News on measuring and increasing the impact of research. Covers research-impact data, AI publishing workflows, open-access programs, and scholarly metrics.
Researchers define a 'core senescent profile' in human colon fibroblasts, revealing potential driver proteins involved in CRC. The study's findings provide insights into therapies for improving overall health and preventing CRC.
Research published in Science found that 21% of rivers worldwide showed significant alterations in seasonal water levels due to climate change. This threatens freshwater biodiversity and water security as river flow seasonality weakens.
A new IIASA study proposes a stochastic modeling framework to improve West Africa's food supply reliability. By sharing risk over time and space, policymakers can make informed decisions to strengthen the resilience of the food system.
Researchers from Shibaura Institute of Technology develop new methodology to accurately simulate soil behavior in rigid state, leveraging MSP method and Bingham fluid biviscosity model. The study highlights the impact of parameters on simulation accuracy and computational costs.
A new study published in Oncotarget reveals a higher prevalence of germline BRCA1 and BRCA2 mutations in ovarian cancer patients from the Salento peninsula, with 28.6% having familial cases and 39.7% having sporadic cases. The study found that 29.8% of patients were carriers of BRCA1/2 mutation.
A new rapid test has been developed to identify hantavirus in South Korea, paving the way for early outbreak control. The Flongle sequencing-based diagnostic is cost-efficient and can detect HTNV genomes within 3 hours.
A new study found that frequent cannabis use is associated with a higher risk of heart attack and stroke, even after controlling for tobacco use and other cardiovascular risk factors. The study analyzed data from over 430,000 adults in the US and found that smoking cannabis was significantly linked to cardiovascular risks.
A new American Heart Association scientific statement highlights the value of AI technology in improving cardiovascular disease patient outcomes. Despite its potential, AI applications face gaps and challenges, including robust clinical validation and addressing biases.
Researchers provided first detailed estimates of sediment supply to coral reef islands, crucial for understanding climate change impacts. They found that around 0.1m³ (100kg) of sediment is delivered to islands per year, helping islands withstand rising seas.
A new study shows that education on dairy nutrition increases purchasing and consumption of dairy products, including a 53% increase in milk consumption. Participants who learned about dairy's nutritional benefits bought and consumed more cheese, ice cream, yogurt, and milk, with average increases of 26%, 20%, 26%, and 23%, respectively.
A recent Mayo Clinic study found that daylight saving time has a minimal impact on heart health. Researchers analyzed data from 36 million adults and found a slight increase in cardiovascular events during the spring and fall transitions, but this was deemed clinically insignificant.
Researchers at UCSF have identified AF1q as a universal biomarker for neuroblastoma, a highly aggressive and fatal form of childhood cancer. High-risk cases have a five-year survival rate of just 50%. The study found that silencing AF1q in neuroblastoma cells induces cell death and weakens tumor progression.
A study by 50 experts reveals five cutting-edge biomedical engineering advances with significant applications in medicine, including precision engineering, on-demand tissue engineering, and advanced brain interface systems. These advances aim to transform the practice of medicine, impacting various conditions and diseases.
A Rutgers Health study found that abdominal fat depots are related to lower cognitive functioning and brain volumes in middle-aged males at high Alzheimer's risk, but not females. The study challenges the use of BMI as a primary measure for assessing obesity-related cognitive risks.
A new study found that living close to pubs, bars, and fast-food restaurants is associated with a higher risk of heart failure. The study, which analyzed data from over 500,000 adults in the UK, also found that proximity and density of ready-to-eat food outlets were linked to an elevated risk of heart failure.
A national multicenter survey found that up to one-third of children who were hospitalized due to COVID-19 did not fully recover and experienced persistent symptoms. Children who had not recovered were more likely to have neurological symptoms, including headache and weakness.
Researchers have discovered a previously unknown neurochemical mechanism behind human tendency to make decisions based on social context. The study reveals the dynamic interactions of dopamine and serotonin in the brain's substantia nigra area, which contribute to our brain's overall assessment of value during social interactions.
Calls to US poison centers involving psilocybin among teens and young adults tripled and doubled, respectively, after decriminalization, leading to alarming concern over potential long-term consequences. Most calls involved intentional consumption, with adverse reactions including hallucinations, agitation, and heart rate issues.
Researchers found GZ17-6.02 alone and in combination with standard-of-care agents was effective in killing MF cells, activating key pathways including ATM, AMPK, NFκB, and macroautophagy. The compound's unique multi-factorial mechanism suggests potential for treating mycosis fungoides.
A recent study by Binghamton University researchers found that 90% of commercial tattoo inks in the US market contain major discrepancies between their actual and labeled contents. The study analyzed 54 inks from nine manufacturers and discovered unlisted polyethylene glycol, propylene glycol, and other contaminants.
