Articles tagged with Schizophrenia
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers identified PERK as a crucial protein for maintaining behavioral flexibility, allowing us to adjust behaviors in response to changing circumstances. The study's findings have implications for addressing neurological disorders such as autism and schizophrenia.
Researchers have discovered compartmentalized neural activity in nematode neurons, which enables movement and encodes body position. This finding has significant implications for understanding neurological disorders like schizophrenia and developing potential treatments.
A comprehensive list of genes associated with schizophrenia has been identified, enabling the development of a predictive test that can estimate an individual's risk of developing the disease. The test, which predicts schizophrenia risk in about two-thirds of cases, holds promise for early intervention and treatment.
A research team identified a comprehensive group of genes linked to schizophrenia and developed a prototype predictive test that can accurately assess an individual's risk of developing the disease. The test was able to predict schizophrenia risk in about two-thirds of cases, providing guidance for early intervention and treatment.
A study of 2,588 Finnish schizophrenic patients found that antidepressive treatment reduced mortality risk by 43%, whereas bensodiazepine use increased the risk of early death and suicide by 91%. The researchers also found no association between taking multiple antipsychotics and increased mortality.
A systematic review of 50 years of data found antipsychotic drugs significantly reduce relapse rates and hospitalizations in patients with schizophrenia. However, they also experience more adverse side effects, including movement disorders and weight gain.
Researchers at University of Liverpool found children who experienced severe trauma are 3 times more likely to develop schizophrenia. The study analyzed data from over 27,000 research papers and suggests environment plays a major role in psychosis development.
A new study by Karolinska Institutet researchers found that DNA methylation levels in white blood cells are lower in patients with schizophrenia and related to age of disease onset and treatment response. The discovery may lead to the development of a simple test to diagnose schizophrenia.
Researchers identify precise genetic links between nature and nurture in schizophrenia risk. Defects in DISC1 protein and environmental stress after birth increase brain development abnormalities and schizophrenia likelihood by 1.4 times.
Research suggests that smoking can increase the impact of genes like TCF4 on acoustic stimulus filtering, potentially leading to schizophrenia. Healthy carriers of the TCF4 gene also exhibit reduced stimulus filtering abilities.
Smartphones can be used to track symptoms and deliver real-time interventions for people with schizophrenia, according to Dartmouth College research. A survey of 1,600 individuals found that 70% had cellphones and used them frequently.
A Wayne State University study found that children of parents with schizophrenia exhibit reduced brain network communication and disordered responses to emotional faces. These findings suggest a potential predictor for the onset of emotional problems in later life.
A six-month pilot program demonstrates measureable benefits for individuals with schizophrenia, improving communication, social interaction, and coping skills. The program, Advancing Standards of Care for People with Schizophrenia, uses evidence-based tools to encourage participants to take control of their mental illness.
Around 70% of young adults with Asperger Syndrome reported at least one episode of depression, while up to 50% experienced repeated episodes. One third of individuals also have ADHD, and characteristics between Asperger and schizophrenia share similarities in autistic traits and social cognitive ability
A study published in Neuron found that intensive computerized cognitive training exercises can improve complex cognitive functions and social cognition in people with schizophrenia. The training improved the ability to distinguish internal thoughts from reality, coinciding with increased activation in the medial prefrontal cortex.
Researchers in British Journal of Ophthalmology reveal that self-inflicted blinding is a rare complication of severe psychosis, such as schizophrenia. The phenomenon has been mistakenly attributed to sexual guilt and the Oedipus complex, but cultural beliefs are not a plausible explanation for this behavior.
Researchers at Karolinska Institutet discovered that pridopidine binds to the sigma-1 receptor, a previously unknown mechanism of action. This finding could lead to new treatments for schizophrenia, Parkinsonian tremors, and neurodegenerative diseases.
A computerized cognitive training program has been shown to improve reality-monitoring tasks and social functioning in individuals with schizophrenia. The study found that 16 weeks of intensive training was associated with increased activation of the medial prefrontal cortex, a critical brain region for reality-monitoring processes.
Researchers at Columbia University's Mailman School of Public Health conducted a case-control study to investigate the link between Borna disease virus and psychiatric illness. The study found no evidence of active or historical infection with BDV in patients with schizophrenia, bipolar disorder, and major depressive disorder.
Researchers have discovered that stem cells from patients with schizophrenia proliferate faster than healthy individuals, indicating dysregulation of the natural cell cycle. This finding provides a potential path to understanding schizophrenia and developing new treatments.
