Researchers at IRB Barcelona discovered that the antibody mAb806 can be used to treat many types of tumors with EGFR mutations, not just a specific one. The study also found that even non-mutated EGFR can be treated to make it susceptible to mAb806 therapy.
Researchers at the University of Sheffield have discovered a mechanism used by bacteria E. faecalis to hide from the immune system, paving the way for new treatments. The study found that the bacteria modifies its cell surface to evade recognition by host immune cells.
A new study found that incarcerated youth are at an increased risk for suicidal behavior, with rates reported to be 2-to-3 times higher than those in the general population. Key risk factors such as history of mental health conditions and substance use were not significantly different between groups.
A large observational study found that oral contraceptives were most protective in young women aged 15-19 years, reducing the risk of reconstructive surgery by 63%. The study suggests that taking oral contraceptives may suppress hormonal surges during the menstrual cycle, leading to a lower rate of injury.
Scientists have found that plant cells adjacent to injured areas re-activate their stem cell programs to produce new cells of the correct type. This process, called 'restorative patterning', allows plants to heal wounds more efficiently.
Cancer cells' acquired resistance to anti-cancer drugs can be exploited as an Achilles heel, according to research that shows removing a MEK1/2 inhibitor drug causes reversal of drug resistance in colon cancer cell populations. This finding may inform decisions about intermittent use rather than continuous exposure.
Researchers at Helmholtz Munich discover key molecules in the cell nucleus that orchestrate paraspeckles formation, a structure linked to ALS progression. The discovery provides new insights into pluripotency and differentiation processes, potentially leading to breakthroughs in regenerative medicine and therapeutic strategies for ALS.
A National Science Foundation study suggests that localized pollution controls on coral reefs won't suffice, highlighting the need for a worldwide effort to reduce global warming. The researchers found that combined stressors from temperature, nutrient enrichment and physical damage significantly impacted the coral microbiome.
Researchers developed a chemical probe that enables live-imaging of microglia in the brain, crucial for understanding brain development and disease. The probe, CDr20, labels microglia in both human- and primate-derived cells, allowing for clinical-relevant studies.
A randomized, double-blind study conducted in Panama found that paromomycin-based topical treatments are effective in curing cutaneous leishmaniasis with an 80% cure rate. The treatment showed high efficacy in children under 12 and teens from 12-17, with cure rates of 84% and 82%, respectively.
A genomic tour-de-force identifies two extinct lineages and suggests speed was only selected for recently in horse evolution. The study sheds light on the complex history of horses, highlighting their diverse past and its impact on conservation and breeding practices.
Researchers at Karolinska Institutet have identified blood-based biomarkers that can determine which patients with advanced prostate cancer will benefit from continued hormonal therapy. The study suggests that patients with a normal TP53 gene and fewer AR resistance markers may benefit more from treatment.
Researchers at the University of Arkansas have discovered a promising new material that can efficiently store information using both magnetic and electric fields. The study suggests this material, bismuth ferrite, could lead to faster and cheaper computer memory.
A team of researchers has identified the first gene associated with LUTO, a rare condition causing urinary tract obstruction in boys. The study found that variants of the BNC2 gene are linked to the disease, which can lead to kidney damage and other complications.
A new study by American Cancer Society researchers finds that more than half of Americans experience medical financial hardship, with 56.0% of adults reporting at least one domain of hardship. The study estimates that 137.1 million adults in the US suffer from this issue, which can lead to delays in care, distress, and economic hardship.
A Yale study reveals that a healthcare program tailored to the needs of recently released prisoners can significantly reduce recidivism by providing community-based primary care. The approach employs community health workers with histories of incarceration, who accompany patients to appointments and provide social support.
A recent study reveals Finnish students excel in social media and online news digital literacy tasks due to their curriculum's emphasis on explicit critical thinking skill development. The US system's implicit approach may contribute to the disparity.
A study found that climate change may lead to increased fertility due to reduced resources for education, as people allocate time and money for child-rearing. The researchers used a quantitative model to examine the economic channels through which climate change affects fertility, finding that it worsens inequalities in richer countries.
A new study finds that kids and teens who consume low-calorie sweetened beverages take in about 200 extra calories on a given day compared to those who drink water. The study also shows that these youth tend to consume more calories from added sugars compared to water consumers.
Researchers at the University of Navarra found that pretreating patients with TNF inhibitors before combining immunotherapy can reduce adverse effects and improve treatment response in animal models. The study suggests a new approach to treating cancer by blocking tumor necrosis factor while applying combination immunotherapy.
