Articles tagged with Medical Research Facilities
The European Nanomedicine Characterization Laboratory (EU-NCL) aims to bring safe and efficient nanotherapeutics faster to patients. EU-NCL partners with international reference facilities to harmonize analytical protocols, providing a trans-disciplinary testing infrastructure for preclinical characterization.
The University of Pittsburgh School of Medicine is leading a national trial to examine methods to reduce unnecessary use of antibiotics in post-acute and long-term care facilities. The trial aims to develop comprehensive guidelines and tools to help facilities better manage urinary tract infections.
A study of children with nonsyndromic orofacial clefts and their relatives found that affected families do not have a significantly higher genetic risk for dental anomalies. Instead, the prevalence of dental anomalies is primarily due to physical consequences of the cleft and surgical interventions.
Greater variability in neural activity may reflect more flexible information processing, supporting better cognitive performance in aging adults. Researchers found that greater BOLD variability was associated with improved memory and fluid intelligence tasks.
A study published at the International Association for Dental Research found that dental pain relief is accompanied by reduced activity in the posterior insula and enhanced connectivity to the midbrain. This discovery provides new insights into the neural mechanisms underlying dental pain.
A study by Bernhard Ganss and colleagues found that amelotin is essential for enamel mineralization and maturation. Ammelotin-deficient mice exhibited weak incisor-edge enamel that fractured and chipped, with delayed enamel mineralization and retention of organic matrix.
The FASEB MARC Program has selected four students and postdoctorates from underrepresented groups to receive travel awards. The awards totaled $7,400 and aim to promote diversity in the biomedical research community. The recipients include Hamid Hussaini, Ibrahim Osumanu, Isavannah Reyes, and Kimberly Herard.
A digital sharing revolution tool, SiteFinder, facilitates research collaborations among tropical medicine researchers and their sites. The Global Health Network's platform ensures quality information and facilitates the sustainability of research capacity.
The Chicago Biomedical Consortium is launching a $3 million Infrastructure Initiative to promote investment in high-impact scientific equipment at its member universities. The initiative aims to make modern instrumentation available to the CBC research community, enabling them to stay at the forefront of biomedical discovery.
A study in mice reveals that dysfunctional ketogenesis promotes fatty liver disease, characterized by excessive hepatic glucose and lipid production. The findings suggest targeting ketogenesis could be a viable approach to treating NAFLD.
A new analysis of Medicare data reveals no significant correlation between nursing home quality and risk of hospital readmission or death within 30 days. However, better staffing ratings, facility inspection scores, and pain management practices were associated with lower rates of readmission.
Severe periodontitis is the sixth most prevalent health condition in the world, affecting over 743 million people worldwide. The global age-standardized prevalence of severe periodontitis remained static at 11.2% between 1990 and 2010.
A new study reveals that instant oatmeal provides greater satiety than equal calories of ready-to-eat oat cereal. The researchers found that eating a bowl of instant oatmeal for breakfast helps manage hunger better than the same amount of calories from a leading oat-based, cold cereal.
A study of active US military personnel found higher rates of Graves disease among blacks and Asian/Pacific Islanders compared to whites. Hashimoto thyroiditis incidence was highest in whites, lowest in blacks and Asians.
This review discusses four key physiologic processes in bone/tooth formation affected by rare bone diseases. The authors highlight causative mutations, etiopathology, and treatments for conditions like fibrous dysplasia, osteogenesis imperfecta, and hypophosphatasia.
The study found higher readmission rates for men, non-Hispanic blacks, and those with longer lengths of stay. The research also identified potential targets for early intervention to reduce readmission rates, such as diagnosis-related groups like kidney and urinary tract infections.
Researchers found that aggressive thyroid cancer cells in microgravity exhibit a redifferentiation to a less aggressive state, offering hope for new treatments. The study's findings suggest potential therapeutic targets for cancer drugs that may be effective on Earth.
The University of Colorado Boulder has been awarded a cooperative agreement worth up to $14.6 million from the Defense Advanced Research Projects Agency (DARPA) to develop a new technological system to rapidly determine how drugs and biological or chemical agents exert their effects on human cells. The Subcellular Pan-Omics for Advance...
Sanford-Burnham researchers identify THRIL molecule that regulates immune response and associates with Kawasaki disease severity. THRIL may also contribute to other inflammatory diseases like rheumatoid arthritis and inflammatory bowel disease.
Dr. Richard Bruick receives the 2014 Edith and Peter O'Donnell Award for his work on cellular responses to maintain oxygen and iron homeostasis. His research has the potential to improve treatments for anemia, renal cancers, and iron overload disorders.
