A new study using genome re-sequencing analyzed 167 yam species and found that cultivated yam was domesticated from a forest species in the Niger River basin. This challenges previous hypotheses on African plant domestication, suggesting West Africa as a major cradle of crop domestication.
Researchers at CNIC have identified a cellular and molecular mechanism that can induce productive angiogenesis in ischemic tissues. The newly discovered mechanism suggests that manipulating it could lead to optimal therapeutic angiogenesis, which may help treat cardiovascular disease.
Researchers detected and measured specific prion forms of amyloid beta (A-β) and tau proteins in human brain tissue, strongly associated with early-onset Alzheimer's disease. The findings suggest that active A-β and tau prions could drive the disease and prompt exploration of new therapies targeting prions.
Researchers at NIST have collected accurate and comprehensive data on the fundamental aspects of laser welding, enabling better computer simulations. This improved understanding could give industries more control over laser welding processes, leading to faster production times and reduced energy consumption.
The pharmaceutical industry is embracing continuous manufacturing processes, offering reduced costs, factory space, and processing time. Companies like Janssen, Eli Lilly, and Pfizer have received approvals for drugs produced by continuous processes, paving the way for more complex chemistries.
NASA's Aqua and Terra satellites tracked Tropical Cyclone Fani as it strengthened and moved north through the Northern Indian Ocean. The storm showed signs of strong thunderstorms with cloud top temperatures as cold as -63 degrees Fahrenheit, indicating heavy rain potential.
Researchers have found that the drug Tadalafil, used to treat erectile dysfunction, slows or even reverses the progression of heart failure in sheep. The study suggests that the drug may also be effective in humans, offering new hope for treatment of this devastating condition.
A recent study by University of Kent researchers found that palm oil's potential to alleviate poverty depends on its social and environmental context. In Kalimantan, Indonesian villages experienced slower improvements in social and environmental well-being when growing oil palm compared to those without it.
A nationwide study found patients with diabetes discharged with low glucose values have a higher risk of death and rehospitalization; physicians should avoid discharging patients until glucose levels are above 100 mg/dl
Researchers analyzed postmortem brain samples from 24 people with Alzheimer's and 24 without the disease to identify cellular pathways affected by the disease. The study found that axon myelination is disrupted in patients, and gene expression patterns vary significantly between men and women, suggesting potential new drug targets.
A new study suggests that vaccination could reduce the impact of white-nose syndrome in bats by providing immunity against the fungus Pseudogymnoascus destructans. Bats immunized against Pd were less likely to develop WNS or die from the disease in two initial scientific trials.
Researchers investigated risk factors for melanoma dissemination and the impact of time on distant relapse. The findings provide valuable information for improving melanoma treatment outcomes.
In a touchscreen-based task, wolves behaved more prosocially towards their fellow pack members than dogs. Wolves opted to deliver significantly more food to an adjacent enclosure when it held a member of their own pack present.
A new study by University of British Columbia researchers found a correlation between excessive engagement with loot boxes and measures of problem gambling, but not problem video gaming. Loot box use was associated with risky gambling behaviours, suggesting that the feature may be contributing to gambling-like problems in gamers.
A new physical mechanism erodes seabed sediment at depths up to 20 meters, adding nutrients stirred by breaking surface waves. This process complements littoral drift and has significant implications for coastal sediment management practices like dredging.
Two new urine tests have shown promise in accurately detecting bladder cancer, determining its severity, and detecting recurrence. The tests use a gene variant called V1, which is elevated in bladder cancer, and have been found to be 90% effective at detecting the disease.
An international team of scientists has secured a five-year, $6.2 million grant to study HIV and tuberculosis (TB) coinfection in children. The researchers will investigate the disease mechanisms and explore potential therapeutic approaches using nonhuman primate experiments.
Scientists investigate how tropical species are adapting to the newly formed pass in St. Joe Bay, a critical ecosystem with seagrass meadows and diverse marine life. The research aims to understand potential changes in seagrass consumption and its impact on juvenile fish, crabs, and shrimp.
Researchers found the Great Whirl, a massive whirlpool off East Africa, is larger and longer-lived than previously thought. It can grow to over 275,000 square kilometers in area and persist for about 200 days.
The Dementia Friendly Hospital Initiative targets comprehensive training for all hospital staff to improve quality and safety for patients with dementia. The program aims to lower rates for in-hospital injuries, length of stay, and 30-day readmissions.
