Articles tagged with Medical Research Facilities
Researchers from six centers worldwide have assembled a vast family dataset to study genetic contributions to common epilepsies. The study reveals distinct family syndromes that could inform future genetic research and treatment development.
A recent study published in Molecular and Cellular Biochemistry found that brain cells contain less polyunsaturated fatty acids compared to other major organs. This discovery, made by Dr. Junhwan Kim, PhD, has significant implications for understanding brain health and conditions like oxygen deprivation.
A Science DMZ architecture can be adapted to meet the needs of the medical research community, allowing for secure sharing of large datasets while protecting individual privacy. The design provides speed and security for moving large data sets, enabling teams of experts to collaborate in real-time.
A new universal surveillance platform is being developed to detect infectious diseases, using Ceres' Nanotrap technology and Tasso's HemoLink device. The platform aims to provide safe and simple blood sample collection in remote environments, improving early response to outbreaks.
The American Association for Dental Research (AADR) suggests that dental schools prioritize research participation, collaboration with other departments, and flexible curricula. AADR also advocates for increased funding from various sources, including the National Institutes of Health, to support dental research and training.
Researchers at Berkeley Lab and UC Berkeley have developed a new mechanism to attach radioactive fluorine atoms to chemical compounds, expanding medical imaging capabilities. This breakthrough enables the creation of new 'radiotracers' for PET scans, which can aid in detecting cancers and understanding biological pathways.
A protein called Blimp-1 regulates the immune system in patients with lupus, leading to an overactive immune response that attacks healthy tissue. The study's findings suggest a link between low Blimp-1 levels and increased risk of lupus in females.
Dr. Ravetch's research on Fc Receptor Biology has led to a deeper understanding of the fine line between healthy immune reactions and autoimmunity, paving the way for new therapies for infectious, neoplastic, and inflammatory diseases.
Hepatitis C patients with substance use disorders face barriers to care, including lack of access to conventional healthcare and fear of stigmatization. Innovative approaches, such as integrated screening and treatment in methadone clinics and telehealth techniques, are being developed to improve outcomes for this population
Researchers at Caltech have discovered the molecular basis for protection of a ribosomal protein from cellular degradation, using X-ray crystallography to solve the structure of the bound pair. This finding has potential applications in developing new cancer drugs by preventing tumor growth.
The Southwest National Primate Research Center at Texas Biomedical Research Institute has received a $40 million NIH grant to continue its research programs using nonhuman primates. The grant renewal will support the Center's breeding and research colonies of NHP species, making them available to the global scientific community.
The VA healthcare system generally delivers safe and effective care similar to other health systems, with some exceptions. However, studies on timeliness, equity, efficiency, and patient-centeredness show mixed results.
The US Veterans Health Administration is implementing various changes to improve LGBT care, including the addition of a self-identified gender identity field to all veteran record systems. These actions aim to provide patient-centered care for sexual and gender minority veterans.
A study found that annual application of SDF solution arrests root caries in community-dwelling elders, with higher effectiveness in non-fluoridated areas. The background water fluoride level had no statistically significant influence on the effectiveness of SDF.
Fluorides are effective in preventing caries, but their use alone cannot prevent the disease when combined with high sugars diets. The effects of reducing sugars intake are modified by fluoride, but the two approaches can work synergistically to reduce caries activity.
The OPPERA study reveals that jaw injuries are strongly associated with temporomandibular disorder (TMD), with increased incidence rates found for extrinsic events, sustained mouth opening, and yawning. Single injuries were sufficient to increase risk of developing painful TMD.
The IADR/AADR published an issue on International Caries Consensus Collaboration's (ICCC) recommendations for managing carious lesions, focusing on evidence-based, patient-centered guidelines. The recommendations support less invasive carious lesion management by preserving tooth tissue and retaining teeth long-term.
Researchers have successfully developed a new treatment for the deadly Junin virus, providing complete protection against the disease. The laboratory-engineered antibody demonstrated effectiveness in guinea pigs and showed promise as a therapeutic solution for patients.
A recent study by University of California, San Diego School of Medicine reports that educating Community Health Workers (CHWs) and other 'citizen scientists' can boost the integrity of scientific research. The Building Research Integrity and Capacity (BRIC) program uses eight modules to teach research ethics and concepts.
The IADR/AADR have released the first issue of JDR Clinical & Translational Research, a journal focusing on the translation of research into clinical practice. The inaugural issue covers various topics in applied oral health research, with an emphasis on rapid dissemination and application.
