass shooting lockdown drills help children who have been exposed to violence feel safer, contradicting previous research conclusions. Lockdown drills may be a way to help students who have been exposed to violence feel safer in schools.
Researchers at Aston University will explore gel electrolyte materials to improve lithium-ion batteries' safety and environmental sustainability. The project aims to replace harmful components with renewable ionogels, addressing the need for scalable methods of storing electrical energy.
A new American Heart Association scientific statement offers the latest knowledge on neurodevelopmental outcomes in people of all ages with congenital heart disease. The statement highlights that neurodevelopmental difficulties are common complications faced by individuals with congenital heart disease, affecting their ability to funct...
Researchers created novel gene editing enzymes with improved precision, reducing off-target RNA edits by over 99%. The technology has potential applications in treating mitochondrial genetic diseases and may lead to transformative treatments within the next five years.
Researchers have introduced an optimization technique that accelerates Bayesian inference without requiring extensive user effort. This new automated method achieves more accurate results faster than another popular approach and offers reliable uncertainty estimates to help scientists understand when to trust their predictions.
University of North Carolina at Chapel Hill researchers have developed a new drug delivery platform that harnesses helical amyloid fibers designed to untwist and release drugs in response to body temperatures. This discovery could be useful in treatment to reverse Alzheimer’s Disease impact by degrading amyloid plaques.
Researchers identified a putative paclitaxel response predictive biomarker for glioblastoma and breast cancer using the whole genome CRISPR knockout screen. The biomarker candidate was validated in two independent breast cancer patient cohorts that received taxane treatment.
A study by UC Davis Health found that a single dose of BCG reduced liver tumor burden and extended the survival of mice with liver cancer. The vaccine boosted the body's immunity, leading to tumor shrinkage and improved liver function.
Researchers at Texas A&M University have developed a coating that bolsters the safety of fresh produce and provides enhanced protection against bacteria and fungi. The coating combines wax with nano-encapsulated cinnamon-bark essential oil in protein carriers to enhance antibacterial properties.
New research led by Johns Hopkins Medicine reveals that age-related changes in fibroblast cells enable pancreatic cancer tumor growth. The study found that older patients have poorer prognoses due to altered proteins released by fibroblasts, which promote cancer cell growth and spread.
Researchers identified NTRK gene fusion in 1.5% of Finnish papillary thyroid cancer patients, with notable co-occurring genetic alterations and favorable treatment outcomes. The study highlights the potential for biobank samples linked to electronic health records to describe patient characteristics and outcomes.
Researchers have confirmed a new method for precise body composition analysis using 3D surface scans and dual-energy X-ray absorptiometry. This approach yields accurate measurements of fat, lean muscle, and bone, surpassing commercial software in clinical settings.
A Princeton-led study found that flexible geothermal power can provide over 100 gigawatts of clean energy in the western US, surpassing the existing nuclear fleet. By leveraging enhanced geothermal's energy storage properties, plants can generate electricity on demand, complementing intermittent sources like solar and wind.
A study co-led by Prof. Kelly Metcalfe finds risk-reducing mastectomies significantly reduce breast cancer risk and death probability in women with a BRCA1 or BRCA2 genetic variant. The procedure reduces the risk of breast cancer by 80% and decreases mortality to less than 1%.
Chemical reactions were long thought to occur along minimum energy paths. However, researchers have now observed 'roaming' reactions that stray from this path even in highly excited energy states. This discovery has significant implications for understanding atmospheric chemistry and the production of molecular oxygen.
A recent study by the University of Surrey analyzed articles published in the Journal of Management Studies over the last decade and found that diverse research teams lead to more citations. The study reveals that internationality, interdisciplinarity, and gender diversity among authors all contribute to increased citation rates.
MIT researchers found that applying a small voltage to a catalyst can significantly increase the rates of non-redox chemical reactions used in petrochemical processing and pharmaceutical manufacture. This discovery has the potential to transform our understanding of catalysis and design new reactors to take advantage of this phenomenon.
A study published in Oncotarget has identified specific mutational and therapeutic landscapes of pancreatic cancer in the Russian population. By applying machine learning models to full exome individual data, researchers received personalized recommendations for targeted treatment options for each clinical case.