Researchers found that people with schizophrenia showed greater brain activity during tests inducing delusional thinking, including the cortical midline structures and dopamine regions. This effect was not seen in a comparison group without schizophrenia.
Adolescents diagnosed with schizophrenia show greater decreases in gray matter volume and increases in cerebrospinal fluid in the frontal lobe compared to healthy peers. Progressive brain changes are also linked to poorer prognosis, including longer hospitalization and reduced symptom improvement.
Researchers found that DNA stays too tightly wound in certain brain cells of schizophrenic subjects, pointing to new therapies. The study suggests treatment might be most effective early on for minimizing or reversing symptoms.
Researchers identify neurobiological characteristics linked to complex neuropsychiatric disorders as potential biomarkers. Cognitive deficits are recognized as core features of schizophrenia, reflecting a broader, more multidimensional illness than traditional diagnosis.
Two University of Pittsburgh professors, Anthony Grace and Christian Schunn, have been recognized as AAAS Fellows for their groundbreaking work in cognition and STEM fields. Their research focuses on understanding the mechanisms of schizophrenia and bridging cognitive science research on reasoning and learning in STEM.
Researchers from Mount Sinai School of Medicine identified the pattern of cell signaling induced by antipsychotic drugs in a complex composed of two brain receptors linked to schizophrenia. This discovery may allow for the prediction of novel compounds' effectiveness and accelerate the development of better antipsychotic drugs.
A recent study reveals the underlying physical causes of mental illnesses such as schizophrenia, depression, and anxiety. The findings suggest that early-life depression and anxiety can alter the structure of the developing brain.
A Canadian study found a link between heavy methamphetamine use and an increased risk of developing schizophrenia. The research compared methamphetamine users to those with other substance dependencies and found a 1.5-3-fold higher risk of diagnosis.
A study using the rubber hand illusion found that people with schizophrenia have a weakened sense of body ownership. This suggests that movement therapy could be helpful for these individuals, particularly those who experience out-of-body experiences. The findings also support the idea that exercise may reduce symptoms of schizophrenia.
Research by University of Bristol neuroscientists found that cannabis disrupts coordinated brain waves, leading to impaired decision-making and memory. The study suggests that 'disorchestrated brains' may contribute to psychiatric diseases like schizophrenia.
A Penn team has identified a key connection between genetic risk factors for schizophrenia and altered sound processing in the brain. By studying mice with a mutated dysbindin gene, they found reduced activity in specific nerve cells that control fast brain activity, leading to symptoms of schizophrenia.
Researchers at Case Western Reserve University have developed virtual brain models that reveal structural differences among healthy and ill brains. The models show that complex network connections are associated with normal EEG patterns, while simpler networks are linked to neurological disorders such as epilepsy and schizophrenia.
Cognitive therapy has been shown to improve the lives of severely impaired schizophrenic patients, reducing symptoms and promoting recovery. By helping patients set concrete goals and overcome defeatist beliefs, treatment encourages engagement in activity and motivation, leading to better functional outcomes and reduced hallucinations.
A twin study at King's College London found significant epigenetic differences between psychosis discordant twins, suggesting a role for epigenetic processes in neuropsychiatric disease. The study provides potential new avenues for treatment and may lead to the development of novel therapeutic drugs.
A genome-wide study involving 50,000 participants has discovered 11 regions on the genome strongly associated with schizophrenia and bipolar disorder. The researchers found that several DNA variations contribute to both diseases, representing a significant advance in understanding their causes.
A large international study confirms that 11 genetic regions contribute to both schizophrenia and bipolar disorder, with many variations affecting both conditions. The research found strong associations between specific genes and the development of these severe brain disorders.
Research reveals 11 genomic regions associated with mental illness, including six previously unknown areas. The findings provide fresh insight into the causes of schizophrenia and bipolar disorder, potentially leading to new treatment options.
A team of researchers has found that common genetic variants contribute to the risk of schizophrenia and bipolar disorder, with many variations found in both diseases. The study identifies six new molecular evidence links with these diseases and suggests disruption of development processes as a factor in mental disorders.
A recent study published in Epilepsia found a strong bidirectional relationship between schizophrenia and epilepsy. Patients with epilepsy were significantly more likely to develop schizophrenia, while those with schizophrenia had a higher incidence of epilepsy. The research suggests shared genetic and environmental factors contributin...
A large international study of over 50,000 adults has identified 11 common genetic variations associated with an increased risk of schizophrenia and bipolar disorder. The study found that many of these variants contribute to both diseases, providing new molecular evidence for the causes of these chronic brain disorders.
