Articles tagged with Life Span
Researchers have identified a protein called eNAMPT that plays a vital role in keeping mice healthy. Supplementing older mice with this protein extends their life spans and slows the decline in health, including improved insulin production, sleep quality, and cognitive function.
Researchers used long-lived roundworms to identify new anti-aging compounds among FDA-approved drugs. They found that these compounds can slow down aging in nematodes and may have therapeutic potential for humans.
Researchers discovered that aging in nematodes is partially programmed and can be therapeutically reversed by several FDA-approved drugs. The study identified 10 compounds that slow down aging, including six previously documented with anti-aging potential.
Researchers identified 10 FDA-approved drugs that can slow down aging in nematodes, with six having previously documented anti-aging potential. These compounds have the advantage of already passing clinical trials and can be used off-label as anti-aging drugs, targeting life-extending compounds.
The study discovered that the 'longevity gene' SIRT6 is responsible for more efficient DNA repair in species with longer lifespans. This gene's enhanced activity in organisms like beavers contributes to their extended lifespan, highlighting a potential target for anti-aging interventions.
A new study found that HIV-infected individuals have a longer lifespan of white blood cells called neutrophils, which may contribute to intestinal inflammation. Lactobacillus bacteria, commonly used in probiotics, could be an effective therapeutic strategy to reduce neutrophil-driven inflammation.
Researchers found four bat lineages that live at least four times longer than other mammals and identified life history features predicting extended life spans. Hibernating bat species in higher latitudes are found to live longer, possibly due to their ability to adjust body temperature.
Researchers at Karolinska Institutet developed a new method to identify compounds that prevent aging by analyzing the transcriptome of human cells. This approach identified several candidate substances, including Hsp90 inhibitors, which have been shown to extend lifespan and improve health in C. elegans.
Researchers at MGH found that mitochondrial permeability determines the impact of autophagy on lifespan, with low levels required for health benefits. Elevated autophagy can be detrimental due to excessive opening of the mitochondrial permeability transition pore.
A new study by Georgia Institute of Technology researchers highlights the challenges of designing products that balance durability and recyclability. While some products, like automobiles, can achieve both goals, many others face trade-offs between increasing device life span and reducing electronic waste. The study's findings suggest ...
Researchers discovered a new candidate gene, unpaired 1, that contributes to lifespan regulation in Drosophila melanogaster. Overexpression of this gene increased lifespan in nervous tissue and fat body, but decreased lifespan in intestine.
Researchers found that offspring from older mothers are more responsive to dietary interventions known to increase lifespan. However, caloric restriction did not improve overall fitness in these offspring.
Scientists at Scripps Research discovered a life-extension pathway in C. elegans worms that modulates a cannabinoid biological pathway, extending lifespan by up to 45%. The study introduces a powerful method for applying chemical probes to lab animals like worms to discover biology relevant to humans.
Researchers at Joslin Diabetes Center have discovered a mechanism linking caloric restriction to immune system regulation, leading to increased longevity. Caloric restriction reduces innate immunity by decreasing p38 activity, triggering a chain reaction effect.
Researchers found that females who had assistance from other female helpers benefitted from a longer, healthier lifespan. Older dominant females really benefit from having female helpers, losing less of their telomeres and aging slower.
Research found that females who received assistance from other female helpers benefitted from a longer, healthier lifespan. The findings provide insight into why social species often have longer lifespans, and suggest cooperative breeding may be key to ageing slower.
A study by University of Groningen biologists found that female Seychelles warblers who receive help from subordinates age more slowly and live longer. The birds' telomere length, a marker of aging, also decreases with assistance. This positive feedback system suggests that cooperative breeding can increase an individual's lifespan.
Researchers found that reducing DAF-2 gene expression increased worm lifespan and improved offspring fitness, challenging the idea that ageing is linked to energy allocation. The study suggests that suboptimal gene expression in adulthood can lead to premature ageing.
A new gene therapy using CRISPR/Cas9 targets the accumulation of toxic proteins in progeria syndrome, a rare genetic disorder. The therapy improves health and life span in mice, providing insight into molecular pathways involved in accelerated aging.
Researchers from Wake Forest University found that female Nazca boobies have a shorter lifespan due to their high reproductive activity. The study suggests that the females' efforts to raise their chicks and find new mates may contribute to their shorter lives.