The Edinburgh Genomics facility will focus on large-scale studies of genetic code, aiming to develop therapies tailored to patients' genes. Scientists will also explore the impact of genetics on animal wellbeing and crop disease in agriculture.
Researchers used patient-derived stem cells to show that a genetic mutation in the alpha-synuclein gene increases vulnerability to pesticides, leading to Parkinson's disease. The study identified a molecule that protects neurons from pesticide damage and may have potential clinical implications for treating the disease.
The Broadcom Foundation has donated hundreds of thousands of dollars to Tel Aviv University to establish a two-year program promoting multidisciplinary research toward new authentication methods. The aim is to develop secure interaction between users and their digital environment, including smartphones, e-banking, and e-health devices.
The institute will utilize its high-throughput, human cell-based assays and induced pluripotent stem cells to analyze thousands of potential toxins. This collaboration aims to provide an early and relevant assessment of potential toxicities in a rapid and cost-effective manner.
The OPTIMISTIC study, a healthcare initiative from Indiana University and the Regenstrief Institute, is underway in 19 Central Indiana nursing facilities. The program focuses on improving care coordination, palliative care, and chronic disease management to reduce avoidable hospitalizations.
A study by Simon Fraser University researchers found nearly 40% of seniors who fall experience head impact, with linoleum or tile flooring being the most common cause. The team suggests designing safer environments, improving procedures for detecting brain injuries, and promoting strengthening exercises to reduce falls.
A large cohort of Swedish residents found no association between long-term fluoride exposure and the risk of hip fractures. The study included nearly half a million individuals exposed to varying levels of fluoride in their drinking water.
Researchers found that amyloid beta stimulates Alpha7 nicotinic receptors, triggering astrocytes to release glutamate and overwhelming synapses. A newly modified Alzheimer's drug may block this destructive pathway.
A systematic analysis reveals that 3.9 billion people globally are affected by oral conditions, with untreated caries being the most widespread. The study estimates 15 million disability-adjusted life-years (DALYs) due to oral conditions worldwide.
A year-long study found that minor modifications to military cafeteria food services resulted in significant improvements in soldiers' nutritional intake, including reduced fat consumption. Customer satisfaction also increased on four criteria, with more favorable results observed over time.
Researchers identified lamin A and lamin B receptor proteins as essential for maintaining gene position in the nucleus. Their absence causes genes to malfunction, leading to heart failure, vascular disease, and muscle wasting. This discovery may lead to new treatments for these diseases.
Research published in the Journal of Dental Research shows that beta-catenin is crucial for odontoblast cell differentiation and root development. Tissue-specific inactivation of beta-catenin in developing odontoblasts resulted in molars lacking roots and thin incisors.
Researchers discover that belly and thigh fat differ significantly in gene expression, with unique homeobox genes influencing fat cell behavior. This finding may lead to targeted treatments for obesity, shifting focus from belly fat to hip and thigh fat.
The university will extend its world-class structural biology facilities by developing a state-of-the-art instrument for the new synchrotron user facility. The grant aims to provide detailed structural information that can benefit the entire scientific community.
Duc Dong, Ph.D., receives NIH New Innovator Award to explore genetic reprogramming as a means to grow replacement organs. The technology aims to induce new tissue development in zebrafish, allowing for rapid screening of genes and chemicals important for efficient genetic reprogramming.
A recent study published in the Journal of Dental Research estimates that approximately 47.2% of US adults have periodontitis, with higher rates among males, Mexican Americans, and those with lower education levels. The study also found significant disparities in periodontal disease prevalence across different age groups.
Researchers at Sanford-Burnham Medical Research Institute discovered that BACE1 disrupts cellular processes required for PKA function, leading to impaired learning and memory. This finding suggests that targeting BACE1 expression in the brain could be a potential therapy for Alzheimer's disease and age-related memory loss.
Researchers have identified a new function for APJ protein in sensing mechanical changes that can lead to heart failure. Without this protein, the heart is less likely to sense danger and undergo hypertrophic pathways leading to heart failure.
Researchers examine past five years of underwater deliveries by HealthNet midwives to determine maternal and baby health indicators, aiming to improve reproductive health care. The study's findings will inform national policy and contribute to the field's adoption of health information technology.
Researchers have reevaluated the Yellowstone volcano's history, finding that its biggest eruption was actually two separate events 6,000 years apart. This new understanding may lead to a revised likelihood of another large eruption in the future.
