Researchers have pinpointed six pivotal signaling pathways driving osteosarcoma progression, offering a roadmap for developing precision therapies. Targeting these pathways simultaneously may curb both primary growth and metastasis in osteosarcoma patients.
Binary indium chalcogenides exhibit unique structural properties and excellent thermoelectric performance, making them valuable for research and applications. The review reveals the importance of mixed valence states and unconventional chemical bonds in regulating electron-phonon transport and achieving low lattice thermal conductivity.
Researchers discovered a way to boost T cells' ability to fight cancer by rewiring their energy metabolism. By blocking Ant2 protein, they created a state of heightened readiness and potency in T cells, leading to greater stamina, faster replication, and sharper targeting of cancerous threats.
A new study from NYU Abu Dhabi found that high-energy particles from space, known as cosmic rays, could create energy needed to support life underground on planets and moons. This process, called radiolysis, can power life even in dark, cold environments with no sunlight.
Researchers found that external cues alleviated pain for all participants but only half reported less pain with placebo treatment. Predictive cues were less impactful when patients received placebo treatment. The study suggests cue-based expectations have more consistent effects than treatment-based expectations.
A recent study using Mendelian randomization found no significant causal links between molybdenum levels and cardiovascular diseases. The research suggests that Mo-based biomaterials are safe for use in vascular interventions, providing critical reassurance for their continued development.
Researchers found that high body-fat percentage was strongly linked to increased mortality risk from any cause and heart disease. In contrast, overweight/obese BMI was not associated with a higher risk of death.
A novel heterojunction nanoparticle filler, TiO2@Zn/Co-ZIF, enhances the ionic conductivity and interfacial stability of PVDF-based composite solid-state electrolytes. The resulting electrolyte demonstrates exceptional performance in Li-ion batteries, including high conductivity and lithium-ion transference numbers.
A study of over 100,000 veterans found that those who secured housing were twice as likely to receive cancer screenings. This improvement in care underscores the importance of sustained investment in supportive housing and person-centered care models.
A new study by Binghamton University reveals that 97.5% of women in STEM graduate programs experience moderate to severe impostor feelings, which can lead to poorer mental health and increased burnout. Strategies such as shifting mindset and social support may help alleviate these feelings.
Researchers have discovered that CMTM3 enhances lipid accumulation and adipogenic gene expression in 3T3-L1 cells. By interacting with PPARγ, CMTM3 boosts its transcriptional activity and protein stability during fat cell differentiation.
Researchers from FAU's Schmidt College of Medicine recommend using high-potency statins as the primary pharmacologic approach in treating and preventing cardiovascular disease. Lifestyle changes, such as regular physical activity and a healthy diet, are also crucial in reducing cardiovascular risk.
The American Heart Association's Get With The Guidelines - Stroke program has been incorporated into US News & World Report's nationwide stroke hospital ratings. Hospitals with an 85% or higher rate of IV thrombolytic administration within 60 minutes of arrival will receive full credit for this new measure.
A large-scale study has identified 48 genes linked to stuttering, shedding light on the neurological pathways of risk. The findings suggest a shared genetic basis with autism, depression, and musicality, providing a foundation for future research.
A study assessing the Enhanced Primary Care Diabetes model found that Black patients were less likely to meet diabetes care goals, despite more frequent nurse touchpoints. Younger age, insulin use, and fewer initial medication counts were associated with slower progress.
A single bout of exercise increases myokine levels, reducing cancer growth by 20-30%. Regular exercise helps reduce inflammation and improve body composition, leading to a lower risk of recurrence and mortality.
Researchers found that certain antiviral genes become less active with age in people with lupus, leading to fewer inflammatory proteins. This reversal of 'inflammaging' may explain why symptoms improve in some older patients, allowing them to approach healthy aging.
Researchers reanalyzed the coelacanth's skull musculature and found that only 13% of previously identified evolutionary muscle novelties were accurate. The study also identified nine new evolutionary transformations related to feeding and respiration, revealing a more similar anatomy to cartilaginous fish and tetrapods.
Robot-assisted lymphovenous bypass surgeries offer reduced pain, faster recovery, and shorter hospital stays for patients with lymphedema. The procedure has improved quality of life dramatically, enabling earlier intervention and reducing swelling.
A new treatment for corneal scarring is being developed by University of Houston optometry researcher Tarsis G. Ferreira. The treatment uses a natural protein called decorin to block scarring and unwanted blood vessel growth, offering hope for people with injured corneas.
New research highlights TNF-α system's involvement in central nervous system disorders such as depression, narcolepsy, multiple sclerosis, Alzheimer's, and Parkinson's disease. The study reveals that psychotropic drugs may activate the TNF-α system through various mechanisms.
