The Center for Translational Exposomics Research (CTER) at USC aims to accelerate environmental health research and find practical solutions. CTER investigates how different exposures impact health across populations using population studies, lab experiments, and community engagement.
Epigenetic changes, driven by oxidative stress, facilitate tumor metastasis through EMT, ECM remodeling, and CTCs survival. Novel therapeutic strategies combining oxidative stress modulators and epigenetic drugs show promise in combating metastasis.
A large-scale clinical trial found that intravenous infusion of exenatide during heart surgeries involving bypass did not significantly reduce the risk of death, stroke, or organ failure. The study included approximately 1,400 adults and a randomized, double-blind, placebo-controlled design.
A study found that pharmacists who received feedback about their heart failure patients increased the frequency of their patient interactions and prescribed more medication adjustments. The intervention, which provided educational resources and monthly audit and feedback emails, led to a significant increase in heart failure management.
A clinical trial found that combining two commonly recommended medications into a single pill lowered blood pressure and was safe among Indian adults. The study's results have significant meaning for South Asian adults, including those living in the US.
In patients with mildly reduced ejection fraction, finerenone resulted in more frequent hyperkalemia but maintained clinical benefit when dose-adjusted. With protocol-directed surveillance, finerenone showed improved clinical outcomes compared to placebo, even at high potassium levels.
The study reveals that atomic resolution SE imaging can distinguish between surface atomic arrangements with high sensitivity, identifying honeycomb-like structures composed of molybdenum and sulfur atoms. The method's depth sensitivity is also demonstrated by the absorption or scattering of SEs from the second layer.
Research highlights edoxaban's effectiveness in reducing stroke and blood clots for patients after bioprosthetic heart valve replacement. Edoxaban was found to be equally or more effective than warfarin, with a predictable pharmacokinetic profile and reduced burden on patients.
The Finerenone Trial found finerenone to be effective in reducing the primary end point in both women and men with heart failure. Finerenone, a mineralocorticoid receptor antagonist, showed similar tolerability in women and men.
A new AI program, PanEcho, has been developed to interpret echocardiography videos independently, reducing wait times and improving timely medical care. The program demonstrated accuracy in estimating continuous echocardiographic parameters and quantifying left ventricle dimensions and function.
Research challenges clonal evolution theory, presenting evidence that tumors can emerge from multiple cells. Single-cell phylogenies were analyzed using DNA barcoding system, revealing striking patterns of parallel clonal expansions within individual lesions.
A new thermochromic hydrogel design can regulate both solar transmission and rapid visible-light stealth at any temperature, with potential applications in energy-efficient windows, military equipment, and anti-counterfeiting. The innovation enables fast response times of just 1 second.
Researchers used Intermountain Risk Score to predict major cardiac events in patients being evaluated for kidney transplant, with a five-year follow-up period showing 171 patients experiencing cardiac events. The study's findings suggest the potential use of calculating such a score in people undergoing kidney transplant evaluation.
A randomized trial found reconditioned pacemakers comparable to new devices in terms of safety and effectiveness up to 90 days after implantation. However, longer-term follow-up is necessary to confirm the safety and efficacy of reconditioned devices.
Researchers developed a dual-function molecule (LXW7)2-SILY to remodel native extracellular matrix at ischemic sites, enhancing endothelial cell adhesion and survival. This approach improved vascularization, blood perfusion, and tissue regeneration in mouse hindlimb ischemia models.
A new study introduces the PWAS Hub, a powerful tool that explores gene-disease connections across 99 common diseases. The platform identifies genes linked to specific conditions and provides valuable genetic insights for clinicians and researchers.
A study found that 64% of clinical trials for the top 30 highest-revenue medicines had their data accessible to researchers, a significant improvement over prior assessments. Companies using independent platforms achieved higher eligibility rates than those relying on internal processes.
Research found that spironolactone reduced the likelihood of heart failure after a heart attack, but did not significantly reduce deaths or other severe heart-related events. The study included over 7,000 adults in 14 countries who had experienced a severe heart attack.
Path planning is vital for navigating micro-/nanorobots in complex and dynamic environments. Micro-/nanorobots play a significant role in advancing medical and biological applications, enabling targeted drug delivery and minimally invasive surgery.
Patients with transthyretin amyloid cardiomyopathy experience frequent decline in kidney function, associated with higher mortality risk. eGFR decline is an independent marker of disease progression guiding treatment optimization.
Research published in European Heart Journal reveals that taking an NSAID with anticoagulant medication increases the risk of internal bleeding. The study found a significant increase in bleeding risks for various organs, including gut, brain, lungs, and bladder.