Researchers found that new mutations, separate from inherited mutations, significantly contribute to the occurrence of schizophrenia. This discovery highlights the significance of personal genome sequencing in understanding complex diseases like schizophrenia.
Researchers have found that de novo protein-altering mutations account for more than 50% of sporadic schizophrenia cases. These genetic errors are present in patients but not in their parents. The study suggests that many more mutations may contribute to the disease, paving the way for new treatments.
Researchers have identified a molecular pathway affected in schizophrenia and successfully alleviated symptoms using a cancer drug. The study found that reducing p35 enzyme levels led to cognitive impairment, which was addressed by administering the cancer drug MS-275.
Researchers found that de novo mutations, genetic errors present in patients but not their parents, are more common in schizophrenic patients. This discovery may help define how the disease results from these mutations and develop new treatments.
Researchers at Vanderbilt University discovered that impairments in the posterior superior temporal sulcus (STS) brain area contribute to difficulties in reading social cues. This abnormal brain activation leads to misconstruing human actions and intentions in individuals with schizophrenia.
Researchers used EEG to measure brain's response to tones, finding smaller mismatch negativity in individuals who developed schizophrenia. The test showed promise as a potential predictor of psychosis development.
The Broad Institute of MIT and Harvard has received a $50 million gift from the Stanley Medical Research Institute to extend funding for its Stanley Center for Psychiatric Research. Researchers will continue to unravel the genetic mysteries of psychiatric illnesses, aiming to develop new treatments for patients.
Research studies found that vulnerable individuals with genetic deletions on chromosome 22, known as velocardiofacial syndrome (VCFS), are at risk for developing schizophrenia. Progressive brain abnormalities emerge during adolescence, including deficits in the volume of temporal cortex gray matter, which predicts psychosis.
A team of researchers used a virtual computer model, called DISCERN, to simulate excessive dopamine release in the brain, revealing distinctly schizophrenic-like memory recall. The study supports the hyperlearning hypothesis and provides insights into how neural networks can help understand human schizophrenia.
A pilot study found that L-lysine reduced severity of symptoms and improved functional ability in eight out of ten patients with schizophrenia. The treatment showed a general trend for improvement due to treatment with lysine, but results were confounded by the beneficial effect of lysine continuing after treatment stopped.
Researchers have developed a method to recreate schizophrenic brain cells from skin cells, enabling safe and effective studies. This approach offers a step towards personalized medicine for patients with schizophrenia and potentially other diseases.
Researchers created patient-derived iPSCs, which were then differentiated into neurons to study schizophrenia. The study found that these neurons connected less frequently with each other and had misregulated gene expression profiles, but Loxapine restored connectivity. The findings provide a new model for understanding the disease mec...
Researchers at Duke University and Johns Hopkins University have identified a key brain switch that regulates neuron migration, which may help in early detection of schizophrenia and other conditions. The study suggests that up to 10% of psychiatric illnesses are driven by defects in this switch system.
Researchers discovered a molecular switch that regulates protein behavior, expanding biomarker possibilities for diagnosing and tracking mental illnesses. The study found a key modification of the Disrupted In Schizophrenia gene (DISC1) governs its functions in new neuron production and neural migration.
Seven GHSU investigators will present their research on schizophrenia and psychiatric disorders, including Dr. Peter Buckley's National Institutes of Mental Health-funded study on relapse prevention. Researchers also explore potential treatments for stress-induced anxiety behavior and prenatal stress-related neuropsychiatric illnesses.
A study by molecular geneticist Shiva Singh found that even identical twins have distinct DNA profiles due to random genetic variations. The research uses monozygotic twins with one having schizophrenia to investigate the genetic determinants of schizophrenia.
Researchers create induced pluripotent stem cells from adult siblings with schizophrenia and DISC1 gene mutation, providing a potential tool for screening treatments and understanding the disease. The stem cells can be coaxed to become brain cells like neurons, offering new insights into the causes of major mental illnesses.
A new Johns Hopkins study shows that each strain of the cat-borne parasite Toxoplasma gondii triggers a unique reaction in human nerve cells, varying the severity of infection. The research found alterations triggered by the most virulent strain to be linked to brain development and central nervous system function.
Researchers found a rare genetic glitch in patients with schizophrenia that could lead to improved treatments. The VIPR2 gene mutation was linked to overactive VIP activity, which can impact brain development and learning, offering potential targets for new therapies.
Researchers discovered a rare gene mutation strongly linked to schizophrenia, which could be a new target for effective treatment. The mutation affects the VIPR2 gene, leading to increased signaling in the Vasoactive Intestinal Peptide pathway.