Researchers at Aston University will explore gel electrolyte materials to improve lithium-ion batteries' safety and environmental sustainability. The project aims to replace harmful components with renewable ionogels, addressing the need for scalable methods of storing electrical energy.
A new study found that mass shooting lockdown drills help children who have been exposed to violence feel safer, contradicting previous research conclusions. Lockdown drills may be a way to help students who have been exposed to violence feel safer in schools.
Researchers created novel gene editing enzymes with improved precision, reducing off-target RNA edits by over 99%. The technology has potential applications in treating mitochondrial genetic diseases and may lead to transformative treatments within the next five years.
A new American Heart Association scientific statement offers the latest knowledge on neurodevelopmental outcomes in people of all ages with congenital heart disease. The statement highlights that neurodevelopmental difficulties are common complications faced by individuals with congenital heart disease, affecting their ability to funct...
A study by UC Davis Health found that a single dose of BCG reduced liver tumor burden and extended the survival of mice with liver cancer. The vaccine boosted the body's immunity, leading to tumor shrinkage and improved liver function.
Researchers have introduced an optimization technique that accelerates Bayesian inference without requiring extensive user effort. This new automated method achieves more accurate results faster than another popular approach and offers reliable uncertainty estimates to help scientists understand when to trust their predictions.
University of North Carolina at Chapel Hill researchers have developed a new drug delivery platform that harnesses helical amyloid fibers designed to untwist and release drugs in response to body temperatures. This discovery could be useful in treatment to reverse Alzheimer’s Disease impact by degrading amyloid plaques.
Researchers identified a putative paclitaxel response predictive biomarker for glioblastoma and breast cancer using the whole genome CRISPR knockout screen. The biomarker candidate was validated in two independent breast cancer patient cohorts that received taxane treatment.
New research led by Johns Hopkins Medicine reveals that age-related changes in fibroblast cells enable pancreatic cancer tumor growth. The study found that older patients have poorer prognoses due to altered proteins released by fibroblasts, which promote cancer cell growth and spread.
Researchers at Texas A&M University have developed a coating that bolsters the safety of fresh produce and provides enhanced protection against bacteria and fungi. The coating combines wax with nano-encapsulated cinnamon-bark essential oil in protein carriers to enhance antibacterial properties.
A Princeton-led study found that flexible geothermal power can provide over 100 gigawatts of clean energy in the western US, surpassing the existing nuclear fleet. By leveraging enhanced geothermal's energy storage properties, plants can generate electricity on demand, complementing intermittent sources like solar and wind.
Researchers identified NTRK gene fusion in 1.5% of Finnish papillary thyroid cancer patients, with notable co-occurring genetic alterations and favorable treatment outcomes. The study highlights the potential for biobank samples linked to electronic health records to describe patient characteristics and outcomes.
Researchers have confirmed a new method for precise body composition analysis using 3D surface scans and dual-energy X-ray absorptiometry. This approach yields accurate measurements of fat, lean muscle, and bone, surpassing commercial software in clinical settings.
A study co-led by Prof. Kelly Metcalfe finds risk-reducing mastectomies significantly reduce breast cancer risk and death probability in women with a BRCA1 or BRCA2 genetic variant. The procedure reduces the risk of breast cancer by 80% and decreases mortality to less than 1%.
MIT researchers found that applying a small voltage to a catalyst can significantly increase the rates of non-redox chemical reactions used in petrochemical processing and pharmaceutical manufacture. This discovery has the potential to transform our understanding of catalysis and design new reactors to take advantage of this phenomenon.
Chemical reactions were long thought to occur along minimum energy paths. However, researchers have now observed 'roaming' reactions that stray from this path even in highly excited energy states. This discovery has significant implications for understanding atmospheric chemistry and the production of molecular oxygen.
A recent study by the University of Surrey analyzed articles published in the Journal of Management Studies over the last decade and found that diverse research teams lead to more citations. The study reveals that internationality, interdisciplinarity, and gender diversity among authors all contribute to increased citation rates.
A study published in Oncotarget has identified specific mutational and therapeutic landscapes of pancreatic cancer in the Russian population. By applying machine learning models to full exome individual data, researchers received personalized recommendations for targeted treatment options for each clinical case.
A team of researchers from the University of Córdoba has translated and validated a scale to evaluate negative attitudes towards bisexuality, highlighting gender differences and correlations with sexism and social dominance. The scale aims to promote equal treatment and move towards a more egalitarian society.
A new study found that 17% of young mothers in Wales experienced at least one child being taken into care between 2014 and 2021. The study also revealed that many care-experienced mothers experience early motherhood and placement instability, leading to concerns about family separation.