Recent studies lending support to the 'grandmother hypothesis' suggest that post-reproductive lifespan is linked to grandmotherly help, which declines with age. The research found that maternal grandmothers aged 50-75 increased grandchild survival, but paternal grandparents over 75 had a detrimental effect.
A new study found that grandmothers can increase toddlers' survival by nearly 30% due to their prolonged longevity. However, older or frail paternal grandmothers are detrimental to grandchild survival. The study suggests that healthy ageing is crucial for multiple benefits.
Researchers have developed a community-agreed model of worm metabolism, which has been re-optimised for relevance to metabolic changes during ageing. The model predicts that Oxaloacetate production becomes limiting in aged worms, potentially leading to extended lifespan by up to 20%.
Research published in the Journal of Epidemiology & Community Health found that body size-height and weight may have a greater impact on women's lifespan. Additionally, daily physical activity was associated with the best chance of reaching 90 for women, with an optimal threshold of around 60 minutes a day.
Researchers discovered a mechanism involving protein alteration that controls cell response to stress, boosting immunity and extending lifespan. The discovery highlights the importance of unfolded protein response (UPR) and its regulation by ULP-4 enzyme in mitigating mitochondrial stress.
Researchers from the Buck Institute report that MANF regulates metabolism and immune response, and replenishing it shows promise as an anti-aging treatment. MANF deficiency has hallmarks of age-related diseases, including inflammation and liver damage.
A recent study from the University of Liverpool found that overweight dogs have a significantly shorter lifespan compared to those at ideal body weights. The study examined over 50,000 dogs across 12 breeds and revealed that being overweight can lead to poorer quality of life, joint disease, breathing issues, and certain types of cancer.
Researchers have identified a molecule called SLO-1 that regulates motor function and lifespan in tiny aging worms. Targeting this molecule may slow down aging in humans and other animals by improving motor function and increasing lifespan.
A new study finds that the decline in mortality among the very old may be due to errors in data collection and analysis, rather than biological factors. The researchers suggest that even small errors can significantly impact mortality rates, particularly at the end of life.
A new study found that the median lifespan increase of Brachionus rotifers varied greatly among genetically distinct strains when exposed to low temperature. The findings indicate that temperature affects lifespan depending on an individual's genes, challenging the long-held free-radical theory of aging.
Researchers at UC San Francisco have found that female mice live longer than males due to the presence of two X chromosomes. Having both female sex chromosomes and gonads extended life in mice, with most of the effect coming from the sex chromosomes.
A parrot genome analysis found high rates of conserved mutations in genes supporting an abnormally long lifespan and cognitive abilities. The study identified several dozen parrot-specific genes important for traits like sound imitation and complex social behaviors.
Researchers have found that individual species in the gut microbiome account for only a quarter of the effect on fly lifespan, while interactions between species play a crucial role in determining fitness. The study highlights the importance of understanding complex microbiome interactions to better comprehend human health.
A study published in eLife reveals that minocycline can increase the lifespan of aged roundworms by preventing the build-up of proteins, a mechanism that could be exploited to prevent neurodegenerative diseases. The antibiotic also reduces protein aggregation and extends lifespan in animals with impaired proteostasis.
Research suggests that reducing nitrogen dioxide pollution in Copenhagen could increase average lifespan by an entire year and lead to improved quality of life. The study found that by 2040, the number of men suffering from cardiovascular diseases could be reduced by 680 per 100,000 men.
A new analysis of an aggregated set of family trees suggests that the heritability of life span is well below past estimates, likely no more than seven percent. This finding could be due to assortative mating, where people select partners with similar traits, including longevity.
A recent study published in Neurology suggests that when Parkinson's disease does not affect thinking skills early on, life span is not affected. The study found people with problems with memory and thinking skills were more likely to die during the study.
Yale-NUS researchers have discovered a combination of pharmaceutical drugs that extend healthy lifespan and delay ageing in microscopic worms. The study, published in Developmental Cell, lays crucial groundwork for further research into designing drug combinations that produce the same effect in mammals.
Researchers developed a polygenic risk score for lifespan based on weighted contributions from relevant genetic variants, predicting which participants were likely to live longest. They also found associations between genetic variants and Alzheimer's disease, heart disease, and smoking-related conditions with overall lifespan.
A new study by Yale researchers found that brand cache plays a significant role in extending smartphone lifespans, with iPhones lasting up to 67 months compared to Samsung phones' 54.5 months. The study analyzed over 500,000 secondhand phone listings on eBay and found that Apple's brand reputation contributes to its longer lifespan.
