News on the use of animals, and their alternatives, in biomedical research. Covers animal models, primate studies, tissue chips, research ethics, and disease modeling.
Researchers investigated neuronal response to excessive iron accumulation associated with age-related neurodegenerative diseases. They identified two genes, CLU and HERPUD1, that responded to aging-related iron accumulation, highlighting potential preventative strategies.
A study by the Leibniz Institute for Zoo and Wildlife Research found that cheetah marking trees serve as hotspots for communication among multiple mammalian species. These trees were visited more frequently by some species, such as black-backed jackals and warthogs, suggesting they gain important information from the scent marks. In co...
Researchers used computer simulations to show that SARS-CoV-2 variants can attach to host cells in both bats and humans using their spike proteins. The study's findings suggest a significant risk of mammalian cross-species infectivity, contradicting initial expectations of reduced transmission.
A new fossil discovery in a London storeroom has revealed that modern lizards originated in the Late Triassic period, 35 million years earlier than previously thought. The fossil, Cryptovaranoides microlanius, is a relative of living lizards and snakes, and its characteristics impact estimates of lizard evolution and diversification.
Research suggests that long-lasting insecticidal malaria nets lost their effectiveness after just one year in Burundi, contradicting the recommended replacement every 3 years. The study found that malaria incidence rose again after two years, highlighting the need for continued epidemiological monitoring and improved resource allocation.
Researchers discovered that synchronized neural oscillations in the right hemisphere of the brain induce empathic behavior in mice, allowing them to perceive and share each other's fear. The study identified the causal relationship between 5-7 Hz oscillations in the cingulo-amygdala circuit and empathic responses.
Through its Integrated Pest Management program, WVU Extension educates growers on safe techniques, including barriers, insect traps, and predatory insects. The goal is to reduce pesticide use and promote environmentally friendly practices.
Researchers discovered that ant pupae secrete a fluid that is consumed by both adults and larvae, highlighting the interconnectedness of different developmental stages within an ant colony. The fluid, derived from molting, is rich in nutrients and psychoactive substances, essential for larval growth and adult metabolism.
A new study found that when there are more females than males in colonies of orb-weaving spiders, males fight less with each other and females exhibit less aggression. The researchers also observed cooperation among spiders in constructing their webs and wrapping prey in silk.
A study by North Carolina State University found that two common veterinary drugs, Fluralaner and Ivermectin, are effective in killing bed bugs on poultry farms. Fluralaner was highly effective against bed bugs with resistance to common insecticides.
A study by Rice University researchers found that tropical mammal communities divide their days similarly, with feeding routines and body sizes influencing activity patterns. The study confirms consistent patterns across Africa, Asia, and the Americas.
Researchers at Hokkaido University discovered a novel sex-determination mechanism in the Amami spiny rat, a species lacking the Y chromosome and Sry gene. The mechanism involves the upregulation of Sox9 gene on chromosome 3, induced by a new regulatory element similar to Enh14.
A new tablet-based vaccine has shown long-lasting protection against bacteria that cause urinary tract infections (UTIs) in mice. The vaccine was found to be comparable to antibiotics in efficacy, with durable antibody responses lasting for the lifetime of a mouse.
A new study compiled data on over 3,000 species to show how climate and geologic changes across Asia influenced the evolution of mammals. The research found clear links between changes in Earth's climate and the distribution of mammals in different regions.
A new study published in the Journal of Zoological and Biological Gardens highlights the successful sea otter rehabilitation program at Monterey Bay Aquarium. The program uses surrogacy as a comprehensive approach to rehabilitation, with 71% of surrogate-reared pups surviving post-release compared to 27% that underwent human-led rehabi...
A new species of herbivore, Transylvanosaurus platycephalus, has been revealed with a remarkably flat head. The discovery challenges the assumption that Europe had low diversity during the Late Cretaceous period.
Great bustards prefer to eat plants with chemical compounds that kill pathogens in vitro. Corn poppies and purple viper's bugloss contain antiprotozoal and nematicidal compounds, as well as antifungal agents.
A University of Maryland study found that domestic cats in Washington D.C. have a high probability of overlapping with native wildlife, including raccoons and opossums, increasing the risk of disease transmission and harming native populations. Keeping cats indoors can significantly reduce these risks.
A University of Cincinnati biologist is using a novel system to track the daily care of 47 northern bobwhite quail. The system uses wireless QR scanners to record health, food, water, and behavioral enrichment, making it easier to collect detailed data on animal welfare.