Researchers aim to harness sunlight into laser beams using photosynthetic structures from bacteria, enabling efficient and sustainable power transmission in space. The project's goal is to provide reliable energy for lunar bases, Mars missions, and terrestrial wireless power transmission.
A recent study published in Journal of Interprofessional Care highlights the importance of strong teamwork and face-to-face communication in improving patient care within hospitals. The research, conducted by researchers at the University of Colorado Anschutz Medical Campus, found that frequent in-person interactions between healthcare...
A randomized clinical trial found partial cardiac denervation effective in preventing postoperative atrial fibrillation after isolated coronary artery bypass grafting without additional complications. This suggests partial cardiac denervation as a viable option for preventing postoperative atrial fibrillation after CABG.
A recent study found that electronic letter reminders highlighting the cardiovascular benefits of influenza vaccines increased vaccination rates among over 2 million adults in Denmark. The strategy showed a greater impact on those who have had a heart attack, improving flu shot rates by potentially being cardioprotective. The research ...
Researchers have developed a mindfulness therapy tailored to teenagers to combat increasing levels of depression and mental health problems. The ATTEND programme teaches participants to manage negative thought patterns and focus on the present moment, offering a family-centred approach to tackling depression.
Researchers found that ablation reduced ICD shocks for ventricular tachycardia and episodes of VT not detected by the ICD. This minimally invasive procedure destroys abnormal heart tissue causing VT, offering a better alternative to long-term medication side effects.
A recent study published at the American Heart Association's Scientific Sessions 2024 found that blood thinners did not reduce cognitive decline in adults younger than age 65 who have atrial fibrillation (AFib) but no other risk factors for stroke. The trial included over 1,200 participants and followed them for an average of 3.7 years...
The international SUMMIT trial found tirzepatide lowered the risk of worsening heart failure events and cardiovascular death in obese adults with preserved ejection fraction. Participants experienced improved health status, physical function, and exercise tolerance compared to placebo.
A new study by Intermountain Health found that air pollution primarily increases inflammation in patients with heart disease, particularly those with heart failure. Elevated inflammatory markers were observed in these patients during periods of poor air quality, suggesting they are more susceptible to the impacts of air pollution.
New research reveals that hormone therapy can alter skeletal size and shape in transgender individuals who previously suppressed puberty. Transgender men treated with puberty blockers and hormone therapy have broader shoulders and a smaller pelvic inlet, while women have a larger pelvis after treatment from early puberty.
A new study reveals that an AI algorithm can accurately detect early-stage metabolic-associated steatotic liver disease (MASLD) in patients who meet the criteria, leaving 83% undiagnosed. This highlights the need for improved screening and diagnosis methods to prevent progression to advanced liver disease.
Researchers evaluated coronary heart disease polygenic risk scores to determine their performance and agreement at the population level. They found that while scores performed similarly, they generated highly variable individual-level risk estimates, highlighting the need for refined statistical methods.
Researchers studied heart failure patients in zero gravity to assess the impact on left ventricular filling pressures. They found that external constraint affects cardiac hemodynamics, leading to changes in blood pressure and potential new treatment avenues for heart failure management.
Climate change is responsible for 19% of the current dengue burden, with a potential to spark an additional 40%-60% spike by 2050. A study found that moderating global warming would also moderate climate impacts on dengue infections.
A recent study found that intensive systolic blood pressure reduction approaches can significantly reduce the risk of major cardiovascular events in adults with Type 2 diabetes. Lowering systolic blood pressure to less than 120mmHg led to a reduced risk of heart attack, stroke, and death from cardiovascular disease.
Researchers found that membership inference attacks on large language models (LLMs) are not effective in measuring information exposure risks. The common method used to test LLM leaks suffers from ambiguity due to the fluidity of language, making it difficult to define a representative set of non-member candidates.
Ochsner Health hospitals have earned a Fall 2024 “A” Hospital Safety Grade from The Leapfrog Group, reflecting their commitment to excellence and patient wellbeing. The Leapfrog Hospital Safety Grade program assigns grades based on performance measures reflecting errors, accidents, injuries, and infections.
The ASPB has appointed five plant biologists as the 2025 Plantae Editors, who will engage and grow the Plantae community alongside the 2025 Fellows. They will facilitate connections across the global plant science community, lead teams, and provide content development expertise.
The VST-SMASH survey captures new images of five galaxies showcasing their unique structures and assembly histories. The Italian National Institute for Astrophysics (INAF) at ESO Paranal observatory used the VST telescope to produce these glorious galaxy portraits.
