Articles tagged with Life Span
Researchers found that the drug mifepristone blocks inflammation and reduces health decline in female fruit flies after mating, leading to longer lifespans. This effect is similar to what happens in women who take the drug, suggesting it may also extend human lifespan.
A study of fruit flies has found that analyzing small molecules involved in cell metabolism can help understand how calorie-restricted diets affect aging and lifespan. The research identified several genes linked to changes in metabolite levels, shedding light on the complex interplay between genetics, environment, and diet.
A new USC-led study demonstrates that the peptide humanin, found in mitochondria, is closely correlated with longer lives and better health in both animals and humans. Higher levels of humanin have been observed in organisms with lower risk for age-related diseases such as Alzheimer's.
A new University of Otago study found that mating with sterile males early in life increases female growth but reduces lifespan. Mating with fertile males later in life has the opposite effect, increasing reproductive output. The findings suggest long-term consequences of social interactions between males and females.
Researchers found that female mice mated with sterile male mice experienced a growth-reproduction trade-off, resulting in weight gain and increased reproductive output in late life. However, this also led to a reduced lifespan compared to those housed with other females.
A study by University of Utah Health found that genetic mutations accumulate at an accelerating rate during puberty, affecting lifespan and fertility. Young adults with slower rates of mutation accumulation lived about five years longer than those with faster rates.
Researchers at Tokyo Institute of Technology found that Kabuki actors had shorter lifespans compared to other traditional arts performers who led sedentary lifestyles. The study suggests that excessive endurance training and physical activity may overwhelm the beneficial aspects of regular exercise.
Research involving 160 genetically distinct strains of fruit flies found that while dietary restriction extended lifespan, its effect on healthspan was less consistent. The study suggests that healthspan, rather than just lifespan, should be the primary focus for those seeking to improve aging outcomes.
Researchers found that death is preceded by accumulation of reactive oxidative species (ROS) in the gut, which can be neutralized to prevent premature death. The study on fruit flies suggests a key role for the gut in causing death from sleep deprivation, and may inform future efforts to address its detrimental effects in humans.
A research team has identified a powerful self-corrective mechanism within synapses that slows down disease progression in animal models of ALS. This mechanism is activated by neurodegeneration and acts to keep the synapse between nerve and muscle working correctly, even though the disease process has already begun to nibble away at it.
Researchers at Clemson University have discovered that the genetic architecture of life span is context-dependent, with different genes and variants having varying effects on males and females and environmental temperatures. The study uses the Drosophila melanogaster model to provide valuable insights into human aging.
A new study suggests that rare, damaging inherited mutations can have a significant impact on an individual's healthspan and longevity. Researchers found that people with more ultra-rare protein-truncating variants (PTVs) had shorter lifespans and healthspans, with each additional variant accounting for a six-month reduction in lifespa...
Chimpanzee cortisol levels increase with age, blunting natural diurnal rhythm and responding to stressors similarly to humans. Sex differences also emerge, with males exhibiting higher levels than females, particularly when exposed to attractive females.
A new study reveals that female wild mammals live 18.6% longer than their male counterparts, contrary to the human lifespan difference of 7.8%. This phenomenon is likely due to differences in energy allocation and physiological characteristics between sexes.
A study of 101 wild mammal species found that females lived 18% longer than males for over 60% of the species, with a similar gap in humans. The researchers suggest complex interactions between environmental conditions and sex-specific costs of reproduction may contribute to this phenomenon.
A study examines the impact of sex on the lifespan and aging rate of mammals. Wild female mammals have an average 18.6% longer lifespan than their male counterparts in 60% of analyzed populations.
Researchers analyzed genetic and clinical data to find that high blood pressure and obesity significantly reduce lifespan, particularly in European ancestry populations. The study, published in Nature Medicine, identifies these traits as major contributors to reduced human lifespan.
Research compiled demographic data for 134 populations of 101 mammalian species, finding that 60% of female mammals live longer than males. Mortality risk is lower among females at all ages, but the rise in mortality with age varies between sexes.
A recent study by Penn State researchers found that communities with more fast food restaurants, higher population density, and jobs in the extraction industry have shorter life expectancies. Conversely, areas with growing populations, good access to physicians, and high social cohesion tend to have longer lifespans.