A new study forecasts that global life expectancy will increase, but nearly half of all nations may face lower life expectancies by 2040. China and several other countries are expected to see significant gains in life expectancy, while Palestine and some high-income nations are forecast to experience declines.
Researchers at the University of Minnesota Medical School have discovered a natural product called Fisetin that reduces the level of damaged cells in the body, causing aging. This compound has been shown to improve health and extend lifespan even when treatment is initiated late in life.
Researchers recommend focusing on healthspan instead of life extension to address frailty and disease towards the end of life. Olshansky advocates for prioritizing health over extending lifespan, citing the need to address disparities in healthcare access and nutritious living.
A team of scientists has identified 25 genetic mutations associated with longer lifespans in humans and primates. These findings provide insights into the complex process of aging and may lead to new therapeutic targets for age-related diseases.
A new study found that air pollution shortens human lives by over a year globally, with better air quality potentially extending lifespans. The researchers analyzed data from 185 countries and quantified the national impact of PM2.5 air pollution on life expectancy.
A recent study by KU Leuven researchers reveals that the lifespan of transplanted kidneys has stagnated despite improvements in the past. The study analyzed data from over 100,000 recipients across Europe and found that the average lifespan of a transplanted kidney is now around 15-20 years.
A mouse model was created to study Rett Syndrome, showing that low-level MECP2 expression extends lifespan and improves neuromotor function. Therapeutic potential for RTT patients was identified with 5-10% MECP2 restoration associated with improved outcomes.
Researchers found that injecting senescent cells into young mice results in physical dysfunction. Treating the mice with a combination of dasatinib and quercetin cleared senescent cells from tissues and restored function.
A new study estimates mortality rates for nearly 4,000 Italians over 105 years old, finding a plateau in death rates after age 105. The research suggests that human longevity is increasing over time, with slight declines in mortality rates across groups born within the same year.
A new study published in Proceedings of the Royal Society B suggests that many species have evolved to prioritize growth over immunity during maturation, leading to increased susceptibility to infections in juveniles. This phenomenon is predicted to be lowest when organisms have lifespans that are neither too short nor too long.
Researchers found a strong negative correlation between pancreatic cell size and lifespan in 24 mammalian species. Animals with larger cells tend to age faster, while smaller cells are associated with longer lifespans.
A recent University of Minnesota Medical School study found a direct link between psychosocial stress and shortened lifespan in mice, identifying cellular senescence mechanisms and diseases associated with aging. The research also observed an increased risk of cardiovascular disease, including early-stage atherosclerosis.
Research links nucleolus to age-related pathways, finding that enlarged nucleoli correlate with shorter lifespans and reduced insulin signaling. A small nucleolus may extend lifespan by balancing cellular renewal and repair.
Research from Indiana University's Kelley School of Business found that US publicly listed companies' chances of surviving over five years have declined significantly since the 1960s. The study suggests that traditional views on company age may no longer predict organizational success, as organizations become increasingly temporary.
A study on grey mouse lemurs found that chronic caloric restriction increased their median survival time to 9.6 years, compared to 6.4 years in control groups. Calorie restriction also delayed the onset of age-related pathologies and preserved motor capacities.
Researchers found that the offspring of elderly mouse-fathers had a shorter lifespan and featured exacerbation of histopathological and molecular aging traits. Epigenetic changes in paternal sperm and offspring were also observed, suggesting intergenerational influences on aging processes.
Researchers at Linköping University found that fruit flies do not have a shorter lifespan due to having one X chromosome. Instead, the study suggests that competition for mates may be responsible for the sex difference in lifespan. Further research will investigate alternative theories.
A study found life expectancy gains slowing globally since 1950, with the sharpest declines in low-lifespan countries. The slowdown, attributed to factors such as governance failure and inadequate public health measures, suggests that efforts to improve life expectancy must focus on promoting political will and social consensus.
A new study found that boosting Sirt4 gene activity extends healthy lifespan in fruit flies, with a 20% increase in longevity seen in modified flies. The researchers also discovered that Sirt4 plays a crucial role in regulating metabolism and fasting responses.
Researchers at Newcastle University found that a small adaptation in the protein p62 helps cells respond to stress and activate autophagy, a process that removes damaged components from cells. This discovery could help explain why humans have increased natural defenses and longer lifespans compared to other organisms.