The Department of Energy's Quantum Computing User Program is releasing a Request for Information to gather input on current and upcoming availability of quantum computing resources. The program aims to understand the readiness of these resources for quantum computing research and engage with the diversity of stakeholders in the field.
Tova Holmes, a UT Physics Professor, has been awarded the prestigious Cottrell Scholar Award for her groundbreaking research on muon particles and collider technology. Her work aims to create a more efficient and streamlined process for studying these elusive particles, which could revolutionize our understanding of the universe.
Keck Hospital of USC has received an 'A' Hospital Safety Grade from The Leapfrog Group for the ninth consecutive year. The hospital's dedication to maintaining high standards of quality and safety is reflected in its ability to meet or exceed performance benchmarks.
The Speech Accessibility Project is working with two new partners, The Matthew Foundation and the Massachusetts Down Syndrome Congress, to recruit adults with Down syndrome and other conditions. The project aims to provide voice command devices to improve inclusion and employment opportunities for individuals with disabilities.
The National Comprehensive Cancer Network (NCCN) is collaborating with leading cancer centers in China to improve cancer treatment and outcomes. NCCN Guidelines provide evidence-based recommendations for cancer treatment, prevention, and supportive care, guiding high-quality care globally.
The University of Tennessee will place 5,000 East Tennesseans on the path to good jobs in the green economy over three years. The initiative focuses on underrepresented workers and addresses growing demand for skilled labor.
Global experts and medical professionals gathered in Tashkent to address rare diseases, enhancing patient care. The forum highlighted key findings on diagnosis and treatment of rare genetic disorders in Uzbekistan.
Goethe University has awarded two prizes, 'Public Service Fellowship' to human geographer Martin Lanzendorf and 'New Horizon' to the Science Garden team, recognizing their commitment to sustainability and social impact. The prizes are intended to motivate university employees and focus attention on important topics.
The university's education across its degree apprenticeship programmes was judged Outstanding in all five categories: quality, behaviour, personal development, leadership and management. This assessment highlights Queen Mary's leading achievements in ensuring graduates have the required skills to compete within a global market.
The NASA Goddard Lidar team has developed a system that can produce higher resolution data within a smaller space, significantly increasing efficiency compared to current models. This technology, known as CASALS, uses artificial intelligence and other technologies to allow the instrument to make its own decisions while in orbit.
Professor Maarja Öpik will lead the journal's international board of Editors, focusing on all aspects of plant biology. She aims to maintain an active and engaging scientific community, publishing inspiring papers that contribute to strengthening New Phytologist.
Researchers at St. Jude Children's Research Hospital identified a key role for glutamine in red blood cell development and disease. Glutamine metabolism plays a critical role in removing toxic byproducts, such as ammonium, that can accumulate during heme production.
A study of 89,530 participants found that more than 10.5 hours of sedentary behavior per day increases the risk of heart failure and cardiovascular death, even among those who meet recommended exercise levels. Replacing excessive sitting time with physical activity can lower heart health risks.
Researchers from China successfully performed a remote robot-assisted laparoscopic hysterectomy across 1,200 km using the Edge MP1000 and 5G technology. The surgery marked a new stage in remote medical technology with low latency, high precision, and high reliability.
Researchers discovered a class of unusually large and red galaxies, called Ultra-red Flattened Objects (UFOs), near the limit of Hubble's observable range. The James Webb Space Telescope's infrared capabilities allowed them to spot these 'dustier cousins' of the Milky Way.
Researchers found consistent formation age of 2807 Ma for 107 basalt fragments from the Chang'e-6 sample, indicating local volcanic activity at the landing site. The oldest lunar basalt sample, dated to 4203 Ma, suggests distinct mantle sources for the two volcanic episodes.
Researchers discovered a specific protein controlling the colour difference in parrots, allowing them to transform red psittacofulvins into yellow. This 'dial-like' mechanism uses an aldehyde dehydrogenase gene to regulate the intensity of colourful plumage.
Scientists have successfully used optogenetics to control seizure activity in living human brain tissue, opening doors to new treatments for epilepsy and other neurological diseases. By switching off specific neurons with light pulses, researchers can prevent seizures from occurring, providing a less invasive alternative to surgery.
Researchers at the University of Birmingham create a ruthenium-based material with complex disordered magnetic properties, fulfilling the Kitaev quantum spin liquid state requirements. This breakthrough opens up new pathways for exploring these states of matter and provides a route to magnetic properties that don't follow classical laws.
Researchers explore potential synergies between chemotherapy, cannabinoids, and intermittent serum starvation in treating colorectal cancer. Combining these therapies could create a strong synergy by depriving cancer cells of glucose, making them more susceptible to treatment.