Articles tagged with Vaccine Research
A large-scale study of over 1.2 million people found breakthrough COVID-19 infections are rare but more frequent and severe in those with weakened immune systems. The study supports the introduction of a third vaccine dose for immunocompromised individuals to increase protection.
A national analysis found that children with poorly controlled asthma are more likely to require hospitalisation than those with well-controlled asthma or without asthma. Vaccinating this group can reduce the risk of COVID-19 infection and associated illness.
A Kaiser Permanente study found the Moderna COVID-19 vaccine to be 87% effective in preventing COVID-19 infection and 96% effective in preventing hospitalization. The vaccine's effectiveness persisted even among those with underlying conditions, providing reassurance about its durability.
A study using GDPR-compliant mobile phone data found significant decreases in household mixing during the first two lockdowns, but increases during the third, coinciding with the vaccine rollout.
A study found that covid infection risk gradually increases after a second vaccine dose, with protection waning over time. The research suggests that a third (booster) dose might be warranted to prevent breakthrough infections.
Antibodies that mimic the SARS-CoV-2 virus may explain lingering symptoms of long-haul COVID-19 and rare vaccine side effects like allergic reactions and blood-clotting. This theory, based on classic immunological concepts, suggests a cascade of immune responses that can lead to adverse effects.
A new study from the University of Georgia found that vaccination results in a more robust immune response than natural infection. Even with waning antibodies, vaccinated individuals still have protective immunity against severe disease and hospitalization.
A retrospective cohort analysis found that an algorithm-based automated text messaging system saved lives and reduced mortality rates by 68% among patients with COVID-19. The system, called COVID Watch, used text messages to monitor symptoms and escalate patients to healthcare providers for further care.
A new study by CUNY SPH found that COVID-VAC scale can inform targeted interventions to increase vaccine uptake among hesitant groups. Key motivators for vaccination included protecting oneself and loved ones from COVID-19, with continued testing crucial in combating misconceptions.
A systematic review of 28 studies identified 13 themes related to COVID-19 vaccination status in older, ethnic minority individuals. Factors facilitating access included vaccination reminders from healthcare providers, while misinformation and personal beliefs were barriers to uptake.
A new study published in The Lancet confirms that HPV vaccination has led to a significant reduction in cervical cancer rates in England. Women who were vaccinated between the ages of 12-13 had an 87% lower incidence of cervical cancer compared to previous generations.
Scientists have developed a software that adds missing sugar components to protein models created with AlphaFold, enabling more accurate structural predictions. This breakthrough has the potential to revolutionize workflows in biology, allowing scientists to understand proteins and their mutations faster than ever.
A massive Israeli study found that a third COVID-19 vaccine dose reduces hospitalization and severe disease risks by up to 93% compared to two doses. The research provides valuable insights into the effectiveness of booster shots in real-world settings.
A 51-country survey reveals that people who feel invincible to COVID-19 are less likely to get vaccinated and believe in the importance of individual actions. The study suggests that messaging emphasizing collective action is crucial in individualistic cultures.
A study published in International Journal of Molecular Sciences found that the Sputnik-V COVID vaccine elicits both robust antibody and T-cell responses. The research suggests that long-term immunity is possible, supporting the effectiveness of the vaccine against local virus variants.
Researchers have opened a novel study for a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease. The phase I trial will determine the maximum tolerated dose of the vaccine in patients with early-stage triple-negative breast cancer.
A recent study by Cedars-Sinai Medical Center found that COVID-19 mRNA vaccines induced detectable antibodies in 99% of patients with bowel disease, regardless of their immunocompromising therapies. Researchers also noted a correlation between the antibody response and effective immunity in the community.
A new study published in The New England Journal of Medicine has found no correlation between COVID-19 vaccinations and risk of first-trimester miscarriages. Vaccination during pregnancy is safe and provides protection to the newborn infant against COVID-19 infection.
Research from University of Pennsylvania team shows that vaccine mandates have positive effects on vaccination intentions, particularly for those who oppose forced behavior. Mandates strengthen vaccination intentions, regardless of racial or ethnic group, and for individuals with a disposition towards psychological reactance.
Researchers quantified COVID-19 vaccine uptake disparities by race and ethnicity within US states, revealing substantial coverage gaps among older adults. The study's findings underscore the need for targeted vaccination strategies to address these disparities.
The study shows that COVID-19 vaccine effectiveness is substantial in adolescents, with a 93% decrease in symptomatic cases and a 90% decrease in documented infections after the second dose. Vaccine effectiveness was lower but still significant before the second dose.