A new study by Penn State researchers found that community characteristics play a significant role in determining life expectancy, with factors such as fast food restaurants, population density, and jobs in the extraction industry negatively affecting lifespan. Conversely, social capital, good access to physicians, and lower population...
A study analyzing data from 49 countries and regions found that increased lifespan equality is associated with higher life expectancy. High reductions in mortality at young ages contribute to both increased life expectancy and greater lifespan equality.
Researchers found that a mere four glial cells in the worm's brain control the stress response in cells throughout its body, increasing lifespan by 75%. This discovery suggests that brain cells may play a crucial role in protecting muscles from wasting away, and potentially lead to new treatments for muscle atrophy and obesity.
Researchers at MDI Biological Laboratory identify two major pathways governing aging in C. elegans, which when combined, amplify lifespan fivefold. This discovery could lead to the development of combination therapies to extend human healthy lifespan.
The Breakthroughs in Gerontology (BIG) Awards support research into human aging and healthspan. Ursula Jakob will study early epigenetic events that extend lifespan, while Norbert Perrimon will investigate organ communication networks influencing aging.
A study in Scientific Reports presents a genetic model that accurately estimates lifespans of different vertebrate species by analyzing 42 selected genes and their CpG sites, which are correlated with lifespan. The 'lifespan clock' reveals high predictive power for various species, including extinct ones.
A study on killer whales found that grandmothers play a crucial role in improving the survival of their grandoffspring. The research suggests that postreproductive females can better provide care due to not having reproductive pressures, potentially contributing to the long lifespan of killer whales.
Researchers at the University of Michigan discovered that oxidative stress in early life increases subsequent stress resistance later in life. Oxidative stress, which occurs when cells produce more oxidants than they can deal with, is part of the aging process but can also arise from stressful conditions.
Researchers found that prolonged blue light exposure damages brain and retinal cells, leading to impaired locomotion in Drosophila melanogaster. Flies without eyes also showed damage, suggesting blue light's harmful effects extend beyond visual perception.
Researchers used a grip-force test to analyze sensorimotor function in people with the FMR1 premutation, identifying subtle symptoms and potential indicators of disease progression. The study aims to improve early diagnosis and treatment for Fragile X-associated tremor/ataxia syndrome (FXTAS) in at-risk individuals.
Researchers found that suppressing neural overactivity extends life span in humans, while excessive activity is linked to shorter life spans. The study suggests a role for the protein REST in modulating neural activity and activating a longevity pathway.
Researchers have discovered a causal link between high blood pressure, obesity, and reduced lifespan in a massive genetic analysis of 700,000 individuals. By analyzing polygenic risk scores, the team identified blood pressure and obesity as key drivers of human longevity.
The University of Warwick has developed a new theory to accurately predict the lifetime of evaporating liquid droplets, which can be exploited for engineering design. The research reveals fascinating new physics in vapour flow, including jumps in temperature across just a few molecules.
Researchers at MDI Biological Laboratory have identified post-transcriptional regulation mechanisms governing longevity, which will aid in screening for new therapies. The study uses C. elegans worms and dietary restriction to understand the genetic complexity of aging.
A triple drug combination of lithium, trametinib, and rapamycin has been shown to extend the lifespan of fruit flies by 48%, a significant increase compared to previous studies. The treatment targets different cellular processes and may have potential benefits for preventing age-related diseases in humans.
A study of 69,744 women and 1,429 men found higher optimism associated with increased odds of exceptional longevity. More optimistic individuals demonstrated 11-15% longer lifespan than less optimistic ones.
A study of 90 Austrian chess players found that both intelligence and practice positively influenced skill level. More intelligent players acquired skills more quickly and retained them longer with the same amount of practice.
Researchers discovered a group of genes whose activity was associated with longevity in response to various interventions. The study used mice as a model organism and identified biomarkers that could facilitate the search for new longevity interventions.
Researchers will track three Boston-based cohorts for over half a century and analyze data on socioeconomic, environmental, and psychosocial factors that impact Alzheimer's disease, cardiometabolic disease, and premature death.
A large-scale study of online task-switching game users reveals that practice enhances relevant task activation time, yet has little effect on deactivation time. Older adults benefit from extensive practice, with improved performance comparable to younger individuals.
Scientists discovered a protein called LIN-53 that controls muscle integrity, lifespan and levels of an essential sugar. The protein is an epigenetic factor that affects gene expression and heritable traits.