Researchers have developed a new approach to stopping viral infections using a live-attenuated DNA virus vaccine. The method employs centanamycin to generate an altered virus that can't reproduce inside cells, stimulating the host's immune system to recognize and eliminate the invading virus particles.
Eduardo Sampaio joined the Captain Darwin expedition to study octopus behavior and discovered they can recognize themselves in mirrors. The project aims to update Darwin's research style with modern methods, including machine learning and computer vision.
Researchers measured phycotoxin concentrations in bull sharks caught in the Indian River Lagoon, finding multiple toxins widespread or persistent in the environment. The study highlights dietary exposure as a key mechanism of toxin transfer to bull sharks.
Researchers found that neonicotinoid chemicals can impair the development of biological motion preference in chicks, similar to autism spectrum disorder in humans. The study suggests that transmission via nicotinic acetylcholine receptors is critical for this process.
Researchers found that high oleic soybean oil improved growth performance and carcass characteristics in pigs, with minimal impact on fat thickness and lean percentage. The studies also showed that HOSO-fed pigs had thicker, firmer bellies and similar loin quality compared to DDGS-fed pigs.
Researchers have detected five emerging tick-borne pathogens in Central Canada, including those causing Lyme disease and babesiosis. Climate change and habitat fragmentation contribute to the spread of these pathogens, highlighting the need for increased awareness and protection measures.
Researchers found that habitat loss and climate-induced food shortages drive pathogen spillover, but preserving and restoring natural habitats can prevent these events. By analyzing data from Australia, the study predicts when viruses like Hendra and Nipah will spill over from bats to humans.
Researchers have discovered that the flight patterns of birds can be used to estimate fine-scale environmental conditions and turbulence levels. The team measured bird altitude and motion using GPS and data loggers attached to pigeons, finding a correlation between the birds' behavior and turbulence strength.
Research at Tel Aviv University found that high-intensity aerobic exercise increases glucose consumption in internal organs, reducing energy availability for tumors. The study reduced the risk of metastatic cancer in humans and animal models by up to 72%.
Scientists have created a way to track brain diseases like depression, Alzheimer's, and strokes using fluorescent mouse blood. The method allows for months-long study of blood flow in the brain, providing new insights into disease progression and development.
Eastern red bats, now the most commonly detected bat in Midwestern forests, have a significant impact on tree regeneration due to their appetite for insect-damaging bugs. Forest managers can benefit from considering these bats' landscape preferences, particularly ponds and smaller forest openings.
Researchers at the University of Tokyo found that rats can move their heads in time to music, demonstrating innate beat synchronization. The optimal tempo for nodding along depends on the brain's time constant, similar across species, suggesting a widespread ability among animals to interact with music.
Researchers from Aarhus University found that seal pups can distinguish and react differently to various rhythms. This study provides a significant step forward in understanding human musicality and language development.
A global analysis of habitat changes in coastal wetlands has clarified the decline of shorebird populations. Changes in intertidal feeding areas and high tide roosting areas have been identified as critical factors contributing to the decline of non-breeding shorebirds.
Researchers found drastic differences in microglia marker Iba1 and factors influencing Sirt1 levels and activity between elder groups. Preserving microglia and Sirt1 functional efficiency is crucial for longevity.
A new study by American Chemical Society researchers found that cooler temperatures and certain bird species can increase the circulation of H7 and H9 strains of avian flu. The study used air samples collected near a wetland in east Asia to detect airborne avian flu viruses.
A new study published in PNAS found that female and male Japanese termites can flip sex roles to form stable same-sex pairs. The researchers discovered that this 'sex role flexibility' allows same-sex pairings to evolve, enabling termites to survive and thrive.
Researchers have developed a videography-based method to track skeletal kinematics in freely moving rodents, providing insights into animal behavior and brain function. The approach uses an anatomically grounded skeleton model and can be applied to multiple furry species.
A high-quality Nile rat genome sequence has been assembled, expanding its potential as a model organism for studying type 2 diabetes and disorders associated with disrupted circadian rhythms. The genome's long contigs and completeness make it suitable for investigating the genetic factors contributing to disease, including epigenetics.
Climate change poses a significant threat to southwestern US reptile and amphibian populations, with limited-dispersal species facing the greatest vulnerability. The study suggests that prioritizing conservation efforts for these species may be crucial to mitigating habitat loss.
Researchers used monoclonal antibodies to suppress the immune system in mice, tracking human neural stem cell survival using luciferase. The study reveals that monoclonal antibody-mediated immunosuppression enabled long-term survival of transplanted human neural stem cells in mouse brains for at least six to eight months.