A new study from the Icahn School of Medicine of Mount Sinai reveals significant variations in emergency medical service (EMS) performance across the United States. The research found that EMS agencies in rural areas were less likely to provide optimal care, including treating low blood sugar and pain for trauma patients.
A team of researchers from the University of Córdoba has translated and validated a scale to evaluate negative attitudes towards bisexuality, highlighting gender differences and correlations with sexism and social dominance. The scale aims to promote equal treatment and move towards a more egalitarian society.
A new study found that 17% of young mothers in Wales experienced at least one child being taken into care between 2014 and 2021. The study also revealed that many care-experienced mothers experience early motherhood and placement instability, leading to concerns about family separation.
Two new EU-funded projects, PollinERA and WildPosh, will investigate the toxicological and ecological impacts of chemical pollution on terrestrial biodiversity and pollinators. The projects will improve risk assessment tools and characterise exposure routes to pesticides in four European regions.
Researchers at Dartmouth's Geisel School of Medicine and Thayer School of Engineering have made significant breakthroughs in understanding how antibodies combat herpes simplex virus (HSV) infections. The study reveals that antibody effector functions play a critical role in protecting against HSV, which may lead to new treatments for n...
Jian Shi, a UH researcher, has developed a carbon-driven framework called "ZERO-Accelerator" to expedite the transition from fossil fuels to clean energy. The framework integrates novel mechanisms and algorithms into current power grid operational practices to achieve a 24/7 zero-carbon power grid.
The new advisory highlights the dramatic advances in understanding and treatment of cardiovascular diseases over the past century. These advancements have saved millions of lives and reduced heart disease death rates by more than half since 1950.
Researchers found Mad2 gene expression levels correlate with chromosomal abnormalities in esophageal squamous cell carcinoma, highlighting potential as a clinical biomarker. The study also revealed the deregulation of the Rb-E2F1 circuit and its impact on histone modifications.
The University of Missouri researchers are developing new technology to rapidly detect and mitigate salmonella and other foodborne pathogens throughout the entire poultry supply chain. The team aims to significantly reduce the risk of foodborne illness in people, with rapid results that can be produced in one hour or less.
The University of Texas at Arlington has selected 16 undergraduate students to join the McNair Scholars Program, a Department of Education-funded grant. The program prepares students for careers in academic research with a stipend, summer research internship, and mentorship from UTA faculty.
A new blood test developed by Indiana University School of Medicine has identified biomarkers that can objectively measure schizophrenia severity and predict future risk. The test enables personalized treatment matching, reducing uncertainty and improving patient outcomes.
The study evaluated the effectiveness of ruxolitinib in treating relapsed/refractory multiple myeloma. Researchers found that ruxolitinib inhibited JAK signaling, leading to enhanced anti-tumor effects and improved patient outcomes.
A new study sheds light on the complex relationship between forests and the climate system, highlighting the impact of forest emissions on cloud formation and global temperatures. Researchers emphasize the need for improved climate models to accurately represent these interactions.
The American Heart Association's PREVENT risk calculator will be evaluated among diverse populations to assess its accuracy and fairness. The research aims to ensure that the tool provides accurate risk predictions for people from various racial, ethnic, and socioeconomic backgrounds.
Researchers found elevated PROX1 levels in advanced colon adenocarcinoma, correlating with poor prognosis. PROX1 modulates CRC cell behavior, influencing invasiveness and survival outcomes. The combined PROX1/α-SMA gene set emerges as a potential CRC prognostic marker.
Researchers discovered two new genetic pathways associated with worse ICH outcomes, including a pathway affecting blood coagulation and cellular interactions. Population data showed a decrease in aneurysmal SAH strokes and a rise in non-aneurysmal subarachnoid hemorrhages, offering encouraging evidence for intervention success.
The American Heart Association and The Children's Heart Foundation have pledged over $10 million in funding to research congenital heart defects. Researchers will advance their work to improve diagnosis, treatment, and prevention of CHDs, giving more children a chance to grow into healthy adults.