A new study from Karolinska Institutet finds that two vaccine doses increase antibody levels in the airways after COVID-19, while a second dose after recovery also boosts levels. The results highlight the importance of completing vaccination with a second dose to achieve optimal immune responses and reduce transmission.
Researchers found that vaccinating more people with a single dose can be beneficial when the vaccine waning rate is low, slowing the spread of the virus. The 'prime first' strategy prioritizes speed over double doses under supply constraints, offering an alternative to traditional vaccination protocols.
A new study found that infants with high levels of antibody-dependent cellular cytotoxicity (ADCC) against their mother's strain of HIV are less likely to get infected through breastfeeding. The study also showed that ADCC is more effective than neutralizing antibodies in protecting infants against HIV transmission and improving outcomes.
Researchers at West Virginia University discovered a significant relationship between Christian nationalism and vaccine hesitancy, citing a national sample of 2,000 U.S. adults. They found that individuals embracing this ideology are less likely to receive the COVID-19 vaccine and express skepticism towards science.
Patients with multiple myeloma often mount a poor antibody response to COVID-19 vaccines and have a weak T cell response, underscoring the need for booster vaccination and safety precautions. Researchers found that these patients are at high risk of severe COVID-19 infection.
A nationwide study in Sweden found that receiving a mix-and-match COVID-19 vaccine schedule reduced the risk of infection by up to 79%. The study, published in The Lancet Regional Health - Europe, showed greater risk reduction for people who received an mRNA vaccine after having received a first dose of a vector-based vaccine.
A new study found a significant increase in adverse outcomes for COVID-19 positive pregnant women, including gestational diabetes, low white blood cell counts, and heavier bleeding during delivery. Respiratory complications were also witnessed in their babies, highlighting the importance of vaccinating all pregnant women against COVID-19.
A Michigan-based study found a dramatic drop in vaccinations across the lifespan during the early pandemic, but a recent rebound has been noted. The researchers emphasize the importance of continued vaccinations to prevent outbreaks of infectious diseases like measles.
Researchers found that asymptomatic patients may not produce significant IgG antibodies, but rather a different kind of antibody count that can indicate disease severity. The study suggests using the ratio of these two counts as a marker to determine if a person has had COVID-19.
Two Gladstone scientists, Leor Weinberger and Vijay Ramani, received NIH Director's Awards to fund groundbreaking research on a single-administration antiviral for COVID-19 and a molecular strategy to fight cancer. Their work has implications for treating various diseases, including cancers.
Researchers found that mRNA COVID vaccines reduced symptomatic illness risk by 89% and 96% for Pfizer-BioNTech and Moderna vaccine recipients respectively. The vaccines' effectiveness was lower in immunocompromised individuals.
A new study published in The Lancet confirms that two doses of Pfizer-BioNTech vaccine are 90% effective against COVID-19 hospitalizations for all variants, including delta. Effectiveness against infection declined over time but remained high against hospitalizations.
Researchers at Bar-Ilan University found that individuals previously infected with COVID-19 require a second dose of the vaccine to achieve optimal protection. This is because infection after the first dose did not increase IgG antibody levels, and those infected post-vaccination had lower antibody levels than never infected individuals.
A study by University of Minnesota Medical School researchers found that fully vaccinated individuals with a previous SARS-CoV-2 infection have a stronger immune response, producing more memory B cells. This increased immune response may reduce the risk of breakthrough infections and potentially fewer doses needed for booster shots.
A recent study by Shilpa Madan found that the salience of choice fuels independence and makes individuals more self-interested. This can lead to a range of positive consequences, including increased tolerance for harassment and discrimination, but also negative consequences for collective action.
Researchers discovered that new mutations in the BRAF gene can lead to gliomas growing back after treatment, suggesting personalized approaches to therapy. The study also explored potential impacts of COVID-19 vaccines on menstruation.
Mathematical modeling suggests that contact-tracing apps can help achieve herd immunity by identifying individuals with greater exposure to others and targeting them for vaccination. The approach, known as 'hot-spotting,' could reduce the number of vaccine doses needed by up to half.
Dr. Laura Payne's research will explore potential links between SARS-CoV-2 vaccination and menstrual cycle changes in adolescent girls. The study aims to measure levels of estradiol, progesterone, inflammation, and antibodies to determine the effects of COVID-19 vaccines on menstrual cycles.
A third dose of the Pfizer-BioNTech vaccine significantly increased neutralizing antibody levels against SARS-CoV-2. The booster dose also improved the ability to inhibit variants, including Beta and Delta strains.