A study by the University of Saskatchewan found that therapy dog visits can significantly improve the comfort levels and positive feelings of hospital waiting patients. The study showed a noticeable reduction in distress levels and an increase in perceived comfort among patients, regardless of wait time duration.
Researchers discovered that tumors subvert endothelial cells' ability to form new blood vessels, using microRNA to control gene expression. Delivering this microRNA to endothelial cells in mice slowed tumor growth and reduced blood vessel formation.
A new reading of the Mesha Stele suggests that biblical King Balak may have been a historical figure, based on high-resolution images revealing three consonants in the monarch's name. The name is now believed to be 'Balak', a king of Moab mentioned in the biblical story of Balaam, rather than the previously accepted 'House of David'.
Researchers at Cornell University discovered a link between diabetes and increased risk of metastatic cancer, attributed to the glycation of collagen matrices. Elevated blood sugar levels lead to structural changes in collagen fibers, facilitating cancer cell movement through the body.
Researchers found that MDM2 interacts with a mitochondrial protein to promote cancer cell death. Nutlin-3A enhances this interaction, helping kill cancer cells.
Researchers have developed a computational approach to simulate the complex bioelectrical interaction at the tissue scale, enabling more accurate and capable virtual experiments of cell behavior. The technique has potential applications in treating cancer and accelerating combat wound healing.
Researchers from NYU Tandon School of Engineering have developed models to assess pollution exposures at the neighborhood level, but propose advancing to individual-level assessments using data from environmental sensors, mobile, and wearable devices. This could provide evidence-based arguments for change, particularly impacting indivi...
Researchers at Harvard University have developed a new tool that records and controls neural activity in real-time using genetically encoded voltage indicators. This breakthrough enables the study of complex behaviors and neural interactions with unprecedented clarity.
Researchers measured farmland nectar supplies throughout the year, revealing hungry gaps when food supply is not meeting pollinator demand. Early spring and late summer are periods of great nectar deficit on UK farmland.
A large study found that quitting cigarette smoking is associated with a reduced risk of bladder cancer in postmenopausal women. The risk continued to decrease after 10 years of quitting, but even after 30 or more years, risk remained higher for those who had smoked than never-smokers.
Researchers found a new pathway to killing cancer cells by targeting ferroptosis, a type of cell death linked to immune cells. The study suggests that combining ferroptosis sensitizer and checkpoint inhibitor treatments creates a strong immune response that fights tumors.
Research suggests that daily activities such as eating and walking are affected early in the course of rheumatoid arthritis, with most patients experiencing functional disabilities. The study also found that persistent excess in functional disability continued even after diagnosis and treatment.
Researchers at Oak Ridge National Laboratory developed a stretchy plant-derived material with superior adhesion properties, while also advancing additive manufacturing techniques for metal parts. Additionally, they utilized the Summit supercomputer to simulate small modular nuclear reactor designs with improved efficiency.
Researchers repurposed shrink films to make strong grippers that can encapsulate materials or be incorporated into soft robotics. The grippers were made by patterned black ink onto polystyrene sheets, which then wrapped around objects to grip them.
Researchers discovered that neutrophils can induce a previously unrecognized type of cell death in tissues, leading to the destabilization of atherosclerotic plaques. This process causes inflammation, which increases the likelihood of plaque rupture and subsequent cardiovascular events.
The largest study of its kind has identified 190 links between genetic code and birth weight, with two-thirds being discovered for the first time. Both maternal and fetal genetic effects play a role in influencing birth weight, with some genes promoting growth while others restrict it.
Researchers are developing novel derivatives of glucagon to improve rescue kits for hypoglycemia, which can be life-threatening if left untreated. The new solutions aim to enable easy delivery methods like an EpiPen-like device and potentially intranasal delivery.
Researchers at Johns Hopkins Medicine have developed a technique that facilitates precise placement of cancer drugs in the brain using positron emission technology and image-guided drug delivery. This approach shows promising results in improving treatment outcomes for difficult-to-treat brain cancers, such as glioblastoma.
Research found that nematode-infected horned passalus beetles process wood 15% faster than uninfected ones, leading to increased decomposition rates. The parasites are beneficial to the forest ecosystem, enabling the beetles to provide a more effective service
Researchers at the Montreal Clinical Research Institute have made a breakthrough in understanding how neurons navigate to their targets, potentially leading to treatments for spinal cord injuries and motor disorders. The study discovered that Sonic hedgehog molecules act like breadcrumbs to guide axons towards specific locations.