Researchers estimate US periodontitis prevalence at state and local levels using a novel SAE method, revealing high risk areas in the southeast and southwest, including Native American reservations. The study informs oral health policy decisions and intervention strategies to increase access to care for populations at higher risk.
The Iris and Junming Le Foundation has donated $500,000 to support the purchase of a powerful super-resolution microscope at Scripps Florida. This advanced technology will enable neuroscientists to see synapses between neurons with unprecedented detail, potentially leading to breakthroughs in Alzheimer's disease research.
A recent study found that a higher monetary cost of dietary intake is associated with improved diet quality, increased fruit and vegetable consumption, and weight management. The researchers monitored 2181 Spanish adults for ten years and discovered that spending more on food led to better health outcomes.
New evidence on dental implants reveals the importance of tooth preservation in patients with gum infections. The studies suggest that teeth compromised by periodontal disease or endodontic problems may have a longer longevity than average implants.
A study of 1,280 patients with myelodysplastic syndrome (MDS) found comparable survival rates at 100 days and two years for those aged 65 and older compared to younger patients. Age was not a determining factor in HCT outcomes, with marrow blasts, cytogenetics, and Sorror co-morbidity scores being independently associated with results.
A large-scale national study on people with dementia in residential aged care found that participants experienced low levels of activity participation and pessimistic attitudes from staff and families. The study suggests improving leisure activities could enhance quality of life for those with dementia living in long-term care.
A new Ebola vaccine has been found to be well-tolerated and stimulate strong immune responses in adults in Mali and the US. The study's findings could offer crucial protection for contacts of patients with confirmed Ebola disease, helping to interrupt transmission.
The Cornell NanoScale Science and Technology Facility will receive $8 million from the National Science Foundation over five years. This grant, combined with a matching commitment from New York state, will provide long-term infrastructure support for ambitious research.
Smiling Brazil launched in 2004 and incorporated oral health into the public healthcare system, adopting an integral care approach. The policy has shown positive results in oral health epidemiological indicators, financial investment, and professional development.
Recent studies published by the International Association for Dental Research (IADR) highlight the significant link between sugar intake and dental caries. The findings emphasize that even low sugars intakes can contribute to the development of caries, underscoring the need for effective health policies.
The European Nanomedicine Characterization Laboratory (EU-NCL) aims to bring safe and efficient nanotherapeutics faster to patients. EU-NCL partners with international reference facilities to harmonize analytical protocols, providing a trans-disciplinary testing infrastructure for preclinical characterization.
The University of Pittsburgh School of Medicine is leading a national trial to examine methods to reduce unnecessary use of antibiotics in post-acute and long-term care facilities. The trial aims to develop comprehensive guidelines and tools to help facilities better manage urinary tract infections.
A study of children with nonsyndromic orofacial clefts and their relatives found that affected families do not have a significantly higher genetic risk for dental anomalies. Instead, the prevalence of dental anomalies is primarily due to physical consequences of the cleft and surgical interventions.
Greater variability in neural activity may reflect more flexible information processing, supporting better cognitive performance in aging adults. Researchers found that greater BOLD variability was associated with improved memory and fluid intelligence tasks.
A study published at the International Association for Dental Research found that dental pain relief is accompanied by reduced activity in the posterior insula and enhanced connectivity to the midbrain. This discovery provides new insights into the neural mechanisms underlying dental pain.
A study by Bernhard Ganss and colleagues found that amelotin is essential for enamel mineralization and maturation. Ammelotin-deficient mice exhibited weak incisor-edge enamel that fractured and chipped, with delayed enamel mineralization and retention of organic matrix.
The FASEB MARC Program has selected four students and postdoctorates from underrepresented groups to receive travel awards. The awards totaled $7,400 and aim to promote diversity in the biomedical research community. The recipients include Hamid Hussaini, Ibrahim Osumanu, Isavannah Reyes, and Kimberly Herard.
A digital sharing revolution tool, SiteFinder, facilitates research collaborations among tropical medicine researchers and their sites. The Global Health Network's platform ensures quality information and facilitates the sustainability of research capacity.
The Chicago Biomedical Consortium is launching a $3 million Infrastructure Initiative to promote investment in high-impact scientific equipment at its member universities. The initiative aims to make modern instrumentation available to the CBC research community, enabling them to stay at the forefront of biomedical discovery.
A study in mice reveals that dysfunctional ketogenesis promotes fatty liver disease, characterized by excessive hepatic glucose and lipid production. The findings suggest targeting ketogenesis could be a viable approach to treating NAFLD.