A new controlled-release device has been tested at UMass Amherst for its effectiveness in preventing tick bites. The device uses synthetic pyrethroids to create a spatial repellent that alters the behavior of ticks, making them less likely to climb and more likely to detach or fall off. The results show promising promise in reducing th...
Researchers believe that changes in the brain's orexin system promote drug-seeking behavior and that existing insomnia treatments could reduce or eliminate cravings. Studies have shown that blocking this system reverses addiction in animals and reduces opioid cravings in human subjects.
Researchers at Kyoto University found that two species of spider mites avoid food plant leaves with active ant chemical traces and walking along ant-traveled stems to evade natural predators. This avoidance behavior may be comparable to direct consumption by the ants, highlighting a non-consumptive effect of predators on prey.
Researchers from Tokyo University of Science found that chronic social defeat stress (cSDS) induced mice showed higher intestinal transit ratio and visceral pain-related behaviors, similar to IBS. The study suggests that prolonged psychological stress can cause IBS-like symptoms in mice without intestinal lesions.
A new label indicating responsible antibiotic use (RAU) in dairy milk could entice conventional farmers to minimize antibiotics, with half of US adults willing to buy RAU-labeled milk. The price point would need to be competitive with conventional milk, but consumers are more willing to pay for the label.
Researchers at Georgia Tech discovered that wingless springtails control their jump, self-right in midair, and land on their feet due to their unique appendages for jumping and adhesion. This unique posture creates aerodynamic torque, effectively self-righting them within 20 milliseconds.
Researchers found distinct gut microbiomes in wild marten from pristine and heavily impacted areas, highlighting a tool for assessing ecosystem health. The study's findings suggest that human disturbance affects carnivores' diets, reflected in their gut microbiomes.
Researchers have developed a new gene therapy that selectively targets overactive brain cells, reducing excitability and suppressing seizures in mice. The treatment shows promise for treating neurological disorders such as epilepsy, Parkinson's disease, schizophrenia, and pain disorders.
Researchers found that rapamycin treatment during developmental growth phase decelerates aging rate and extends lifespan in animals. A transient late-life treatment is not effective, but a transient early-life treatment can reprogram aging.
The new guidelines aim to improve the cat's emotional experience during veterinary visits. They provide practical tips on creating a more reassuring environment, such as minimizing visual stimulation and using synthetic feline pheromones. The guidance also emphasizes the importance of remaining 'cat-focused' during interactions.
Researchers found that permanent daylight savings time reduces deer-vehicle collisions by 16 percent, resulting in fewer animal deaths and human injuries. The study predicts that year-round DST could prevent up to 36,550 deer deaths annually.
A new study found that bats play a crucial role in protecting young tree seedlings from insect damage, with three times fewer bugs and five times more defoliation when bats are absent. The research reveals a mutually beneficial relationship between bats and oak trees, with bats serving as a key predator for insects that harm the trees.
A new study reveals that global warming can lead to an exponential increase in heat injury accumulation for ectothermic organisms, with temperatures exceeding their tolerance level resulting in severe injuries. The rate of heat injury doubles for each degree the temperature rises.
Researchers measured rhino horns from photographs taken between 1886 and 2018, finding a significant decrease in length across all five species. The decline is believed to be caused by intensive hunting, which has also led to a shift in human perceptions of rhinos from hunting to conservation.
Scientists have discovered a new species of scops-owl on Príncipe Island, characterized by its unique 'tuu' call. The population is estimated at around 1000-1500 individuals and is considered Critically Endangered due to habitat loss and the construction of a hydro-electric dam.
A new study by Pitt mathematicians uses math borrowed from neuroscience to describe how swarms of synchronous fireflies coordinate their light show. The researchers found that varying distances between fireflies affects the resulting blinks, producing patterns like ripples or spirals.
Researchers found a longer PR interval and prolonged QT duration in genetically modified pig hearts after transplantation into humans, indicating signs of electrical disease. The study provides a foundation for future research to better understand xenotransplantation's effects on the heart's electrical system.
A study led by Stockholm University researchers discovers a protein that Toxoplasma uses to reprogram the immune system, allowing it to spread efficiently. The parasite infects immune cells and tricks them into thinking they are other types of cells, changing their gene expression and behavior.
Researchers from the University of Wyoming used NASA's Global Ecosystem Dynamics Investigation (GEDI) mission to collect high-resolution forest data, which improved their understanding of habitat relationships between forest carnivores and their prey species in the Greater Yellowstone ecosystem. The study paired GEDI data with other re...
A study published in Animal Behaviour found that bumble bees engage in playful behavior by rolling wooden balls repeatedly. The research showed that younger and male bees rolled the balls more than older and female bees, respectively.