A recent study published in the Academy of Management Journal found that overconfidence and prolonged joy can lead to decreased funding. Presenters who flashed their biggest smiles for three seconds received more funding than those who did so for just two seconds, but those who smiled for four seconds lost funding
Tropical Cyclone Fani is strengthening due to favorable conditions of warm sea surface temperatures and low wind shear. The storm's organization improved, with a tight circular area of powerful thunderstorms around its center of circulation.
Researchers studied how microglia cells in the brain respond to toxic proteins associated with Alzheimer's disease. The study found that age, sex, and genetics affect microglial response, suggesting that modulating this response could lead to new treatments.
A new study reveals that disrupting normal circadian rhythms promotes tumor growth and suppresses the effects of a tumor-fighting drug. Circadian rhythm disruption increases cell proliferation by activating key proteins involved in cell cycle regulation.
A study suggests that the proportion of UK adults on low incomes who face hunger has almost doubled since 2004, with those who are unemployed or disabled being most vulnerable. Nearly one-third of adults with children under 16 were food insecure in 2016.
A new multigene test called EndoPredict has been found to predict chemotherapy benefit in women with hormone receptor-positive, HER2-negative breast cancer. The test was successful in identifying patients who would benefit from chemotherapy and those who could opt out of the treatment.
A 12-year retrospective clinical study shows the long-term effectiveness of PRRT, allowing patients to maintain a high quality of life. The overall response rate is about 70-80 percent, and prognosis is generally favorable for patients who respond to therapy.
A team of international scientists, including those from Samara University, has discovered a new method for synthesizing helicenes, a class of polycyclic aromatic hydrocarbons. This breakthrough may help explain the formation of biological molecules and better understand the mechanisms of combustion reactions.
A small study found that teenagers' fear of being seen while seeking sexual health advice online is a significant barrier to accessing reliable information. The researchers call for more sensitive and user-friendly digital content to address this issue.
Researchers at Université de Montréal found that MEK inhibitor trametinib can reverse hypertrophic cardiomyopathy and valvular obstruction in patients with RIT1-associated NS. Dramatic improvement was seen in two infants treated with the drug, suggesting a new treatment option for life-threatening heart disease.
Studies suggest that fruit flies co-evolving with viruses have increased genetic variation underlying their susceptibility to future infections. The findings have implications for reducing disease, particularly in mosquito populations.
A novel method assesses combined risk of multiple tap water pollutants in California, estimating over 15,000 cancer cases. The study uses a cumulative approach to calculate health impacts of carcinogens and toxic contaminants in public water systems.
Research found that HSV-1 and HSV-2 are mixing together to result in several new, different recombinant versions of herpes. This blurring of lines has important implications for HSV vaccine development.
A new study published in Military Medicine found that a ketogenic diet can lead to significant weight loss and improvements in insulin sensitivity among military personnel. Participants on the keto diet lost an average of 17 pounds and reduced their body fat by 5%, while those on a normal diet experienced no such changes.
Six University of Houston students have earned NSF graduate research fellowships, pursuing research in augmented reality, Mars geology, biomedical engineering, and more. The awards recognize outstanding STEM graduates who will receive a three-year stipend and education allowance.
A group of invasive species experts warns of the economic and environmental risks posed by biological invasions in the US, citing climate change as a major factor. The Trump Administration's budget cut is seen as reckless and inadequate to address the growing threat.
Pork enthusiasts can improve taste, juiciness, and tenderness by cooking chops to the new USDA standard of 145 degrees Fahrenheit. Consumers strongly prefer pork chops cooked to 145 over the old standard of 160 degrees.
A study using family-based genetic analysis has identified the DENND1A gene as playing a major role in PCOS, enabling personalized medicine approaches and better disease prediction. The findings suggest that rare genetic variants in this gene contribute to the disorder's distinctive hormonal profile.
Researchers at Thomas Jefferson University have discovered a way to target both of a bacteria's defenses with one hit, weakening its ability to develop antibiotic resistance. By interfering with a specific type of tRNA molecule, the team was able to make bacteria more susceptible to antibiotics.
A new report calls for increased research into 'limbic-predominant age-related TDP-43 encephalopathy,' or LATE, a degenerative brain disease that affects the elderly and mimics Alzheimer's. Researchers aim to improve prevention, diagnosis, and treatment through better understanding of the condition.