A new analysis of Medicare data reveals no significant correlation between nursing home quality and risk of hospital readmission or death within 30 days. However, better staffing ratings, facility inspection scores, and pain management practices were associated with lower rates of readmission.
Severe periodontitis is the sixth most prevalent health condition in the world, affecting over 743 million people worldwide. The global age-standardized prevalence of severe periodontitis remained static at 11.2% between 1990 and 2010.
A new study reveals that instant oatmeal provides greater satiety than equal calories of ready-to-eat oat cereal. The researchers found that eating a bowl of instant oatmeal for breakfast helps manage hunger better than the same amount of calories from a leading oat-based, cold cereal.
A study of active US military personnel found higher rates of Graves disease among blacks and Asian/Pacific Islanders compared to whites. Hashimoto thyroiditis incidence was highest in whites, lowest in blacks and Asians.
This review discusses four key physiologic processes in bone/tooth formation affected by rare bone diseases. The authors highlight causative mutations, etiopathology, and treatments for conditions like fibrous dysplasia, osteogenesis imperfecta, and hypophosphatasia.
The study found higher readmission rates for men, non-Hispanic blacks, and those with longer lengths of stay. The research also identified potential targets for early intervention to reduce readmission rates, such as diagnosis-related groups like kidney and urinary tract infections.
Researchers found that aggressive thyroid cancer cells in microgravity exhibit a redifferentiation to a less aggressive state, offering hope for new treatments. The study's findings suggest potential therapeutic targets for cancer drugs that may be effective on Earth.
The University of Colorado Boulder has been awarded a cooperative agreement worth up to $14.6 million from the Defense Advanced Research Projects Agency (DARPA) to develop a new technological system to rapidly determine how drugs and biological or chemical agents exert their effects on human cells. The Subcellular Pan-Omics for Advance...
Sanford-Burnham researchers identify THRIL molecule that regulates immune response and associates with Kawasaki disease severity. THRIL may also contribute to other inflammatory diseases like rheumatoid arthritis and inflammatory bowel disease.
Dr. Richard Bruick receives the 2014 Edith and Peter O'Donnell Award for his work on cellular responses to maintain oxygen and iron homeostasis. His research has the potential to improve treatments for anemia, renal cancers, and iron overload disorders.
The Edinburgh Genomics facility will focus on large-scale studies of genetic code, aiming to develop therapies tailored to patients' genes. Scientists will also explore the impact of genetics on animal wellbeing and crop disease in agriculture.
Researchers used patient-derived stem cells to show that a genetic mutation in the alpha-synuclein gene increases vulnerability to pesticides, leading to Parkinson's disease. The study identified a molecule that protects neurons from pesticide damage and may have potential clinical implications for treating the disease.
The Broadcom Foundation has donated hundreds of thousands of dollars to Tel Aviv University to establish a two-year program promoting multidisciplinary research toward new authentication methods. The aim is to develop secure interaction between users and their digital environment, including smartphones, e-banking, and e-health devices.
The institute will utilize its high-throughput, human cell-based assays and induced pluripotent stem cells to analyze thousands of potential toxins. This collaboration aims to provide an early and relevant assessment of potential toxicities in a rapid and cost-effective manner.
The OPTIMISTIC study, a healthcare initiative from Indiana University and the Regenstrief Institute, is underway in 19 Central Indiana nursing facilities. The program focuses on improving care coordination, palliative care, and chronic disease management to reduce avoidable hospitalizations.
A study by Simon Fraser University researchers found nearly 40% of seniors who fall experience head impact, with linoleum or tile flooring being the most common cause. The team suggests designing safer environments, improving procedures for detecting brain injuries, and promoting strengthening exercises to reduce falls.
A large cohort of Swedish residents found no association between long-term fluoride exposure and the risk of hip fractures. The study included nearly half a million individuals exposed to varying levels of fluoride in their drinking water.
Researchers found that amyloid beta stimulates Alpha7 nicotinic receptors, triggering astrocytes to release glutamate and overwhelming synapses. A newly modified Alzheimer's drug may block this destructive pathway.
A systematic analysis reveals that 3.9 billion people globally are affected by oral conditions, with untreated caries being the most widespread. The study estimates 15 million disability-adjusted life-years (DALYs) due to oral conditions worldwide.
A year-long study found that minor modifications to military cafeteria food services resulted in significant improvements in soldiers' nutritional intake, including reduced fat consumption. Customer satisfaction also increased on four criteria, with more favorable results observed over time.