Researchers aim to produce enough mRNA vaccines from spinach and lettuce to rival traditional shots. They're exploring chloroplasts as a key to making plant-based mRNA vaccines that can be stored at room temperature.
Researchers at Karolinska Institutet discovered that B cells choose between cell fates to balance acute and memory responses. This understanding could optimize vaccines against viruses or other pathogens.
A Michigan Medicine study found that most patients with mild COVID-19 infections produce antibodies that persist and protect them from reinfection for up to six months. Nearly 90% of participants produced spike and nucleocapsid antibody responses, and all but one had persistent antibody levels at follow-up.
Researchers investigated antibody response to Pfizer-BioNTech vaccine in 117 allogeneic hematopoietic stem cell transplant recipients. The study aimed to assess vaccine safety and immune response in this population. Key findings were not reported in the article.
Scholars argue that well-done vaccine selfies can encourage others to get vaccinated and share personal stories about the effects of the vaccine. The practice can create a bandwagon effect, highlighting health, joy, and optimism and positively shaping public perception of COVID-19 vaccines.
A new study by Columbia University Mailman School of Public Health reveals stark racial, ethnic, and socioeconomic inequities in COVID-19 vaccination rates across neighborhoods in the largest US cities. High-vaccination neighborhoods were predominantly white with fewer people of color, higher incomes, and lower poverty rates.
A national study of 75,000 US adults found a near 18 percentage point increase in those willing to get vaccinated, but also a rise in skepticism among certain groups. Disparities persist in vaccine confidence, particularly among younger adults, non-Hispanic Black or multiple races, and lower socioeconomic status.
A comprehensive study of 6.2 million patients found no serious health effects linked to mRNA COVID-19 vaccines, with some early findings previously reported at CDC meetings. The Vaccine Safety Datalink's COVID-19 rapid cycle analysis will continue tracking vaccinated patients for at least 2 years.
A recent study reveals significant inequities in COVID-19 vaccination rates among the nine largest US cities. The research found that racial and socioeconomic disparities contribute to these disparities.
A new study from the University of Virginia Health System found that Moderna's vaccine produced higher antibody levels than Pfizer's, especially in older subjects. The researchers caution that measuring antibody levels does not necessarily predict vaccine effectiveness.
Researchers compared antibody responses in adults receiving Pfizer/BioNTech and Moderna COVID-19 vaccines. The study found differences in antibody responses among young and older adults. Younger recipients showed higher antibody levels after vaccination.
A new study finds that HPV vaccination will significantly reduce rates of throat and mouth cancers in younger age groups, but the overall impact may not be seen until 2045. The study projects a substantial decline in oropharyngeal cancer rates among well-vaccinated individuals aged 36-45 and 46-55 between 2018 and 2045.
A large-scale UK study confirms that COVID-19 vaccines are effective in reducing severe illness and hospitalisation. The study found that people who received one or two vaccine doses had lower odds of severe disease or hospitalisation than unvaccinated individuals, with a significant reduction in long COVID cases.
A study assessing Pfizer-BioNTech vaccine safety in highly allergic individuals found a lower incidence of severe adverse reactions compared to previously reported rates. The results suggest the vaccine may be a viable option for these high-risk groups.
A new study published in the New England Journal of Medicine found that a combination of seasonal vaccination with RTS,S/AS01 E and antimalarial drugs significantly reduces clinical episodes, hospital admissions, and deaths from malaria. The results show a 70% reduction in these outcomes compared to current interventions.
Researchers have identified a potential advantage of weakened SARS-CoV-2 variants as immunogens, sparking interest in their use for live-attenuated vaccines. The variants, which emerge rapidly during cell culture propagation, show resistance to subsequent infection with both the parental strain and emerging variants.
Researchers identified and contacted patients with cancer who could benefit from targeted nonelectronic communication regarding COVID-19 immunization. The study used an analytics-based approach to reach marginalized populations, highlighting the importance of targeted outreach in increasing vaccine uptake.
Researchers investigated short-term COVID-19 vaccine reactions in pregnant and lactating individuals compared to those planning pregnancy. The study found that vaccinated pregnant and lactating women experienced fewer severe adverse events than unvaccinated women.
Researchers found that some medications used to treat autoimmune rheumatic diseases can weaken the immune response to COVID-19 vaccines. Vaccination still induced an immune response in patients, but at a lower rate than in those without autoimmune diseases.
Researchers developed a protein-based COVID-19 vaccine that mimics the SARS-CoV-2 virus shape, eliciting both antibody and T cell responses. The vaccine, using polymersomes decorated with multiple copies of the receptor binding domain antigen, shows promise for longer-lasting immunity.