Researchers developed a new 3D printing method that creates strong, high-quality silicon carbide (SiC) ceramic parts at lower temperatures. The method uses vat-polymerization and adds silica to improve material quality, resulting in comparable strength to ceramics sintered at higher temperatures.
Researchers from Hebei University of Engineering developed a novel strategy for Al2O3 ceramic toughening using TiC-coated SiCw core-shell structured whiskers, achieving remarkable fracture toughness. The unique core-shell architecture creates multiscale heterogeneity, generating intricate stress fields that activate multiple energy-dis...
Researchers discovered that indole, a key tryptophan metabolite produced by gut bacteria, can restore enteroendocrine cells in the intestines, which are diminished in obesity. The study suggests that microbial metabolites derived from dietary tryptophan may hold promise as a novel therapy for obesity-associated metabolic complications.
Researchers developed a novel fabrication technique that sidesteps traditional etching by applying a soft PDMS mask during insulation. This approach achieved uniformly exposed tips with minimal residue, resulting in excellent signal clarity and structural reliability.
The RTVS network, launched in 2020, provides a range of virtual services to support patients, physicians, and health care providers in rural communities. The program has seen increased use and benefits, including improved access to primary, emergency, and specialized care.
Researchers at Washington University in St. Louis have developed a new type of bioplastic, called LEAFF, which is strong, biodegradable, and printable. This innovation uses cellulose nanofibers to address the limitations of current bioplastics and has potential applications for sustainable packaging.
Phytochemicals have shown promising effects against leishmaniasis, disrupting mitochondrial function and inducing apoptosis in Leishmania parasites. The study highlights the potential of these compounds to modulate host immune responses and target parasite enzymes.
A new silicone patch with star-shaped microneedles, called the ExoPatch, distinguishes melanoma from healthy skin in mice, capturing cancer biomarkers from exosomes. The test shows promise for early detection of the most aggressive form of skin cancer without a biopsy or blood draw.
A new study suggests that offering self-collection kits during routine GP appointments can increase participation rates among women overdue for cervical screening. The approach shows promise in reducing the number of cases and saving lives.
A study found that public support for releasing women first is widespread, but linked to beliefs about gender, with benevolent sexism being a key predictor. Attitudes also followed a pattern tied to ideals of motherhood, suggesting that these cultural narratives may weigh more heavily than gender alone in shaping public judgment.
A new study from Karolinska Institutet shows that healthy diets can slow down the accumulation of chronic diseases in older adults, while inflammatory diets accelerate it. Researchers followed over 2,400 older adults for 15 years and found those on healthy diets had a slower development of cardiovascular disease and dementia.
The US POINTER trial found that a structured lifestyle intervention of regular exercise, adherence to the MIND diet and social engagement had greater benefits on global cognition compared to an unstructured intervention. The study showed significant cognitive benefit after two years in older adults at elevated risk of Alzheimer disease.
New research reveals neutrophils' complex role in cancer, with both pro-tumor and anti-tumor effects. Understanding their plasticity is crucial for developing novel therapeutic strategies that harness their anti-tumor potential.
A comprehensive review synthesizes decades of research on Asian monsoon climate prediction, highlighting three key pillars: ENSO, atmospheric teleconnections, and monsoon-ocean interactions. The study emphasizes the need for a multi-pronged approach to overcome challenges in forecasting, including leveraging AI and improving model accu...
Triboelectric nanogenerator (TENG)-enabled smart sports offer self-powered sensing fabrics, AI-enhanced analytics, and eco-friendly materials. These innovations enable real-time data monitoring, injury prevention, and rehabilitation, redefining training, competition, and athletic performance.
A preference for domestic vaccines was observed in various countries during the pandemic, including Brazil, Mexico, India, Iran, and the US. Researchers identified a clear pattern of people choosing vaccines from their own country or those from Western nations like Germany, the UK, and the US.
Patients with type 2 diabetes experience more severe financial difficulties compared to those without the condition. The study emphasizes the importance of considering patient financial health when treating type 2 diabetes, particularly for vulnerable populations.
Researchers develop efficient template-guided method for synthesizing endo-functionalized oligophenylene cages with yields up to 68%. The approach enables precise control over internal environments, leading to selective molecular encapsulation and recognition capabilities.
MIT researchers developed a fully autonomous experimental platform that can efficiently identify optimal polymer blends. The system uses a genetic algorithm to explore a wide range of potential combinations and autonomously identifies hundreds of blends that outperform their constituent polymers. This workflow could lead to advancement...