A new study from the Icahn School of Medicine of Mount Sinai reveals significant variations in emergency medical service (EMS) performance across the United States. The research found that EMS agencies in rural areas were less likely to provide optimal care, including treating low blood sugar and pain for trauma patients.
Jian Shi, a UH researcher, has developed a carbon-driven framework called "ZERO-Accelerator" to expedite the transition from fossil fuels to clean energy. The framework integrates novel mechanisms and algorithms into current power grid operational practices to achieve a 24/7 zero-carbon power grid.
The new advisory highlights the dramatic advances in understanding and treatment of cardiovascular diseases over the past century. These advancements have saved millions of lives and reduced heart disease death rates by more than half since 1950.
Researchers found Mad2 gene expression levels correlate with chromosomal abnormalities in esophageal squamous cell carcinoma, highlighting potential as a clinical biomarker. The study also revealed the deregulation of the Rb-E2F1 circuit and its impact on histone modifications.
Two new EU-funded projects, PollinERA and WildPosh, will investigate the toxicological and ecological impacts of chemical pollution on terrestrial biodiversity and pollinators. The projects will improve risk assessment tools and characterise exposure routes to pesticides in four European regions.
Researchers at Dartmouth's Geisel School of Medicine and Thayer School of Engineering have made significant breakthroughs in understanding how antibodies combat herpes simplex virus (HSV) infections. The study reveals that antibody effector functions play a critical role in protecting against HSV, which may lead to new treatments for n...
The University of Missouri researchers are developing new technology to rapidly detect and mitigate salmonella and other foodborne pathogens throughout the entire poultry supply chain. The team aims to significantly reduce the risk of foodborne illness in people, with rapid results that can be produced in one hour or less.
A new blood test developed by Indiana University School of Medicine has identified biomarkers that can objectively measure schizophrenia severity and predict future risk. The test enables personalized treatment matching, reducing uncertainty and improving patient outcomes.
The University of Texas at Arlington has selected 16 undergraduate students to join the McNair Scholars Program, a Department of Education-funded grant. The program prepares students for careers in academic research with a stipend, summer research internship, and mentorship from UTA faculty.
The American Heart Association's PREVENT risk calculator will be evaluated among diverse populations to assess its accuracy and fairness. The research aims to ensure that the tool provides accurate risk predictions for people from various racial, ethnic, and socioeconomic backgrounds.
Researchers found elevated PROX1 levels in advanced colon adenocarcinoma, correlating with poor prognosis. PROX1 modulates CRC cell behavior, influencing invasiveness and survival outcomes. The combined PROX1/α-SMA gene set emerges as a potential CRC prognostic marker.
Researchers discovered two new genetic pathways associated with worse ICH outcomes, including a pathway affecting blood coagulation and cellular interactions. Population data showed a decrease in aneurysmal SAH strokes and a rise in non-aneurysmal subarachnoid hemorrhages, offering encouraging evidence for intervention success.
The American Heart Association and The Children's Heart Foundation have pledged over $10 million in funding to research congenital heart defects. Researchers will advance their work to improve diagnosis, treatment, and prevention of CHDs, giving more children a chance to grow into healthy adults.
The study evaluated the effectiveness of ruxolitinib in treating relapsed/refractory multiple myeloma. Researchers found that ruxolitinib inhibited JAK signaling, leading to enhanced anti-tumor effects and improved patient outcomes.
A new study sheds light on the complex relationship between forests and the climate system, highlighting the impact of forest emissions on cloud formation and global temperatures. Researchers emphasize the need for improved climate models to accurately represent these interactions.
Christi Bergin's research focuses on improving prosocial behavior in classrooms and communities, leading to better student engagement, academic achievement, and relationships. Her approach aims to reduce teacher stress and burnout by promoting empathy and kindness among students.
Researchers at UBC Okanagan have developed a new modeling framework called TOSCA, which helps improve wind energy forecasts and productivity. The framework can capture the interaction between large wind farms and the oncoming wind, leading to more accurate estimates of power output.
A longitudinal study found that higher consumption of tea, processed meats, and food prepared outside the home is associated with increased levels of PFAS in the body over time. This suggests potential solutions for protecting the public from these harmful chemicals.
A study of over 580 children found that childhood trauma disrupts neural networks involved in self-focus and problem-solving. The research suggests that trauma therapies should address not only thoughts but also the impact on the body, sense of self, emotional processing, and relationships.
Black adults in the US suffer from short and very short sleep after exposure to news about police killings of unarmed Black individuals. The study's findings suggest that poor sleep health is another tragic byproduct of exposure to these events.