Researchers identified 239 genes with altered activity in long-living fruit fly strains, including those involved in metabolism. The mutation triggers a global alteration of metabolism, affecting carbohydrate, lipid, and nucleotide metabolism, as well as immune response genes.
A mutant worm with a change in one mitochondrial gene produces more ROS, but lives twice as long due to a detoxification pathway. The study reveals that this pathway is conserved throughout the animal kingdom and essential for longevity.
The study describes a system that incorporates microscale silicon electronic components and light emitting diodes, with layouts customized to the size and functional heterogeneity of the human brain. The flexible bioelectronic systems enable optoelectronic signaling and/or electrophysiological monitoring.
New research suggests that climate change could lead to the extinction of loggerhead turtles in Cape Verde due to rising temperatures and changing sex ratios. The study projects that by 2100, more than 90% of nests may incubate at lethal temperatures, killing most hatchlings before they can emerge.
A study found that telomere shortening rate predicts species lifespan, rather than initial telomere length. Body weight and heart rate were less powerful predictors of lifespan.
Researchers have identified a protein called eNAMPT that plays a vital role in keeping mice healthy. Supplementing older mice with this protein extends their life spans and slows the decline in health, including improved insulin production, sleep quality, and cognitive function.
Researchers used long-lived roundworms to identify new anti-aging compounds among FDA-approved drugs. They found that these compounds can slow down aging in nematodes and may have therapeutic potential for humans.
Researchers discovered that aging in nematodes is partially programmed and can be therapeutically reversed by several FDA-approved drugs. The study identified 10 compounds that slow down aging, including six previously documented with anti-aging potential.
Researchers identified 10 FDA-approved drugs that can slow down aging in nematodes, with six having previously documented anti-aging potential. These compounds have the advantage of already passing clinical trials and can be used off-label as anti-aging drugs, targeting life-extending compounds.
The study discovered that the 'longevity gene' SIRT6 is responsible for more efficient DNA repair in species with longer lifespans. This gene's enhanced activity in organisms like beavers contributes to their extended lifespan, highlighting a potential target for anti-aging interventions.
A new study found that HIV-infected individuals have a longer lifespan of white blood cells called neutrophils, which may contribute to intestinal inflammation. Lactobacillus bacteria, commonly used in probiotics, could be an effective therapeutic strategy to reduce neutrophil-driven inflammation.
Researchers found four bat lineages that live at least four times longer than other mammals and identified life history features predicting extended life spans. Hibernating bat species in higher latitudes are found to live longer, possibly due to their ability to adjust body temperature.
Researchers at Karolinska Institutet developed a new method to identify compounds that prevent aging by analyzing the transcriptome of human cells. This approach identified several candidate substances, including Hsp90 inhibitors, which have been shown to extend lifespan and improve health in C. elegans.
A new study by Georgia Institute of Technology researchers highlights the challenges of designing products that balance durability and recyclability. While some products, like automobiles, can achieve both goals, many others face trade-offs between increasing device life span and reducing electronic waste. The study's findings suggest ...
Researchers at MGH found that mitochondrial permeability determines the impact of autophagy on lifespan, with low levels required for health benefits. Elevated autophagy can be detrimental due to excessive opening of the mitochondrial permeability transition pore.
Researchers discovered a new candidate gene, unpaired 1, that contributes to lifespan regulation in Drosophila melanogaster. Overexpression of this gene increased lifespan in nervous tissue and fat body, but decreased lifespan in intestine.
Researchers found that offspring from older mothers are more responsive to dietary interventions known to increase lifespan. However, caloric restriction did not improve overall fitness in these offspring.
Scientists at Scripps Research discovered a life-extension pathway in C. elegans worms that modulates a cannabinoid biological pathway, extending lifespan by up to 45%. The study introduces a powerful method for applying chemical probes to lab animals like worms to discover biology relevant to humans.
A study by University of Groningen biologists found that female Seychelles warblers who receive help from subordinates age more slowly and live longer. The birds' telomere length, a marker of aging, also decreases with assistance. This positive feedback system suggests that cooperative breeding can increase an individual's lifespan.
Researchers at Joslin Diabetes Center have discovered a mechanism linking caloric restriction to immune system regulation, leading to increased longevity. Caloric restriction reduces innate immunity by decreasing p38 activity, triggering a chain reaction effect.