Christi Bergin's research focuses on improving prosocial behavior in classrooms and communities, leading to better student engagement, academic achievement, and relationships. Her approach aims to reduce teacher stress and burnout by promoting empathy and kindness among students.
Researchers at UBC Okanagan have developed a new modeling framework called TOSCA, which helps improve wind energy forecasts and productivity. The framework can capture the interaction between large wind farms and the oncoming wind, leading to more accurate estimates of power output.
The lack of synergy between academia and industry in drug discovery hinders the development of effective treatments. Researchers discuss why many therapeutic molecules fail to reach clinical trials despite pre-clinical efficacy.
The 2024 Hill Prizes were announced by Lyda Hill Philanthropies, awarding $2.5 million to five Texas researchers for their groundbreaking work in medicine, engineering, and biological sciences. The prizes aim to accelerate high-risk research ideas with significant potential for real-world impact.
Researchers created mathematical models to examine aspects of human behavior affecting pandemic trends. They found that risk perception and adherence to preventive measures are crucial in understanding why similar policies resulted in different outcomes.
The study identifies areas with high carbon footprints, including those reliant on fossil fuels and manufacturing, highlighting the need for targeted economic assistance programs. The research provides a precise way to assess industrial composition, helping policymakers incorporate considerations into future policies.
A longitudinal study found that higher consumption of tea, processed meats, and food prepared outside the home is associated with increased levels of PFAS in the body over time. This suggests potential solutions for protecting the public from these harmful chemicals.
A study of over 580 children found that childhood trauma disrupts neural networks involved in self-focus and problem-solving. The research suggests that trauma therapies should address not only thoughts but also the impact on the body, sense of self, emotional processing, and relationships.
Black adults in the US suffer from short and very short sleep after exposure to news about police killings of unarmed Black individuals. The study's findings suggest that poor sleep health is another tragic byproduct of exposure to these events.
The University of Texas at Arlington is advancing its understanding of deadly disease tuberculosis (TB) with a new research project led by associate professor Kayunta Johnson-Winters. The project aims to understand why certain types of Mycobacterium tuberculosis bacteria do not respond to treatments.
People with stroke mimics are at a higher risk of developing post-traumatic stress disorder (PTSD) than those with confirmed strokes. Researchers found that patients with stroke mimics experience significant psychological distress and increased cardiovascular health risks.
A preliminary study presented at the American Stroke Association's International Stroke Conference 2024 found that lifetime exposure to sexual assault and other traumatic stressors can negatively impact subsequent stroke recovery. Researchers analyzed data from the STRONG study and discovered that stroke survivors exposed to sexual ass...
Researchers identified 180,940 people who had suffered a recent stroke and matched them to control groups to evaluate dementia risk after stroke. The study found that the rate of post-stroke dementia was higher than the rate of recurrent stroke over the same time period.
The electrospinning and electrospraying synergism (ESS) technology has the potential to revolutionize various sectors such as bioengineering, textile technology, medical treatment, and energy conversion. By combining these two twin-tech methods, researchers can create complex structures with unique properties.
Researchers identified senescence-related tumor microenvironment genes associated with poor prognosis, genetic alterations, and reduced responsiveness to immunotherapy in HNSC. The study highlights the importance of precision medicine approaches for personalized treatment.
Researchers have uncovered the molecular and ultrastructural features of BCAS1+ cells in diffuse gliomas, highlighting their proliferative capacity and distribution. The study provides a comprehensive characterization of the BCAS1+ cell population within diffuse gliomas, shedding light on its role in tumor malignancy.
Researchers at Delft University of Technology have developed pioneering advancements in the purification of isopropanol and acetone from waste gases through engineered bacteria. The novel process shows high-purity yields with recoveries over 99.2%, marking a significant step forward in sustainable industrial fermentation.
The study proposes technical, legal, and economic interventions to transition the global plastics system to net zero emissions by 2050. The authors emphasize the need for concerted action across four target areas: smart materials design, waste management, recycling, and reducing future demand.
West Virginia University has been awarded a $1 million National Science Foundation grant to drive energy technology and infrastructure development in the region. The initiative aims to identify pathways for workforce development and policy development that accelerates adoption of energy technologies.