A study reveals that nearly half of protected areas face staffing shortages, affecting conservation progress. Meanwhile, researchers identify remote high-elevation areas with ancient trees in China. Fuel breaks aim to prevent wildfires but may create new problems, such as altering predator migration routes.
A new study by University of California, Irvine researchers tracked several dozen male collegiate water polo players over three seasons to map out the frequency of head injuries in the sport. The study found that offensive players were more likely to get battered than defensive and transition positions.
Researchers at the University of Bristol have successfully demonstrated a new material's ultra-high thermal conductivity, twice that of copper. This breakthrough paves the way for energy-efficient devices in mobile phones, radars, and electric cars, leading to better performance and safety.
A global Therapeutic Area Standard has been released to represent data in research studies pertaining to CDAD, driven by the need for a major medical and infection control problem. The standard aims to accelerate clinical research and improve public health outcomes.
Researchers have developed a method to print complex vascular networks in biocompatible hydrogels using food dye #5, mimicking the architecture of biological tissues. This breakthrough has significant implications for tissue engineering and organ transplantation.
A study analyzing 15 years of mosquito surveillance data found that Culex tarsalis is the most likely species to transmit West Nile virus in Iowa, particularly in western counties along the Missouri River. The research also identified increased risk areas and recommended preventive measures.
A new species of edrioasteroid echinoderm, Totiglobus spencensis, has been discovered, providing insight into the evolution of echinoderms from living stuck to marine sediment grains to attached to hard surfaces. This discovery sheds light on a critical time in the evolution of organisms and marine ecosystems.
A study by Kellogg Eye Center reveals that herpes zoster ophthalmicus (HZO) cases tripled in 12 years, mostly affecting older adults. Shingles vaccination provides strong protection from HZO complications, but its use is not widespread.
Astronomers discover that a violent neutron star collision near the solar system created 0.3% of Earth's heaviest elements, such as gold and platinum, 4.6 billion years ago. This cosmic event is believed to have occurred in our neighborhood, about 1000 light years from the cradle of Earth.
Researchers at Boston University School of Medicine examined coatings on drug-coated balloon catheters using microscopy and cell cultures to improve delivery efficiency. They found that coating shape affects drug transfer, leading to better device performance and potential outcomes.
Research suggests that US schools can harness the power of solar panels to reduce their energy bills and carbon footprint. The study found that schools in sunny states like Texas, California, and Florida have the greatest potential for generating electricity from solar panels on school rooftops.
A phase 3 study involving 336 participants found that isradipine did not slow the progression of Parkinson's symptoms over three years. Researchers will continue to work on finding a treatment for the disease despite negative results.
A new study investigates potential botanical-drug interactions (BDIs) with Boswellia serrata extract, a widely used anti-inflammatory supplement. The study compared two in vitro methods and found that the sandwich-cultured human hepatocyte model is a more accurate predictor of BDIs.
A new study found that traditional labels of 'gay', 'bisexual', and 'straight' do not accurately describe the complex patterns of attraction and identity over time. Women showed greater fluidity in sexual preference, with one in six identifying as bisexual or in the middle of the sexuality continuum.
A team of researchers has developed a mathematical model to calculate the cost - time and energy - to complete a task based on the number of drones and recharging stations available. The model considers the energy required for each drone to complete its portion of the task and fly to a charging station as needed.
The Gulf killifish has developed adaptive resistance to pollutants in Galveston Bay, Texas, through hybridization with the Atlantic Killifish. This genetic exchange has enabled the species to persist in polluted waters, highlighting the role of inter-species connectivity in adaptation to environmental changes.
Andrea Alù, a leading researcher at The Graduate Center, has been awarded the Vannevar Bush Faculty Fellowship to develop novel materials for extreme wave manipulation in thermal radiation and heat management. His research aims to advance various technologies, including infrared sources and detectors.
A year-long randomized controlled study is being conducted to evaluate the impact of switching from cigarettes to glo on markers of smoking-related disease development. The study aims to observe any favorable changes and determine if THPs may provide a less risky alternative to cigarette smoking.
A field experiment in Uganda found that raising tenants' share of crops from 50% to 75% can increase agricultural output by 60%, thanks to higher investment and risk-taking. The change also led to a sharp gain in overall welfare for tenants, but a 20% drop in landlords' income.
A study analyzed 57 indigenous communities' knowledge of palm trees, revealing that the network is fragile and minimal loss has significant consequences. The researchers highlighted the importance of cultural factors and transdisciplinary collaboration to strengthen indigenous resilience.