Researchers from Notre Dame's Eck Institute for Global Health have developed a novel method using a gene chip to identify malaria drug resistance. This technology enables real-time response and modification of treatment strategies to combat emerging resistance.
Boston Medical Center physician Jeffrey Samet, MD, received a $1.4 million NIDA grant to develop the Research in Addiction Medicine Scholars (RAMS) Program, which aims to create formal addiction medicine training programs with strong research components.
Dr. Richard H. Carmona receives AADR's Honorary Membership for his dedication to promoting oral health as U.S. Surgeon General and beyond. The American Association for Dental Research recognizes Dr. Carmona's significant contributions to dental research.
Researchers at University of Leicester found a significant link between the Y chromosome and an increased risk of coronary artery disease in men. The study analyzed DNA from over 3,000 men and found that 90% of British Y chromosomes belong to two major groups that increase the risk by 50%.
A symposium on tissue injury and pulp regeneration has published proceedings that highlight the potential of dental pulp engineering for regenerating functional dentin. Researchers present data on stem cells, scaffolds, and differentiation factors, demonstrating proof of principle for pulp/dentin regeneration.
The Broad Institute of MIT and Harvard has received a $50 million gift from the Stanley Medical Research Institute to extend funding for its Stanley Center for Psychiatric Research. Researchers will continue to unravel the genetic mysteries of psychiatric illnesses, aiming to develop new treatments for patients.
Researchers are developing a new antidote to regenerate an enzyme that ages after exposure to deadly chemical warfare agents. Dr. Christopher Hadad is using supercomputers to test reagents for this treatment, which could provide complete recovery from severe muscle spasms and death.
Researchers compared two pulp extraction techniques on dental pulp stem cells (DPSC) quality and quantity. The study found that the second technique resulted in higher stem cell integrity, growth rate, and quality, while also improving quantity.
This study evaluated three-dimensional changes in the mandible and glenoid fossa of skeletal Class III patients treated with bone-anchored maxillary protraction. The results showed posterior displacement of the mandible and remodeling of the glenoid fossa, suggesting a favorable control of mandibular growth.
Researchers found that Fuz plays a crucial role in regulating craniofacial development, with defects leading to severe deformities. The study also highlights the importance of Fuz in negative feedback loops of canonical Wnt signaling.
A symposium at the International Association for Dental Research conference will present cutting-edge technologies to minimize caries damage and potentially eradicate caries disease. High-level evidence supporting new approaches will be discussed, including their potential effects on future healthcare costs.
A new study finds that a measure of HDL function, called cholesterol efflux capacity, is more closely associated with protection against heart disease than HDL cholesterol levels. Increasing efflux capacity was linked to decreased likelihood of coronary artery disease and improved cardiovascular health.
NIDCR funding to US dental schools decreased by 10% between 2005 and 2009, with dollars from other NIH Institutes and Centers increasing 34.6%. This trend may threaten the identity of dental schools as a profession if research infrastructure is not strengthened.
The new BD LSR-9 Flow Cytometer with its nine lasers will help Australian researchers analyze rare cell populations more accurately and directly. This technology will aid in fighting against various life-threatening diseases, including cancer and asthma.
Scientists have developed transparent thin films capable of absorbing light and generating electric charge over large areas. The material combines elements for light harvesting and electric charge transport, enabling potential applications in energy-generating solar windows and transparent solar panels.
Researchers at Penn School Medicine identified the steps controlling CD45 protein's different forms, essential for activating the immune system. The study's findings have implications for understanding autoimmune and neurological diseases.
The La Jolla Institute will host research projects throughout the San Diego biomedical community, exploring genetic triggers of disease and developing new therapies for cancer and other diseases. The Center is expected to propel immunology research and catalyze a broad base of basic and clinical investigations.
The international consortium's completion of the turkey genome sequence promises to provide new insights into avian genetics and improve turkey quality. The sequence will enable scientists to better understand specific genes important in meat yield, health, and disease resistance.
Insite, Vancouver's sanctioned supervised safe injection site, has been at odds with Canada's anti-drug policy since its opening in 2003. The facility's fate is uncertain, with the federal government appealing decisions to keep it open despite opposition from Conservative politicians.
A recent study suggests that Porphyromonas gingivalis (P.g.) infection may contribute to the chronicity of inflammatory disorders leading to oral cancers. The research found that P.g. induces expression of immune-regulating receptors B7-H1 and B7-DC in squamous cell carcinoma cells, facilitating immune evasion.