A recent Irish study analyzed national prescription data for over 533,000 community-dwelling adults aged 65 and found five significant prescribing cascades. These cascades involve medications prescribed together, such as calcium channel blockers with diuretics or benzodiazepines with antipsychotics.
Researchers at the Institute for Basic Science have discovered that excessive GABA produced by astrocytes impairs fear extinction in PTSD. A new brain-permeable drug called KDS2010 has reversed PTSD-like symptoms in mice, providing a promising therapeutic approach.
A new study by Chinese researchers uses high-resolution satellite data to quantify global methane emissions from landfills, revealing open dumps emit 4.8 times more methane than engineered sanitary landfills.
A new study found that B.C.'s universal, no-cost coverage policy led to a significant increase in the use of long-acting reversible contraception among reproductive-aged women. The study tracked nearly 860,000 women and discovered that cost was a major barrier to accessing effective birth control methods like IUDs and implants.
Researchers have discovered a link between ecosystem productivity and methane emissions in Arctic lake sediments. Higher productivity is associated with higher methane production, which can accelerate warming. The study suggests that even small environmental changes can have significant effects on methane emissions.
Researchers grew a 'whole-brain' organoid with neural tissues and rudimentary blood vessels, opening possibilities for studying neuropsychiatric disorders. The multi-region brain organoid retained a broad range of neuronal cell types and formed electrical activity, allowing for real-time study of neurodevelopmental disorders.
Genethon is launching a Phase 3 clinical trial in Europe for its low-dose microdystrophin gene therapy GNT0004, targeting boys aged 6 to 10 with retained walking ability. The trial aims to demonstrate efficacy and tolerance of the treatment.
Researchers developed a refined imaging method using fifth-order near-field signals to sharpen visualization of nanoscale materials under infrared light. The technique captures subtle plasmonic effects and material interfaces with high fidelity, surpassing the resolution of standard atomic force microscopy.
A new artificial biosensor developed by University of California, Santa Cruz's Andy Yeh can accurately measure cortisol levels across all relevant ranges for human health. The sensor uses a smartphone camera to detect light emissions, providing high sensitivity and dynamic range for detecting small molecule analytes.
A new study reveals that pedestrians are now walking faster and spending less time in public spaces. Researchers analyzed 40 years of video footage to find a 14% decline in people lingering in these areas.
Mayo Clinic has deployed NVIDIA Blackwell infrastructure to accelerate pathomics, drug discovery, and precision medicine using generative AI. The new infrastructure enables faster pathology slide analysis and foundation model development, reducing work time from four weeks to one week.
Researchers at the University of Tokyo found that certain scent compounds in female body odor increase during ovulation and can subtly influence how men feel, making them perceive the scent as more pleasant and reducing stress. The study suggests that smell may play a role in shaping human interactions.
Adults with moderate or severe substance-use symptoms have a higher chance of initiating and staying on OUD medication treatment. The study found that most primary care patients with opioid use disorder symptoms did not receive evidence-based treatment, but those who initiated treatment remained engaged.
Dr. Muhammad Mamdani advocates for reframing Canada's approach to funding health research and commercialization to focus on clinical uses and align with healthcare organizations. This will help reduce the failure rate of health start-ups, which are often disconnected from clinical environments.
A study by Professor Alex Coad found that university startup entrepreneurs lack the commercial acumen and autonomy needed for success, with a focus on societal impact rather than financial performance. This can be overcome with guidance, peer networks, and support institutions, enabling them to adapt to their entrepreneurial role.
Researchers have demonstrated a novel vaccine delivery method using dental floss, which stimulates the production of antibodies in mucosal surfaces, such as the lining of the nose and lungs. This technique has shown superior antibody response compared to current oral vaccination methods.
Researchers used machine learning to detect subtle behavioral changes in mouse models of Parkinson's disease, revealing that high-speed movements are the first affected behaviors. Levodopa treatment improves movement speed but not other attributes of these movements.
A recent study analyzed data from community health centers in the US between 2012-2020, finding that U.S.-born Latinos have significantly higher obesity rates compared to foreign-born Latino and non-Hispanic White youth. The researchers noted a trend of increasing obesity prevalence over time across all three groups.
A multi-omics study identified three critical genes—HCK, LILRA4, and PPT1—that are closely linked to OSCC risk, immune regulation, and treatment sensitivity. The study highlights how these genes could serve as powerful biomarkers for early detection and personalized treatment.
Researchers have created tiny artificial cells that accurately keep time, shedding light on biological clocks and their mechanisms. The study reveals that high concentrations of clock proteins are necessary to maintain proper function and synchronizing timing across a population plays a crucial role.