Scientists found that honey bees share immunity with each other and their offspring through RNA 'vaccines' transmitted via royal jelly. This discovery could lead to new ways to protect bees against viruses and diseases.
The study provides a reference framework for breeding and improvement of the peanut crop, revealing the origin of peanut in South America and genetic mechanisms that generated diversity. The team mapped the entire peanut genome, identifying key traits like seed size and disease resistance.
A University of Oklahoma-led study found that explosive volcanic eruptions were more frequent during the Late Paleozoic Ice Age and helped keep large ice sheets stable by blocking sunlight. The research suggests that lessons from this period can inform strategies to mitigate climate change, including stratospheric aerosol geoengineering.
A team of scientists conducted a comprehensive health evaluation on Bronx River turtles, discovering the presence of various environmental contaminants, including PCBs, heavy metals, viruses, and bacteria. The study established a baseline for future comparisons, expanding knowledge of turtle health markers and ecosystems.
Researchers have upgraded a device to test lithium's ability to maintain heat and protect walls in a tokamak, which could help bring fusion energy to Earth. The machine uses a coating of lithium to cover the interior wall of the small tokamak, aiming to replicate fusion on Earth for virtually inexhaustible power.
A species of fish in Texas' Houston Ship Channel adapted to extreme pollution due to its large population, good genes, and luck. The Gulf killifish benefited from genetic resources from a long-distant relative, the Atlantic Coast killifish, which helped it develop resilience and resistance to toxins.
Researchers discovered a new gene mutation that reduces fear and anxiety and increases social interaction in mice, according to a study published in Neuropharmacology. The P4h-tm knockout mice showed striking courage and a lack of learned helplessness compared to control mice.
Stand Up To Cancer has awarded five research teams a total of $1.25 million to explore cross-cutting questions in cancer treatment through innovative collaboration. The grant program aims to bring together outstanding researchers from different teams to make use of the extraordinary talent across the SU2C community.
A UNIGE study found that the number of immigrants Switzerland welcomes greatly affects citizens' opinions, with figures in the media playing a significant role. The researchers discovered that anchoring bias influences public opinion, with high or low initial numbers leading to differing responses.
A new analysis suggests that eliminating emissions from dirty household fuels like wood, dung, coal, and kerosene could bring India's outdoor air pollution levels below the country's standard. This could reduce air pollution-related deaths by approximately 13% and save around 270,000 lives annually.
Researchers found that MSI intensity and mutational load significantly impact MMR-deficient tumors' response to PD-1 therapy. Higher mutational loads result in better responses to treatment.
Researchers identified risks associated with popular alternative treatments like kratom, Imodium, and Xanax, which can cause substantial side effects and high abuse rates. The study also found that 'stacks' or kits combining substances are being used to combat withdrawal symptoms.
Researchers at the University of Bern studied spider venom from the Cupiennius salei species, discovering a dual prey-inactivation strategy involving neurotoxins and metabolic pathways. This complex effect mechanism attacks an organism's muscles, nervous system, and internal homeostasis, causing paralysis, pain, and inflammation.
Researchers found that Zebra Finches preferentially visit nests with large broods, based on chick calls, and not visual cues. This study provides the first evidence that wild birds can use calls from chicks as a social signal to infer breeding success.
Researchers controlled specific neurons in macaques' brains with images generated by artificial neural networks, demonstrating a new tool for neuroscientists to design experiments. This breakthrough uses current computer vision applications to predict and control visually evoked neural responses in primate brains.
Chronic short sleep is linked to clogged arteries and increased mortality rates. Lowered levels of microRNA molecules are now recognized as sensitive biomarkers for cardiovascular health, inflammation, and disease.
Hippos play a key role in transporting silicon from land to water through their faeces, influencing over 76% of the total silicon transported along the Mara River. This process is crucial for ecosystems like Lake Victoria, where a lack of silicon can lead to food shortages and ecosystem collapse.
Researchers identified long-term global effects on water supplies, with drying soils in North America and Eurasia, and wetter regions like the Indian subcontinent. The study suggests severe consequences for humans as warmer temperatures intensify droughts in dry regions.
A Swedish study found that preterm and early term birth are strong risk factors for the development of chronic kidney disease from childhood into mid-adulthood. Preterm birth interrupts kidney development, leading to fewer nephrons forming and an increased risk of high blood pressure and progressive kidney disease.
Researchers at Princeton University have developed a process to isolate hydrogen from industrial wastewater using sunlight and bacteria. This technique doubles the currently accepted rate for scalable technologies that produce hydrogen by splitting water.